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Protein

Tropomyosin alpha-3 chain

Gene

TPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

GO - Biological processi

  • movement of cell or subcellular component Source: UniProtKB
  • muscle contraction Source: Reactome
  • muscle filament sliding Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-3 chain
Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3
Tropomyosin-5
Short name:
hTM5
Gene namesi
Name:TPM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12012. TPM3.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • muscle thin filament tropomyosin Source: UniProtKB
  • stress fiber Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Nemaline myopathy 1 (NEM1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are disorders characterized by muscle weakness of varying onset and severity, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Autosomal dominant NEM1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate to severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
See also OMIM:609284
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 Publications
Corresponds to variant rs80358247 [ dbSNP | Ensembl ].
VAR_013460
Natural varianti88 – 881S → F in NEM1 and CAPM1. 1 Publication
VAR_071500
Natural varianti168 – 1681R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 Publications
Corresponds to variant rs121964854 [ dbSNP | Ensembl ].
VAR_070067
Natural varianti168 – 1681R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 Publications
Corresponds to variant rs121964852 [ dbSNP | Ensembl ].
VAR_070069

A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.

Myopathy, congenital, with fiber-type disproportion (CFTD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
See also OMIM:255310
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41A → V in CFTD. 1 Publication
Corresponds to variant rs199474711 [ dbSNP | Ensembl ].
VAR_071499
Natural varianti91 – 911R → P in CFTD. 1 Publication
Corresponds to variant rs199474713 [ dbSNP | Ensembl ].
VAR_071502
Natural varianti100 – 1001L → M in CFTD. 1 Publication
Corresponds to variant rs121964853 [ dbSNP | Ensembl ].
VAR_070066
Natural varianti100 – 1001L → V in CFTD. 1 Publication
VAR_071503
Natural varianti168 – 1681R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 Publications
Corresponds to variant rs121964854 [ dbSNP | Ensembl ].
VAR_070067
Natural varianti168 – 1681R → G in CFTD. 1 Publication
Corresponds to variant rs121964854 [ dbSNP | Ensembl ].
VAR_070068
Natural varianti168 – 1681R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 Publications
Corresponds to variant rs121964852 [ dbSNP | Ensembl ].
VAR_070069
Natural varianti169 – 1691K → E in CFTD. 1 Publication
Corresponds to variant rs199474715 [ dbSNP | Ensembl ].
VAR_070070
Natural varianti174 – 1741E → A in CFTD. 1 Publication
Corresponds to variant rs199474716 [ dbSNP | Ensembl ].
VAR_071506
Natural varianti241 – 2411E → K in CFTD. 1 Publication
Corresponds to variant rs199474717 [ dbSNP | Ensembl ].
VAR_071507
Natural varianti245 – 2451R → G in CFTD. 1 Publication
Corresponds to variant rs199474718 [ dbSNP | Ensembl ].
VAR_070071
Cap myopathy 1 (CAPM1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and slowly progressive muscle weakness. Respiratory problems are common.
See also OMIM:609284
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti88 – 881S → F in NEM1 and CAPM1. 1 Publication
VAR_071500
Natural varianti149 – 1491L → I in CAPM1. 1 Publication
VAR_071504
Natural varianti151 – 1511E → A in CAPM1. 1 Publication
VAR_071505
Natural varianti168 – 1681R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 Publications
Corresponds to variant rs121964854 [ dbSNP | Ensembl ].
VAR_070067
Natural varianti168 – 1681R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 Publications
Corresponds to variant rs121964852 [ dbSNP | Ensembl ].
VAR_070069
Natural varianti245 – 2451R → I in CAPM1. 1 Publication
VAR_071508

Keywords - Diseasei

Disease mutation, Nemaline myopathy, Proto-oncogene

Organism-specific databases

MalaCardsiTPM3.
MIMi255310. phenotype.
609284. phenotype.
Orphaneti171881. Cap myopathy.
171439. Childhood-onset nemaline myopathy.
2020. Congenital fiber-type disproportion myopathy.
178342. Inflammatory myofibroblastic tumor.
171433. Intermediate nemaline myopathy.
PharmGKBiPA36692.

Polymorphism and mutation databases

DMDMi519668659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 285284Tropomyosin alpha-3 chainPRO_0000205632Add
BLAST
Isoform 2 (identifier: P06753-2)
Initiator methionineiRemovedCombined sourcesCurated
Isoform 3 (identifier: P06753-3)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylmethionineBy similarity
Modified residuei54 – 541PhosphothreonineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity
Cross-linki78 – 78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei88 – 881PhosphoserineCombined sources
Modified residuei109 – 1091PhosphothreonineBy similarity
Modified residuei207 – 2071PhosphoserineBy similarity
Modified residuei216 – 2161PhosphoserineBy similarity
Modified residuei253 – 2531PhosphothreonineBy similarity
Modified residuei262 – 2621PhosphotyrosineBy similarity
Modified residuei272 – 2721PhosphoserineBy similarity
Modified residuei283 – 2831PhosphothreonineBy similarity
Modified residuei284 – 2841PhosphoserineBy similarity
Isoform 2 (identifier: P06753-2)
Modified residuei2 – 21N-acetylalanineCombined sourcesCurated
Modified residuei177 – 1771N6-acetyllysineCombined sourcesCurated
Modified residuei215 – 2151N6-acetyllysineCombined sourcesCurated
Isoform 3 (identifier: P06753-3)
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei177 – 1771N6-acetyllysineCombined sources
Isoform 7 (identifier: P06753-7)
Modified residuei125 – 1251N6-acetyllysineCombined sources
Isoform 6 (identifier: P06753-6)
Modified residuei177 – 1771N6-acetyllysineCombined sources
Isoform 5 (identifier: P06753-5)
Modified residuei215 – 2151N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP06753.
MaxQBiP06753.
PaxDbiP06753.
PeptideAtlasiP06753.
PRIDEiP06753.

2D gel databases

DOSAC-COBS-2DPAGEP06753.
SWISS-2DPAGEP06753.

PTM databases

iPTMnetiP06753.
PhosphoSiteiP06753.
SwissPalmiP06753.

Expressioni

Gene expression databases

BgeeiENSG00000143549.
CleanExiHS_TPM3.
ExpressionAtlasiP06753. baseline and differential.
GenevisibleiP06753. HS.

Organism-specific databases

HPAiHPA000261.
HPA009066.
HPA047089.
HPA053624.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain. Binds to TMOD1.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCHCR1Q8TD31-33EBI-355607,EBI-10175300
FAM9CQ8IZT93EBI-355607,EBI-2870039
HSF2Q039333EBI-355607,EBI-2556750
KXD1Q9BQD34EBI-355607,EBI-739657
LCA5LO954473EBI-355607,EBI-8473670
LURAP1Q96LR23EBI-355607,EBI-741355
MAD1L1Q9Y6D94EBI-355607,EBI-742610
OIP5O434823EBI-355607,EBI-536879
SYCE1Q8N0S23EBI-355607,EBI-6872807
TFPTA0A024R4Q56EBI-355607,EBI-11527449
TFPTG5E9B53EBI-355607,EBI-10178002
VPS52Q8N1B43EBI-355607,EBI-2799833

Protein-protein interaction databases

BioGridi113023. 128 interactions.
IntActiP06753. 47 interactions.
MINTiMINT-1142638.
STRINGi9606.ENSP00000357516.

Structurei

3D structure databases

ProteinModelPortaliP06753.
SMRiP06753. Positions 9-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 285285By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiP06753.
KOiK09290.
OMAiXKCSELE.
OrthoDBiEOG091G0UO7.
PhylomeDBiP06753.
TreeFamiTF351519.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P06753-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK
60 70 80 90 100
LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL
110 120 130 140 150
DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK
160 170 180 190 200
EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN
210 220 230 240 250
VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL
260 270 280
EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI
Length:285
Mass (Da):32,950
Last modified:June 26, 2013 - v2
Checksum:i99EAD24C45460A14
GO
Isoform 2 (identifier: P06753-2) [UniParc]FASTAAdd to basket
Also known as: Cytoskeletal, TM30nm

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS.Combined sourcesCurated PubMed:16201836 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues.Combined sourcesCurated
Show »
Length:248
Mass (Da):29,033
Checksum:i5C049312A337BC19
GO
Isoform 3 (identifier: P06753-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     259-285: DELYAQKLKYKAISEELDHALNDMTSI → ERLYSQLERNRLLSNELKLTLHDLCD

Note: Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS.Combined sources
Show »
Length:247
Mass (Da):28,955
Checksum:i4929E6D4591374D3
GO
Isoform 4 (identifier: P06753-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     259-260: DE → ER
     263-285: AQKLKYKAISEELDHALNDMTSI → SQLERNRLLSNELKLTLHDLCD

Note: Gene prediction based on EST data.
Show »
Length:247
Mass (Da):28,793
Checksum:i239796CBE73C98AE
GO
Isoform 5 (identifier: P06753-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: Gene prediction based on EST data.Combined sources
Show »
Length:248
Mass (Da):28,870
Checksum:i179E2D62BC8993F5
GO
Isoform 6 (identifier: P06753-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE

Note: No experimental confirmation available.Combined sources
Show »
Length:248
Mass (Da):28,922
Checksum:i5427F068894BF936
GO
Isoform 7 (identifier: P06753-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: No experimental confirmation available. Gene prediction based on EST data.Combined sources
Show »
Length:158
Mass (Da):18,603
Checksum:iD3F876D8EFC7265F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501K → E in CAA27243 (PubMed:12574106).Curated
Isoform 2 (identifier: P06753-2)
Sequence conflicti33 – 331R → Q in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti43 – 431E → K in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti66 – 661A → P in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti85 – 851D → G in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti110 – 1101I → L in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti135 – 1351I → T in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti150 – 1501A → T in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti192 – 1921L → F in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti196 – 1961L → P in ABC40673 (PubMed:16201836).Combined sourcesCurated
Sequence conflicti202 – 2021R → C in ABC40673 (PubMed:16201836).Combined sourcesCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41A → V in CFTD. 1 Publication
Corresponds to variant rs199474711 [ dbSNP | Ensembl ].
VAR_071499
Natural varianti9 – 91M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 Publications
Corresponds to variant rs80358247 [ dbSNP | Ensembl ].
VAR_013460
Natural varianti88 – 881S → F in NEM1 and CAPM1. 1 Publication
VAR_071500
Natural varianti91 – 911R → C Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication
VAR_071501
Natural varianti91 – 911R → P in CFTD. 1 Publication
Corresponds to variant rs199474713 [ dbSNP | Ensembl ].
VAR_071502
Natural varianti100 – 1001L → M in CFTD. 1 Publication
Corresponds to variant rs121964853 [ dbSNP | Ensembl ].
VAR_070066
Natural varianti100 – 1001L → V in CFTD. 1 Publication
VAR_071503
Natural varianti149 – 1491L → I in CAPM1. 1 Publication
VAR_071504
Natural varianti151 – 1511E → A in CAPM1. 1 Publication
VAR_071505
Natural varianti168 – 1681R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 Publications
Corresponds to variant rs121964854 [ dbSNP | Ensembl ].
VAR_070067
Natural varianti168 – 1681R → G in CFTD. 1 Publication
Corresponds to variant rs121964854 [ dbSNP | Ensembl ].
VAR_070068
Natural varianti168 – 1681R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 Publications
Corresponds to variant rs121964852 [ dbSNP | Ensembl ].
VAR_070069
Natural varianti169 – 1691K → E in CFTD. 1 Publication
Corresponds to variant rs199474715 [ dbSNP | Ensembl ].
VAR_070070
Natural varianti174 – 1741E → A in CFTD. 1 Publication
Corresponds to variant rs199474716 [ dbSNP | Ensembl ].
VAR_071506
Natural varianti241 – 2411E → K in CFTD. 1 Publication
Corresponds to variant rs199474717 [ dbSNP | Ensembl ].
VAR_071507
Natural varianti245 – 2451R → G in CFTD. 1 Publication
Corresponds to variant rs199474718 [ dbSNP | Ensembl ].
VAR_070071
Natural varianti245 – 2451R → I in CAPM1. 1 Publication
VAR_071508
Natural varianti253 – 2531T → K Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication
VAR_071509

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 127127Missing in isoform 7. CuratedVSP_054792Add
BLAST
Alternative sequencei1 – 8181MMEAI…KKAAD → MAGITTIEAVKRKIQVLQQQ ADDAEERAERLQREVEGERR AREQ in isoform 2, isoform 3 and isoform 6. 2 PublicationsVSP_006604Add
BLAST
Alternative sequencei1 – 22MM → MAGITTI in isoform 4 and isoform 5. CuratedVSP_047302
Alternative sequencei5 – 2117IKKKM…ENALD → VKRKIQVLQQQADDAEE in isoform 4 and isoform 5. CuratedVSP_047303Add
BLAST
Alternative sequencei25 – 8157QAEAE…KKAAD → RLQREVEGERRAREQ in isoform 4 and isoform 5. CuratedVSP_047304Add
BLAST
Alternative sequencei190 – 21223KCSEL…LEAQA → RCREMDEQIRLMDQNLKCLS AAE in isoform 2, isoform 3 and isoform 6. 2 PublicationsVSP_006605Add
BLAST
Alternative sequencei259 – 28527DELYA…DMTSI → ERLYSQLERNRLLSNELKLT LHDLCD in isoform 3. CuratedVSP_006607Add
BLAST
Alternative sequencei259 – 2602DE → ER in isoform 4. CuratedVSP_047305
Alternative sequencei260 – 28526ELYAQ…DMTSI → KLKCTKEEHLCTQRMLDQTL LDLNEM in isoform 2, isoform 5 and isoform 7. 2 PublicationsVSP_006606Add
BLAST
Alternative sequencei263 – 28523AQKLK…DMTSI → SQLERNRLLSNELKLTLHDL CD in isoform 4. CuratedVSP_047306Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04201 mRNA. Translation: CAA27798.1.
AY004867 mRNA. Translation: AAF87083.1.
X04588 mRNA. Translation: CAB37185.1.
AL590431 Genomic DNA. Translation: CAH71264.1.
AL590431 Genomic DNA. Translation: CAH71269.1.
CH471121 Genomic DNA. Translation: EAW53229.1.
CH471121 Genomic DNA. Translation: EAW53230.1.
CH471121 Genomic DNA. Translation: EAW53231.1.
CH471121 Genomic DNA. Translation: EAW53235.1.
BC000771 mRNA. Translation: AAH00771.1.
BC008407 mRNA. Translation: AAH08407.1.
BC008425 mRNA. Translation: AAH08425.1.
BC015403 mRNA. Translation: AAH15403.1.
BC072428 mRNA. Translation: AAH72428.1.
DQ120714 Genomic DNA. Translation: ABC40673.1.
X03541 mRNA. Translation: CAA27243.1. Different termination.
AF474157 mRNA. Translation: AAL84570.1.
CCDSiCCDS1060.1. [P06753-2]
CCDS41400.1. [P06753-5]
CCDS41401.1. [P06753-4]
CCDS41402.1. [P06753-3]
CCDS41403.1. [P06753-1]
CCDS60274.1. [P06753-7]
CCDS60275.1. [P06753-6]
PIRiA25530.
S06210. A24199.
RefSeqiNP_001036816.1. NM_001043351.1. [P06753-5]
NP_001036817.1. NM_001043352.1. [P06753-3]
NP_001036818.1. NM_001043353.1. [P06753-4]
NP_001265118.1. NM_001278189.1. [P06753-6]
NP_001265120.1. NM_001278191.1. [P06753-7]
NP_689476.2. NM_152263.3. [P06753-1]
NP_705935.1. NM_153649.3. [P06753-2]
UniGeneiHs.535581.
Hs.578978.
Hs.644306.
Hs.654421.

Genome annotation databases

EnsembliENST00000302206; ENSP00000307712; ENSG00000143549. [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549. [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549. [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549. [P06753-5]
ENST00000368530; ENSP00000357516; ENSG00000143549. [P06753-1]
ENST00000368531; ENSP00000357517; ENSG00000143549. [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549. [P06753-2]
GeneIDi7170.
KEGGihsa:7170.
UCSCiuc001fdy.2. human. [P06753-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04201 mRNA. Translation: CAA27798.1.
AY004867 mRNA. Translation: AAF87083.1.
X04588 mRNA. Translation: CAB37185.1.
AL590431 Genomic DNA. Translation: CAH71264.1.
AL590431 Genomic DNA. Translation: CAH71269.1.
CH471121 Genomic DNA. Translation: EAW53229.1.
CH471121 Genomic DNA. Translation: EAW53230.1.
CH471121 Genomic DNA. Translation: EAW53231.1.
CH471121 Genomic DNA. Translation: EAW53235.1.
BC000771 mRNA. Translation: AAH00771.1.
BC008407 mRNA. Translation: AAH08407.1.
BC008425 mRNA. Translation: AAH08425.1.
BC015403 mRNA. Translation: AAH15403.1.
BC072428 mRNA. Translation: AAH72428.1.
DQ120714 Genomic DNA. Translation: ABC40673.1.
X03541 mRNA. Translation: CAA27243.1. Different termination.
AF474157 mRNA. Translation: AAL84570.1.
CCDSiCCDS1060.1. [P06753-2]
CCDS41400.1. [P06753-5]
CCDS41401.1. [P06753-4]
CCDS41402.1. [P06753-3]
CCDS41403.1. [P06753-1]
CCDS60274.1. [P06753-7]
CCDS60275.1. [P06753-6]
PIRiA25530.
S06210. A24199.
RefSeqiNP_001036816.1. NM_001043351.1. [P06753-5]
NP_001036817.1. NM_001043352.1. [P06753-3]
NP_001036818.1. NM_001043353.1. [P06753-4]
NP_001265118.1. NM_001278189.1. [P06753-6]
NP_001265120.1. NM_001278191.1. [P06753-7]
NP_689476.2. NM_152263.3. [P06753-1]
NP_705935.1. NM_153649.3. [P06753-2]
UniGeneiHs.535581.
Hs.578978.
Hs.644306.
Hs.654421.

3D structure databases

ProteinModelPortaliP06753.
SMRiP06753. Positions 9-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113023. 128 interactions.
IntActiP06753. 47 interactions.
MINTiMINT-1142638.
STRINGi9606.ENSP00000357516.

PTM databases

iPTMnetiP06753.
PhosphoSiteiP06753.
SwissPalmiP06753.

Polymorphism and mutation databases

DMDMi519668659.

2D gel databases

DOSAC-COBS-2DPAGEP06753.
SWISS-2DPAGEP06753.

Proteomic databases

EPDiP06753.
MaxQBiP06753.
PaxDbiP06753.
PeptideAtlasiP06753.
PRIDEiP06753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302206; ENSP00000307712; ENSG00000143549. [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549. [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549. [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549. [P06753-5]
ENST00000368530; ENSP00000357516; ENSG00000143549. [P06753-1]
ENST00000368531; ENSP00000357517; ENSG00000143549. [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549. [P06753-2]
GeneIDi7170.
KEGGihsa:7170.
UCSCiuc001fdy.2. human. [P06753-1]

Organism-specific databases

CTDi7170.
GeneCardsiTPM3.
GeneReviewsiTPM3.
HGNCiHGNC:12012. TPM3.
HPAiHPA000261.
HPA009066.
HPA047089.
HPA053624.
MalaCardsiTPM3.
MIMi164970. gene.
191030. gene.
255310. phenotype.
609284. phenotype.
neXtProtiNX_P06753.
Orphaneti171881. Cap myopathy.
171439. Childhood-onset nemaline myopathy.
2020. Congenital fiber-type disproportion myopathy.
178342. Inflammatory myofibroblastic tumor.
171433. Intermediate nemaline myopathy.
PharmGKBiPA36692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiP06753.
KOiK09290.
OMAiXKCSELE.
OrthoDBiEOG091G0UO7.
PhylomeDBiP06753.
TreeFamiTF351519.

Enzyme and pathway databases

ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiTPM3. human.
GeneWikiiTropomyosin_3.
GenomeRNAii7170.
PROiP06753.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143549.
CleanExiHS_TPM3.
ExpressionAtlasiP06753. baseline and differential.
GenevisibleiP06753. HS.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM3_HUMAN
AccessioniPrimary (citable) accession number: P06753
Secondary accession number(s): D3DV71
, P12324, Q2QD06, Q5VU58, Q5VU63, Q5VU66, Q5VU71, Q5VU72, Q8TCG3, Q969Q2, Q9NQH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: June 26, 2013
Last modified: September 7, 2016
This is version 192 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.