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Protein

Histidine permease

Gene

HIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity permease for histidine.

Miscellaneous

Present with 688 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • high-affinity L-histidine transmembrane transporter activity Source: SGD

GO - Biological processi

  • histidine transport Source: SGD
  • manganese ion transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30880-MONOMER

Protein family/group databases

TCDBi2.A.3.10.1 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine permease
Gene namesi
Name:HIP1
Ordered Locus Names:YGR191W
ORF Names:G7572
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR191W
SGDiS000003423 HIP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 121ExtracellularSequence analysis5
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 165CytoplasmicSequence analysisAdd BLAST23
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Topological domaini186 – 203ExtracellularSequence analysisAdd BLAST18
Transmembranei204 – 223HelicalSequence analysisAdd BLAST20
Topological domaini224 – 236CytoplasmicSequence analysisAdd BLAST13
Transmembranei237 – 255HelicalSequence analysisAdd BLAST19
Topological domaini256 – 279ExtracellularSequence analysisAdd BLAST24
Transmembranei280 – 297HelicalSequence analysisAdd BLAST18
Topological domaini298 – 321CytoplasmicSequence analysisAdd BLAST24
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 376ExtracellularSequence analysisAdd BLAST34
Transmembranei377 – 396HelicalSequence analysisAdd BLAST20
Topological domaini397 – 423CytoplasmicSequence analysisAdd BLAST27
Transmembranei424 – 442HelicalSequence analysisAdd BLAST19
Topological domaini443 – 451ExtracellularSequence analysis9
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 491CytoplasmicSequence analysisAdd BLAST19
Transmembranei492 – 510HelicalSequence analysisAdd BLAST19
Topological domaini511 – 530ExtracellularSequence analysisAdd BLAST20
Transmembranei531 – 549HelicalSequence analysisAdd BLAST19
Topological domaini550 – 603CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541541 – 603Histidine permeaseAdd BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP06775
PaxDbiP06775
PRIDEiP06775

PTM databases

iPTMnetiP06775
SwissPalmiP06775

Interactioni

Protein-protein interaction databases

BioGridi33444, 21 interactors
DIPiDIP-5549N
IntActiP06775, 6 interactors
MINTiP06775
STRINGi4932.YGR191W

Structurei

3D structure databases

ProteinModelPortaliP06775
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744
HOGENOMiHOG000261848
InParanoidiP06775
KOiK16261
OMAiVLIASFW
OrthoDBiEOG092C164R

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P06775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNPLKKEY WADVVDGFKP ATSPAFENEK ESTTFVTELT SKTDSAFPLS
60 70 80 90 100
SKDSPGINQT TNDITSSDRF RRNEDTEQED INNTNLSKDL SVRHLLTLAV
110 120 130 140 150
GGAIGTGLYV NTGAALSTGG PASLVIDWVI ISTCLFTVIN SLGELSAAFP
160 170 180 190 200
VVGGFNVYSM RFIEPSFAFA VNLNYLAQWL VLLPLELVAA SITIKYWNDK
210 220 230 240 250
INSDAWVAIF YATIALANML DVKSFGETEF VLSMIKILSI IGFTILGIVL
260 270 280 290 300
SCGGGPHGGY IGGKYWHDPG AFVGHSSGTQ FKGLCSVFVT AAFSYSGIEM
310 320 330 340 350
TAVSAAESKN PRETIPKAAK RTFWLITASY VTILTLIGCL VPSNDPRLLN
360 370 380 390 400
GSSSVDAASS PLVIAIENGG IKGLPSLMNA IILIAVVSVA NSAVYACSRC
410 420 430 440 450
MVAMAHIGNL PKFLNRVDKR GRPMNAILLT LFFGLLSFVA ASDKQAEVFT
460 470 480 490 500
WLSALSGLST IFCWMAINLS HIRFRQAMKV QERSLDELPF ISQTGVKGSW
510 520 530 540 550
YGFIVLFLVL IASFWTSLFP LGGSGASAES FFEGYLSFPI LIVCYVGHKL
560 570 580 590 600
YTRNWTLMVK LEDMDLDTGR KQVDLTLRRE EMRIERETLA KRSFVTRFLH

FWC
Length:603
Mass (Da):66,006
Last modified:February 1, 1995 - v2
Checksum:i77DD34F1DA95E75F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11980 Genomic DNA Translation: AAA34673.1
X82408 Genomic DNA Translation: CAA57802.1
Z72975 Genomic DNA Translation: CAA97217.1
BK006941 Genomic DNA Translation: DAA08284.1
PIRiS55869
RefSeqiNP_011707.1, NM_001181320.1

Genome annotation databases

EnsemblFungiiYGR191W; YGR191W; YGR191W
GeneIDi853104
KEGGisce:YGR191W

Similar proteinsi

Entry informationi

Entry nameiHIP1_YEAST
AccessioniPrimary (citable) accession number: P06775
Secondary accession number(s): D6VUX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health