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P06731

- CEAM5_HUMAN

UniProt

P06731 - CEAM5_HUMAN

Protein

Carcinoembryonic antigen-related cell adhesion molecule 5

Gene

CEACAM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.1 Publication

    GO - Molecular functioni

    1. GPI anchor binding Source: UniProt
    2. identical protein binding Source: IntAct
    3. protein homodimerization activity Source: UniProt

    GO - Biological processi

    1. homotypic cell-cell adhesion Source: UniProt
    2. negative regulation of anoikis Source: UniProt
    3. negative regulation of apoptotic process Source: UniProt
    4. negative regulation of myotube differentiation Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 5
    Alternative name(s):
    Carcinoembryonic antigen
    Short name:
    CEA
    Meconium antigen 100
    CD_antigen: CD66e
    Gene namesi
    Name:CEACAM5
    Synonyms:CEA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1817. CEACAM5.

    Subcellular locationi

    Cell membrane 2 Publications; Lipid-anchorGPI-anchor 2 Publications

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. basolateral plasma membrane Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of external side of plasma membrane Source: UniProt
    5. integral component of plasma membrane Source: UniProt

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi63 – 631F → I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
    Mutagenesisi63 – 631F → R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
    Mutagenesisi66 – 661S → N: Abolishes dimerization. 2 Publications
    Mutagenesisi68 – 681Y → A: Abolishes dimerization. 1 Publication
    Mutagenesisi68 – 681Y → F: No effect on dimerization. 1 Publication
    Mutagenesisi69 – 691K → A: Abolishes dimerization. 1 Publication
    Mutagenesisi73 – 731V → A: Abolishes dimerization. 1 Publication
    Mutagenesisi74 – 741D → A: No effect on dimerization. 1 Publication
    Mutagenesisi74 – 741D → L or R: Abolishes dimerization. 1 Publication
    Mutagenesisi78 – 781Q → L or R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 2 Publications
    Mutagenesisi125 – 1251I → A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
    Mutagenesisi129 – 1291L → A or C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
    Mutagenesisi129 – 1291L → S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
    Mutagenesisi133 – 1331E → A: Abolishes dimerization. 1 Publication

    Organism-specific databases

    PharmGKBiPA26361.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Add
    BLAST
    Chaini35 – 685651Carcinoembryonic antigen-related cell adhesion molecule 5PRO_0000014566Add
    BLAST
    Propeptidei686 – 70217Removed in mature formSequence AnalysisPRO_0000014567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...)1 Publication
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi560 – 5601N-linked (GlcNAc...)1 Publication
    Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi650 – 6501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
    Lipidationi685 – 6851GPI-anchor amidated alanineSequence Analysis

    Post-translational modificationi

    Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiP06731.
    PaxDbiP06731.
    PRIDEiP06731.

    PTM databases

    PhosphoSiteiP06731.

    Expressioni

    Tissue specificityi

    Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

    Gene expression databases

    ArrayExpressiP06731.
    BgeeiP06731.
    CleanExiHS_CEACAM5.
    GenevestigatoriP06731.

    Organism-specific databases

    HPAiCAB000021.
    CAB000022.
    CAB002146.
    HPA011041.
    HPA019758.

    Interactioni

    Subunit structurei

    Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself6EBI-3914938,EBI-3914938

    Protein-protein interaction databases

    BioGridi107478. 6 interactions.
    DIPiDIP-57769N.
    IntActiP06731. 5 interactions.
    MINTiMINT-1472001.
    STRINGi9606.ENSP00000221992.

    Structurei

    Secondary structure

    1
    702
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 4610
    Beta strandi51 – 577
    Beta strandi60 – 7213
    Helixi75 – 773
    Beta strandi78 – 836
    Turni84 – 874
    Beta strandi88 – 914
    Beta strandi99 – 1013
    Beta strandi107 – 1093
    Helixi114 – 1163
    Beta strandi118 – 1269
    Beta strandi132 – 14110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1E07X-ray-A35-676[»]
    2QSQX-ray1.95A/B34-144[»]
    2QSTX-ray2.90A/B34-144[»]
    2VERNMR-N35-144[»]
    ProteinModelPortaliP06731.
    SMRiP06731. Positions 34-676.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP06731.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 144110Ig-like 1Add
    BLAST
    Domaini146 – 23792Ig-like 2Add
    BLAST
    Domaini238 – 32285Ig-like 3Add
    BLAST
    Domaini324 – 41592Ig-like 4Add
    BLAST
    Domaini416 – 49883Ig-like 5Add
    BLAST
    Domaini502 – 59392Ig-like 6Add
    BLAST
    Domaini594 – 67784Ig-like 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. CEA family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG265547.
    HOGENOMiHOG000233417.
    HOVERGENiHBG007922.
    InParanoidiP06731.
    KOiK06499.
    OMAiGPDDPTI.
    OrthoDBiEOG74BJS7.
    PhylomeDBiP06731.
    TreeFamiTF336859.

    Family and domain databases

    Gene3Di2.60.40.10. 7 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07679. I-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    SM00408. IGc2. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P06731-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE    50
    VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI 100
    IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS 150
    SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL 200
    TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR 250
    SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 300
    AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ 350
    NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNKLS 400
    VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL 450
    IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL 500
    PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS 550
    NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP 600
    PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN 650
    GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA 700
    LI 702
    Length:702
    Mass (Da):76,795
    Last modified:January 11, 2011 - v3
    Checksum:i86318E244155DB58
    GO
    Isoform 2 (identifier: P06731-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         320-320: Missing.

    Show »
    Length:701
    Mass (Da):76,724
    Checksum:i19149D8E5BDE18E5
    GO

    Sequence cautioni

    The sequence AAA62835.1 differs from that shown. Reason: Frameshift at positions 359 and 361.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti641 – 6411F → L in AAA62835. (PubMed:2342461)Curated
    Sequence conflicti646 – 6461T → Q in AAA62835. (PubMed:2342461)Curated
    Sequence conflicti689 – 6891V → A in AAA62835. (PubMed:2342461)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801I → V.
    Corresponds to variant rs12971352 [ dbSNP | Ensembl ].
    VAR_061310
    Natural varianti83 – 831V → A.
    Corresponds to variant rs28683503 [ dbSNP | Ensembl ].
    VAR_061311
    Natural varianti137 – 1371Q → P.
    Corresponds to variant rs3815780 [ dbSNP | Ensembl ].
    VAR_056028
    Natural varianti340 – 3401A → D.
    Corresponds to variant rs10407503 [ dbSNP | Ensembl ].
    VAR_031091
    Natural varianti398 – 3981K → E.5 Publications
    Corresponds to variant rs7249230 [ dbSNP | Ensembl ].
    VAR_024493
    Natural varianti664 – 6641R → S.
    Corresponds to variant rs10423171 [ dbSNP | Ensembl ].
    VAR_031092
    Natural varianti678 – 6781G → R.
    Corresponds to variant rs11545767 [ dbSNP | Ensembl ].
    VAR_056029

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei320 – 3201Missing in isoform 2. 1 PublicationVSP_053414

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17303 Genomic DNA. Translation: AAB59513.1.
    M29540 mRNA. Translation: AAA51967.1.
    M59262
    , M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA. Translation: AAA62835.1. Frameshift.
    M59709 Genomic DNA. No translation available.
    M59710 Genomic DNA. No translation available.
    AC008999 Genomic DNA. No translation available.
    X16455 mRNA. Translation: CAA34474.1.
    M15042 mRNA. Translation: AAA51963.1.
    M16234 mRNA. Translation: AAA51972.1.
    CCDSiCCDS12584.1. [P06731-1]
    PIRiA36319.
    RefSeqiNP_001278413.1. NM_001291484.1.
    NP_004354.3. NM_004363.4.
    UniGeneiHs.709196.

    Genome annotation databases

    EnsembliENST00000221992; ENSP00000221992; ENSG00000105388. [P06731-1]
    ENST00000398599; ENSP00000381600; ENSG00000105388. [P06731-2]
    ENST00000405816; ENSP00000385072; ENSG00000105388. [P06731-1]
    GeneIDi1048.
    KEGGihsa:1048.
    UCSCiuc002orl.3. human. [P06731-1]

    Polymorphism databases

    DMDMi317373456.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17303 Genomic DNA. Translation: AAB59513.1 .
    M29540 mRNA. Translation: AAA51967.1 .
    M59262
    , M59255 , M59256 , M59257 , M59258 , M59259 , M59260 , M59261 Genomic DNA. Translation: AAA62835.1 . Frameshift.
    M59709 Genomic DNA. No translation available.
    M59710 Genomic DNA. No translation available.
    AC008999 Genomic DNA. No translation available.
    X16455 mRNA. Translation: CAA34474.1 .
    M15042 mRNA. Translation: AAA51963.1 .
    M16234 mRNA. Translation: AAA51972.1 .
    CCDSi CCDS12584.1. [P06731-1 ]
    PIRi A36319.
    RefSeqi NP_001278413.1. NM_001291484.1.
    NP_004354.3. NM_004363.4.
    UniGenei Hs.709196.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1E07 X-ray - A 35-676 [» ]
    2QSQ X-ray 1.95 A/B 34-144 [» ]
    2QST X-ray 2.90 A/B 34-144 [» ]
    2VER NMR - N 35-144 [» ]
    ProteinModelPortali P06731.
    SMRi P06731. Positions 34-676.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107478. 6 interactions.
    DIPi DIP-57769N.
    IntActi P06731. 5 interactions.
    MINTi MINT-1472001.
    STRINGi 9606.ENSP00000221992.

    PTM databases

    PhosphoSitei P06731.

    Polymorphism databases

    DMDMi 317373456.

    Proteomic databases

    MaxQBi P06731.
    PaxDbi P06731.
    PRIDEi P06731.

    Protocols and materials databases

    DNASUi 1048.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221992 ; ENSP00000221992 ; ENSG00000105388 . [P06731-1 ]
    ENST00000398599 ; ENSP00000381600 ; ENSG00000105388 . [P06731-2 ]
    ENST00000405816 ; ENSP00000385072 ; ENSG00000105388 . [P06731-1 ]
    GeneIDi 1048.
    KEGGi hsa:1048.
    UCSCi uc002orl.3. human. [P06731-1 ]

    Organism-specific databases

    CTDi 1048.
    GeneCardsi GC19P042212.
    H-InvDB HIX0027513.
    HGNCi HGNC:1817. CEACAM5.
    HPAi CAB000021.
    CAB000022.
    CAB002146.
    HPA011041.
    HPA019758.
    MIMi 114890. gene.
    neXtProti NX_P06731.
    PharmGKBi PA26361.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265547.
    HOGENOMi HOG000233417.
    HOVERGENi HBG007922.
    InParanoidi P06731.
    KOi K06499.
    OMAi GPDDPTI.
    OrthoDBi EOG74BJS7.
    PhylomeDBi P06731.
    TreeFami TF336859.

    Miscellaneous databases

    EvolutionaryTracei P06731.
    GeneWikii CEACAM5.
    GenomeRNAii 1048.
    NextBioi 35531126.
    PROi P06731.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P06731.
    Bgeei P06731.
    CleanExi HS_CEACAM5.
    Genevestigatori P06731.

    Family and domain databases

    Gene3Di 2.60.40.10. 7 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07679. I-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    SM00408. IGc2. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen."
      Beauchemin N., Benchimol S., Cournoyer D., Fuks A., Stanners C.P.
      Mol. Cell. Biol. 7:3221-3230(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-398.
    2. "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains."
      Barnett T., Goebel S.J., Nothdurft M.A., Elting J.J.
      Genomics 3:59-66(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-398.
    3. "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression."
      Schrewe H., Thompson J., Bona M., Hefta L.J.F., Maruya A., Hassauer M., Shively J.E., von Kleist S., Zimmermann W.
      Mol. Cell. Biol. 10:2738-2748(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-398.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence."
      Oikawa S., Nakazato H., Kosaki G.
      Biochem. Biophys. Res. Commun. 142:511-518(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-702 (ISOFORM 2), VARIANT GLU-398.
    6. "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure."
      Zimmermann W., Ortlieb B., Friedrich R., von Kleist S.
      Proc. Natl. Acad. Sci. U.S.A. 84:2960-2964(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 331-702 (ISOFORM 1), VARIANT GLU-398.
    7. "Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion."
      Taheri M., Saragovi U., Fuks A., Makkerh J., Mort J., Stanners C.P.
      J. Biol. Chem. 275:26935-26943(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF SER-66; TYR-68; LYS-69 AND GLN-78, SUBCELLULAR LOCATION.
    8. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-560.
      Tissue: Saliva.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-246.
      Tissue: Liver.
    10. "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23."
      Boehm M.K., Perkins S.J.
      FEBS Lett. 475:11-16(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 35-676.
    11. "Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation."
      Korotkova N., Yang Y., Le Trong I., Cota E., Demeler B., Marchant J., Thomas W.E., Stenkamp R.E., Moseley S.L., Matthews S.
      Mol. Microbiol. 67:420-434(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 34-144 IN COMPLEX WITH E.COLI DR ADHESIN, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-63; SER-66; VAL-73; ASP-74; GLN-78; ILE-125; LEU-129 AND GLU-133.

    Entry informationi

    Entry nameiCEAM5_HUMAN
    AccessioniPrimary (citable) accession number: P06731
    Secondary accession number(s): H9KVA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3