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P06773

- DCTD_YEAST

UniProt

P06773 - DCTD_YEAST

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Protein

Deoxycytidylate deaminase

Gene
DCD1, YHR144C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zinc By similarity.

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi233 – 2331Zinc; catalytic By similarity
Active sitei235 – 2351Proton donor By similarity
Metal bindingi260 – 2601Zinc; catalytic By similarity
Metal bindingi263 – 2631Zinc; catalytic By similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: SGD
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. dTMP biosynthetic process Source: SGD
  2. dUMP biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YHR144C-MONOMER.
YEAST:YHR144C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:DCD1
Ordered Locus Names:YHR144C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR144c.
SGDiS000001187. DCD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Deoxycytidylate deaminasePRO_0000171697Add
BLAST

Proteomic databases

MaxQBiP06773.
PaxDbiP06773.
PRIDEiP06773.

Expressioni

Gene expression databases

GenevestigatoriP06773.

Interactioni

Protein-protein interaction databases

BioGridi36578. 18 interactions.
DIPiDIP-4028N.
IntActiP06773. 1 interaction.
MINTiMINT-498279.
STRINGi4932.YHR144C.

Structurei

3D structure databases

ProteinModelPortaliP06773.
SMRiP06773. Positions 160-283.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2131.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000217578.
KOiK01493.
OMAiPDACISI.
OrthoDBiEOG7BCNPR.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06773-1 [UniParc]FASTAAdd to Basket

« Hide

MLIGVSGTKF CGCEDVINML VDHFHFELLN HLDNPEEILD YATKNYTKNS    50
VIFLEKLSLL EKLEKRPFFV HLSIDAPVTT RVALYRKTTQ AESLSLEQII 100
QAIDQHDFQP EGIKLREKSH LRFKIVNEDR RGRRQSLINN ITTQLKILDD 150
KEKQMAPLMR PSWDSYFMKL ATLAASRSNC MKRRVGCVIV RECRVIATGY 200
NGTPRHLTNC FNGGCPRCND GDSRNLHTCL CLHAEENALL EAGRDRVGQN 250
ATLYCDTCPC LTCSVKIVQT GISEVVYSQS YRMDEESFKV LKNAGITVRQ 300
FSFTEEPRIV MI 312
Length:312
Mass (Da):35,646
Last modified:February 1, 1995 - v2
Checksum:i780B47CDA561D24B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781V → A in AAA34561. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13010 Genomic DNA. Translation: AAA34561.1.
U10397 Genomic DNA. Translation: AAB68985.1.
BK006934 Genomic DNA. Translation: DAA06838.1.
PIRiS46762.
RefSeqiNP_012014.1. NM_001179275.1.

Genome annotation databases

EnsemblFungiiYHR144C; YHR144C; YHR144C.
GeneIDi856548.
KEGGisce:YHR144C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13010 Genomic DNA. Translation: AAA34561.1 .
U10397 Genomic DNA. Translation: AAB68985.1 .
BK006934 Genomic DNA. Translation: DAA06838.1 .
PIRi S46762.
RefSeqi NP_012014.1. NM_001179275.1.

3D structure databases

ProteinModelPortali P06773.
SMRi P06773. Positions 160-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36578. 18 interactions.
DIPi DIP-4028N.
IntActi P06773. 1 interaction.
MINTi MINT-498279.
STRINGi 4932.YHR144C.

Proteomic databases

MaxQBi P06773.
PaxDbi P06773.
PRIDEi P06773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR144C ; YHR144C ; YHR144C .
GeneIDi 856548.
KEGGi sce:YHR144C.

Organism-specific databases

CYGDi YHR144c.
SGDi S000001187. DCD1.

Phylogenomic databases

eggNOGi COG2131.
GeneTreei ENSGT00390000000501.
HOGENOMi HOG000217578.
KOi K01493.
OMAi PDACISI.
OrthoDBi EOG7BCNPR.

Enzyme and pathway databases

BioCyci MetaCyc:YHR144C-MONOMER.
YEAST:YHR144C-MONOMER.

Miscellaneous databases

NextBioi 982352.

Gene expression databases

Genevestigatori P06773.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR015517. dCMP_deaminase-rel.
[Graphical view ]
PANTHERi PTHR11086. PTHR11086. 1 hit.
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and expression of the dCMP deaminase gene (DCD1) of Saccharomyces cerevisiae."
    McIntosh E.M., Haynes R.H.
    Mol. Cell. Biol. 6:1711-1721(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCTD_YEAST
AccessioniPrimary (citable) accession number: P06773
Secondary accession number(s): D3DL94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1510 molecules/cell in log phase SD medium.

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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