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Protein

Myosin light chain alkali

Gene

Mlc1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • microfilament motor activity Source: UniProtKB

GO - Biological processi

  • mesoderm development Source: FlyBase
  • muscle contraction Source: UniProtKB

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain alkali
Gene namesi
Name:Mlc1
Synonyms:MLC-ALK
ORF Names:CG5596
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002772 Mlc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987091 – 155Myosin light chain alkaliAdd BLAST155

Proteomic databases

PaxDbiP06742
PRIDEiP06742

Expressioni

Tissue specificityi

Indirect flight muscle isoform is found only in the indirect flight muscles. The larval and adult isoform is present in the larval and adult musculature.2 Publications

Developmental stagei

Expressed during late embryogenesis, larval instars, late stages of pupariation and adult.2 Publications

Gene expression databases

BgeeiFBgn0002772
ExpressionAtlasiP06742 differential
GenevisibleiP06742 DM

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi68205, 47 interactors
DIPiDIP-23903N
IntActiP06742, 20 interactors
STRINGi7227.FBpp0084565

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 19Combined sources14
Turni22 – 24Combined sources3
Beta strandi25 – 27Combined sources3
Helixi28 – 30Combined sources3
Helixi31 – 37Combined sources7
Helixi44 – 49Combined sources6
Helixi63 – 74Combined sources12
Helixi82 – 89Combined sources8
Helixi90 – 92Combined sources3
Beta strandi96 – 101Combined sources6
Helixi102 – 111Combined sources10
Beta strandi112 – 114Combined sources3
Helixi118 – 128Combined sources11
Beta strandi137 – 139Combined sources3
Helixi140 – 147Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QBDX-ray2.23B/D1-151[»]
ProteinModelPortaliP06742
SMRiP06742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 41EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini80 – 115EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ISFW Eukaryota
ENOG4111WV2 LUCA
GeneTreeiENSGT00590000082921
InParanoidiP06742
OMAiCMDPEDE
OrthoDBiEOG091G0TQL
PhylomeDBiP06742

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR029655 Mlc1
PANTHERiPTHR23048:SF12 PTHR23048:SF12, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Larval-adult (identifier: P06742-1) [UniParc]FASTAAdd to basket
Also known as: Larval-non-IFM

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADVPKREVE NVEFVFEVMG SPGEGIDAVD LGDALRALNL NPTLALIEKL
60 70 80 90 100
GGTKKRNEKK IKLDEFLPIY SQVKKEKEQG CYEDFIECLK LYDKEENGTM
110 120 130 140 150
LLAELQHALL ALGESLDDEQ VETLFADCMD PEDDEGFIPY SQFVQRLMSD

PVVFD
Length:155
Mass (Da):17,524
Last modified:January 27, 2003 - v4
Checksum:i65C92CD17995ECF5
GO
Isoform Indirect flight muscle (identifier: P06742-2) [UniParc]FASTAAdd to basket
Also known as: Pupa, Adult flight muscle

The sequence of this isoform differs from the canonical sequence as follows:
     142-155: QFVQRLMSDPVVFD → PFLARMCDRPDQLK

Show »
Length:155
Mass (Da):17,533
Checksum:i5B12DC95EB8A16ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → V (PubMed:2982157).Curated1
Sequence conflicti67L → M in AAA53454 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53458 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53460 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53466 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53468 (PubMed:7535717).Curated1
Sequence conflicti150D → H (PubMed:2982157).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003367142 – 155QFVQR…PVVFD → PFLARMCDRPDQLK in isoform Indirect flight muscle. CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10125 Genomic DNA Translation: AAA28711.1
M10125 Genomic DNA Translation: AAA28712.1
K01567 mRNA Translation: AAA28710.1
AE014297 Genomic DNA Translation: AAF56733.2
AE014297 Genomic DNA Translation: AAN14121.1
AY070972 mRNA Translation: AAL48594.1
L37312 Genomic DNA Translation: AAA53441.1
L37312 Genomic DNA Translation: AAA53442.1
L37313 Genomic DNA Translation: AAA53443.1
L37313 Genomic DNA Translation: AAA53444.1
L37314 Genomic DNA Translation: AAA53445.1
L37314 Genomic DNA Translation: AAA53446.1
L37315 Genomic DNA Translation: AAA53447.1 Sequence problems.
L37315 Genomic DNA Translation: AAA53448.1 Sequence problems.
L37316 Genomic DNA Translation: AAA56798.1
L37316 Genomic DNA Translation: AAA56799.1 Sequence problems.
L37317 Genomic DNA Translation: AAA53449.1
L37317 Genomic DNA Translation: AAA53450.1
L37318 Genomic DNA Translation: AAA53451.1
L37318 Genomic DNA Translation: AAA53452.1
L37319 Genomic DNA Translation: AAA53453.1
L37319 Genomic DNA Translation: AAA53454.1
L37320 Genomic DNA Translation: AAA53455.1
L37320 Genomic DNA Translation: AAA53456.1
L37321 Genomic DNA Translation: AAA53457.1
L37321 Genomic DNA Translation: AAA53458.1
L37322 Genomic DNA Translation: AAA53459.1
L37322 Genomic DNA Translation: AAA53460.1
L37323 Genomic DNA Translation: AAA53461.1
L37323 Genomic DNA Translation: AAA53462.1
L37324 Genomic DNA Translation: AAA53463.1
L37324 Genomic DNA Translation: AAA53464.1
L37325 Genomic DNA Translation: AAA53465.1
L37325 Genomic DNA Translation: AAA53466.1
L37326 Genomic DNA Translation: AAA53467.1
L37326 Genomic DNA Translation: AAA53468.1
L37327 Genomic DNA Translation: AAA53469.1
L37327 Genomic DNA Translation: AAA53470.1
RefSeqiNP_001287569.1, NM_001300640.1 [P06742-1]
NP_476639.1, NM_057291.4 [P06742-2]
NP_476640.1, NM_057292.4 [P06742-1]
UniGeneiDm.6719

Genome annotation databases

EnsemblMetazoaiFBtr0085195; FBpp0084565; FBgn0002772 [P06742-2]
FBtr0085196; FBpp0084566; FBgn0002772 [P06742-1]
FBtr0344131; FBpp0310544; FBgn0002772 [P06742-1]
GeneIDi43323
KEGGidme:Dmel_CG5596

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMLC1_DROME
AccessioniPrimary (citable) accession number: P06742
Secondary accession number(s): P06743
, P92155, P92156, P92157, P92183, P92187, P92196, Q24380, Q24381, Q24382, Q24383, Q27304, Q27315, Q27381, Q27414, Q94988, Q9VB12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 27, 2003
Last modified: May 23, 2018
This is version 168 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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