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Protein

Tropomyosin alpha-3 chain

Gene

TPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

GO - Biological processi

  • movement of cell or subcellular component Source: UniProtKB
  • muscle contraction Source: Reactome
  • muscle filament sliding Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143549-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-3 chain
Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3
Tropomyosin-5
Short name:
hTM5
Gene namesi
Name:TPM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12012. TPM3.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • muscle thin filament tropomyosin Source: UniProtKB
  • stress fiber Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Nemaline myopathy 1 (NEM1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are disorders characterized by muscle weakness of varying onset and severity, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Autosomal dominant NEM1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate to severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
See also OMIM:609284
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0134609M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant rs80358247dbSNPEnsembl.1
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant rs121964854dbSNPEnsembl.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant rs121964852dbSNPEnsembl.1

A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.

Myopathy, congenital, with fiber-type disproportion (CFTD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
See also OMIM:255310
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714994A → V in CFTD. 1 PublicationCorresponds to variant rs199474711dbSNPEnsembl.1
Natural variantiVAR_07150291R → P in CFTD. 1 PublicationCorresponds to variant rs199474713dbSNPEnsembl.1
Natural variantiVAR_070066100L → M in CFTD. 1 PublicationCorresponds to variant rs121964853dbSNPEnsembl.1
Natural variantiVAR_071503100L → V in CFTD. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant rs121964854dbSNPEnsembl.1
Natural variantiVAR_070068168R → G in CFTD. 1 PublicationCorresponds to variant rs121964854dbSNPEnsembl.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant rs121964852dbSNPEnsembl.1
Natural variantiVAR_070070169K → E in CFTD. 1 PublicationCorresponds to variant rs199474715dbSNPEnsembl.1
Natural variantiVAR_071506174E → A in CFTD. 1 PublicationCorresponds to variant rs199474716dbSNPEnsembl.1
Natural variantiVAR_071507241E → K in CFTD. 1 PublicationCorresponds to variant rs199474717dbSNPEnsembl.1
Natural variantiVAR_070071245R → G in CFTD. 1 PublicationCorresponds to variant rs199474718dbSNPEnsembl.1
Cap myopathy 1 (CAPM1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and slowly progressive muscle weakness. Respiratory problems are common.
See also OMIM:609284
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_071504149L → I in CAPM1. 1 Publication1
Natural variantiVAR_071505151E → A in CAPM1. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant rs121964854dbSNPEnsembl.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant rs121964852dbSNPEnsembl.1
Natural variantiVAR_071508245R → I in CAPM1. 1 Publication1

Keywords - Diseasei

Disease mutation, Nemaline myopathy, Proto-oncogene

Organism-specific databases

DisGeNETi7170.
MalaCardsiTPM3.
MIMi255310. phenotype.
609284. phenotype.
OpenTargetsiENSG00000143549.
Orphaneti171881. Cap myopathy.
171439. Childhood-onset nemaline myopathy.
2020. Congenital fiber-type disproportion myopathy.
178342. Inflammatory myofibroblastic tumor.
171433. Intermediate nemaline myopathy.
PharmGKBiPA36692.

Polymorphism and mutation databases

DMDMi519668659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002056322 – 285Tropomyosin alpha-3 chainAdd BLAST284
Isoform 2 (identifier: P06753-2)
Initiator methionineiRemovedCombined sourcesCurated2 Publications
Isoform 3 (identifier: P06753-3)
Initiator methionineiRemovedCombined sources2 Publications

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylmethionineBy similarity1
Modified residuei54PhosphothreonineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei88PhosphoserineCombined sources1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei253PhosphothreonineBy similarity1
Modified residuei262PhosphotyrosineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei283PhosphothreonineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Isoform 2 (identifier: P06753-2)
Modified residuei2N-acetylalanineCombined sourcesCurated2 Publications1
Modified residuei177N6-acetyllysineCombined sourcesCurated2 Publications1
Modified residuei215N6-acetyllysineCombined sourcesCurated2 Publications1
Isoform 3 (identifier: P06753-3)
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei177N6-acetyllysineCombined sources2 Publications1
Isoform 7 (identifier: P06753-7)
Modified residuei125N6-acetyllysineCombined sources1
Isoform 6 (identifier: P06753-6)
Modified residuei177N6-acetyllysineCombined sources1
Isoform 5 (identifier: P06753-5)
Modified residuei215N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP06753.
MaxQBiP06753.
PaxDbiP06753.
PeptideAtlasiP06753.
PRIDEiP06753.

2D gel databases

DOSAC-COBS-2DPAGEP06753.
SWISS-2DPAGEP06753.

PTM databases

iPTMnetiP06753.
PhosphoSitePlusiP06753.
SwissPalmiP06753.

Expressioni

Gene expression databases

BgeeiENSG00000143549.
CleanExiHS_TPM3.
ExpressionAtlasiP06753. baseline and differential.
GenevisibleiP06753. HS.

Organism-specific databases

HPAiHPA000261.
HPA009066.
HPA047089.
HPA053624.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain. Binds to TMOD1.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCHCR1Q8TD31-35EBI-355607,EBI-10175300
FAM9CQ8IZT93EBI-355607,EBI-2870039
HSF2Q039335EBI-355607,EBI-2556750
KXD1Q9BQD36EBI-355607,EBI-739657
LCA5LO954473EBI-355607,EBI-8473670
LURAP1Q96LR23EBI-355607,EBI-741355
MAD1L1Q9Y6D96EBI-355607,EBI-742610
OIP5O434825EBI-355607,EBI-536879
SYCE1Q8N0S23EBI-355607,EBI-6872807
TFPTA0A024R4Q56EBI-355607,EBI-11527449
TFPTG5E9B53EBI-355607,EBI-10178002
VPS52Q8N1B43EBI-355607,EBI-2799833

Protein-protein interaction databases

BioGridi113023. 128 interactors.
IntActiP06753. 51 interactors.
MINTiMINT-1142638.
STRINGi9606.ENSP00000357516.

Structurei

3D structure databases

ProteinModelPortaliP06753.
SMRiP06753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 285By similarityAdd BLAST285

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiP06753.
KOiK09290.
OMAiXKCSELE.
OrthoDBiEOG091G0UO7.
PhylomeDBiP06753.
TreeFamiTF351519.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P06753-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK
60 70 80 90 100
LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL
110 120 130 140 150
DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK
160 170 180 190 200
EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN
210 220 230 240 250
VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL
260 270 280
EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI
Length:285
Mass (Da):32,950
Last modified:June 26, 2013 - v2
Checksum:i99EAD24C45460A14
GO
Isoform 2 (identifier: P06753-2) [UniParc]FASTAAdd to basket
Also known as: Cytoskeletal, TM30nm

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS.Combined sourcesCurated2 Publications PubMed:16201836 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues.Combined sourcesCurated2 Publications
Show »
Length:248
Mass (Da):29,033
Checksum:i5C049312A337BC19
GO
Isoform 3 (identifier: P06753-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     259-285: DELYAQKLKYKAISEELDHALNDMTSI → ERLYSQLERNRLLSNELKLTLHDLCD

Note: Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS.Combined sources2 Publications
Show »
Length:247
Mass (Da):28,955
Checksum:i4929E6D4591374D3
GO
Isoform 4 (identifier: P06753-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     259-260: DE → ER
     263-285: AQKLKYKAISEELDHALNDMTSI → SQLERNRLLSNELKLTLHDLCD

Note: Gene prediction based on EST data.
Show »
Length:247
Mass (Da):28,793
Checksum:i239796CBE73C98AE
GO
Isoform 5 (identifier: P06753-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: Gene prediction based on EST data.Combined sources
Show »
Length:248
Mass (Da):28,870
Checksum:i179E2D62BC8993F5
GO
Isoform 6 (identifier: P06753-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE

Note: No experimental confirmation available.Combined sources
Show »
Length:248
Mass (Da):28,922
Checksum:i5427F068894BF936
GO
Isoform 7 (identifier: P06753-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: No experimental confirmation available. Gene prediction based on EST data.Combined sources
Show »
Length:158
Mass (Da):18,603
Checksum:iD3F876D8EFC7265F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150K → E in CAA27243 (PubMed:12574106).Curated1
Isoform 2 (identifier: P06753-2)
Sequence conflicti33R → Q in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti43E → K in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti66A → P in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti85D → G in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti110I → L in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti135I → T in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti150A → T in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti192L → F in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti196L → P in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti202R → C in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714994A → V in CFTD. 1 PublicationCorresponds to variant rs199474711dbSNPEnsembl.1
Natural variantiVAR_0134609M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant rs80358247dbSNPEnsembl.1
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_07150191R → C Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_07150291R → P in CFTD. 1 PublicationCorresponds to variant rs199474713dbSNPEnsembl.1
Natural variantiVAR_070066100L → M in CFTD. 1 PublicationCorresponds to variant rs121964853dbSNPEnsembl.1
Natural variantiVAR_071503100L → V in CFTD. 1 Publication1
Natural variantiVAR_071504149L → I in CAPM1. 1 Publication1
Natural variantiVAR_071505151E → A in CAPM1. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant rs121964854dbSNPEnsembl.1
Natural variantiVAR_070068168R → G in CFTD. 1 PublicationCorresponds to variant rs121964854dbSNPEnsembl.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant rs121964852dbSNPEnsembl.1
Natural variantiVAR_070070169K → E in CFTD. 1 PublicationCorresponds to variant rs199474715dbSNPEnsembl.1
Natural variantiVAR_071506174E → A in CFTD. 1 PublicationCorresponds to variant rs199474716dbSNPEnsembl.1
Natural variantiVAR_071507241E → K in CFTD. 1 PublicationCorresponds to variant rs199474717dbSNPEnsembl.1
Natural variantiVAR_070071245R → G in CFTD. 1 PublicationCorresponds to variant rs199474718dbSNPEnsembl.1
Natural variantiVAR_071508245R → I in CAPM1. 1 Publication1
Natural variantiVAR_071509253T → K Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547921 – 127Missing in isoform 7. CuratedAdd BLAST127
Alternative sequenceiVSP_0066041 – 81MMEAI…KKAAD → MAGITTIEAVKRKIQVLQQQ ADDAEERAERLQREVEGERR AREQ in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_0473021 – 2MM → MAGITTI in isoform 4 and isoform 5. Curated2
Alternative sequenceiVSP_0473035 – 21IKKKM…ENALD → VKRKIQVLQQQADDAEE in isoform 4 and isoform 5. CuratedAdd BLAST17
Alternative sequenceiVSP_04730425 – 81QAEAE…KKAAD → RLQREVEGERRAREQ in isoform 4 and isoform 5. CuratedAdd BLAST57
Alternative sequenceiVSP_006605190 – 212KCSEL…LEAQA → RCREMDEQIRLMDQNLKCLS AAE in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_006607259 – 285DELYA…DMTSI → ERLYSQLERNRLLSNELKLT LHDLCD in isoform 3. CuratedAdd BLAST27
Alternative sequenceiVSP_047305259 – 260DE → ER in isoform 4. Curated2
Alternative sequenceiVSP_006606260 – 285ELYAQ…DMTSI → KLKCTKEEHLCTQRMLDQTL LDLNEM in isoform 2, isoform 5 and isoform 7. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_047306263 – 285AQKLK…DMTSI → SQLERNRLLSNELKLTLHDL CD in isoform 4. CuratedAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04201 mRNA. Translation: CAA27798.1.
AY004867 mRNA. Translation: AAF87083.1.
X04588 mRNA. Translation: CAB37185.1.
AL590431 Genomic DNA. Translation: CAH71264.1.
AL590431 Genomic DNA. Translation: CAH71269.1.
CH471121 Genomic DNA. Translation: EAW53229.1.
CH471121 Genomic DNA. Translation: EAW53230.1.
CH471121 Genomic DNA. Translation: EAW53231.1.
CH471121 Genomic DNA. Translation: EAW53235.1.
BC000771 mRNA. Translation: AAH00771.1.
BC008407 mRNA. Translation: AAH08407.1.
BC008425 mRNA. Translation: AAH08425.1.
BC015403 mRNA. Translation: AAH15403.1.
BC072428 mRNA. Translation: AAH72428.1.
DQ120714 Genomic DNA. Translation: ABC40673.1.
X03541 mRNA. Translation: CAA27243.1. Different termination.
AF474157 mRNA. Translation: AAL84570.1.
CCDSiCCDS1060.1. [P06753-2]
CCDS41400.1. [P06753-5]
CCDS41401.1. [P06753-4]
CCDS41402.1. [P06753-3]
CCDS41403.1. [P06753-1]
CCDS60274.1. [P06753-7]
CCDS60275.1. [P06753-6]
PIRiA25530.
S06210. A24199.
RefSeqiNP_001036816.1. NM_001043351.1. [P06753-5]
NP_001036817.1. NM_001043352.1. [P06753-3]
NP_001036818.1. NM_001043353.1. [P06753-4]
NP_001265118.1. NM_001278189.1. [P06753-6]
NP_001265120.1. NM_001278191.1. [P06753-7]
NP_689476.2. NM_152263.3. [P06753-1]
NP_705935.1. NM_153649.3. [P06753-2]
UniGeneiHs.535581.
Hs.578978.
Hs.644306.
Hs.654421.

Genome annotation databases

EnsembliENST00000302206; ENSP00000307712; ENSG00000143549. [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549. [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549. [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549. [P06753-5]
ENST00000368530; ENSP00000357516; ENSG00000143549. [P06753-1]
ENST00000368531; ENSP00000357517; ENSG00000143549. [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549. [P06753-2]
GeneIDi7170.
KEGGihsa:7170.
UCSCiuc001fdy.2. human. [P06753-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04201 mRNA. Translation: CAA27798.1.
AY004867 mRNA. Translation: AAF87083.1.
X04588 mRNA. Translation: CAB37185.1.
AL590431 Genomic DNA. Translation: CAH71264.1.
AL590431 Genomic DNA. Translation: CAH71269.1.
CH471121 Genomic DNA. Translation: EAW53229.1.
CH471121 Genomic DNA. Translation: EAW53230.1.
CH471121 Genomic DNA. Translation: EAW53231.1.
CH471121 Genomic DNA. Translation: EAW53235.1.
BC000771 mRNA. Translation: AAH00771.1.
BC008407 mRNA. Translation: AAH08407.1.
BC008425 mRNA. Translation: AAH08425.1.
BC015403 mRNA. Translation: AAH15403.1.
BC072428 mRNA. Translation: AAH72428.1.
DQ120714 Genomic DNA. Translation: ABC40673.1.
X03541 mRNA. Translation: CAA27243.1. Different termination.
AF474157 mRNA. Translation: AAL84570.1.
CCDSiCCDS1060.1. [P06753-2]
CCDS41400.1. [P06753-5]
CCDS41401.1. [P06753-4]
CCDS41402.1. [P06753-3]
CCDS41403.1. [P06753-1]
CCDS60274.1. [P06753-7]
CCDS60275.1. [P06753-6]
PIRiA25530.
S06210. A24199.
RefSeqiNP_001036816.1. NM_001043351.1. [P06753-5]
NP_001036817.1. NM_001043352.1. [P06753-3]
NP_001036818.1. NM_001043353.1. [P06753-4]
NP_001265118.1. NM_001278189.1. [P06753-6]
NP_001265120.1. NM_001278191.1. [P06753-7]
NP_689476.2. NM_152263.3. [P06753-1]
NP_705935.1. NM_153649.3. [P06753-2]
UniGeneiHs.535581.
Hs.578978.
Hs.644306.
Hs.654421.

3D structure databases

ProteinModelPortaliP06753.
SMRiP06753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113023. 128 interactors.
IntActiP06753. 51 interactors.
MINTiMINT-1142638.
STRINGi9606.ENSP00000357516.

PTM databases

iPTMnetiP06753.
PhosphoSitePlusiP06753.
SwissPalmiP06753.

Polymorphism and mutation databases

DMDMi519668659.

2D gel databases

DOSAC-COBS-2DPAGEP06753.
SWISS-2DPAGEP06753.

Proteomic databases

EPDiP06753.
MaxQBiP06753.
PaxDbiP06753.
PeptideAtlasiP06753.
PRIDEiP06753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302206; ENSP00000307712; ENSG00000143549. [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549. [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549. [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549. [P06753-5]
ENST00000368530; ENSP00000357516; ENSG00000143549. [P06753-1]
ENST00000368531; ENSP00000357517; ENSG00000143549. [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549. [P06753-2]
GeneIDi7170.
KEGGihsa:7170.
UCSCiuc001fdy.2. human. [P06753-1]

Organism-specific databases

CTDi7170.
DisGeNETi7170.
GeneCardsiTPM3.
GeneReviewsiTPM3.
HGNCiHGNC:12012. TPM3.
HPAiHPA000261.
HPA009066.
HPA047089.
HPA053624.
MalaCardsiTPM3.
MIMi164970. gene.
191030. gene.
255310. phenotype.
609284. phenotype.
neXtProtiNX_P06753.
OpenTargetsiENSG00000143549.
Orphaneti171881. Cap myopathy.
171439. Childhood-onset nemaline myopathy.
2020. Congenital fiber-type disproportion myopathy.
178342. Inflammatory myofibroblastic tumor.
171433. Intermediate nemaline myopathy.
PharmGKBiPA36692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiP06753.
KOiK09290.
OMAiXKCSELE.
OrthoDBiEOG091G0UO7.
PhylomeDBiP06753.
TreeFamiTF351519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143549-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
R-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiTPM3. human.
GeneWikiiTropomyosin_3.
GenomeRNAii7170.
PROiP06753.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143549.
CleanExiHS_TPM3.
ExpressionAtlasiP06753. baseline and differential.
GenevisibleiP06753. HS.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM3_HUMAN
AccessioniPrimary (citable) accession number: P06753
Secondary accession number(s): D3DV71
, P12324, Q2QD06, Q5VU58, Q5VU63, Q5VU66, Q5VU71, Q5VU72, Q8TCG3, Q969Q2, Q9NQH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: June 26, 2013
Last modified: November 30, 2016
This is version 195 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.