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Protein

Retinol-binding protein 2

Gene

Rbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41Retinoic acidBy similarity1
Binding sitei109Retinoic acid1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: RGD
  • transporter activity Source: InterPro

GO - Biological processi

  • retinol metabolic process Source: RGD
  • vitamin A metabolic process Source: InterPro

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 2
Alternative name(s):
Cellular retinol-binding protein II
Short name:
CRBP-II
Gene namesi
Name:Rbp2
Synonyms:Crbpii
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3544. Rbp2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673982 – 134Retinol-binding protein 2Add BLAST133

Proteomic databases

PaxDbiP06768.
PRIDEiP06768.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013932.
GenevisibleiP06768. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018755.

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 16Combined sources10
Helixi17 – 23Combined sources7
Helixi28 – 34Combined sources7
Beta strandi40 – 46Combined sources7
Beta strandi49 – 55Combined sources7
Beta strandi60 – 66Combined sources7
Beta strandi71 – 74Combined sources4
Turni76 – 79Combined sources4
Beta strandi82 – 90Combined sources9
Beta strandi93 – 102Combined sources10
Beta strandi106 – 112Combined sources7
Beta strandi115 – 122Combined sources8
Beta strandi125 – 133Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B4MNMR-A1-134[»]
1EIINMR-A1-134[»]
1OPAX-ray1.90A/B1-134[»]
1OPBX-ray1.90A/B/C/D1-134[»]
ProteinModelPortaliP06768.
SMRiP06768.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06768.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP06768.
KOiK14622.
OMAiENRGWKQ.
OrthoDBiEOG091G0QSV.
PhylomeDBiP06768.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR031266. CRBP-II.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF102. PTHR11955:SF102. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KIIVQDGDNF
60 70 80 90 100
KTKTNSTFRN YDLDFTVGVE FDEHTKGLDG RNVKTLVTWE GNTLVCVQKG
110 120 130
EKENRGWKQW VEGDKLYLEL TCGDQVCRQV FKKK
Length:134
Mass (Da):15,585
Last modified:January 23, 2007 - v3
Checksum:i68491539A0115208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13949 mRNA. Translation: AAA42022.1.
M16402, M16400, M16401 Genomic DNA. Translation: AAA40963.1. Sequence problems.
PIRiA92626. A29065.
RefSeqiNP_036772.2. NM_012640.2.
XP_006243669.1. XM_006243607.1.
XP_017450964.1. XM_017595475.1.
UniGeneiRn.9828.

Genome annotation databases

EnsembliENSRNOT00000018755; ENSRNOP00000018755; ENSRNOG00000013932.
GeneIDi24710.
KEGGirno:24710.
UCSCiRGD:3544. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRET2_RAT
AccessioniPrimary (citable) accession number: P06768
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families