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Protein

Alcohol dehydrogenase 1

Gene

Adh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalytic
Metal bindingi68 – 681Zinc 1; catalytic
Metal bindingi98 – 981Zinc 2
Metal bindingi101 – 1011Zinc 2
Metal bindingi104 – 1041Zinc 2
Metal bindingi112 – 1121Zinc 2
Metal bindingi176 – 1761Zinc 1; catalytic
Binding sitei225 – 2251NADBy similarity
Binding sitei230 – 2301NADBy similarity
Binding sitei371 – 3711NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2066NADBy similarity
Nucleotide bindingi294 – 2963NADBy similarity

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: RGD
  • drug binding Source: RGD
  • ethanol binding Source: RGD
  • NAD binding Source: RGD
  • retinol dehydrogenase activity Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • acetaldehyde biosynthetic process Source: RGD
  • ethanol oxidation Source: RGD
  • organ regeneration Source: RGD
  • response to progesterone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-2161541. Abacavir metabolism.
R-RNO-5365859. RA biosynthesis pathway.
R-RNO-71384. Ethanol oxidation.
SABIO-RKP06757.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase A subunit
Gene namesi
Name:Adh1
Synonyms:Adh-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2044. Adh1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 376375Alcohol dehydrogenase 1PRO_0000160669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei235 – 2351N6-succinyllysineBy similarity
Modified residuei341 – 3411N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP06757.
PRIDEiP06757.

PTM databases

iPTMnetiP06757.
PhosphoSiteiP06757.

Expressioni

Gene expression databases

ExpressionAtlasiP06757. baseline and differential.
GenevisibleiP06757. RN.

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of three types (A, B, C), which are coded by 3 separate genes at different loci.

Protein-protein interaction databases

MINTiMINT-4575526.
STRINGi10116.ENSRNOP00000016346.

Structurei

3D structure databases

ProteinModelPortaliP06757.
SMRiP06757. Positions 2-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiP06757.
KOiK13951.
OMAiLWELNSP.
PhylomeDBiP06757.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAGKVIKC KAAVLWEPHK PFTIEDIEVA PPKAHEVRIK MVATGVCRSD
60 70 80 90 100
DHAVSGSLFT PLPAVLGHEG AGIVESIGEG VTCVKPGDKV IPLFSPQCGK
110 120 130 140 150
CRICKHPESN LCCQTKNLTQ PKGALLDGTS RFSCRGKPIH HFISTSTFSQ
160 170 180 190 200
YTVVDDIAVA KIDAAAPLDK VCLIGCGFST GYGSAVQVAK VTPGSTCAVF
210 220 230 240 250
GLGGVGLSVV IGCKTAGAAK IIAVDINKDK FAKAKELGAT DCINPQDYTK
260 270 280 290 300
PIQEVLQEMT DGGVDFSFEV IGRLDTMTSA LLSCHSACGV SVIVGVPPSA
310 320 330 340 350
QSLSVNPMSL LLGRTWKGAI FGGFKSKDAV PKLVADFMAK KFPLEPLITH
360 370
VLPFEKINEA FDLLRAGKSI RTVLTF
Length:376
Mass (Da):39,645
Last modified:January 23, 2007 - v3
Checksum:i3C7026C6D7C0ED76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431I → L in AAA40681 (PubMed:2881847).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29523
, M29516, M29517, M29518, M29519, M29520, M29521, M29522 Genomic DNA. Translation: AAA85462.1.
M15327 mRNA. Translation: AAA40681.1.
BC062403 mRNA. Translation: AAH62403.1.
PIRiA26468.
RefSeqiNP_062159.3. NM_019286.4.
UniGeneiRn.40222.

Genome annotation databases

EnsembliENSRNOT00000083682; ENSRNOP00000072955; ENSRNOG00000012436.
GeneIDi24172.
KEGGirno:24172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29523
, M29516, M29517, M29518, M29519, M29520, M29521, M29522 Genomic DNA. Translation: AAA85462.1.
M15327 mRNA. Translation: AAA40681.1.
BC062403 mRNA. Translation: AAH62403.1.
PIRiA26468.
RefSeqiNP_062159.3. NM_019286.4.
UniGeneiRn.40222.

3D structure databases

ProteinModelPortaliP06757.
SMRiP06757. Positions 2-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4575526.
STRINGi10116.ENSRNOP00000016346.

Chemistry

ChEMBLiCHEMBL4862.

PTM databases

iPTMnetiP06757.
PhosphoSiteiP06757.

Proteomic databases

PaxDbiP06757.
PRIDEiP06757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083682; ENSRNOP00000072955; ENSRNOG00000012436.
GeneIDi24172.
KEGGirno:24172.

Organism-specific databases

CTDi11522.
RGDi2044. Adh1.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiP06757.
KOiK13951.
OMAiLWELNSP.
PhylomeDBiP06757.

Enzyme and pathway databases

ReactomeiR-RNO-2161541. Abacavir metabolism.
R-RNO-5365859. RA biosynthesis pathway.
R-RNO-71384. Ethanol oxidation.
SABIO-RKP06757.

Miscellaneous databases

PROiP06757.

Gene expression databases

ExpressionAtlasiP06757. baseline and differential.
GenevisibleiP06757. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_RAT
AccessioniPrimary (citable) accession number: P06757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.