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Protein

Alcohol dehydrogenase 1

Gene

Adh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi176Zinc 1; catalytic1
Binding sitei225NADBy similarity1
Binding sitei230NADBy similarity1
Binding sitei371NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 206NADBy similarity6
Nucleotide bindingi294 – 296NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: RGD
  • drug binding Source: RGD
  • ethanol binding Source: RGD
  • NAD binding Source: RGD
  • retinol dehydrogenase activity Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • acetaldehyde biosynthetic process Source: RGD
  • animal organ regeneration Source: RGD
  • ethanol oxidation Source: RGD
  • response to progesterone Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-2161541 Abacavir metabolism
R-RNO-5365859 RA biosynthesis pathway
R-RNO-71384 Ethanol oxidation
SABIO-RKiP06757

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase A subunit
Gene namesi
Name:Adh1
Synonyms:Adh-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2044 Adh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4862

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606692 – 376Alcohol dehydrogenase 1Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei235N6-succinyllysineBy similarity1
Modified residuei341N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP06757
PRIDEiP06757

PTM databases

iPTMnetiP06757
PhosphoSitePlusiP06757

Expressioni

Gene expression databases

BgeeiENSRNOG00000012436
ExpressionAtlasiP06757 baseline and differential
GenevisibleiP06757 RN

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of three types (A, B, C), which are coded by 3 separate genes at different loci.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016346

Structurei

3D structure databases

ProteinModelPortaliP06757
SMRiP06757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP06757
KOiK13951
OMAiCNVCKHP
PhylomeDBiP06757

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAGKVIKC KAAVLWEPHK PFTIEDIEVA PPKAHEVRIK MVATGVCRSD
60 70 80 90 100
DHAVSGSLFT PLPAVLGHEG AGIVESIGEG VTCVKPGDKV IPLFSPQCGK
110 120 130 140 150
CRICKHPESN LCCQTKNLTQ PKGALLDGTS RFSCRGKPIH HFISTSTFSQ
160 170 180 190 200
YTVVDDIAVA KIDAAAPLDK VCLIGCGFST GYGSAVQVAK VTPGSTCAVF
210 220 230 240 250
GLGGVGLSVV IGCKTAGAAK IIAVDINKDK FAKAKELGAT DCINPQDYTK
260 270 280 290 300
PIQEVLQEMT DGGVDFSFEV IGRLDTMTSA LLSCHSACGV SVIVGVPPSA
310 320 330 340 350
QSLSVNPMSL LLGRTWKGAI FGGFKSKDAV PKLVADFMAK KFPLEPLITH
360 370
VLPFEKINEA FDLLRAGKSI RTVLTF
Length:376
Mass (Da):39,645
Last modified:January 23, 2007 - v3
Checksum:i3C7026C6D7C0ED76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143I → L in AAA40681 (PubMed:2881847).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29523
, M29516, M29517, M29518, M29519, M29520, M29521, M29522 Genomic DNA Translation: AAA85462.1
M15327 mRNA Translation: AAA40681.1
BC062403 mRNA Translation: AAH62403.1
PIRiA26468
RefSeqiNP_062159.3, NM_019286.4
UniGeneiRn.40222

Genome annotation databases

EnsembliENSRNOT00000083682; ENSRNOP00000072955; ENSRNOG00000012436
GeneIDi24172
KEGGirno:24172

Similar proteinsi

Entry informationi

Entry nameiADH1_RAT
AccessioniPrimary (citable) accession number: P06757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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