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Protein

Platelet factor 4

Gene

Pf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.
R-RNO-140875. Common Pathway of Fibrin Clot Formation.
R-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet factor 4
Short name:
PF-4
Alternative name(s):
C-X-C motif chemokine 4
Gene namesi
Name:Pf4
Synonyms:Cxcl4, Scyb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi3305. Pf4.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • platelet alpha granule Source: RGD
  • protein complex Source: RGD
  • vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Chaini30 – 10576Platelet factor 4PRO_0000005070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311O-linked (GalNAc...); partial1 Publication
Disulfide bondi44 ↔ 71By similarity
Disulfide bondi46 ↔ 87By similarity
Modified residuei61 – 611PhosphoserineCombined sources

Post-translational modificationi

O-linked glycan consists of Gal-GalNAc disaccharide which is modified with sialic acid residues (microheterogeneity).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06765.

PTM databases

iPTMnetiP06765.
PhosphoSiteiP06765.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028015.
GenevisibleiP06765. RN.

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP06765. 1 interaction.
STRINGi10116.ENSRNOP00000032276.

Structurei

3D structure databases

ProteinModelPortaliP06765.
SMRiP06765. Positions 40-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 1027Heparin-bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J314. Eukaryota.
ENOG4111556. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP06765.
KOiK05407.
OMAiCAVPQLI.
OrthoDBiEOG091G14JD.
PhylomeDBiP06765.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027222. PF4.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF43. PTHR10179:SF43. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAVFRGL RPSPELLLLG LLLLPAVVAV TRASPEESDG DLSCVCVKTS
60 70 80 90 100
SSRIHLKRIT SLEVIKAGPH CAVPQLIATL KNGSKICLDR QVPLYKKIIK

KLLES
Length:105
Mass (Da):11,287
Last modified:January 1, 1988 - v1
Checksum:iD9CCAD2B6A284496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15254 Genomic DNA. Translation: AAA41832.1.
PIRiA26774.
RefSeqiNP_001007730.1. NM_001007729.1.
UniGeneiRn.6800.

Genome annotation databases

EnsembliENSRNOT00000033406; ENSRNOP00000032276; ENSRNOG00000028015.
GeneIDi360918.
KEGGirno:360918.
UCSCiRGD:3305. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15254 Genomic DNA. Translation: AAA41832.1.
PIRiA26774.
RefSeqiNP_001007730.1. NM_001007729.1.
UniGeneiRn.6800.

3D structure databases

ProteinModelPortaliP06765.
SMRiP06765. Positions 40-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06765. 1 interaction.
STRINGi10116.ENSRNOP00000032276.

PTM databases

iPTMnetiP06765.
PhosphoSiteiP06765.

Proteomic databases

PaxDbiP06765.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033406; ENSRNOP00000032276; ENSRNOG00000028015.
GeneIDi360918.
KEGGirno:360918.
UCSCiRGD:3305. rat.

Organism-specific databases

CTDi5196.
RGDi3305. Pf4.

Phylogenomic databases

eggNOGiENOG410J314. Eukaryota.
ENOG4111556. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP06765.
KOiK05407.
OMAiCAVPQLI.
OrthoDBiEOG091G14JD.
PhylomeDBiP06765.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.
R-RNO-140875. Common Pathway of Fibrin Clot Formation.
R-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP06765.

Gene expression databases

BgeeiENSRNOG00000028015.
GenevisibleiP06765. RN.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027222. PF4.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF43. PTHR10179:SF43. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLF4_RAT
AccessioniPrimary (citable) accession number: P06765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.