ID NPM_HUMAN Reviewed; 294 AA. AC P06748-1; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1990, sequence version 2. DT 27-MAR-2024, entry version 263. DE RecName: Full=Isoform 1 of Nucleophosmin; DE Short=NPM; DE AltName: Full=Nucleolar phosphoprotein B23; DE AltName: Full=Nucleolar protein NO38; DE AltName: Full=Numatrin; GN Name=NPM1; Synonyms=NPM; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=2713355; DOI=10.1021/bi00429a017; RA Chan W.-Y., Liu Q.R., Borjigin J., Busch H., Rennert O.M., Tease L.A., RA Chan P.-K.; RT "Characterization of the cDNA encoding human nucleophosmin and studies of RT its role in normal and abnormal growth."; RL Biochemistry 28:1033-1039(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=B-cell lymphoma; RX PubMed=2775293; DOI=10.1016/0006-291x(89)92100-1; RA Li X., McNeilage L.J., Whittingham S.; RT "The nucleotide sequence of a human cDNA encoding the highly conserved RT nucleolar phosphoprotein B23."; RL Biochem. Biophys. Res. Commun. 163:72-78(1989). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Amnion; RX PubMed=2478125; DOI=10.1016/0006-291x(89)91699-9; RA Zhang X.T., Thomis D.C., Samuel C.E.; RT "Isolation and characterization of a molecular cDNA clone of a human mRNA RT from interferon-treated cells encoding nucleolar protein B23, numatrin."; RL Biochem. Biophys. Res. Commun. 164:176-184(1989). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). RX PubMed=9092633; DOI=10.1093/nar/25.6.1225; RA Chan P.-K., Chan F.Y., Morris S.W., Xie Z.; RT "Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: RT identification of the YY1 binding site at the 5' enhancer region."; RL Nucleic Acids Res. 25:1225-1232(1997). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). RA Okuwaki M., Nagata K.; RT "Human homologue of Rat B23.2."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND RP INVOLVEMENT IN ACUTE MYELOGENOUS LEUKEMIA. RC TISSUE=Bone marrow; RX PubMed=15659725; DOI=10.1056/nejmoa041974; RA Falini B., Mecucci C., Tiacci E., Alcalay M., Rosati R., Pasqualucci L., RA La Starza R., Diverio D., Colombo E., Santucci A., Bigerna B., Pacini R., RA Pucciarini A., Liso A., Vignetti M., Fazi P., Meani N., Pettirossi V., RA Saglio G., Mandelli F., Lo-Coco F., Pelicci P.-G., Martelli M.F.; RT "Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal RT karyotype."; RL N. Engl. J. Med. 352:254-266(2005). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=16574551; DOI=10.1016/s1470-2045(06)70661-1; RA Bolli N., Galimberti S., Martelli M.P., Tabarrini A., Roti G., Mecucci C., RA Martelli M.F., Petrini M., Falini B.; RT "Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after RT diagnosis of acute myeloid leukaemia."; RL Lancet Oncol. 7:350-352(2006). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Testis; RA Lu L., Huang X.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M., Sha J.H.; RT "Cloning of a new transcript of nucleophosmin in testis."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Embryo; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=19054851; DOI=10.1038/nmeth.1273; RA Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., RA Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., RA Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B., RA Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., RA Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., RA Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., RA Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., RA Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., RA Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., RA Nomura N.; RT "Human protein factory for converting the transcriptome into an in vitro- RT expressed proteome."; RL Nat. Methods 5:1011-1017(2008). RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [13] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC TISSUE=Bone marrow, Brain, Kidney, Lung, Prostate, Testis, and Urinary RC bladder; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [14] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-133, AND CHROMOSOMAL TRANSLOCATION WITH RP RARA. RC TISSUE=Bone marrow; RX PubMed=8562957; RA Redner R.L., Rush E.A., Faas S., Rudert W.A., Corey S.J.; RT "The t(5;17) variant of acute promyelocytic leukemia expresses a RT nucleophosmin-retinoic acid receptor fusion."; RL Blood 87:882-886(1996). RN [15] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-117, AND CHROMOSOMAL TRANSLOCATION WITH RP ALK. RC TISSUE=T-cell lymphoma; RX PubMed=8122112; DOI=10.1126/science.8122112; RA Morris S.W., Kirstein M.N., Valentine M.B., Dittmer K.G., Shapiro D.N., RA Saltman D.L., Look A.T.; RT "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non- RT Hodgkin's lymphoma."; RL Science 263:1281-1284(1994). RN [16] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-117, AND CHROMOSOMAL TRANSLOCATION WITH RP ALK. RC TISSUE=Lymphoma; RX PubMed=8633037; DOI=10.1073/pnas.93.9.4181; RA Fujimoto J., Shiota M., Iwahara T., Seki N., Satoh H., Mori S., RA Yamamoto T.; RT "Characterization of the transforming activity of p80, a RT hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal RT translocation t(2;5)."; RL Proc. Natl. Acad. Sci. U.S.A. 93:4181-4186(1996). RN [17] RP PROTEIN SEQUENCE OF 1-24; 33-101; 104-141; 240-248 AND 278-291, ACETYLATION RP AT MET-1, PHOSPHORYLATION AT SER-125, AND IDENTIFICATION BY MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RA Bienvenut W.V., Waridel P., Quadroni M.; RL Submitted (MAR-2009) to UniProtKB. RN [18] RP NUCLEOTIDE SEQUENCE [MRNA] OF 15-294 (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=2602120; RA Hale T.K., Mansfield B.C.; RT "Nucleotide sequence of a cDNA clone representing a third allele of human RT protein B23."; RL Nucleic Acids Res. 17:10112-10112(1989). RN [19] RP PROTEIN SEQUENCE OF 33-54. RC TISSUE=Colon carcinoma; RX PubMed=9150948; DOI=10.1002/elps.1150180344; RA Ji H., Reid G.E., Moritz R.L., Eddes J.S., Burgess A.W., Simpson R.J.; RT "A two-dimensional gel database of human colon carcinoma proteins."; RL Electrophoresis 18:605-613(1997). RN [20] RP PROTEIN SEQUENCE OF 34-42; 50-67; 137-151; 218-227; 252-266 AND 277-286 RP (ISOFORM 1), AND INTERACTION WITH HTLV1 REX PROTEIN (MICROBIAL INFECTION). RX PubMed=8314759; DOI=10.1016/s0021-9258(19)85191-8; RA Adachi Y., Copeland T.D., Hatanaka M., Oroszlan S.; RT "Nucleolar targeting signal of Rex protein of human T-cell leukemia virus RT type I specifically binds to nucleolar shuttle protein B-23."; RL J. Biol. Chem. 268:13930-13934(1993). RN [21] RP PROTEIN SEQUENCE OF 33-42; 213-221; 251-257 AND 268-274, FUNCTION, RP INTERACTION WITH EIF2AK2, AND PHOSPHORYLATION. RX PubMed=12882984; DOI=10.1074/jbc.m301392200; RA Pang Q., Christianson T.A., Koretsky T., Carlson H., David L., Keeble W., RA Faulkner G.R., Speckhart A., Bagby G.C.; RT "Nucleophosmin interacts with and inhibits the catalytic function of RT eukaryotic initiation factor 2 kinase PKR."; RL J. Biol. Chem. 278:41709-41717(2003). RN [22] RP PROTEIN SEQUENCE OF 115-134. RX PubMed=3944116; DOI=10.1016/s0021-9258(17)36022-2; RA Chan P.-K., Aldrich M.B., Cook R.G., Busch H.; RT "Amino acid sequence of protein B23 phosphorylation site."; RL J. Biol. Chem. 261:1868-1872(1986). RN [23] RP NUCLEOTIDE SEQUENCE [MRNA] OF 213-294 (ISOFORM 1), AND PROTEIN SEQUENCE OF RP 227-294. RX PubMed=2429957; DOI=10.1016/s0021-9258(18)67023-1; RA Chan P.-K., Chan W.-Y., Yung B.Y.M., Cook R.G., Aldrich M.B., Ku D., RA Goldknopf I.L., Busch H.; RT "Amino acid sequence of a specific antigenic peptide of protein B23."; RL J. Biol. Chem. 261:14335-14341(1986). RN [24] RP ADP-RIBOSYLATION. RX PubMed=7631008; DOI=10.2307/3579152; RA Ramsamooj P., Notario V., Dritschilo A.; RT "Modification of nucleolar protein B23 after exposure to ionizing RT radiation."; RL Radiat. Res. 143:158-164(1995). RN [25] RP CHROMOSOMAL TRANSLOCATION WITH MLF1. RX PubMed=8570204; RA Yoneda-Kato N., Look A.T., Kirstein M.N., Valentine M.B., Raimondi S.C., RA Cohen K.J., Carroll A.J., Morris S.W.; RT "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid RT leukemia produces a novel fusion gene, NPM-MLF1."; RL Oncogene 12:265-275(1996). RN [26] RP PHOSPHORYLATION BY CDK2. RX PubMed=11051553; DOI=10.1016/s0092-8674(00)00093-3; RA Okuda M., Horn H.F., Tarapore P., Tokuyama Y., Smulian A.G., Chan P.K., RA Knudsen E.S., Hofmann I.A., Snyder J.D., Bove K.E., Fukasawa K.; RT "Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome RT duplication."; RL Cell 103:127-140(2000). RN [27] RP INTERACTION WITH HEPATITIS DELTA VIRUS S-HDAG (MICROBIAL INFECTION). RX PubMed=11309377; DOI=10.1074/jbc.m010087200; RA Huang W.H., Yung B.Y., Syu W.J., Lee Y.H.; RT "The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens RT and modulates the hepatitis delta virus RNA replication."; RL J. Biol. Chem. 276:25166-25175(2001). RN [28] RP PHOSPHORYLATION AT THR-199; THR-219 AND THR-237, AND MUTAGENESIS OF RP THR-199; THR-219; THR-234 AND THR-237. RX PubMed=12058066; DOI=10.1091/mbc.02-03-0036; RA Okuwaki M., Tsujimoto M., Nagata K.; RT "The RNA binding activity of a ribosome biogenesis factor, RT nucleophosmin/B23, is modulated by phosphorylation with a cell cycle- RT dependent kinase and by association with its subtype."; RL Mol. Biol. Cell 13:2016-2030(2002). RN [29] RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=12429849; DOI=10.1091/mbc.e02-05-0271; RA Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., RA Greco A., Hochstrasser D.F., Diaz J.-J.; RT "Functional proteomic analysis of human nucleolus."; RL Mol. Biol. Cell 13:4100-4109(2002). RN [30] RP REVIEW. RX PubMed=12214246; RA Okuda M.; RT "The role of nucleophosmin in centrosome duplication."; RL Oncogene 21:6170-6174(2002). RN [31] RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE RP ANALYSIS]. RC TISSUE=Lymphoblast; RX PubMed=14654843; DOI=10.1038/nature02166; RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.; RT "Proteomic characterization of the human centrosome by protein correlation RT profiling."; RL Nature 426:570-574(2003). RN [32] RP SUBCELLULAR LOCATION, PHOSPHORYLATION, AND INTERACTION WITH NEK2. RX PubMed=15388344; DOI=10.1016/j.febslet.2004.08.047; RA Yao J., Fu C., Ding X., Guo Z., Zenreski A., Chen Y., Ahmed K., Liao J., RA Dou Z., Yao X.; RT "Nek2A kinase regulates the localization of numatrin to centrosome in RT mitosis."; RL FEBS Lett. 575:112-118(2004). RN [33] RP PHOSPHORYLATION AT SER-4 BY PLK1. RX PubMed=15190079; DOI=10.1074/jbc.m403264200; RA Zhang H., Shi X., Paddon H., Hampong M., Dai W., Pelech S.; RT "B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of RT polo-like kinase 1."; RL J. Biol. Chem. 279:35726-35734(2004). RN [34] RP INTERACTION WITH RPGR. RX PubMed=15772089; DOI=10.1093/hmg/ddi129; RA Shu X., Fry A.M., Tulloch B., Manson F.D., Crabb J.W., Khanna H., RA Faragher A.J., Lennon A., He S., Trojan P., Giessl A., Wolfrum U., RA Vervoort R., Swaroop A., Wright A.F.; RT "RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal RT bodies and interacts with nucleophosmin."; RL Hum. Mol. Genet. 14:1183-1197(2005). RN [35] RP ACETYLATION AT LYS-212; LYS-229; LYS-230; LYS-250; LYS-257 AND LYS-292, AND RP FUNCTION AS A CHAPERONE. RX PubMed=16107701; DOI=10.1128/mcb.25.17.7534-7545.2005; RA Swaminathan V., Kishore A.H., Febitha K.K., Kundu T.K.; RT "Human histone chaperone nucleophosmin enhances acetylation-dependent RT chromatin transcription."; RL Mol. Cell. Biol. 25:7534-7545(2005). RN [36] RP SUMOYLATION AT LYS-230 AND LYS-263. RX PubMed=15897463; DOI=10.1073/pnas.0502978102; RA Tago K., Chiocca S., Sherr C.J.; RT "Sumoylation induced by the Arf tumor suppressor: a p53-independent RT function."; RL Proc. Natl. Acad. Sci. U.S.A. 102:7689-7694(2005). RN [37] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70 AND THR-95, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling RT networks."; RL Cell 127:635-648(2006). RN [38] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-150; LYS-154 AND LYS-212, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=16916647; DOI=10.1016/j.molcel.2006.06.026; RA Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., RA Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; RT "Substrate and functional diversity of lysine acetylation revealed by a RT proteomics survey."; RL Mol. Cell 23:607-618(2006). RN [39] RP FUNCTION, AND INTERACTION WITH ROCK2. RX PubMed=17015463; DOI=10.1128/mcb.01383-06; RA Ma Z., Kanai M., Kawamura K., Kaibuchi K., Ye K., Fukasawa K.; RT "Interaction between ROCK II and nucleophosmin/B23 in the regulation of RT centrosome duplication."; RL Mol. Cell. Biol. 26:9016-9034(2006). RN [40] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; THR-199 AND SER-254, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=17924679; DOI=10.1021/pr070152u; RA Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; RT "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells RT and high confident phosphopeptide identification by cross-validation of RT MS/MS and MS/MS/MS spectra."; RL J. Proteome Res. 6:4150-4162(2007). RN [41] RP INTERACTION WITH NSUN2. RX PubMed=17215513; DOI=10.1091/mbc.e06-11-1021; RA Sakita-Suto S., Kanda A., Suzuki F., Sato S., Takata T., Tatsuka M.; RT "Aurora-B regulates RNA methyltransferase NSUN2."; RL Mol. Biol. Cell 18:1107-1117(2007). RN [42] RP INTERACTION WITH SENP3, AND MUTAGENESIS OF LYS-263. RX PubMed=18259216; DOI=10.1038/embor.2008.3; RA Haindl M., Harasim T., Eick D., Muller S.; RT "The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of RT nucleophosmin and is required for rRNA processing."; RL EMBO Rep. 9:273-279(2008). RN [43] RP INTERACTION WITH SENP3, AND SUBCELLULAR LOCATION. RX PubMed=19015314; DOI=10.1083/jcb.200807185; RA Yun C., Wang Y., Mukhopadhyay D., Backlund P., Kolli N., Yergey A., RA Wilkinson K.D., Dasso M.; RT "Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway RT through SENP3 and SENP5 proteases."; RL J. Cell Biol. 183:589-595(2008). RN [44] RP REVIEW. RX PubMed=18024471; DOI=10.1093/jb/mvm222; RA Okuwaki M.; RT "The structure and functions of NPM1/Nucleophosmin/B23, a multifunctional RT nucleolar acidic protein."; RL J. Biochem. 143:441-448(2008). RN [45] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-125 AND THR-279, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18220336; DOI=10.1021/pr0705441; RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III; RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient RT phosphoproteomic analysis."; RL J. Proteome Res. 7:1346-1351(2008). RN [46] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70 AND SER-125, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the RT kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [47] RP FUNCTION. RX PubMed=18809582; DOI=10.1128/mcb.01548-07; RA Maggi L.B. Jr., Kuchenruether M., Dadey D.Y., Schwope R.M., Grisendi S., RA Townsend R.R., Pandolfi P.P., Weber J.D.; RT "Nucleophosmin serves as a rate-limiting nuclear export chaperone for the RT Mammalian ribosome."; RL Mol. Cell. Biol. 28:7050-7065(2008). RN [48] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; THR-75; THR-95; SER-125; RP SER-139; THR-234; THR-237 AND SER-243, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [49] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=18318008; DOI=10.1002/pmic.200700884; RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., RA Zou H., Gu J.; RT "Large-scale phosphoproteome analysis of human liver tissue by enrichment RT and fractionation of phosphopeptides with strong anion exchange RT chromatography."; RL Proteomics 8:1346-1361(2008). RN [50] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [51] RP INTERACTION WITH RRP1B. RX PubMed=19710015; DOI=10.1074/jbc.m109.023457; RA Crawford N.P., Yang H., Mattaini K.R., Hunter K.W.; RT "The metastasis efficiency modifier ribosomal RNA processing 1 homolog B RT (RRP1B) is a chromatin-associated factor."; RL J. Biol. Chem. 284:28660-28673(2009). RN [52] RP SUBCELLULAR LOCATION, UBIQUITINATION, AND DEUBIQUITINATION BY USP36. RX PubMed=19208757; DOI=10.1242/jcs.044461; RA Endo A., Matsumoto M., Inada T., Yamamoto A., Nakayama K.I., Kitamura N., RA Komada M.; RT "Nucleolar structure and function are regulated by the deubiquitylating RT enzyme USP36."; RL J. Cell Sci. 122:678-686(2009). RN [53] RP FUNCTION, INTERACTION WITH APEX1, IDENTIFICATION BY MASS SPECTROMETRY, AND RP SUBCELLULAR LOCATION. RX PubMed=19188445; DOI=10.1128/mcb.01337-08; RA Vascotto C., Fantini D., Romanello M., Cesaratto L., Deganuto M., RA Leonardi A., Radicella J.P., Kelley M.R., D'Ambrosio C., Scaloni A., RA Quadrifoglio F., Tell G.; RT "APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the RT rRNA quality control process."; RL Mol. Cell. Biol. 29:1834-1854(2009). RN [54] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200; RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., RA Mann M., Daub H.; RT "Large-scale proteomics analysis of the human kinome."; RL Mol. Cell. Proteomics 8:1751-1764(2009). RN [55] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70 AND SER-125, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [56] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-150; LYS-257; LYS-267 AND RP LYS-273, ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-257 (ISOFORM 3), AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [57] RP INTERACTION WITH CEBPA. RX PubMed=20075868; DOI=10.1038/emboj.2009.404; RA Muller C., Bremer A., Schreiber S., Eichwald S., Calkhoven C.F.; RT "Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA RT transcription and cell size."; RL EMBO J. 29:897-909(2010). RN [58] RP SUBCELLULAR LOCATION, AND INTERACTION WITH RPS10. RX PubMed=20159986; DOI=10.1074/jbc.m110.103911; RA Ren J., Wang Y., Liang Y., Zhang Y., Bao S., Xu Z.; RT "Methylation of ribosomal protein S10 by protein-arginine methyltransferase RT 5 regulates ribosome biogenesis."; RL J. Biol. Chem. 285:12695-12705(2010). RN [59] RP INTERACTION WITH RRP1B. RX PubMed=20926688; DOI=10.1091/mbc.e10-04-0287; RA Chamousset D., De Wever V., Moorhead G.B., Chen Y., Boisvert F.M., RA Lamond A.I., Trinkle-Mulcahy L.; RT "RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre- RT 60S ribosomal subunits."; RL Mol. Biol. Cell 21:4212-4226(2010). RN [60] RP FUNCTION, PHOSPHORYLATION AT SER-4 BY PLK2, AND MUTAGENESIS OF SER-4; RP THR-95; SER-125 AND THR-199. RX PubMed=20352051; DOI=10.1371/journal.pone.0009849; RA Krause A., Hoffmann I.; RT "Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 RT triggers centriole duplication."; RL PLoS ONE 5:E9849-E9849(2010). RN [61] RP PHOSPHORYLATION AT THR-199 BY CDK6. RX PubMed=20333249; DOI=10.1371/journal.ppat.1000818; RA Sarek G., Jaerviluoma A., Moore H.M., Tojkander S., Vartia S., RA Biberfeld P., Laiho M., Ojala P.M.; RT "Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency."; RL PLoS Pathog. 6:E1000818-E1000818(2010). RN [62] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE RP ANALYSIS] AT SER-4; SER-10; SER-70; THR-95; SER-125; SER-137; SER-139; RP THR-199; SER-242; SER-243; SER-260 AND THR-279, PHOSPHORYLATION [LARGE RP SCALE ANALYSIS] AT SER-254 (ISOFORM 3), AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [63] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [64] RP FUNCTION, AND INTERACTION WITH BRCA2. RX PubMed=21084279; DOI=10.1158/0008-5472.can-10-0030; RA Wang H.F., Takenaka K., Nakanishi A., Miki Y.; RT "BRCA2 and nucleophosmin coregulate centrosome amplification and form a RT complex with the Rho effector kinase ROCK2."; RL Cancer Res. 71:68-77(2011). RN [65] RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH CENPW. RX PubMed=22002061; DOI=10.1074/jbc.m111.228411; RA Chun Y., Park B., Koh W., Lee S., Cheon Y., Kim R., Che L., Lee S.; RT "New centromeric component CENP-W is an RNA-associated nuclear matrix RT protein that interacts with nucleophosmin/B23 protein."; RL J. Biol. Chem. 286:42758-42769(2011). RN [66] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE RP ANALYSIS] AT SER-4; SER-70; SER-125; SER-227; SER-243 AND SER-254, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [67] RP FUNCTION, INTERACTION WITH ATF5, AND SUBCELLULAR LOCATION. RX PubMed=22528486; DOI=10.1074/jbc.m112.363622; RA Liu X., Liu D., Qian D., Dai J., An Y., Jiang S., Stanley B., Yang J., RA Wang B., Liu X., Liu D.X.; RT "Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 RT (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 RT degradation in hepatocellular carcinoma cells."; RL J. Biol. Chem. 287:19599-19609(2012). RN [68] RP INTERACTION WITH DDX31. RX PubMed=23019224; DOI=10.1158/0008-5472.can-12-1645; RA Fukawa T., Ono M., Matsuo T., Uehara H., Miki T., Nakamura Y., RA Kanayama H.O., Katagiri T.; RT "DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through RT its interaction with NPM1 in renal cell carcinomas."; RL Cancer Res. 72:5867-5877(2012). RN [69] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22223895; DOI=10.1074/mcp.m111.015131; RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., RA Giglione C.; RT "Comparative large-scale characterisation of plant vs. mammal proteins RT reveals similar and idiosyncratic N-alpha acetylation features."; RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012). RN [70] RP INTERACTION WITH NPM3. RX PubMed=22362753; DOI=10.1093/nar/gks162; RA Okuwaki M., Sumi A., Hisaoka M., Saotome-Nakamura A., Akashi S., RA Nishimura Y., Nagata K.; RT "Function of homo- and hetero-oligomers of human RT nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during RT sperm chromatin remodeling."; RL Nucleic Acids Res. 40:4861-4878(2012). RN [71] RP INTERACTION WITH ALKBH2. RX PubMed=23972994; DOI=10.1016/j.celrep.2013.07.027; RA Li P., Gao S., Wang L., Yu F., Li J., Wang C., Li J., Wong J.; RT "ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation RT repair."; RL Cell Rep. 4:817-829(2013). RN [72] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-10; SER-43; SER-70; RP THR-95; SER-125; SER-139; THR-234; THR-237; SER-242; SER-243; SER-254 AND RP SER-260, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [73] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70 AND SER-243, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [74] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-27; LYS-32; LYS-248 AND LYS-250, RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25218447; DOI=10.1038/nsmb.2890; RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., RA Vertegaal A.C.; RT "Uncovering global SUMOylation signaling networks in a site-specific RT manner."; RL Nat. Struct. Mol. Biol. 21:927-936(2014). RN [75] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-248; LYS-257 AND LYS-267, RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25114211; DOI=10.1073/pnas.1413825111; RA Impens F., Radoshevich L., Cossart P., Ribet D.; RT "Mapping of SUMO sites and analysis of SUMOylation changes induced by RT external stimuli."; RL Proc. Natl. Acad. Sci. U.S.A. 111:12432-12437(2014). RN [76] RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MYC AND NOP53. RX PubMed=25956029; DOI=10.1016/j.ajpath.2015.03.016; RA Kim J.Y., Cho Y.E., Park J.H.; RT "The nucleolar protein GLTSCR2 is an upstream negative regulator of the RT oncogenic Nucleophosmin-MYC axis."; RL Am. J. Pathol. 185:2061-2068(2015). RN [77] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-32 AND LYS-215, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033; RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., RA Vertegaal A.C.; RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."; RL Cell Rep. 10:1778-1791(2015). RN [78] RP SUBUNIT, SUBCELLULAR LOCATION, AND UBIQUITINATION. RX PubMed=25818168; DOI=10.1111/jcmm.12474; RA Kim J.Y., Cho Y.E., An Y.M., Kim S.H., Lee Y.G., Park J.H., Lee S.; RT "GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical RT cancer."; RL J. Cell. Mol. Med. 19:1245-1252(2015). RN [79] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-32, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25755297; DOI=10.1074/mcp.o114.044792; RA Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., RA Vertegaal A.C.; RT "System-wide analysis of SUMOylation dynamics in response to replication RT stress reveals novel small ubiquitin-like modified target proteins and RT acceptor lysines relevant for genome stability."; RL Mol. Cell. Proteomics 14:1419-1434(2015). RN [80] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [81] RP ADP-RIBOSYLATION AT SER-207. RX PubMed=28190768; DOI=10.1016/j.molcel.2017.01.003; RA Bonfiglio J.J., Fontana P., Zhang Q., Colby T., Gibbs-Seymour I., RA Atanassov I., Bartlett E., Zaja R., Ahel I., Matic I.; RT "Serine ADP-ribosylation depends on HPF1."; RL Mol. Cell 0:0-0(2017). RN [82] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-141; LYS-150; LYS-215; RP LYS-248; LYS-250; LYS-257; LYS-263; LYS-267 AND LYS-273, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). RN [83] RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 9-124. RX PubMed=17879352; DOI=10.1002/prot.21504; RA Lee H.H., Kim H.S., Kang J.Y., Lee B.I., Ha J.Y., Yoon H.J., Lim S.O., RA Jung G., Suh S.W.; RT "Crystal structure of human nucleophosmin-core reveals plasticity of the RT pentamer-pentamer interface."; RL Proteins 69:672-678(2007). RN [84] RP STRUCTURE BY NMR OF 243-294, AND MUTAGENESIS OF LYS-248; LYS-250; LYS-267; RP PHE-268; PHE-276; TRP-288 AND TRP-290. RX PubMed=18511415; DOI=10.1074/jbc.m801706200; RA Grummitt C.G., Townsley F.M., Johnson C.M., Warren A.J., Bycroft M.; RT "Structural consequences of nucleophosmin mutations in acute myeloid RT leukemia."; RL J. Biol. Chem. 283:23326-23332(2008). CC -!- INTERACTION: CC P06748-1; P49450-1: CENPA; NbExp=3; IntAct=EBI-354150, EBI-15826012; CC P06748-1; P63165: SUMO1; NbExp=3; IntAct=EBI-354150, EBI-80140; CC P06748-1; P04637: TP53; NbExp=3; IntAct=EBI-354150, EBI-366083; CC P06748-1; Q14669: TRIP12; NbExp=2; IntAct=EBI-354150, EBI-308443; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=P06748-1; Sequence=Displayed; CC Name=2; CC IsoId=P06748-2; Sequence=VSP_003616; CC Name=3; CC IsoId=P06748-3; Sequence=VSP_043599; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR CCDS; CCDS4376.1; -. DR RefSeq; NP_002511.1; NM_002520.6. DR ProteomicsDB; 51927; -. DR TopDownProteomics; P06748-1; -. DR Ensembl; ENST00000296930.10; ENSP00000296930.5; ENSG00000181163.14. DR Ensembl; ENST00000517671.5; ENSP00000428755.1; ENSG00000181163.14. DR UCSC; uc003mbh.4; human. DR Proteomes; UP000005640; Chromosome 5. PE 1: Evidence at protein level; SQ SEQUENCE 294 AA; 32575 MW; 620BC7BA2E4A0054 CRC64; MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL //