Low affinity immunoglobulin epsilon Fc receptor

Names and origin

Protein attributes

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Ontologies

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Reviewed, UniProtKB/Swiss-Prot P06734 (FCER2_HUMAN)

Last modified November 24, 2009. Version 116. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Protein names

Recommended name:
    Low affinity immunoglobulin epsilon Fc receptor
Alternative name(s):
    Lymphocyte IgE receptor
    Fc-epsilon-RII
    BLAST-2
    Immunoglobulin E-binding factor
    CD_antigen=CD23
Cleaved into the following 2 chains:
    1- Recommended name:
            Low affinity immunoglobulin epsilon Fc receptor membrane-bound form
    2- Recommended name:
            Low affinity immunoglobulin epsilon Fc receptor soluble form

Gene names

Name:	FCER2
Synonyms:	CD23A, FCE2, IGEBF

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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Function	This receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Subcellular location	Cell membrane; Single-pass type II membrane protein. Secreted. Note: Also exists as a soluble excreted form.
Post-translational modification	N- and O-glycosylated.
Miscellaneous	There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.
Sequence similarities	Contains 1 C-type lectin domain.

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Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal-anchor Transmembrane
Ligand	IgE-binding protein Lectin
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	positive regulation of killing of cells of another organism Inferred from direct assay. Source: UniProtKB positive regulation of nitric-oxide synthase 2 biosynthetic process Inferred from direct assay. Source: UniProtKB positive regulation of nitric-oxide synthase activity Inferred from direct assay. Source: UniProtKB
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	IgE binding Inferred from electronic annotation. Source: UniProtKB-KW integrin binding Traceable author statement. Source: ProtInc receptor activity Inferred from electronic annotation. Source: UniProtKB-KW sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 321

321

Low affinity immunoglobulin epsilon Fc receptor membrane-bound form

PRO_0000017391

Chain

150 – 321

172

Low affinity immunoglobulin epsilon Fc receptor soluble form

PRO_0000017392

Topological domain

1 – 21

Cytoplasmic Potential

Transmembrane

22 – 47

Signal-anchor for type II membrane protein Potential

Topological domain

48 – 321

274

Extracellular Potential

Repeat

Repeat

Repeat

Domain

123

C-type lectin

Site

149 – 150

Cleavage

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

160 ↔ 288

By similarity

Disulfide bond

163 ↔ 174

By similarity

Disulfide bond

Disulfide bond

Alternative sequence

1 – 7

MEEGQYS → MNPPSQ in isoform B.

VSP_003057

Natural variant

R → W: dbSNP rs2228137.

VAR_035387

Natural variant

284

R → Q: dbSNP rs8102872.

VAR_035388

Sequence conflict

269

N → T in CAA28465. Ref.3

321

Helix Strand Turn

Details...

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Sequence		Length	Mass (Da)
Isoform A [UniParc]. Last modified January 1, 1988. Version 1. Checksum: F86708C0E6515B87 Show »	FASTA	321	36,469
10 20 30 40 50 60 MEEGQYSEIE ELPRRRCCRR GTQIVLLGLV TAALWAGLLT LLLLWHWDTT QSLKQLEERA 70 80 90 100 110 120 ARNVSQVSKN LESHHGDQMA QKSQSTQISQ ELEELRAEQQ RLKSQDLELS WNLNGLQADL 130 140 150 160 170 180 SSFKSQELNE RNEASDLLER LREEVTKLRM ELQVSSGFVC NTCPEKWINF QRKCYYFGKG 190 200 210 220 230 240 TKQWVHARYA CDDMEGQLVS IHSPEEQDFL TKHASHTGSW IGLRNLDLKG EFIWVDGSHV 250 260 270 280 290 300 DYSNWAPGEP TSRSQGEDCV MMRGSGRWND AFCDRKLGAW VCDRLATCTP PASEGSAESM 310 320 GPDSRPDPDG RLPTPSAPLH S « Hide
Isoform B. Checksum: 7BAE201DC57FCF85 Show »	FASTA	320	36,299
10 20 30 40 50 60 MNPPSQEIEE LPRRRCCRRG TQIVLLGLVT AALWAGLLTL LLLWHWDTTQ SLKQLEERAA 70 80 90 100 110 120 RNVSQVSKNL ESHHGDQMAQ KSQSTQISQE LEELRAEQQR LKSQDLELSW NLNGLQADLS 130 140 150 160 170 180 SFKSQELNER NEASDLLERL REEVTKLRME LQVSSGFVCN TCPEKWINFQ RKCYYFGKGT 190 200 210 220 230 240 KQWVHARYAC DDMEGQLVSI HSPEEQDFLT KHASHTGSWI GLRNLDLKGE FIWVDGSHVD 250 260 270 280 290 300 YSNWAPGEPT SRSQGEDCVM MRGSGRWNDA FCDRKLGAWV CDRLATCTPP ASEGSAESMG 310 320 PDSRPDPDGR LPTPSAPLHS « Hide

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	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins." Ikuta K., Takami M., Kim C.W., Honjo T., Miyoshi T., Tagaya Y., Kawabe T., Yodoi J. Proc. Natl. Acad. Sci. U.S.A. 84:819-823(1987) [PubMed: 2949326] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular structure of human lymphocyte receptor for immunoglobulin E." Kikutani H., Inui S., Sato R., Barsumian E.L., Owaki H., Yamasaki K., Kaisho T., Uchibayashi N., Hardy R.R., Hirano T., Tsunasawa S., Sakiyama F., Suemura M., Kishimoto T. Cell 47:657-665(1986) [PubMed: 2877743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor." Luedin C., Hofstetter H., Sarfati M., Levy C.A., Suter U., Alaimo D., Kilchherr E., Frost H., Delespesse G. EMBO J. 6:109-114(1987) [PubMed: 3034567] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: B-cell and Blood.
[5]	"Partial characterization of natural and recombinant human soluble CD23." Rose K., Turcatti G., Graber P., Pochon S., Regamey P.-O., Jansen K.U., Magnenat E., Aubonney N., Bonnefoy J.-Y. Biochem. J. 286:819-824(1992) [PubMed: 1417742] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
[6]	"Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression." Yokota A., Kikutani H., Tanaka T., Sato R., Barsumian E.L., Suemura M., Kishimoto T. Cell 55:611-618(1988) [PubMed: 2972386] [Abstract] Cited for: ALTERNATIVE SPLICING.
[7]	"Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)." Padlan E.A., Helm B.A. Receptor 3:325-341(1993) [PubMed: 8142907] [Abstract] Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN.
[8]	"Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models." Bajorath J., Aruffo A. Protein Sci. 5:240-247(1996) [PubMed: 8745401] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 173-285.
+	Additional computationally mapped references.

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Functional Glycomics Gateway - Glycan Binding

CD23

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M15059 mRNA. Translation: AAA52434.1.
M14766 mRNA. Translation: AAA52435.1.
X04772 mRNA. Translation: CAA28465.1.
M23562 Genomic DNA. Translation: AAA52433.1.
BC014108 mRNA. Translation: AAH14108.1.
BC062591 mRNA. Translation: AAH62591.1.

IPI

IPI00027491.
IPI00217263.

PIR

LNHUER. A26067.

RefSeq

NP_001993.2.

UniGene

Hs.465778

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HLI	model	-	A	173-285	[»]
1KJE	model	-	A	173-285	[»]
1T8C	NMR	-	A	156-298	[»]
1T8D	NMR	-	A	156-298	[»]
2H2R	X-ray	1.50	A/B	150-321	[»]
2H2T	X-ray	1.30	B	150-321	[»]

ModBase

Search...

STRING

P06734.

PRIDE

P06734.

Ensembl

ENST00000346664; ENSP00000264072; ENSG00000104921; Homo sapiens. [Genome view]
ENST00000394208; ENSP00000377758; ENSG00000104921; Homo sapiens. [Genome view]

GeneID

2208.

KEGG

hsa:2208.

UCSC

uc002mhm.1. human.

CTD

2208.

GeneCards

GC19M007659.

H-InvDB

HIX0018076.

HGNC

HGNC:3612. FCER2.

HPA

CAB002624.
HPA008928.

MIM

151445. gene.

PharmGKB

PA28058.

GenAtlas

Search...

HOGENOM

P06734.

HOVERGEN

P06734.

OMA

KCYYFGE

OrthoDB

EOG9HX7KF

Pathway_Interaction_DB

il4_2pathway. IL4-mediated signaling events.

ArrayExpress

P06734.

Bgee

P06734.

CleanEx

HS_FCER2.

Genevestigator

P06734.

GermOnline

ENSG00000104921. Homo sapiens.

InterPro

IPR002353. AntifreezeII.
IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]

Gene3D

G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.

Pfam

PF00059. Lectin_C. 1 hit.
[Graphical view]

PRINTS

PR00356. ANTIFREEZEII.

SMART

SM00034. CLECT. 1 hit.
[Graphical view]

PROSITE

PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

NextBio

8943.

PMAP-CutDB

P06734.

SOURCE

Search...

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This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P06734-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P06734-2)

The sequence of this isoform differs from the canonical sequence as follows:
1-7: MEEGQYS → MNPPSQ

Entry name

FCER2_HUMAN

Accession

Primary (citable) accession number: P06734

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	November 24, 2009
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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