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Protein

Carcinoembryonic antigen-related cell adhesion molecule 5

Gene

CEACAM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.1 Publication

GO - Molecular functioni

  • GPI anchor binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • homotypic cell-cell adhesion Source: UniProtKB
  • negative regulation of anoikis Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of myotube differentiation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105388-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 5
Alternative name(s):
Carcinoembryonic antigen
Short name:
CEA
Meconium antigen 100
CD_antigen: CD66e
Gene namesi
Name:CEACAM5
Synonyms:CEA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1817. CEACAM5.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • basolateral plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of external side of plasma membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63F → I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi63F → R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi66S → N: Abolishes dimerization. 2 Publications1
Mutagenesisi68Y → A: Abolishes dimerization. 1 Publication1
Mutagenesisi68Y → F: No effect on dimerization. 1 Publication1
Mutagenesisi69K → A: Abolishes dimerization. 1 Publication1
Mutagenesisi73V → A: Abolishes dimerization. 1 Publication1
Mutagenesisi74D → A: No effect on dimerization. 1 Publication1
Mutagenesisi74D → L or R: Abolishes dimerization. 1 Publication1
Mutagenesisi78Q → L or R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 2 Publications1
Mutagenesisi125I → A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi129L → A or C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi129L → S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi133E → A: Abolishes dimerization. 1 Publication1

Organism-specific databases

DisGeNETi1048.
PharmGKBiPA26361.

Polymorphism and mutation databases

BioMutaiCEACAM5.
DMDMi317373456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001456635 – 685Carcinoembryonic antigen-related cell adhesion molecule 5Add BLAST651
PropeptideiPRO_0000014567686 – 702Removed in mature formSequence analysisAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi204N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi246N-linked (GlcNAc...)1 Publication1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi351N-linked (GlcNAc...)Sequence analysis1
Glycosylationi360N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1
Glycosylationi432N-linked (GlcNAc...)Sequence analysis1
Glycosylationi466N-linked (GlcNAc...)Sequence analysis1
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1
Glycosylationi508N-linked (GlcNAc...)Sequence analysis1
Glycosylationi529N-linked (GlcNAc...)Sequence analysis1
Glycosylationi553N-linked (GlcNAc...)Sequence analysis1
Glycosylationi560N-linked (GlcNAc...)1 Publication1
Glycosylationi580N-linked (GlcNAc...)Sequence analysis1
Glycosylationi612N-linked (GlcNAc...)Sequence analysis1
Glycosylationi650N-linked (GlcNAc...)Sequence analysis1
Glycosylationi665N-linked (GlcNAc...)Sequence analysis1
Lipidationi685GPI-anchor amidated alanineSequence analysis1

Post-translational modificationi

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP06731.
PaxDbiP06731.
PeptideAtlasiP06731.
PRIDEiP06731.

PTM databases

iPTMnetiP06731.
PhosphoSitePlusiP06731.

Expressioni

Tissue specificityi

Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Gene expression databases

BgeeiENSG00000105388.
CleanExiHS_CEACAM5.
ExpressionAtlasiP06731. baseline and differential.
GenevisibleiP06731. HS.

Organism-specific databases

HPAiCAB000021.
CAB000022.
HPA011041.
HPA019758.

Interactioni

Subunit structurei

Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-3914938,EBI-3914938

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107478. 6 interactors.
DIPiDIP-57769N.
IntActiP06731. 5 interactors.
MINTiMINT-1472001.
STRINGi9606.ENSP00000221992.

Structurei

Secondary structure

1702
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 46Combined sources10
Beta strandi51 – 57Combined sources7
Beta strandi60 – 72Combined sources13
Helixi75 – 77Combined sources3
Beta strandi78 – 83Combined sources6
Turni84 – 87Combined sources4
Beta strandi88 – 91Combined sources4
Beta strandi99 – 101Combined sources3
Beta strandi107 – 109Combined sources3
Helixi114 – 116Combined sources3
Beta strandi118 – 126Combined sources9
Beta strandi132 – 141Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E07X-ray-A35-676[»]
2QSQX-ray1.95A/B34-144[»]
2QSTX-ray2.90A/B34-144[»]
2VERNMR-N35-144[»]
ProteinModelPortaliP06731.
SMRiP06731.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06731.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like 1Add BLAST110
Domaini146 – 237Ig-like 2Add BLAST92
Domaini238 – 322Ig-like 3Add BLAST85
Domaini324 – 415Ig-like 4Add BLAST92
Domaini416 – 498Ig-like 5Add BLAST83
Domaini502 – 593Ig-like 6Add BLAST92
Domaini594 – 677Ig-like 7Add BLAST84

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP06731.
KOiK06499.
PhylomeDBiP06731.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 3 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P06731-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI
110 120 130 140 150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS
160 170 180 190 200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR
260 270 280 290 300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ
310 320 330 340 350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ
360 370 380 390 400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNKLS
410 420 430 440 450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL
460 470 480 490 500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL
510 520 530 540 550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS
560 570 580 590 600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP
610 620 630 640 650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN
660 670 680 690 700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA

LI
Length:702
Mass (Da):76,795
Last modified:January 11, 2011 - v3
Checksum:i86318E244155DB58
GO
Isoform 2 (identifier: P06731-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-320: Missing.

Show »
Length:701
Mass (Da):76,724
Checksum:i19149D8E5BDE18E5
GO

Sequence cautioni

The sequence AAA62835 differs from that shown. Reason: Frameshift at positions 359 and 361.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti641F → L in AAA62835 (PubMed:2342461).Curated1
Sequence conflicti646T → Q in AAA62835 (PubMed:2342461).Curated1
Sequence conflicti689V → A in AAA62835 (PubMed:2342461).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06131080I → V.Corresponds to variant rs12971352dbSNPEnsembl.1
Natural variantiVAR_06131183V → A.Corresponds to variant rs28683503dbSNPEnsembl.1
Natural variantiVAR_056028137Q → P.Corresponds to variant rs3815780dbSNPEnsembl.1
Natural variantiVAR_031091340A → D.Corresponds to variant rs10407503dbSNPEnsembl.1
Natural variantiVAR_024493398K → E.5 PublicationsCorresponds to variant rs7249230dbSNPEnsembl.1
Natural variantiVAR_031092664R → S.Corresponds to variant rs10423171dbSNPEnsembl.1
Natural variantiVAR_056029678G → R.Corresponds to variant rs11545767dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053414320Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17303 Genomic DNA. Translation: AAB59513.1.
M29540 mRNA. Translation: AAA51967.1.
M59262
, M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA. Translation: AAA62835.1. Frameshift.
M59709 Genomic DNA. No translation available.
M59710 Genomic DNA. No translation available.
AC008999 Genomic DNA. No translation available.
X16455 mRNA. Translation: CAA34474.1.
M15042 mRNA. Translation: AAA51963.1.
M16234 mRNA. Translation: AAA51972.1.
CCDSiCCDS12584.1. [P06731-1]
CCDS77302.1. [P06731-2]
PIRiA36319.
RefSeqiNP_001278413.1. NM_001291484.2.
NP_001295327.1. NM_001308398.1.
NP_004354.3. NM_004363.5.
UniGeneiHs.709196.

Genome annotation databases

EnsembliENST00000221992; ENSP00000221992; ENSG00000105388.
ENST00000398599; ENSP00000381600; ENSG00000105388.
ENST00000405816; ENSP00000385072; ENSG00000105388.
GeneIDi1048.
KEGGihsa:1048.
UCSCiuc002orj.2. human. [P06731-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17303 Genomic DNA. Translation: AAB59513.1.
M29540 mRNA. Translation: AAA51967.1.
M59262
, M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA. Translation: AAA62835.1. Frameshift.
M59709 Genomic DNA. No translation available.
M59710 Genomic DNA. No translation available.
AC008999 Genomic DNA. No translation available.
X16455 mRNA. Translation: CAA34474.1.
M15042 mRNA. Translation: AAA51963.1.
M16234 mRNA. Translation: AAA51972.1.
CCDSiCCDS12584.1. [P06731-1]
CCDS77302.1. [P06731-2]
PIRiA36319.
RefSeqiNP_001278413.1. NM_001291484.2.
NP_001295327.1. NM_001308398.1.
NP_004354.3. NM_004363.5.
UniGeneiHs.709196.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E07X-ray-A35-676[»]
2QSQX-ray1.95A/B34-144[»]
2QSTX-ray2.90A/B34-144[»]
2VERNMR-N35-144[»]
ProteinModelPortaliP06731.
SMRiP06731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107478. 6 interactors.
DIPiDIP-57769N.
IntActiP06731. 5 interactors.
MINTiMINT-1472001.
STRINGi9606.ENSP00000221992.

PTM databases

iPTMnetiP06731.
PhosphoSitePlusiP06731.

Polymorphism and mutation databases

BioMutaiCEACAM5.
DMDMi317373456.

Proteomic databases

MaxQBiP06731.
PaxDbiP06731.
PeptideAtlasiP06731.
PRIDEiP06731.

Protocols and materials databases

DNASUi1048.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221992; ENSP00000221992; ENSG00000105388.
ENST00000398599; ENSP00000381600; ENSG00000105388.
ENST00000405816; ENSP00000385072; ENSG00000105388.
GeneIDi1048.
KEGGihsa:1048.
UCSCiuc002orj.2. human. [P06731-1]

Organism-specific databases

CTDi1048.
DisGeNETi1048.
GeneCardsiCEACAM5.
H-InvDBHIX0027513.
HGNCiHGNC:1817. CEACAM5.
HPAiCAB000021.
CAB000022.
HPA011041.
HPA019758.
MIMi114890. gene.
neXtProtiNX_P06731.
PharmGKBiPA26361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP06731.
KOiK06499.
PhylomeDBiP06731.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105388-MONOMER.

Miscellaneous databases

ChiTaRSiCEACAM5. human.
EvolutionaryTraceiP06731.
GeneWikiiCEACAM5.
GenomeRNAii1048.
PROiP06731.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105388.
CleanExiHS_CEACAM5.
ExpressionAtlasiP06731. baseline and differential.
GenevisibleiP06731. HS.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 3 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM5_HUMAN
AccessioniPrimary (citable) accession number: P06731
Secondary accession number(s): H9KVA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.