##gff-version 3 P06748 UniProtKB Chain 1 294 . . . ID=PRO_0000219481;Note=Nucleophosmin P06748 UniProtKB Region 1 186 . . . Note=Required for interaction with SENP3 P06748 UniProtKB Region 1 117 . . . Note=Necessary for interaction with APEX1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19188445;Dbxref=PMID:19188445 P06748 UniProtKB Region 120 247 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06748 UniProtKB Region 243 294 . . . Note=Required for nucleolar localization P06748 UniProtKB Motif 152 157 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06748 UniProtKB Motif 191 197 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06748 UniProtKB Compositional bias 162 186 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06748 UniProtKB Compositional bias 201 224 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06748 UniProtKB Site 55 55 . . . Note=Interaction between pentamers;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06748 UniProtKB Site 80 80 . . . Note=Interaction between pentamers;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06748 UniProtKB Site 175 176 . . . Note=Breakpoint for translocation to form NPM1-MLF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8570204;Dbxref=PMID:8570204 P06748 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|Ref.17,ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:22223895;Dbxref=PMID:19413330,PMID:20068231,PMID:21406692,PMID:22223895 P06748 UniProtKB Modified residue 4 4 . . . Note=Phosphoserine%3B by PLK1 and PLK2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:15190079,ECO:0000269|PubMed:20352051,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:15190079,PMID:20068231,PMID:20352051,PMID:21406692,PMID:23186163 P06748 UniProtKB Modified residue 10 10 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 P06748 UniProtKB Modified residue 32 32 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06748 UniProtKB Modified residue 43 43 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P06748 UniProtKB Modified residue 67 67 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61937 P06748 UniProtKB Modified residue 70 70 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:17924679,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:17081983,PMID:17924679,PMID:18220336,PMID:18669648,PMID:18691976,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 P06748 UniProtKB Modified residue 75 75 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P06748 UniProtKB Modified residue 95 95 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:20068231,PMID:23186163 P06748 UniProtKB Modified residue 125 125 . . . Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|Ref.17,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18318008,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18220336,PMID:18318008,PMID:18669648,PMID:18691976,PMID:19369195,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 P06748 UniProtKB Modified residue 137 137 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 P06748 UniProtKB Modified residue 139 139 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 P06748 UniProtKB Modified residue 150 150 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16916647,ECO:0007744|PubMed:19608861;Dbxref=PMID:16916647,PMID:19608861 P06748 UniProtKB Modified residue 154 154 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:16916647;Dbxref=PMID:16916647 P06748 UniProtKB Modified residue 199 199 . . . Note=Phosphothreonine%3B by CDK1%2C CDK2 and CDK6;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:12058066,ECO:0000269|PubMed:20333249,ECO:0007744|PubMed:17924679,ECO:0007744|PubMed:20068231;Dbxref=PMID:12058066,PMID:17924679,PMID:20068231,PMID:20333249 P06748 UniProtKB Modified residue 207 207 . . . Note=ADP-ribosylserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28190768;Dbxref=PMID:28190768 P06748 UniProtKB Modified residue 212 212 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:16107701,ECO:0007744|PubMed:16916647;Dbxref=PMID:16107701,PMID:16916647 P06748 UniProtKB Modified residue 219 219 . . . Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:12058066;Dbxref=PMID:12058066 P06748 UniProtKB Modified residue 227 227 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 P06748 UniProtKB Modified residue 229 229 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16107701;Dbxref=PMID:16107701 P06748 UniProtKB Modified residue 230 230 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16107701;Dbxref=PMID:16107701 P06748 UniProtKB Modified residue 234 234 . . . Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 P06748 UniProtKB Modified residue 237 237 . . . Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:12058066,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:12058066,PMID:18669648,PMID:23186163 P06748 UniProtKB Modified residue 242 242 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 P06748 UniProtKB Modified residue 243 243 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 P06748 UniProtKB Modified residue 250 250 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16107701;Dbxref=PMID:16107701 P06748 UniProtKB Modified residue 254 254 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17924679,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:17924679,PMID:21406692,PMID:23186163 P06748 UniProtKB Modified residue 257 257 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:16107701,ECO:0007744|PubMed:19608861;Dbxref=PMID:16107701,PMID:19608861 P06748 UniProtKB Modified residue 260 260 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 P06748 UniProtKB Modified residue 267 267 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06748 UniProtKB Modified residue 267 267 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61937 P06748 UniProtKB Modified residue 273 273 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P06748 UniProtKB Modified residue 279 279 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:20068231;Dbxref=PMID:18220336,PMID:20068231 P06748 UniProtKB Modified residue 292 292 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16107701;Dbxref=PMID:16107701 P06748 UniProtKB Cross-link 27 27 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25218447;Dbxref=PMID:25218447 P06748 UniProtKB Cross-link 32 32 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 P06748 UniProtKB Cross-link 32 32 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733 P06748 UniProtKB Cross-link 141 141 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P06748 UniProtKB Cross-link 150 150 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P06748 UniProtKB Cross-link 215 215 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733 P06748 UniProtKB Cross-link 230 230 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate P06748 UniProtKB Cross-link 248 248 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 P06748 UniProtKB Cross-link 248 248 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:28112733 P06748 UniProtKB Cross-link 250 250 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 P06748 UniProtKB Cross-link 257 257 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 P06748 UniProtKB Cross-link 257 257 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:28112733 P06748 UniProtKB Cross-link 263 263 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15897463;Dbxref=PMID:15897463 P06748 UniProtKB Cross-link 263 263 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P06748 UniProtKB Cross-link 267 267 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 P06748 UniProtKB Cross-link 267 267 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P06748 UniProtKB Cross-link 273 273 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P06748 UniProtKB Alternative sequence 195 223 . . . ID=VSP_003616;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P06748 UniProtKB Alternative sequence 258 294 . . . ID=VSP_043599;Note=In isoform 3. GGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL->AH;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334 P06748 UniProtKB Mutagenesis 4 4 . . . Note=Abolishes phosphorylation by PLK2 and impairs centriole duplication. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20352051;Dbxref=PMID:20352051 P06748 UniProtKB Mutagenesis 4 4 . . . Note=Mimicks phosphorylation state%2C inducing accumulation of centrioles. S->D%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20352051;Dbxref=PMID:20352051 P06748 UniProtKB Mutagenesis 95 95 . . . Note=Does not affect phosphorylation by PLK2. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20352051;Dbxref=PMID:20352051 P06748 UniProtKB Mutagenesis 125 125 . . . Note=Does not affect phosphorylation by PLK2. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20352051;Dbxref=PMID:20352051 P06748 UniProtKB Mutagenesis 199 199 . . . Note=Partial loss of phosphorylation. Does not affect phosphorylation by PLK2. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12058066,ECO:0000269|PubMed:20352051;Dbxref=PMID:12058066,PMID:20352051 P06748 UniProtKB Mutagenesis 219 219 . . . Note=Partial loss of phosphorylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12058066;Dbxref=PMID:12058066 P06748 UniProtKB Mutagenesis 234 234 . . . Note=Partial loss of phosphorylation%3B when associated with A-237. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12058066;Dbxref=PMID:12058066 P06748 UniProtKB Mutagenesis 237 237 . . . Note=Partial loss of phosphorylation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12058066;Dbxref=PMID:12058066 P06748 UniProtKB Mutagenesis 248 248 . . . Note=Partial destabilization of the structure. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18511415;Dbxref=PMID:18511415 P06748 UniProtKB Mutagenesis 250 250 . . . Note=Increase in the stabilization of the structure. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18511415;Dbxref=PMID:18511415 P06748 UniProtKB Mutagenesis 263 263 . . . Note=Increase in the stabilization of the structure and partial delocalization to the nucleoplasm. Complete delocalization to the nucleoplasm%3B when associated with A-267. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18259216;Dbxref=PMID:18259216 P06748 UniProtKB Mutagenesis 263 263 . . . Note=No change in the sumoylation level. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18259216;Dbxref=PMID:18259216 P06748 UniProtKB Mutagenesis 267 267 . . . Note=Increase in the stabilization of the structure and complete delocalization to the nucleoplasm. Complete delocalization to the nucleoplasm%3B when associated with A-263. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18511415;Dbxref=PMID:18511415 P06748 UniProtKB Mutagenesis 268 268 . . . Note=Complete destabilization of the structure and loss of nucleolus localization%3B when associated with A-276. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18511415;Dbxref=PMID:18511415 P06748 UniProtKB Mutagenesis 276 276 . . . Note=Complete destabilization of the structure and loss of nucleolus localization%3B when associated with A-268. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18511415;Dbxref=PMID:18511415 P06748 UniProtKB Mutagenesis 288 288 . . . Note=Complete destabilization of the structure%3B when associated with A-290. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18511415;Dbxref=PMID:18511415 P06748 UniProtKB Mutagenesis 290 290 . . . Note=Partial destabilization of the structure. Complete destabilization of the structure%3B when associated with A-288. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18511415;Dbxref=PMID:18511415 P06748 UniProtKB Sequence conflict 80 80 . . . Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 129 129 . . . Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 168 168 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 178 178 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 183 183 . . . Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 213 213 . . . Note=D->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 214 214 . . . Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 216 216 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 219 221 . . . Note=TPR->SSS;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 231 231 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 271 271 . . . Note=Y->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 287 287 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 288 294 . . . Note=WQWRKSL->CLAVEEVSLRK;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 288 294 . . . Note=WQWRKSL->CMAVEEVSLRK;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 288 294 . . . Note=WQWRKSL->CVAVEEVSLRK;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 290 294 . . . Note=WRKSL->SLAQVSLRK;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Sequence conflict 290 294 . . . Note=WRKSL->SLEKVSLRK;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06748 UniProtKB Beta strand 15 24 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Beta strand 29 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Beta strand 40 49 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Beta strand 58 65 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Beta strand 71 80 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Turn 81 83 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Beta strand 84 94 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Beta strand 96 104 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Beta strand 109 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHD P06748 UniProtKB Helix 244 257 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LLH P06748 UniProtKB Helix 265 275 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LLH P06748 UniProtKB Helix 281 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2LLH P06748 UniProtKB Modified residue 254 254 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 P06748 UniProtKB Modified residue 257 257 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861