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P06773

- DCTD_YEAST

UniProt

P06773 - DCTD_YEAST

Protein

Deoxycytidylate deaminase

Gene

DCD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Supplies the nucleotide substrate for thymidylate synthetase.

    Catalytic activityi

    dCMP + H2O = dUMP + NH3.

    Cofactori

    Zinc.By similarity

    Enzyme regulationi

    Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi233 – 2331Zinc; catalyticBy similarity
    Active sitei235 – 2351Proton donorBy similarity
    Metal bindingi260 – 2601Zinc; catalyticBy similarity
    Metal bindingi263 – 2631Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. dCMP deaminase activity Source: SGD
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. dTMP biosynthetic process Source: SGD
    2. dUMP biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMetaCyc:YHR144C-MONOMER.
    YEAST:YHR144C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxycytidylate deaminase (EC:3.5.4.12)
    Alternative name(s):
    dCMP deaminase
    Gene namesi
    Name:DCD1
    Ordered Locus Names:YHR144C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR144c.
    SGDiS000001187. DCD1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Deoxycytidylate deaminasePRO_0000171697Add
    BLAST

    Proteomic databases

    MaxQBiP06773.
    PaxDbiP06773.
    PRIDEiP06773.

    Expressioni

    Gene expression databases

    GenevestigatoriP06773.

    Interactioni

    Protein-protein interaction databases

    BioGridi36578. 18 interactions.
    DIPiDIP-4028N.
    IntActiP06773. 1 interaction.
    MINTiMINT-498279.
    STRINGi4932.YHR144C.

    Structurei

    3D structure databases

    ProteinModelPortaliP06773.
    SMRiP06773. Positions 160-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2131.
    GeneTreeiENSGT00390000000501.
    HOGENOMiHOG000217578.
    KOiK01493.
    OMAiPDACISI.
    OrthoDBiEOG7BCNPR.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view]
    PANTHERiPTHR11086. PTHR11086. 1 hit.
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P06773-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIGVSGTKF CGCEDVINML VDHFHFELLN HLDNPEEILD YATKNYTKNS    50
    VIFLEKLSLL EKLEKRPFFV HLSIDAPVTT RVALYRKTTQ AESLSLEQII 100
    QAIDQHDFQP EGIKLREKSH LRFKIVNEDR RGRRQSLINN ITTQLKILDD 150
    KEKQMAPLMR PSWDSYFMKL ATLAASRSNC MKRRVGCVIV RECRVIATGY 200
    NGTPRHLTNC FNGGCPRCND GDSRNLHTCL CLHAEENALL EAGRDRVGQN 250
    ATLYCDTCPC LTCSVKIVQT GISEVVYSQS YRMDEESFKV LKNAGITVRQ 300
    FSFTEEPRIV MI 312
    Length:312
    Mass (Da):35,646
    Last modified:February 1, 1995 - v2
    Checksum:i780B47CDA561D24B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781V → A in AAA34561. (PubMed:3023902)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13010 Genomic DNA. Translation: AAA34561.1.
    U10397 Genomic DNA. Translation: AAB68985.1.
    BK006934 Genomic DNA. Translation: DAA06838.1.
    PIRiS46762.
    RefSeqiNP_012014.1. NM_001179275.1.

    Genome annotation databases

    EnsemblFungiiYHR144C; YHR144C; YHR144C.
    GeneIDi856548.
    KEGGisce:YHR144C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13010 Genomic DNA. Translation: AAA34561.1 .
    U10397 Genomic DNA. Translation: AAB68985.1 .
    BK006934 Genomic DNA. Translation: DAA06838.1 .
    PIRi S46762.
    RefSeqi NP_012014.1. NM_001179275.1.

    3D structure databases

    ProteinModelPortali P06773.
    SMRi P06773. Positions 160-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36578. 18 interactions.
    DIPi DIP-4028N.
    IntActi P06773. 1 interaction.
    MINTi MINT-498279.
    STRINGi 4932.YHR144C.

    Proteomic databases

    MaxQBi P06773.
    PaxDbi P06773.
    PRIDEi P06773.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR144C ; YHR144C ; YHR144C .
    GeneIDi 856548.
    KEGGi sce:YHR144C.

    Organism-specific databases

    CYGDi YHR144c.
    SGDi S000001187. DCD1.

    Phylogenomic databases

    eggNOGi COG2131.
    GeneTreei ENSGT00390000000501.
    HOGENOMi HOG000217578.
    KOi K01493.
    OMAi PDACISI.
    OrthoDBi EOG7BCNPR.

    Enzyme and pathway databases

    BioCyci MetaCyc:YHR144C-MONOMER.
    YEAST:YHR144C-MONOMER.

    Miscellaneous databases

    NextBioi 982352.

    Gene expression databases

    Genevestigatori P06773.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view ]
    PANTHERi PTHR11086. PTHR11086. 1 hit.
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and expression of the dCMP deaminase gene (DCD1) of Saccharomyces cerevisiae."
      McIntosh E.M., Haynes R.H.
      Mol. Cell. Biol. 6:1711-1721(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDCTD_YEAST
    AccessioniPrimary (citable) accession number: P06773
    Secondary accession number(s): D3DL94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1510 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3