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Protein

Histidine permease

Gene

HIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity permease for histidine.

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • high-affinity L-histidine transmembrane transporter activity Source: SGD

GO - Biological processi

  • histidine transport Source: SGD
  • manganese ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30880-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.1. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine permease
Gene namesi
Name:HIP1
Ordered Locus Names:YGR191W
ORF Names:G7572
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR191W.
SGDiS000003423. HIP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95CytoplasmicSequence analysisAdd BLAST95
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 121ExtracellularSequence analysis5
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 165CytoplasmicSequence analysisAdd BLAST23
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Topological domaini186 – 203ExtracellularSequence analysisAdd BLAST18
Transmembranei204 – 223HelicalSequence analysisAdd BLAST20
Topological domaini224 – 236CytoplasmicSequence analysisAdd BLAST13
Transmembranei237 – 255HelicalSequence analysisAdd BLAST19
Topological domaini256 – 279ExtracellularSequence analysisAdd BLAST24
Transmembranei280 – 297HelicalSequence analysisAdd BLAST18
Topological domaini298 – 321CytoplasmicSequence analysisAdd BLAST24
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 376ExtracellularSequence analysisAdd BLAST34
Transmembranei377 – 396HelicalSequence analysisAdd BLAST20
Topological domaini397 – 423CytoplasmicSequence analysisAdd BLAST27
Transmembranei424 – 442HelicalSequence analysisAdd BLAST19
Topological domaini443 – 451ExtracellularSequence analysis9
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 491CytoplasmicSequence analysisAdd BLAST19
Transmembranei492 – 510HelicalSequence analysisAdd BLAST19
Topological domaini511 – 530ExtracellularSequence analysisAdd BLAST20
Transmembranei531 – 549HelicalSequence analysisAdd BLAST19
Topological domaini550 – 603CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
  • vacuole Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541541 – 603Histidine permeaseAdd BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP06775.
PRIDEiP06775.

PTM databases

iPTMnetiP06775.
SwissPalmiP06775.

Interactioni

Protein-protein interaction databases

BioGridi33444. 19 interactors.
DIPiDIP-5549N.
IntActiP06775. 2 interactors.
MINTiMINT-515006.

Structurei

3D structure databases

ProteinModelPortaliP06775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP06775.
KOiK16261.
OMAiNMLDVKS.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNPLKKEY WADVVDGFKP ATSPAFENEK ESTTFVTELT SKTDSAFPLS
60 70 80 90 100
SKDSPGINQT TNDITSSDRF RRNEDTEQED INNTNLSKDL SVRHLLTLAV
110 120 130 140 150
GGAIGTGLYV NTGAALSTGG PASLVIDWVI ISTCLFTVIN SLGELSAAFP
160 170 180 190 200
VVGGFNVYSM RFIEPSFAFA VNLNYLAQWL VLLPLELVAA SITIKYWNDK
210 220 230 240 250
INSDAWVAIF YATIALANML DVKSFGETEF VLSMIKILSI IGFTILGIVL
260 270 280 290 300
SCGGGPHGGY IGGKYWHDPG AFVGHSSGTQ FKGLCSVFVT AAFSYSGIEM
310 320 330 340 350
TAVSAAESKN PRETIPKAAK RTFWLITASY VTILTLIGCL VPSNDPRLLN
360 370 380 390 400
GSSSVDAASS PLVIAIENGG IKGLPSLMNA IILIAVVSVA NSAVYACSRC
410 420 430 440 450
MVAMAHIGNL PKFLNRVDKR GRPMNAILLT LFFGLLSFVA ASDKQAEVFT
460 470 480 490 500
WLSALSGLST IFCWMAINLS HIRFRQAMKV QERSLDELPF ISQTGVKGSW
510 520 530 540 550
YGFIVLFLVL IASFWTSLFP LGGSGASAES FFEGYLSFPI LIVCYVGHKL
560 570 580 590 600
YTRNWTLMVK LEDMDLDTGR KQVDLTLRRE EMRIERETLA KRSFVTRFLH

FWC
Length:603
Mass (Da):66,006
Last modified:February 1, 1995 - v2
Checksum:i77DD34F1DA95E75F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11980 Genomic DNA. Translation: AAA34673.1.
X82408 Genomic DNA. Translation: CAA57802.1.
Z72975 Genomic DNA. Translation: CAA97217.1.
BK006941 Genomic DNA. Translation: DAA08284.1.
PIRiS55869.
RefSeqiNP_011707.1. NM_001181320.1.

Genome annotation databases

EnsemblFungiiYGR191W; YGR191W; YGR191W.
GeneIDi853104.
KEGGisce:YGR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11980 Genomic DNA. Translation: AAA34673.1.
X82408 Genomic DNA. Translation: CAA57802.1.
Z72975 Genomic DNA. Translation: CAA97217.1.
BK006941 Genomic DNA. Translation: DAA08284.1.
PIRiS55869.
RefSeqiNP_011707.1. NM_001181320.1.

3D structure databases

ProteinModelPortaliP06775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33444. 19 interactors.
DIPiDIP-5549N.
IntActiP06775. 2 interactors.
MINTiMINT-515006.

Protein family/group databases

TCDBi2.A.3.10.1. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP06775.
SwissPalmiP06775.

Proteomic databases

MaxQBiP06775.
PRIDEiP06775.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR191W; YGR191W; YGR191W.
GeneIDi853104.
KEGGisce:YGR191W.

Organism-specific databases

EuPathDBiFungiDB:YGR191W.
SGDiS000003423. HIP1.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP06775.
KOiK16261.
OMAiNMLDVKS.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-30880-MONOMER.

Miscellaneous databases

PROiP06775.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIP1_YEAST
AccessioniPrimary (citable) accession number: P06775
Secondary accession number(s): D6VUX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 688 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.