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Protein

Hemolysin secretion protein D, plasmid

Gene

hlyD

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of hemolysin A.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytolysis, Hemolysis, Transport

Protein family/group databases

TCDBi8.A.1.3.1. the membrane fusion protein (mfp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemolysin secretion protein D, plasmid
Gene namesi
Name:hlyD
Encoded oniPlasmid IncI2 pHLY1520 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959Cytoplasmic1 PublicationAdd
BLAST
Transmembranei60 – 8021Helical; Signal-anchor for type II membrane proteinCuratedAdd
BLAST
Topological domaini81 – 478398Periplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Hemolysin secretion protein D, plasmidPRO_0000201874Add
BLAST

Proteomic databases

PRIDEiP06739.

Interactioni

Protein-protein interaction databases

DIPiDIP-28121N.
STRINGi199310.c3574.

Structurei

3D structure databases

ProteinModelPortaliP06739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C42. Bacteria.
ENOG410XNME. LUCA.

Family and domain databases

InterProiIPR003997. Rtx_secretion_protD_GmN_bac.
IPR006144. Secretion_HlyD_CS.
IPR010129. T1SS_HlyD.
[Graphical view]
PRINTSiPR01490. RTXTOXIND.
TIGRFAMsiTIGR01843. type_I_hlyD. 1 hit.
PROSITEiPS00543. HLYD_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTWLMGFSE FLLRYKLVWS ETWKIRKQLD TPVREKDENE FLPAHLELIE
60 70 80 90 100
TPVSRRPRLV AYFIMGFLVI AFILSVLGQV EIVATANGKL THSGRSKEIK
110 120 130 140 150
PIENSIVKEI IVKEGESVRK GDVLLKLTAL GAEADTLKTQ SSLLQARLEQ
160 170 180 190 200
TRYQILSRSI ELNKLPELKL PDEPYFQNVS EEEVLRLTSL IKEQFSTWQN
210 220 230 240 250
QKYQKELNLD KKRAERLTVL ARINRYENLS RVEKSRLDDF SSLLHKQAIA
260 270 280 290 300
KHAVLEQENK YVEAVNELRV YKSQLEQIES EILSAKEEYQ LVTQLFKNEI
310 320 330 340 350
LDKLRQTTDN IGLLTLELAK NEERQQASVI RAPVSVKVQQ LKVHTEGGVV
360 370 380 390 400
TTAETLMVIV PEDDTLEVTA LVQNKDIGFI NVGQNAIIKV EAFPYTRYGY
410 420 430 440 450
LVGKVKNINL DAIEDQRLGL VFNVIISIEE NCLSTGNKNI PLSSGMAVTA
460 470
EIKTGMRSVI SYLLSPLEES VTESLRER
Length:478
Mass (Da):54,541
Last modified:January 1, 1988 - v1
Checksum:iD286252A35EE3DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14107 Genomic DNA. Translation: AAA98235.1.
PIRiS10058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14107 Genomic DNA. Translation: AAA98235.1.
PIRiS10058.

3D structure databases

ProteinModelPortaliP06739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-28121N.
STRINGi199310.c3574.

Protein family/group databases

TCDBi8.A.1.3.1. the membrane fusion protein (mfp) family.

Proteomic databases

PRIDEiP06739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105C42. Bacteria.
ENOG410XNME. LUCA.

Family and domain databases

InterProiIPR003997. Rtx_secretion_protD_GmN_bac.
IPR006144. Secretion_HlyD_CS.
IPR010129. T1SS_HlyD.
[Graphical view]
PRINTSiPR01490. RTXTOXIND.
TIGRFAMsiTIGR01843. type_I_hlyD. 1 hit.
PROSITEiPS00543. HLYD_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a plasmid-encoded hemolysin determinant and its comparison with a corresponding chromosomal hemolysin sequence."
    Hess J., Wels W., Vogel M., Goebel W.
    FEMS Microbiol. Lett. 34:1-11(1986)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A topological model for the haemolysin translocator protein HlyD."
    Schuelein R., Gentschev I., Mollenkopf H.-J., Goebel W.
    Mol. Gen. Genet. 234:155-163(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.

Entry informationi

Entry nameiHLYDP_ECOLX
AccessioniPrimary (citable) accession number: P06739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.