P06759 (APOC3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein C-III
Short name=Apo-CIII
Short name=ApoC-III

Alternative name(s):
Apolipoprotein C3

Gene names

Name:

Apoc3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular location	Secreted.
Tissue specificity	Mainly VLDL and also in HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Sequence similarities	Belongs to the apolipoprotein C3 family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism Lipid transport Transport
Cellular component	Chylomicron Secreted VLDL
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara cellular response to glucose stimulus Inferred from direct assay PubMed 21183731. Source: RGD cholesterol efflux Inferred from electronic annotation. Source: Compara cholesterol homeostasis Inferred from electronic annotation. Source: Compara cholesterol metabolic process Inferred from electronic annotation. Source: Compara chylomicron remnant clearance Inferred from electronic annotation. Source: Compara high-density lipoprotein particle remodeling Inferred from electronic annotation. Source: Compara inflammatory response Inferred from expression pattern PubMed 8491512. Source: RGD lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro lipoprotein transport Inferred from direct assay PubMed 4020294. Source: RGD negative regulation of cholesterol import Inferred from electronic annotation. Source: Compara negative regulation of fatty acid biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of high-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara negative regulation of lipoprotein lipase activity Inferred from electronic annotation. Source: Compara negative regulation of low-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara negative regulation of receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara negative regulation of triglyceride catabolic process Inferred from electronic annotation. Source: Compara negative regulation of very-low-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara phospholipid efflux Inferred from electronic annotation. Source: Compara regulation of Cdc42 protein signal transduction Inferred from electronic annotation. Source: Compara response to drug Inferred from expression pattern PubMed 9888873. Source: RGD response to nutrient Inferred from expression pattern PubMed 7811230. Source: RGD response to peptide hormone stimulus Inferred from direct assay PubMed 8429259. Source: RGD triglyceride catabolic process Inferred from electronic annotation. Source: Compara triglyceride homeostasis Inferred from electronic annotation. Source: Compara triglyceride mobilization Inferred from electronic annotation. Source: Compara
Cellular_component	chylomicron Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from direct assay PubMed 21183731PubMed 6419747. Source: RGD intermediate-density lipoprotein particle Inferred from electronic annotation. Source: Compara spherical high-density lipoprotein particle Inferred from electronic annotation. Source: Compara very-low-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipase inhibitor activity Inferred from electronic annotation. Source: Compara lipid transporter activity Traceable author statement Ref.1. Source: RGD phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 101	81	Apolipoprotein C-III		PRO_0000002035
Regions
	Region	69 – 101	33	Lipid-binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06759 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 1A7260DB909692D2	FASTA	101	11,117
	10 20 30 40 50 60 MQPRMLLIVA LVALLASARA DEGEGSLLLG SMQGYMEQAS KTVQDALSSM QESDIAVVAS 70 80 90 100 RGWMDNRFKS LKGYWSKFTD KFTGLWESGP EDQLTTPTLE P

References

[1]	"Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes." Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K. J. Biol. Chem. 261:13268-13277(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 60.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02596 Genomic DNA. Translation: AAA40746.1.
IPI	IPI00206600.
PIR	B24700.
UniGene	Rn.129547. Rn.195323.
3D structure databases
ProteinModelPortal	P06759.
SMR	P06759. Positions 21-96.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000074942; ENSRNOP00000067045; ENSRNOG00000047503.
Organism-specific databases
RGD	2136. Apoc3.
Phylogenomic databases
GeneTree	ENSGT00390000015395.
HOVERGEN	HBG050549.
Gene expression databases
Genevestigator	P06759.
Family and domain databases
InterPro	IPR008403. Apo-CIII. [Graphical view]
PANTHER	PTHR14225. PTHR14225. 1 hit.
Pfam	PF05778. Apo-CIII. 1 hit. [Graphical view]
ProDom	PD010414. Apo-CIII. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	602601.

Entry information

Entry name

APOC3_RAT

Accession

Primary (citable) accession number: P06759

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program