Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidine permease

Gene

HIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity permease for histidine.

GO - Molecular functioni

  • high-affinity L-histidine transmembrane transporter activity Source: SGD

GO - Biological processi

  • histidine transport Source: SGD
  • L-histidine transmembrane transport Source: GOC
  • manganese ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30880-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.1. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine permease
Gene namesi
Name:HIP1
Ordered Locus Names:YGR191W
ORF Names:G7572
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR191W.
SGDiS000003423. HIP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595CytoplasmicSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Topological domaini117 – 1215ExtracellularSequence analysis
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST
Topological domaini143 – 16523CytoplasmicSequence analysisAdd
BLAST
Transmembranei166 – 18520HelicalSequence analysisAdd
BLAST
Topological domaini186 – 20318ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22320HelicalSequence analysisAdd
BLAST
Topological domaini224 – 23613CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25519HelicalSequence analysisAdd
BLAST
Topological domaini256 – 27924ExtracellularSequence analysisAdd
BLAST
Transmembranei280 – 29718HelicalSequence analysisAdd
BLAST
Topological domaini298 – 32124CytoplasmicSequence analysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence analysisAdd
BLAST
Topological domaini343 – 37634ExtracellularSequence analysisAdd
BLAST
Transmembranei377 – 39620HelicalSequence analysisAdd
BLAST
Topological domaini397 – 42327CytoplasmicSequence analysisAdd
BLAST
Transmembranei424 – 44219HelicalSequence analysisAdd
BLAST
Topological domaini443 – 4519ExtracellularSequence analysis
Transmembranei452 – 47221HelicalSequence analysisAdd
BLAST
Topological domaini473 – 49119CytoplasmicSequence analysisAdd
BLAST
Transmembranei492 – 51019HelicalSequence analysisAdd
BLAST
Topological domaini511 – 53020ExtracellularSequence analysisAdd
BLAST
Transmembranei531 – 54919HelicalSequence analysisAdd
BLAST
Topological domaini550 – 60354CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603Histidine permeasePRO_0000054154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP06775.
PeptideAtlasiP06775.

PTM databases

iPTMnetiP06775.
SwissPalmiP06775.

Interactioni

Protein-protein interaction databases

BioGridi33444. 19 interactions.
DIPiDIP-5549N.
IntActiP06775. 2 interactions.
MINTiMINT-515006.

Structurei

3D structure databases

ProteinModelPortaliP06775.
SMRiP06775. Positions 96-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP06775.
KOiK16261.
OMAiNMLDVKS.
OrthoDBiEOG74J9HZ.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNPLKKEY WADVVDGFKP ATSPAFENEK ESTTFVTELT SKTDSAFPLS
60 70 80 90 100
SKDSPGINQT TNDITSSDRF RRNEDTEQED INNTNLSKDL SVRHLLTLAV
110 120 130 140 150
GGAIGTGLYV NTGAALSTGG PASLVIDWVI ISTCLFTVIN SLGELSAAFP
160 170 180 190 200
VVGGFNVYSM RFIEPSFAFA VNLNYLAQWL VLLPLELVAA SITIKYWNDK
210 220 230 240 250
INSDAWVAIF YATIALANML DVKSFGETEF VLSMIKILSI IGFTILGIVL
260 270 280 290 300
SCGGGPHGGY IGGKYWHDPG AFVGHSSGTQ FKGLCSVFVT AAFSYSGIEM
310 320 330 340 350
TAVSAAESKN PRETIPKAAK RTFWLITASY VTILTLIGCL VPSNDPRLLN
360 370 380 390 400
GSSSVDAASS PLVIAIENGG IKGLPSLMNA IILIAVVSVA NSAVYACSRC
410 420 430 440 450
MVAMAHIGNL PKFLNRVDKR GRPMNAILLT LFFGLLSFVA ASDKQAEVFT
460 470 480 490 500
WLSALSGLST IFCWMAINLS HIRFRQAMKV QERSLDELPF ISQTGVKGSW
510 520 530 540 550
YGFIVLFLVL IASFWTSLFP LGGSGASAES FFEGYLSFPI LIVCYVGHKL
560 570 580 590 600
YTRNWTLMVK LEDMDLDTGR KQVDLTLRRE EMRIERETLA KRSFVTRFLH

FWC
Length:603
Mass (Da):66,006
Last modified:February 1, 1995 - v2
Checksum:i77DD34F1DA95E75F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11980 Genomic DNA. Translation: AAA34673.1.
X82408 Genomic DNA. Translation: CAA57802.1.
Z72975 Genomic DNA. Translation: CAA97217.1.
BK006941 Genomic DNA. Translation: DAA08284.1.
PIRiS55869.
RefSeqiNP_011707.1. NM_001181320.1.

Genome annotation databases

EnsemblFungiiYGR191W; YGR191W; YGR191W.
GeneIDi853104.
KEGGisce:YGR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11980 Genomic DNA. Translation: AAA34673.1.
X82408 Genomic DNA. Translation: CAA57802.1.
Z72975 Genomic DNA. Translation: CAA97217.1.
BK006941 Genomic DNA. Translation: DAA08284.1.
PIRiS55869.
RefSeqiNP_011707.1. NM_001181320.1.

3D structure databases

ProteinModelPortaliP06775.
SMRiP06775. Positions 96-477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33444. 19 interactions.
DIPiDIP-5549N.
IntActiP06775. 2 interactions.
MINTiMINT-515006.

Protein family/group databases

TCDBi2.A.3.10.1. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP06775.
SwissPalmiP06775.

Proteomic databases

MaxQBiP06775.
PeptideAtlasiP06775.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR191W; YGR191W; YGR191W.
GeneIDi853104.
KEGGisce:YGR191W.

Organism-specific databases

EuPathDBiFungiDB:YGR191W.
SGDiS000003423. HIP1.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP06775.
KOiK16261.
OMAiNMLDVKS.
OrthoDBiEOG74J9HZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30880-MONOMER.

Miscellaneous databases

NextBioi973109.
PROiP06775.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The histidine permease gene (HIP1) of Saccharomyces cerevisiae."
    Tanaka J., Fink G.R.
    Gene 38:205-214(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII."
    Arroyo J., Garcia-Gonzalez M., Garcia-Saez M.I., Sanchez M., Nombela C.
    Yeast 11:587-591(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHIP1_YEAST
AccessioniPrimary (citable) accession number: P06775
Secondary accession number(s): D6VUX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 688 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.