##gff-version 3 P06753 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58776 P06753 UniProtKB Chain 2 285 . . . ID=PRO_0000205632;Note=Tropomyosin alpha-3 chain P06753 UniProtKB Region 16 44 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06753 UniProtKB Coiled coil 1 285 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P06753 UniProtKB Modified residue 2 2 . . . Note=N-acetylmethionine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58776 P06753 UniProtKB Modified residue 54 54 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07951 P06753 UniProtKB Modified residue 62 62 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58774 P06753 UniProtKB Modified residue 88 88 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P06753 UniProtKB Modified residue 109 109 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07951 P06753 UniProtKB Modified residue 207 207 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07951 P06753 UniProtKB Modified residue 216 216 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58775 P06753 UniProtKB Modified residue 253 253 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07951 P06753 UniProtKB Modified residue 262 262 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P58775 P06753 UniProtKB Modified residue 272 272 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21107 P06753 UniProtKB Modified residue 283 283 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07951 P06753 UniProtKB Modified residue 284 284 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21107 P06753 UniProtKB Alternative sequence 1 127 . . . ID=VSP_054792;Note=In isoform 7. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Alternative sequence 1 81 . . . ID=VSP_006604;Note=In isoform 2%2C isoform 3 and isoform 6. MMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD->MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3024106;Dbxref=PMID:15489334,PMID:3024106 P06753 UniProtKB Alternative sequence 1 2 . . . ID=VSP_047302;Note=In isoform 4 and isoform 5. MM->MAGITTI;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Alternative sequence 5 21 . . . ID=VSP_047303;Note=In isoform 4 and isoform 5. IKKKMQMLKLDKENALD->VKRKIQVLQQQADDAEE;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Alternative sequence 25 81 . . . ID=VSP_047304;Note=In isoform 4 and isoform 5. QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD->RLQREVEGERRAREQ;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Alternative sequence 190 212 . . . ID=VSP_006605;Note=In isoform 2%2C isoform 3 and isoform 6. KCSELEEELKNVTNNLKSLEAQA->RCREMDEQIRLMDQNLKCLSAAE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3024106;Dbxref=PMID:15489334,PMID:3024106 P06753 UniProtKB Alternative sequence 259 285 . . . ID=VSP_006607;Note=In isoform 3. DELYAQKLKYKAISEELDHALNDMTSI->ERLYSQLERNRLLSNELKLTLHDLCD;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Alternative sequence 259 260 . . . ID=VSP_047305;Note=In isoform 4. DE->ER;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Alternative sequence 260 285 . . . ID=VSP_006606;Note=In isoform 2%2C isoform 5 and isoform 7. ELYAQKLKYKAISEELDHALNDMTSI->KLKCTKEEHLCTQRMLDQTLLDLNEM;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:3024106;Dbxref=PMID:15489334,PMID:3024106 P06753 UniProtKB Alternative sequence 263 285 . . . ID=VSP_047306;Note=In isoform 4. AQKLKYKAISEELDHALNDMTSI->SQLERNRLLSNELKLTLHDLCD;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Natural variant 4 4 . . . ID=VAR_071499;Note=In CMYP4A. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953533;Dbxref=dbSNP:rs199474711,PMID:19953533 P06753 UniProtKB Natural variant 9 9 . . . ID=VAR_013460;Note=In CMYP4A%3B decrease in the sensitivity of contraction to activating calcium. M->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10587521,ECO:0000269|PubMed:7704029;Dbxref=dbSNP:rs80358247,PMID:10587521,PMID:7704029 P06753 UniProtKB Natural variant 88 88 . . . ID=VAR_071500;Note=In CMYP4A. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=PMID:24692096 P06753 UniProtKB Natural variant 91 91 . . . ID=VAR_071501;Note=Found in patients with undefined congenital myopathy%3B likely pathogenic. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=dbSNP:rs1571418855,PMID:24692096 P06753 UniProtKB Natural variant 91 91 . . . ID=VAR_071502;Note=In CMYP4A. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953533;Dbxref=dbSNP:rs199474713,PMID:19953533 P06753 UniProtKB Natural variant 100 100 . . . ID=VAR_070066;Note=In CMYP4A. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18300303;Dbxref=dbSNP:rs121964853,PMID:18300303 P06753 UniProtKB Natural variant 100 100 . . . ID=VAR_071503;Note=In CMYP4A. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=dbSNP:rs121964853,PMID:24692096 P06753 UniProtKB Natural variant 149 149 . . . ID=VAR_071504;Note=In CMYP4A. L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24239060;Dbxref=PMID:24239060 P06753 UniProtKB Natural variant 151 151 . . . ID=VAR_071505;Note=In CMYP4A. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=PMID:24692096 P06753 UniProtKB Natural variant 168 168 . . . ID=VAR_070067;Note=In CMYP4A%3B also found in patients with undefined congenital myopathy. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18300303,ECO:0000269|PubMed:19487656,ECO:0000269|PubMed:24692096;Dbxref=dbSNP:rs121964854,PMID:18300303,PMID:19487656,PMID:24692096 P06753 UniProtKB Natural variant 168 168 . . . ID=VAR_070068;Note=In CMYP4A. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18300303;Dbxref=dbSNP:rs121964854,PMID:18300303 P06753 UniProtKB Natural variant 168 168 . . . ID=VAR_070069;Note=In CMYP4A%3B also found in patients with undefined congenital myopathy. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17376686,ECO:0000269|PubMed:18300303,ECO:0000269|PubMed:19553118,ECO:0000269|PubMed:19953533,ECO:0000269|PubMed:20951040,ECO:0000269|PubMed:24692096;Dbxref=dbSNP:rs121964852,PMID:17376686,PMID:18300303,PMID:19553118,PMID:19953533,PMID:20951040,PMID:24692096 P06753 UniProtKB Natural variant 169 169 . . . ID=VAR_070070;Note=In CMYP4A. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18300303;Dbxref=dbSNP:rs199474715,PMID:18300303 P06753 UniProtKB Natural variant 174 174 . . . ID=VAR_071506;Note=In CMYP4A. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20951040;Dbxref=dbSNP:rs199474716,PMID:20951040 P06753 UniProtKB Natural variant 241 241 . . . ID=VAR_071507;Note=In CMYP4A. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19953533;Dbxref=dbSNP:rs199474717,PMID:19953533 P06753 UniProtKB Natural variant 245 245 . . . ID=VAR_070071;Note=In CMYP4A. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18300303;Dbxref=dbSNP:rs199474718,PMID:18300303 P06753 UniProtKB Natural variant 245 245 . . . ID=VAR_071508;Note=In CMYP4A. R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=dbSNP:rs797046047,PMID:24692096 P06753 UniProtKB Natural variant 253 253 . . . ID=VAR_071509;Note=Found in patients with undefined congenital myopathy%3B likely pathogenic. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692096;Dbxref=dbSNP:rs1553248515,PMID:24692096 P06753 UniProtKB Sequence conflict 150 150 . . . Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Helix 44 110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OTN P06753 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Modified residue 177 177 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06753 UniProtKB Modified residue 215 215 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06753 UniProtKB Sequence conflict 33 33 . . . Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 43 43 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 66 66 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 85 85 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 110 110 . . . Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 135 135 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 150 150 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 192 192 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 196 196 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Sequence conflict 202 202 . . . Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06753 UniProtKB Modified residue 177 177 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06753 UniProtKB Modified residue 215 215 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06753 UniProtKB Modified residue 177 177 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06753 UniProtKB Modified residue 125 125 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861