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Protein

Protachykinin-1

Gene

Tac1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Molecular functioni

  • substance P receptor binding Source: RGD

GO - Biological processi

  • antibacterial humoral response Source: Ensembl
  • antifungal humoral response Source: Ensembl
  • associative learning Source: RGD
  • cellular response to nerve growth factor stimulus Source: Ensembl
  • chemical synaptic transmission Source: UniProtKB-KW
  • defense response to Gram-negative bacterium Source: Ensembl
  • defense response to Gram-positive bacterium Source: Ensembl
  • inflammatory response Source: Ensembl
  • innate immune response Source: Ensembl
  • long-term memory Source: RGD
  • negative regulation of heart rate Source: RGD
  • neuropeptide signaling pathway Source: UniProtKB-KW
  • positive regulation of action potential Source: RGD
  • positive regulation of acute inflammatory response Source: RGD
  • positive regulation of corticosterone secretion Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of epithelial cell migration Source: RGD
  • positive regulation of lymphocyte proliferation Source: RGD
  • positive regulation of ossification Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of saliva secretion Source: RGD
  • positive regulation of stress fiber assembly Source: RGD
  • positive regulation of synaptic transmission, cholinergic Source: RGD
  • positive regulation of synaptic transmission, GABAergic Source: RGD
  • regulation of blood pressure Source: RGD
  • response to hormone Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to morphine Source: RGD
  • response to pain Source: Ensembl
  • response to yeast Source: Ensembl
  • sensory perception of pain Source: Ensembl
  • tachykinin receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
Gene namesi
Name:Tac1
Synonyms:Nka, Nkna, Tac2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3807. Tac1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytosol Source: Ensembl
  • extracellular space Source: RGD
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 5637Sequence analysisPRO_0000033550Add
BLAST
Peptidei58 – 6811Substance PPRO_0000033551Add
BLAST
Peptidei72 – 10736Neuropeptide KPRO_0000033552Add
BLAST
Peptidei72 – 732Neuropeptide gamma, 1st partPRO_0000033553
Peptidei89 – 10719Neuropeptide gamma, 2nd partPRO_0000033554Add
BLAST
Peptidei98 – 10710Neurokinin APRO_0000033555
Peptidei111 – 12616C-terminal-flanking peptidePRO_0000033556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681Methionine amideBy similarity
Modified residuei107 – 1071Methionine amideBy similarity

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei59 – 602Cleavage; by FAPBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP06767.

Miscellaneous databases

PMAP-CutDBP06767.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007374.
GenevisibleiP06767. RN.

Interactioni

GO - Molecular functioni

  • substance P receptor binding Source: RGD

Protein-protein interaction databases

MINTiMINT-1510170.
STRINGi10116.ENSRNOP00000009888.

Structurei

3D structure databases

ProteinModelPortaliP06767.
SMRiP06767. Positions 72-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZZ. Eukaryota.
ENOG4112BW1. LUCA.
GeneTreeiENSGT00390000002457.
HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP06767.
KOiK05239.
OMAiEMGANDD.
OrthoDBiEOG091G0Y2V.
PhylomeDBiP06767.
TreeFamiTF333405.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P06767-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVAVAVF FLVSTQLFAE EIGANDDLNY WSDWSDSDQI KEAMPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT
110 120 130
DSFVGLMGKR ALNSVAYERS AMQNYERRRK
Length:130
Mass (Da):15,001
Last modified:May 30, 2000 - v2
Checksum:iB22EFE860DCCD75A
GO
Isoform Alpha (identifier: P06767-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-114: Missing.
     115-115: V → M

Show »
Length:112
Mass (Da):13,034
Checksum:i5B21D8FED8E0D76E
GO
Isoform Gamma (identifier: P06767-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:115
Mass (Da):13,341
Checksum:i83E021DCFF1F01F0
GO
Isoform Delta (identifier: P06767-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.
     97-114: Missing.
     115-115: V → M

Show »
Length:97
Mass (Da):11,374
Checksum:iC2A5A1F3565232A2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 8815Missing in isoform Gamma and isoform Delta. 4 PublicationsVSP_006380Add
BLAST
Alternative sequencei97 – 11418Missing in isoform Alpha and isoform Delta. 3 PublicationsVSP_006381Add
BLAST
Alternative sequencei115 – 1151V → M in isoform Alpha and isoform Delta. 3 PublicationsVSP_006382

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34162
, M34159, M34160, M34161 Genomic DNA. Translation: AAA41926.1.
M34184 mRNA. Translation: AAA41925.1.
M34183 mRNA. Translation: AAA41929.1.
M15191 mRNA. Translation: AAA41928.1.
M14312 mRNA. Translation: AAA41927.1.
L07328 Genomic DNA. Translation: AAA41924.1.
X56306 mRNA. Translation: CAA39752.1.
S72369 mRNA. Translation: AAB31499.1.
PIRiA37163. SPRTB.
B26590. SPRTA.
S12958.
RefSeqiNP_001118240.1. NM_001124768.1. [P06767-3]
NP_001118241.1. NM_001124769.1. [P06767-4]
NP_001118242.1. NM_001124770.1. [P06767-2]
NP_036798.1. NM_012666.2. [P06767-1]
UniGeneiRn.1920.

Genome annotation databases

EnsembliENSRNOT00000009888; ENSRNOP00000009888; ENSRNOG00000007374. [P06767-1]
ENSRNOT00000034719; ENSRNOP00000033246; ENSRNOG00000007374. [P06767-3]
ENSRNOT00000052333; ENSRNOP00000048764; ENSRNOG00000007374. [P06767-2]
GeneIDi24806.
KEGGirno:24806.
UCSCiRGD:3807. rat. [P06767-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34162
, M34159, M34160, M34161 Genomic DNA. Translation: AAA41926.1.
M34184 mRNA. Translation: AAA41925.1.
M34183 mRNA. Translation: AAA41929.1.
M15191 mRNA. Translation: AAA41928.1.
M14312 mRNA. Translation: AAA41927.1.
L07328 Genomic DNA. Translation: AAA41924.1.
X56306 mRNA. Translation: CAA39752.1.
S72369 mRNA. Translation: AAB31499.1.
PIRiA37163. SPRTB.
B26590. SPRTA.
S12958.
RefSeqiNP_001118240.1. NM_001124768.1. [P06767-3]
NP_001118241.1. NM_001124769.1. [P06767-4]
NP_001118242.1. NM_001124770.1. [P06767-2]
NP_036798.1. NM_012666.2. [P06767-1]
UniGeneiRn.1920.

3D structure databases

ProteinModelPortaliP06767.
SMRiP06767. Positions 72-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1510170.
STRINGi10116.ENSRNOP00000009888.

Proteomic databases

PaxDbiP06767.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009888; ENSRNOP00000009888; ENSRNOG00000007374. [P06767-1]
ENSRNOT00000034719; ENSRNOP00000033246; ENSRNOG00000007374. [P06767-3]
ENSRNOT00000052333; ENSRNOP00000048764; ENSRNOG00000007374. [P06767-2]
GeneIDi24806.
KEGGirno:24806.
UCSCiRGD:3807. rat. [P06767-1]

Organism-specific databases

CTDi6863.
RGDi3807. Tac1.

Phylogenomic databases

eggNOGiENOG410IWZZ. Eukaryota.
ENOG4112BW1. LUCA.
GeneTreeiENSGT00390000002457.
HOGENOMiHOG000082514.
HOVERGENiHBG000127.
InParanoidiP06767.
KOiK05239.
OMAiEMGANDD.
OrthoDBiEOG091G0Y2V.
PhylomeDBiP06767.
TreeFamiTF333405.

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PMAP-CutDBP06767.
PROiP06767.

Gene expression databases

BgeeiENSRNOG00000007374.
GenevisibleiP06767. RN.

Family and domain databases

InterProiIPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
IPR008216. Tachykinin_fam.
[Graphical view]
PANTHERiPTHR11250. PTHR11250. 1 hit.
PRINTSiPR01829. PROTACHYKNIN.
SMARTiSM00203. TK. 2 hits.
[Graphical view]
PROSITEiPS00267. TACHYKININ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTKN1_RAT
AccessioniPrimary (citable) accession number: P06767
Secondary accession number(s): P08856
, P08857, P22356, Q6LD93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.