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Protein

Apolipoprotein C-III

Gene

Apoc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41May interact with the LDL receptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • cholesterol homeostasis Source: GO_Central
  • inflammatory response Source: RGD
  • lipid catabolic process Source: UniProtKB-KW
  • lipid transport Source: RGD
  • lipoprotein metabolic process Source: InterPro
  • lipoprotein transport Source: RGD
  • negative regulation of high-density lipoprotein particle clearance Source: GO_Central
  • negative regulation of lipoprotein lipase activity Source: GO_Central
  • negative regulation of low-density lipoprotein particle clearance Source: GO_Central
  • negative regulation of oxidative phosphorylation Source: RGD
  • negative regulation of triglyceride catabolic process Source: GO_Central
  • negative regulation of very-low-density lipoprotein particle clearance Source: GO_Central
  • positive regulation of triglyceride biosynthetic process Source: RGD
  • response to drug Source: RGD
  • response to fatty acid Source: RGD
  • response to nutrient Source: RGD
  • response to peptide hormone Source: RGD
  • response to triglyceride Source: RGD
  • response to vitamin A Source: RGD
  • triglyceride homeostasis Source: GO_Central
  • very-low-density lipoprotein particle assembly Source: GO_Central

Keywordsi

Biological processLipid degradation, Lipid metabolism, Lipid transport, Transport
LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-III
Short name:
Apo-CIII
Short name:
ApoC-III
Alternative name(s):
Apolipoprotein C3
Gene namesi
Name:Apoc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2136. Apoc3.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chylomicron, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000203521 – 101Apolipoprotein C-IIIAdd BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Methionine sulfoxideBy similarity1
Glycosylationi96O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-96 with a core 1 or possibly core 8 glycan.By similarity

Keywords - PTMi

Glycoprotein, Oxidation

Proteomic databases

PaxDbiP06759.
PRIDEiP06759.

PTM databases

iPTMnetiP06759.
PhosphoSitePlusiP06759.

Expressioni

Tissue specificityi

Synthesized predominantly in liver and to a lesser degree in intestine.1 Publication

Gene expression databases

GenevisibleiP06759. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4655487.
STRINGi10116.ENSRNOP00000067045.

Structurei

3D structure databases

ProteinModelPortaliP06759.
SMRiP06759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 101Lipid-bindingBy similarityAdd BLAST33

Sequence similaritiesi

Belongs to the apolipoprotein C3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE3N. Eukaryota.
ENOG4111APE. LUCA.
HOVERGENiHBG050549.
InParanoidiP06759.
PhylomeDBiP06759.

Family and domain databases

InterProiView protein in InterPro
IPR008403. Apo-CIII.
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiView protein in Pfam
PF05778. Apo-CIII. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010414. Apo-CIII. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRMLLIVA LVALLASARA DEGEGSLLLG SMQGYMEQAS KTVQDALSSM
60 70 80 90 100
QESDIAVVAS RGWMDNRFKS LKGYWSKFTD KFTGLWESGP EDQLTTPTLE

P
Length:101
Mass (Da):11,117
Last modified:May 30, 2000 - v2
Checksum:i1A7260DB909692D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02596 Genomic DNA. Translation: AAA40746.1.
PIRiB24700.
UniGeneiRn.129547.

Similar proteinsi

Entry informationi

Entry nameiAPOC3_RAT
AccessioniPrimary (citable) accession number: P06759
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: May 30, 2000
Last modified: August 30, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families