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Protein

Platelet factor 4

Gene

Pf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-140875 Common Pathway of Fibrin Clot Formation
R-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-380108 Chemokine receptors bind chemokines
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet factor 4
Short name:
PF-4
Alternative name(s):
C-X-C motif chemokine 4
Gene namesi
Name:Pf4
Synonyms:Cxcl4, Scyb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi3305 Pf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000000507030 – 105Platelet factor 4Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31O-linked (GalNAc...) threonine; partial1 Publication1
Disulfide bondi44 ↔ 71By similarity
Disulfide bondi46 ↔ 87By similarity
Modified residuei61PhosphoserineCombined sources1

Post-translational modificationi

O-linked glycan consists of Gal-GalNAc disaccharide which is modified with sialic acid residues (microheterogeneity).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06765
PRIDEiP06765

PTM databases

iPTMnetiP06765
PhosphoSitePlusiP06765

Expressioni

Gene expression databases

BgeeiENSRNOG00000028015
GenevisibleiP06765 RN

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP06765, 1 interactor
STRINGi10116.ENSRNOP00000032276

Structurei

3D structure databases

ProteinModelPortaliP06765
SMRiP06765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 102Heparin-bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J314 Eukaryota
ENOG4111556 LUCA
GeneTreeiENSGT00910000144355
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP06765
KOiK05407
OMAiGAGLHCP
OrthoDBiEOG091G14JD
PhylomeDBiP06765
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF43 PTHR10179:SF43, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAAVFRGL RPSPELLLLG LLLLPAVVAV TRASPEESDG DLSCVCVKTS
60 70 80 90 100
SSRIHLKRIT SLEVIKAGPH CAVPQLIATL KNGSKICLDR QVPLYKKIIK

KLLES
Length:105
Mass (Da):11,287
Last modified:January 1, 1988 - v1
Checksum:iD9CCAD2B6A284496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15254 Genomic DNA Translation: AAA41832.1
PIRiA26774
RefSeqiNP_001007730.1, NM_001007729.1
UniGeneiRn.6800

Genome annotation databases

EnsembliENSRNOT00000033406; ENSRNOP00000032276; ENSRNOG00000028015
GeneIDi360918
KEGGirno:360918
UCSCiRGD:3305 rat

Similar proteinsi

Entry informationi

Entry nameiPLF4_RAT
AccessioniPrimary (citable) accession number: P06765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health