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P06773 (DCTD_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxycytidylate deaminase

EC=3.5.4.12
Alternative name(s):
dCMP deaminase
Gene names
Name:DCD1
Ordered Locus Names:YHR144C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Supplies the nucleotide substrate for thymidylate synthetase.

Catalytic activity

dCMP + H2O = dUMP + NH3.

Cofactor

Zinc By similarity.

Enzyme regulation

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.

Miscellaneous

Present with 1510 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Deoxycytidylate deaminase
PRO_0000171697

Sites

Active site2351Proton donor By similarity
Metal binding2331Zinc; catalytic By similarity
Metal binding2601Zinc; catalytic By similarity
Metal binding2631Zinc; catalytic By similarity

Experimental info

Sequence conflict781V → A in AAA34561. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P06773 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 780B47CDA561D24B

FASTA31235,646
        10         20         30         40         50         60 
MLIGVSGTKF CGCEDVINML VDHFHFELLN HLDNPEEILD YATKNYTKNS VIFLEKLSLL 

        70         80         90        100        110        120 
EKLEKRPFFV HLSIDAPVTT RVALYRKTTQ AESLSLEQII QAIDQHDFQP EGIKLREKSH 

       130        140        150        160        170        180 
LRFKIVNEDR RGRRQSLINN ITTQLKILDD KEKQMAPLMR PSWDSYFMKL ATLAASRSNC 

       190        200        210        220        230        240 
MKRRVGCVIV RECRVIATGY NGTPRHLTNC FNGGCPRCND GDSRNLHTCL CLHAEENALL 

       250        260        270        280        290        300 
EAGRDRVGQN ATLYCDTCPC LTCSVKIVQT GISEVVYSQS YRMDEESFKV LKNAGITVRQ 

       310 
FSFTEEPRIV MI 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and expression of the dCMP deaminase gene (DCD1) of Saccharomyces cerevisiae."
McIntosh E.M., Haynes R.H.
Mol. Cell. Biol. 6:1711-1721(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13010 Genomic DNA. Translation: AAA34561.1.
U10397 Genomic DNA. Translation: AAB68985.1.
BK006934 Genomic DNA. Translation: DAA06838.1.
PIRS46762.
RefSeqNP_012014.1. NM_001179275.1.

3D structure databases

ProteinModelPortalP06773.
SMRP06773. Positions 160-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36578. 18 interactions.
DIPDIP-4028N.
IntActP06773. 1 interaction.
MINTMINT-498279.
STRING4932.YHR144C.

Proteomic databases

MaxQBP06773.
PaxDbP06773.
PRIDEP06773.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR144C; YHR144C; YHR144C.
GeneID856548.
KEGGsce:YHR144C.

Organism-specific databases

CYGDYHR144c.
SGDS000001187. DCD1.

Phylogenomic databases

eggNOGCOG2131.
GeneTreeENSGT00390000000501.
HOGENOMHOG000217578.
KOK01493.
OMAPDACISI.
OrthoDBEOG7BCNPR.

Enzyme and pathway databases

BioCycMetaCyc:YHR144C-MONOMER.
YEAST:YHR144C-MONOMER.

Gene expression databases

GenevestigatorP06773.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR015517. Cyt_deaminase.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PANTHERPTHR11086. PTHR11086. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMSSF53927. SSF53927. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982352.

Entry information

Entry nameDCTD_YEAST
AccessionPrimary (citable) accession number: P06773
Secondary accession number(s): D3DL94
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families