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Protein

Apolipoprotein C-III

Gene

Apoc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.By similarity

GO - Molecular functioni

  • lipid binding Source: InterPro
  • lipid transporter activity Source: RGD

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • inflammatory response Source: RGD
  • lipid catabolic process Source: UniProtKB-KW
  • lipid transport Source: RGD
  • lipoprotein metabolic process Source: InterPro
  • lipoprotein transport Source: RGD
  • negative regulation of oxidative phosphorylation Source: RGD
  • positive regulation of triglyceride biosynthetic process Source: RGD
  • response to drug Source: RGD
  • response to fatty acid Source: RGD
  • response to nutrient Source: RGD
  • response to peptide hormone Source: RGD
  • response to simvastatin Source: RGD
  • response to triglyceride Source: RGD
  • response to vitamin A Source: RGD
Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Sialic acid

Enzyme and pathway databases

ReactomeiR-RNO-174800. Chylomicron-mediated lipid transport.
R-RNO-194223. HDL-mediated lipid transport.
R-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-III
Short name:
Apo-CIII
Short name:
ApoC-III
Alternative name(s):
Apolipoprotein C3
Gene namesi
Name:Apoc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2136. Apoc3.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • cell Source: GOC
  • chylomicron Source: UniProtKB-KW
  • extracellular space Source: RGD
  • very-low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 10181Apolipoprotein C-IIIPRO_0000002035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Methionine sulfoxideBy similarity
Glycosylationi96 – 961O-linked (GalNAc...)By similarity

Post-translational modificationi

The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-96 with a core 1 or possibly core 8 glycan.By similarity

Keywords - PTMi

Glycoprotein, Oxidation

Proteomic databases

PaxDbiP06759.
PRIDEiP06759.

PTM databases

iPTMnetiP06759.

Expressioni

Tissue specificityi

Synthesized predominantly in liver and to a lesser degree in intestine.1 Publication

Gene expression databases

GenevisibleiP06759. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4655487.
STRINGi10116.ENSRNOP00000067045.

Structurei

3D structure databases

ProteinModelPortaliP06759.
SMRiP06759. Positions 21-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 10133Lipid-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein C3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE3N. Eukaryota.
ENOG4111APE. LUCA.
HOVERGENiHBG050549.
InParanoidiP06759.
OMAiSLKDYWS.
OrthoDBiEOG7B31QW.
PhylomeDBiP06759.

Family and domain databases

InterProiIPR008403. Apo-CIII.
[Graphical view]
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiPF05778. Apo-CIII. 1 hit.
[Graphical view]
ProDomiPD010414. Apo-CIII. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRMLLIVA LVALLASARA DEGEGSLLLG SMQGYMEQAS KTVQDALSSM
60 70 80 90 100
QESDIAVVAS RGWMDNRFKS LKGYWSKFTD KFTGLWESGP EDQLTTPTLE

P
Length:101
Mass (Da):11,117
Last modified:May 30, 2000 - v2
Checksum:i1A7260DB909692D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02596 Genomic DNA. Translation: AAA40746.1.
PIRiB24700.
UniGeneiRn.129547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02596 Genomic DNA. Translation: AAA40746.1.
PIRiB24700.
UniGeneiRn.129547.

3D structure databases

ProteinModelPortaliP06759.
SMRiP06759. Positions 21-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4655487.
STRINGi10116.ENSRNOP00000067045.

PTM databases

iPTMnetiP06759.

Proteomic databases

PaxDbiP06759.
PRIDEiP06759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2136. Apoc3.

Phylogenomic databases

eggNOGiENOG410JE3N. Eukaryota.
ENOG4111APE. LUCA.
HOVERGENiHBG050549.
InParanoidiP06759.
OMAiSLKDYWS.
OrthoDBiEOG7B31QW.
PhylomeDBiP06759.

Enzyme and pathway databases

ReactomeiR-RNO-174800. Chylomicron-mediated lipid transport.
R-RNO-194223. HDL-mediated lipid transport.
R-RNO-975634. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi602601.
PROiP06759.

Gene expression databases

GenevisibleiP06759. RN.

Family and domain databases

InterProiIPR008403. Apo-CIII.
[Graphical view]
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiPF05778. Apo-CIII. 1 hit.
[Graphical view]
ProDomiPD010414. Apo-CIII. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes."
    Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K.
    J. Biol. Chem. 261:13268-13277(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 60.

Entry informationi

Entry nameiAPOC3_RAT
AccessioniPrimary (citable) accession number: P06759
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.