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Protein

Glycogen phosphorylase, liver form

Gene

PYGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

Catalytic activityi

((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.

Cofactori

Enzyme regulationi

Activity of phosphorylase is controlled both by allosteric means (through the noncovalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76AMPBy similarity1
Sitei109Involved in the association of subunitsBy similarity1
Sitei143Involved in the association of subunitsBy similarity1
Sitei156May be involved in allosteric controlBy similarity1

GO - Molecular functioni

  • AMP binding Source: UniProtKB
  • ATP binding Source: UniProtKB
  • bile acid binding Source: UniProtKB
  • drug binding Source: UniProtKB
  • glucose binding Source: UniProtKB
  • glycogen phosphorylase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • purine nucleobase binding Source: UniProtKB
  • pyridoxal phosphate binding Source: GO_Central
  • vitamin binding Source: UniProtKB

GO - Biological processi

  • 5-phosphoribose 1-diphosphate biosynthetic process Source: Ensembl
  • glucose homeostasis Source: UniProtKB
  • glycogen catabolic process Source: GO_Central
  • glycogen metabolic process Source: UniProtKB
  • necroptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Keywords - Ligandi

Nucleotide-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS02099-MONOMER.
ZFISH:HS02099-MONOMER.
BRENDAi2.4.1.1. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-70221. Glycogen breakdown (glycogenolysis).
SIGNORiP06737.

Protein family/group databases

CAZyiGT35. Glycosyltransferase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen phosphorylase, liver form (EC:2.4.1.1)
Gene namesi
Name:PYGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9725. PYGL.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Glycogen storage disease 6 (GSD6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.
See also OMIM:232700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007908339N → S in GSD6. 1 PublicationCorresponds to variant rs113993976dbSNPEnsembl.1
Natural variantiVAR_007909377N → K in GSD6. 1 PublicationCorresponds to variant rs113993977dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNETi5836.
MalaCardsiPYGL.
MIMi232700. phenotype.
OpenTargetsiENSG00000100504.
Orphaneti369. Glycogen storage disease due to liver glycogen phosphorylase deficiency.
PharmGKBiPA34068.

Chemistry databases

ChEMBLiCHEMBL2568.
DrugBankiDB00131. Adenosine monophosphate.

Polymorphism and mutation databases

BioMutaiPYGL.
DMDMi6648082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001885242 – 847Glycogen phosphorylase, liver formAdd BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei15Phosphoserine; by PHK; in form phosphorylase A1 Publication1
Modified residuei204PhosphotyrosineBy similarity1
Modified residuei227PhosphotyrosineBy similarity1
Modified residuei364N6-succinyllysineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei524PhosphoserineBy similarity1
Modified residuei561PhosphoserineBy similarity1
Modified residuei639PhosphoserineCombined sources1
Modified residuei681N6-(pyridoxal phosphate)lysineBy similarity1

Post-translational modificationi

Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP06737.
MaxQBiP06737.
PaxDbiP06737.
PeptideAtlasiP06737.
PRIDEiP06737.

PTM databases

iPTMnetiP06737.
PhosphoSitePlusiP06737.

Expressioni

Gene expression databases

BgeeiENSG00000100504.
CleanExiHS_PYGL.
ExpressionAtlasiP06737. baseline and differential.
GenevisibleiP06737. HS.

Organism-specific databases

HPAiHPA000962.
HPA004119.

Interactioni

Subunit structurei

Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Interacts with PPP1R3B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PYGBP112165EBI-2511865,EBI-1047231

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi111794. 41 interactors.
IntActiP06737. 13 interactors.
MINTiMINT-1208599.
STRINGi9606.ENSP00000216392.

Chemistry databases

BindingDBiP06737.

Structurei

Secondary structure

1847
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni8 – 10Combined sources3
Helixi11 – 13Combined sources3
Beta strandi14 – 17Combined sources4
Helixi19 – 38Combined sources20
Helixi44 – 46Combined sources3
Helixi49 – 62Combined sources14
Helixi65 – 78Combined sources14
Beta strandi82 – 86Combined sources5
Beta strandi90 – 93Combined sources4
Helixi96 – 102Combined sources7
Helixi106 – 115Combined sources10
Helixi120 – 125Combined sources6
Beta strandi130 – 135Combined sources6
Helixi136 – 150Combined sources15
Beta strandi155 – 160Combined sources6
Beta strandi168 – 172Combined sources5
Beta strandi175 – 179Combined sources5
Turni183 – 186Combined sources4
Helixi195 – 197Combined sources3
Beta strandi199 – 204Combined sources6
Beta strandi206 – 210Combined sources5
Beta strandi213 – 218Combined sources6
Beta strandi220 – 232Combined sources13
Beta strandi234 – 237Combined sources4
Beta strandi239 – 248Combined sources10
Helixi255 – 260Combined sources6
Helixi263 – 268Combined sources6
Helixi270 – 274Combined sources5
Helixi275 – 277Combined sources3
Helixi291 – 314Combined sources24
Beta strandi315 – 317Combined sources3
Beta strandi322 – 325Combined sources4
Helixi327 – 329Combined sources3
Helixi330 – 333Combined sources4
Beta strandi334 – 341Combined sources8
Turni342 – 345Combined sources4
Helixi346 – 356Combined sources11
Helixi362 – 372Combined sources11
Beta strandi373 – 376Combined sources4
Helixi382 – 384Combined sources3
Beta strandi387 – 389Combined sources3
Helixi390 – 396Combined sources7
Helixi398 – 418Combined sources21
Beta strandi419 – 421Combined sources3
Helixi423 – 429Combined sources7
Beta strandi431 – 433Combined sources3
Beta strandi435 – 437Combined sources3
Beta strandi439 – 441Combined sources3
Helixi442 – 448Combined sources7
Beta strandi451 – 457Combined sources7
Helixi458 – 466Combined sources9
Turni467 – 469Combined sources3
Helixi470 – 475Combined sources6
Helixi477 – 479Combined sources3
Beta strandi480 – 482Combined sources3
Helixi490 – 495Combined sources6
Helixi498 – 508Combined sources11
Helixi511 – 513Combined sources3
Helixi516 – 525Combined sources10
Helixi529 – 553Combined sources25
Beta strandi554 – 556Combined sources3
Beta strandi562 – 569Combined sources8
Turni573 – 576Combined sources4
Helixi577 – 593Combined sources17
Beta strandi595 – 597Combined sources3
Beta strandi602 – 607Combined sources6
Helixi615 – 633Combined sources19
Turni635 – 637Combined sources3
Helixi638 – 640Combined sources3
Beta strandi641 – 646Combined sources6
Helixi651 – 657Combined sources7
Helixi658 – 660Combined sources3
Beta strandi662 – 666Combined sources5
Turni670 – 672Combined sources3
Helixi678 – 684Combined sources7
Beta strandi688 – 691Combined sources4
Helixi697 – 704Combined sources8
Helixi706 – 708Combined sources3
Beta strandi709 – 711Combined sources3
Helixi716 – 725Combined sources10
Helixi729 – 735Combined sources7
Helixi737 – 748Combined sources12
Turni749 – 751Combined sources3
Turni756 – 759Combined sources4
Helixi760 – 768Combined sources9
Helixi774 – 792Combined sources19
Helixi795 – 806Combined sources12
Helixi810 – 812Combined sources3
Helixi814 – 824Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EM6X-ray2.20A/B1-847[»]
1EXVX-ray2.40A/B1-847[»]
1FA9X-ray2.40A2-847[»]
1FC0X-ray2.40A/B2-847[»]
1L5QX-ray2.25A/B1-847[»]
1L5RX-ray2.10A/B1-847[»]
1L5SX-ray2.10A/B1-847[»]
1L7XX-ray2.30A/B1-847[»]
1XOIX-ray2.10A/B2-847[»]
2ATIX-ray1.90A/B2-847[»]
2QLLX-ray2.56A1-847[»]
2ZB2X-ray2.45A/B1-847[»]
3CEHX-ray2.80A/B24-832[»]
3CEJX-ray3.30A/B24-832[»]
3CEMX-ray2.47A/B24-832[»]
3DD1X-ray2.57A/B2-847[»]
3DDSX-ray1.80A/B2-847[»]
3DDWX-ray1.90A/B2-847[»]
ProteinModelPortaliP06737.
SMRiP06737.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06737.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycogen phosphorylase family.Curated

Phylogenomic databases

eggNOGiKOG2099. Eukaryota.
COG0058. LUCA.
GeneTreeiENSGT00390000016886.
HOVERGENiHBG006848.
InParanoidiP06737.
KOiK00688.
OMAiKRAWAEF.
OrthoDBiEOG091G03RB.
PhylomeDBiP06737.
TreeFamiTF300309.

Family and domain databases

CDDicd04300. GT1_Glycogen_Phosphorylase. 1 hit.
InterProiIPR011833. Glycg_phsphrylas.
IPR000811. Glyco_trans_35.
[Graphical view]
PANTHERiPTHR11468. PTHR11468. 1 hit.
PfamiPF00343. Phosphorylase. 1 hit.
[Graphical view]
PIRSFiPIRSF000460. Pprylas_GlgP. 1 hit.
TIGRFAMsiTIGR02093. P_ylase. 1 hit.
PROSITEiPS00102. PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P06737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKPLTDQEK RRQISIRGIV GVENVAELKK SFNRHLHFTL VKDRNVATTR
60 70 80 90 100
DYYFALAHTV RDHLVGRWIR TQQHYYDKCP KRVYYLSLEF YMGRTLQNTM
110 120 130 140 150
INLGLQNACD EAIYQLGLDI EELEEIEEDA GLGNGGLGRL AACFLDSMAT
160 170 180 190 200
LGLAAYGYGI RYEYGIFNQK IRDGWQVEEA DDWLRYGNPW EKSRPEFMLP
210 220 230 240 250
VHFYGKVEHT NTGTKWIDTQ VVLALPYDTP VPGYMNNTVN TMRLWSARAP
260 270 280 290 300
NDFNLRDFNV GDYIQAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV
310 320 330 340 350
VAATLQDIIR RFKASKFGST RGAGTVFDAF PDQVAIQLND THPALAIPEL
360 370 380 390 400
MRIFVDIEKL PWSKAWELTQ KTFAYTNHTV LPEALERWPV DLVEKLLPRH
410 420 430 440 450
LEIIYEINQK HLDRIVALFP KDVDRLRRMS LIEEEGSKRI NMAHLCIVGS
460 470 480 490 500
HAVNGVAKIH SDIVKTKVFK DFSELEPDKF QNKTNGITPR RWLLLCNPGL
510 520 530 540 550
AELIAEKIGE DYVKDLSQLT KLHSFLGDDV FLRELAKVKQ ENKLKFSQFL
560 570 580 590 600
ETEYKVKINP SSMFDVQVKR IHEYKRQLLN CLHVITMYNR IKKDPKKLFV
610 620 630 640 650
PRTVIIGGKA APGYHMAKMI IKLITSVADV VNNDPMVGSK LKVIFLENYR
660 670 680 690 700
VSLAEKVIPA TDLSEQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM
710 720 730 740 750
AEEAGEENLF IFGMRIDDVA ALDKKGYEAK EYYEALPELK LVIDQIDNGF
760 770 780 790 800
FSPKQPDLFK DIINMLFYHD RFKVFADYEA YVKCQDKVSQ LYMNPKAWNT
810 820 830 840
MVLKNIAASG KFSSDRTIKE YAQNIWNVEP SDLKISLSNE SNKVNGN
Length:847
Mass (Da):97,149
Last modified:January 23, 2007 - v4
Checksum:i74017E8125FB5735
GO
Isoform 2 (identifier: P06737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-115: Missing.

Note: No experimental confirmation available.
Show »
Length:813
Mass (Da):93,134
Checksum:i40B7DB0528A64AAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AK → GE in AAA52577 (PubMed:2877458).Curated2
Sequence conflicti2 – 3AK → GE in AAC18079 (PubMed:9536091).Curated2
Sequence conflicti83V → E in AAA52577 (PubMed:2877458).Curated1
Sequence conflicti323A → Q in AAA52577 (PubMed:2877458).Curated1
Sequence conflicti344 – 345AL → RI in AAA52577 (PubMed:2877458).Curated2
Sequence conflicti369T → N in AAA52577 (PubMed:2877458).Curated1
Sequence conflicti369T → N in AAC18079 (PubMed:9536091).Curated1
Sequence conflicti570R → S in AAC17450 (Ref. 2) Curated1
Sequence conflicti683Missing in AAH09895 (PubMed:15489334).Curated1
Sequence conflicti715R → G in BAG62279 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007907222V → I.1 PublicationCorresponds to variant rs946616dbSNPEnsembl.1
Natural variantiVAR_013095231V → E.Corresponds to variant rs1042195dbSNPEnsembl.1
Natural variantiVAR_007908339N → S in GSD6. 1 PublicationCorresponds to variant rs113993976dbSNPEnsembl.1
Natural variantiVAR_007909377N → K in GSD6. 1 PublicationCorresponds to variant rs113993977dbSNPEnsembl.1
Natural variantiVAR_034425425R → P.1 PublicationCorresponds to variant rs2228499dbSNPEnsembl.1
Natural variantiVAR_034426698V → G.Corresponds to variant rs35831273dbSNPEnsembl.1
Natural variantiVAR_013096715R → S.Corresponds to variant rs1042210dbSNPEnsembl.1
Natural variantiVAR_034427806I → L.Corresponds to variant rs34313873dbSNPEnsembl.1
Natural variantiVAR_069054845N → S.1 PublicationCorresponds to variant rs78558135dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04533982 – 115Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14636 mRNA. Translation: AAA52577.1.
AF066858 mRNA. Translation: AAC17450.1.
AF046798
, AF046787, AF046788, AF046789, AF046790, AF046791, AF046792, AF046793, AF046794, AF046795, AF046796, AF046797 Genomic DNA. Translation: AAC18079.1.
AF046785 mRNA. Translation: AAC23504.1.
Y15233 mRNA. Translation: CAA75517.1.
AK300580 mRNA. Translation: BAG62279.1.
AL358334 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65685.1.
BC009895 mRNA. Translation: AAH09895.3.
BC082229 mRNA. Translation: AAH82229.2.
BC095850 mRNA. Translation: AAH95850.2.
BC110791 mRNA. Translation: AAI10792.2.
M36807 mRNA. Translation: AAA35906.1.
CCDSiCCDS32080.1. [P06737-1]
CCDS53894.1. [P06737-2]
PIRiA25518.
RefSeqiNP_001157412.1. NM_001163940.1. [P06737-2]
NP_002854.3. NM_002863.4. [P06737-1]
UniGeneiHs.282417.

Genome annotation databases

EnsembliENST00000216392; ENSP00000216392; ENSG00000100504. [P06737-1]
ENST00000544180; ENSP00000443787; ENSG00000100504. [P06737-2]
GeneIDi5836.
KEGGihsa:5836.
UCSCiuc001wyu.4. human. [P06737-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14636 mRNA. Translation: AAA52577.1.
AF066858 mRNA. Translation: AAC17450.1.
AF046798
, AF046787, AF046788, AF046789, AF046790, AF046791, AF046792, AF046793, AF046794, AF046795, AF046796, AF046797 Genomic DNA. Translation: AAC18079.1.
AF046785 mRNA. Translation: AAC23504.1.
Y15233 mRNA. Translation: CAA75517.1.
AK300580 mRNA. Translation: BAG62279.1.
AL358334 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65685.1.
BC009895 mRNA. Translation: AAH09895.3.
BC082229 mRNA. Translation: AAH82229.2.
BC095850 mRNA. Translation: AAH95850.2.
BC110791 mRNA. Translation: AAI10792.2.
M36807 mRNA. Translation: AAA35906.1.
CCDSiCCDS32080.1. [P06737-1]
CCDS53894.1. [P06737-2]
PIRiA25518.
RefSeqiNP_001157412.1. NM_001163940.1. [P06737-2]
NP_002854.3. NM_002863.4. [P06737-1]
UniGeneiHs.282417.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EM6X-ray2.20A/B1-847[»]
1EXVX-ray2.40A/B1-847[»]
1FA9X-ray2.40A2-847[»]
1FC0X-ray2.40A/B2-847[»]
1L5QX-ray2.25A/B1-847[»]
1L5RX-ray2.10A/B1-847[»]
1L5SX-ray2.10A/B1-847[»]
1L7XX-ray2.30A/B1-847[»]
1XOIX-ray2.10A/B2-847[»]
2ATIX-ray1.90A/B2-847[»]
2QLLX-ray2.56A1-847[»]
2ZB2X-ray2.45A/B1-847[»]
3CEHX-ray2.80A/B24-832[»]
3CEJX-ray3.30A/B24-832[»]
3CEMX-ray2.47A/B24-832[»]
3DD1X-ray2.57A/B2-847[»]
3DDSX-ray1.80A/B2-847[»]
3DDWX-ray1.90A/B2-847[»]
ProteinModelPortaliP06737.
SMRiP06737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111794. 41 interactors.
IntActiP06737. 13 interactors.
MINTiMINT-1208599.
STRINGi9606.ENSP00000216392.

Chemistry databases

BindingDBiP06737.
ChEMBLiCHEMBL2568.
DrugBankiDB00131. Adenosine monophosphate.

Protein family/group databases

CAZyiGT35. Glycosyltransferase Family 35.

PTM databases

iPTMnetiP06737.
PhosphoSitePlusiP06737.

Polymorphism and mutation databases

BioMutaiPYGL.
DMDMi6648082.

Proteomic databases

EPDiP06737.
MaxQBiP06737.
PaxDbiP06737.
PeptideAtlasiP06737.
PRIDEiP06737.

Protocols and materials databases

DNASUi5836.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216392; ENSP00000216392; ENSG00000100504. [P06737-1]
ENST00000544180; ENSP00000443787; ENSG00000100504. [P06737-2]
GeneIDi5836.
KEGGihsa:5836.
UCSCiuc001wyu.4. human. [P06737-1]

Organism-specific databases

CTDi5836.
DisGeNETi5836.
GeneCardsiPYGL.
HGNCiHGNC:9725. PYGL.
HPAiHPA000962.
HPA004119.
MalaCardsiPYGL.
MIMi232700. phenotype.
613741. gene.
neXtProtiNX_P06737.
OpenTargetsiENSG00000100504.
Orphaneti369. Glycogen storage disease due to liver glycogen phosphorylase deficiency.
PharmGKBiPA34068.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2099. Eukaryota.
COG0058. LUCA.
GeneTreeiENSGT00390000016886.
HOVERGENiHBG006848.
InParanoidiP06737.
KOiK00688.
OMAiKRAWAEF.
OrthoDBiEOG091G03RB.
PhylomeDBiP06737.
TreeFamiTF300309.

Enzyme and pathway databases

BioCyciMetaCyc:HS02099-MONOMER.
ZFISH:HS02099-MONOMER.
BRENDAi2.4.1.1. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-70221. Glycogen breakdown (glycogenolysis).
SIGNORiP06737.

Miscellaneous databases

ChiTaRSiPYGL. human.
EvolutionaryTraceiP06737.
GenomeRNAii5836.
PROiP06737.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100504.
CleanExiHS_PYGL.
ExpressionAtlasiP06737. baseline and differential.
GenevisibleiP06737. HS.

Family and domain databases

CDDicd04300. GT1_Glycogen_Phosphorylase. 1 hit.
InterProiIPR011833. Glycg_phsphrylas.
IPR000811. Glyco_trans_35.
[Graphical view]
PANTHERiPTHR11468. PTHR11468. 1 hit.
PfamiPF00343. Phosphorylase. 1 hit.
[Graphical view]
PIRSFiPIRSF000460. Pprylas_GlgP. 1 hit.
TIGRFAMsiTIGR02093. P_ylase. 1 hit.
PROSITEiPS00102. PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYGL_HUMAN
AccessioniPrimary (citable) accession number: P06737
Secondary accession number(s): A6NDQ4
, B4DUB7, F5H816, O60567, O60752, O60913, Q501V9, Q641R5, Q96G82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 200 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.