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Protein

Deoxycytidylate deaminase

Gene

DCD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.

Miscellaneous

Present with 1510 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarity

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi233Zinc; catalyticBy similarity1
Active sitei235Proton donorBy similarity1
Metal bindingi260Zinc; catalyticBy similarity1
Metal bindingi263Zinc; catalyticBy similarity1

GO - Molecular functioni

  • dCMP deaminase activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • dTMP biosynthetic process Source: SGD
  • dUMP biosynthetic process Source: SGD

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase
Biological processNucleotide biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YHR144C-MONOMER
YEAST:YHR144C-MONOMER
ReactomeiR-SCE-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:DCD1
Ordered Locus Names:YHR144C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR144C
SGDiS000001187 DCD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716971 – 312Deoxycytidylate deaminaseAdd BLAST312

Proteomic databases

MaxQBiP06773
PaxDbiP06773
PRIDEiP06773

Interactioni

Protein-protein interaction databases

BioGridi36578, 125 interactors
DIPiDIP-4028N
IntActiP06773, 1 interactor
MINTiP06773
STRINGi4932.YHR144C

Structurei

3D structure databases

ProteinModelPortaliP06773
SMRiP06773
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 291CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000000501
HOGENOMiHOG000217578
InParanoidiP06773
KOiK01493
OMAiRCNDGDS
OrthoDBiEOG092C46M0

Family and domain databases

CDDicd01286 deoxycytidylate_deaminase, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
IPR015517 dCMP_deaminase-rel
IPR035105 Deoxycytidylate_deaminase_dom
PANTHERiPTHR11086 PTHR11086, 1 hit
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

P06773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIGVSGTKF CGCEDVINML VDHFHFELLN HLDNPEEILD YATKNYTKNS
60 70 80 90 100
VIFLEKLSLL EKLEKRPFFV HLSIDAPVTT RVALYRKTTQ AESLSLEQII
110 120 130 140 150
QAIDQHDFQP EGIKLREKSH LRFKIVNEDR RGRRQSLINN ITTQLKILDD
160 170 180 190 200
KEKQMAPLMR PSWDSYFMKL ATLAASRSNC MKRRVGCVIV RECRVIATGY
210 220 230 240 250
NGTPRHLTNC FNGGCPRCND GDSRNLHTCL CLHAEENALL EAGRDRVGQN
260 270 280 290 300
ATLYCDTCPC LTCSVKIVQT GISEVVYSQS YRMDEESFKV LKNAGITVRQ
310
FSFTEEPRIV MI
Length:312
Mass (Da):35,646
Last modified:February 1, 1995 - v2
Checksum:i780B47CDA561D24B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78V → A in AAA34561 (PubMed:3023902).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13010 Genomic DNA Translation: AAA34561.1
U10397 Genomic DNA Translation: AAB68985.1
BK006934 Genomic DNA Translation: DAA06838.1
PIRiS46762
RefSeqiNP_012014.1, NM_001179275.1

Genome annotation databases

EnsemblFungiiYHR144C; YHR144C; YHR144C
GeneIDi856548
KEGGisce:YHR144C

Similar proteinsi

Entry informationi

Entry nameiDCTD_YEAST
AccessioniPrimary (citable) accession number: P06773
Secondary accession number(s): D3DL94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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