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Protein

Retinol-binding protein 2

Gene

Rbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Retinoic acidBy similarity
Binding sitei109 – 1091Retinoic acid

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: RGD
  • transporter activity Source: InterPro

GO - Biological processi

  • retinol metabolic process Source: RGD
  • vitamin A metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 2
Alternative name(s):
Cellular retinol-binding protein II
Short name:
CRBP-II
Gene namesi
Name:Rbp2
Synonyms:Crbpii
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3544. Rbp2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 134133Retinol-binding protein 2PRO_0000067398Add
BLAST

Proteomic databases

PaxDbiP06768.
PRIDEiP06768.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013932.
GenevisibleiP06768. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018755.

Structurei

Secondary structure

1
134
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 1610Combined sources
Helixi17 – 237Combined sources
Helixi28 – 347Combined sources
Beta strandi40 – 467Combined sources
Beta strandi49 – 557Combined sources
Beta strandi60 – 667Combined sources
Beta strandi71 – 744Combined sources
Turni76 – 794Combined sources
Beta strandi82 – 909Combined sources
Beta strandi93 – 10210Combined sources
Beta strandi106 – 1127Combined sources
Beta strandi115 – 1228Combined sources
Beta strandi125 – 1339Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B4MNMR-A1-134[»]
1EIINMR-A1-134[»]
1OPAX-ray1.90A/B1-134[»]
1OPBX-ray1.90A/B/C/D1-134[»]
ProteinModelPortaliP06768.
SMRiP06768. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06768.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP06768.
KOiK14622.
OMAiENRGWKQ.
OrthoDBiEOG091G0QSV.
PhylomeDBiP06768.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031266. CRBP-II.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF59. PTHR11955:SF59. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KIIVQDGDNF
60 70 80 90 100
KTKTNSTFRN YDLDFTVGVE FDEHTKGLDG RNVKTLVTWE GNTLVCVQKG
110 120 130
EKENRGWKQW VEGDKLYLEL TCGDQVCRQV FKKK
Length:134
Mass (Da):15,585
Last modified:January 23, 2007 - v3
Checksum:i68491539A0115208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13949 mRNA. Translation: AAA42022.1.
M16402, M16400, M16401 Genomic DNA. Translation: AAA40963.1. Sequence problems.
PIRiA92626. A29065.
RefSeqiNP_036772.2. NM_012640.2.
XP_006243669.1. XM_006243607.1.
UniGeneiRn.9828.

Genome annotation databases

EnsembliENSRNOT00000018755; ENSRNOP00000018755; ENSRNOG00000013932.
GeneIDi24710.
KEGGirno:24710.
UCSCiRGD:3544. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13949 mRNA. Translation: AAA42022.1.
M16402, M16400, M16401 Genomic DNA. Translation: AAA40963.1. Sequence problems.
PIRiA92626. A29065.
RefSeqiNP_036772.2. NM_012640.2.
XP_006243669.1. XM_006243607.1.
UniGeneiRn.9828.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B4MNMR-A1-134[»]
1EIINMR-A1-134[»]
1OPAX-ray1.90A/B1-134[»]
1OPBX-ray1.90A/B/C/D1-134[»]
ProteinModelPortaliP06768.
SMRiP06768. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018755.

Proteomic databases

PaxDbiP06768.
PRIDEiP06768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018755; ENSRNOP00000018755; ENSRNOG00000013932.
GeneIDi24710.
KEGGirno:24710.
UCSCiRGD:3544. rat.

Organism-specific databases

CTDi5948.
RGDi3544. Rbp2.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP06768.
KOiK14622.
OMAiENRGWKQ.
OrthoDBiEOG091G0QSV.
PhylomeDBiP06768.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-RNO-975634. Retinoid metabolism and transport.

Miscellaneous databases

EvolutionaryTraceiP06768.
PROiP06768.

Gene expression databases

BgeeiENSRNOG00000013932.
GenevisibleiP06768. RN.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031266. CRBP-II.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF59. PTHR11955:SF59. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRET2_RAT
AccessioniPrimary (citable) accession number: P06768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.