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P06731

- CEAM5_HUMAN

UniProt

P06731 - CEAM5_HUMAN

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Protein

Carcinoembryonic antigen-related cell adhesion molecule 5

Gene

CEACAM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.1 Publication

GO - Molecular functioni

  1. GPI anchor binding Source: UniProt
  2. identical protein binding Source: IntAct
  3. protein homodimerization activity Source: UniProt

GO - Biological processi

  1. homotypic cell-cell adhesion Source: UniProt
  2. negative regulation of anoikis Source: UniProt
  3. negative regulation of apoptotic process Source: UniProt
  4. negative regulation of myotube differentiation Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 5
Alternative name(s):
Carcinoembryonic antigen
Short name:
CEA
Meconium antigen 100
CD_antigen: CD66e
Gene namesi
Name:CEACAM5
Synonyms:CEA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1817. CEACAM5.

Subcellular locationi

Cell membrane 2 Publications; Lipid-anchorGPI-anchor 2 Publications

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. basolateral plasma membrane Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. integral component of external side of plasma membrane Source: UniProt
  5. integral component of plasma membrane Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi63 – 631F → I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
Mutagenesisi63 – 631F → R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
Mutagenesisi66 – 661S → N: Abolishes dimerization. 2 Publications
Mutagenesisi68 – 681Y → A: Abolishes dimerization. 1 Publication
Mutagenesisi68 – 681Y → F: No effect on dimerization. 1 Publication
Mutagenesisi69 – 691K → A: Abolishes dimerization. 1 Publication
Mutagenesisi73 – 731V → A: Abolishes dimerization. 1 Publication
Mutagenesisi74 – 741D → A: No effect on dimerization. 1 Publication
Mutagenesisi74 – 741D → L or R: Abolishes dimerization. 1 Publication
Mutagenesisi78 – 781Q → L or R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 2 Publications
Mutagenesisi125 – 1251I → A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
Mutagenesisi129 – 1291L → A or C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
Mutagenesisi129 – 1291L → S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication
Mutagenesisi133 – 1331E → A: Abolishes dimerization. 1 Publication

Organism-specific databases

PharmGKBiPA26361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Add
BLAST
Chaini35 – 685651Carcinoembryonic antigen-related cell adhesion molecule 5PRO_0000014566Add
BLAST
Propeptidei686 – 70217Removed in mature formSequence AnalysisPRO_0000014567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)1 Publication
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi560 – 5601N-linked (GlcNAc...)1 Publication
Glycosylationi580 – 5801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi650 – 6501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
Lipidationi685 – 6851GPI-anchor amidated alanineSequence Analysis

Post-translational modificationi

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP06731.
PaxDbiP06731.
PRIDEiP06731.

PTM databases

PhosphoSiteiP06731.

Expressioni

Tissue specificityi

Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Gene expression databases

BgeeiP06731.
CleanExiHS_CEACAM5.
ExpressionAtlasiP06731. baseline and differential.
GenevestigatoriP06731.

Organism-specific databases

HPAiCAB000021.
CAB000022.
CAB002146.
HPA011041.
HPA019758.

Interactioni

Subunit structurei

Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-3914938,EBI-3914938

Protein-protein interaction databases

BioGridi107478. 6 interactions.
DIPiDIP-57769N.
IntActiP06731. 5 interactions.
MINTiMINT-1472001.
STRINGi9606.ENSP00000221992.

Structurei

Secondary structure

1
702
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4610Combined sources
Beta strandi51 – 577Combined sources
Beta strandi60 – 7213Combined sources
Helixi75 – 773Combined sources
Beta strandi78 – 836Combined sources
Turni84 – 874Combined sources
Beta strandi88 – 914Combined sources
Beta strandi99 – 1013Combined sources
Beta strandi107 – 1093Combined sources
Helixi114 – 1163Combined sources
Beta strandi118 – 1269Combined sources
Beta strandi132 – 14110Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E07X-ray-A35-676[»]
2QSQX-ray1.95A/B34-144[»]
2QSTX-ray2.90A/B34-144[»]
2VERNMR-N35-144[»]
ProteinModelPortaliP06731.
SMRiP06731. Positions 34-676.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06731.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like 1Add
BLAST
Domaini146 – 23792Ig-like 2Add
BLAST
Domaini238 – 32285Ig-like 3Add
BLAST
Domaini324 – 41592Ig-like 4Add
BLAST
Domaini416 – 49883Ig-like 5Add
BLAST
Domaini502 – 59392Ig-like 6Add
BLAST
Domaini594 – 67784Ig-like 7Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG265547.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP06731.
KOiK06499.
OMAiGPDDPTI.
OrthoDBiEOG74BJS7.
PhylomeDBiP06731.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P06731-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI
110 120 130 140 150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS
160 170 180 190 200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR
260 270 280 290 300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ
310 320 330 340 350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ
360 370 380 390 400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNKLS
410 420 430 440 450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL
460 470 480 490 500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL
510 520 530 540 550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS
560 570 580 590 600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP
610 620 630 640 650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN
660 670 680 690 700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA

LI
Length:702
Mass (Da):76,795
Last modified:January 11, 2011 - v3
Checksum:i86318E244155DB58
GO
Isoform 2 (identifier: P06731-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-320: Missing.

Show »
Length:701
Mass (Da):76,724
Checksum:i19149D8E5BDE18E5
GO

Sequence cautioni

The sequence AAA62835.1 differs from that shown. Reason: Frameshift at positions 359 and 361. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti641 – 6411F → L in AAA62835. (PubMed:2342461)Curated
Sequence conflicti646 – 6461T → Q in AAA62835. (PubMed:2342461)Curated
Sequence conflicti689 – 6891V → A in AAA62835. (PubMed:2342461)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801I → V.
Corresponds to variant rs12971352 [ dbSNP | Ensembl ].
VAR_061310
Natural varianti83 – 831V → A.
Corresponds to variant rs28683503 [ dbSNP | Ensembl ].
VAR_061311
Natural varianti137 – 1371Q → P.
Corresponds to variant rs3815780 [ dbSNP | Ensembl ].
VAR_056028
Natural varianti340 – 3401A → D.
Corresponds to variant rs10407503 [ dbSNP | Ensembl ].
VAR_031091
Natural varianti398 – 3981K → E.5 Publications
Corresponds to variant rs7249230 [ dbSNP | Ensembl ].
VAR_024493
Natural varianti664 – 6641R → S.
Corresponds to variant rs10423171 [ dbSNP | Ensembl ].
VAR_031092
Natural varianti678 – 6781G → R.
Corresponds to variant rs11545767 [ dbSNP | Ensembl ].
VAR_056029

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei320 – 3201Missing in isoform 2. 1 PublicationVSP_053414

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17303 Genomic DNA. Translation: AAB59513.1.
M29540 mRNA. Translation: AAA51967.1.
M59262
, M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA. Translation: AAA62835.1. Frameshift.
M59709 Genomic DNA. No translation available.
M59710 Genomic DNA. No translation available.
AC008999 Genomic DNA. No translation available.
X16455 mRNA. Translation: CAA34474.1.
M15042 mRNA. Translation: AAA51963.1.
M16234 mRNA. Translation: AAA51972.1.
CCDSiCCDS12584.1. [P06731-1]
PIRiA36319.
RefSeqiNP_001278413.1. NM_001291484.1.
NP_004354.3. NM_004363.4.
UniGeneiHs.709196.

Genome annotation databases

EnsembliENST00000221992; ENSP00000221992; ENSG00000105388.
ENST00000398599; ENSP00000381600; ENSG00000105388.
ENST00000405816; ENSP00000385072; ENSG00000105388.
GeneIDi1048.
KEGGihsa:1048.
UCSCiuc002orl.3. human. [P06731-1]

Polymorphism databases

DMDMi317373456.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17303 Genomic DNA. Translation: AAB59513.1 .
M29540 mRNA. Translation: AAA51967.1 .
M59262
, M59255 , M59256 , M59257 , M59258 , M59259 , M59260 , M59261 Genomic DNA. Translation: AAA62835.1 . Frameshift.
M59709 Genomic DNA. No translation available.
M59710 Genomic DNA. No translation available.
AC008999 Genomic DNA. No translation available.
X16455 mRNA. Translation: CAA34474.1 .
M15042 mRNA. Translation: AAA51963.1 .
M16234 mRNA. Translation: AAA51972.1 .
CCDSi CCDS12584.1. [P06731-1 ]
PIRi A36319.
RefSeqi NP_001278413.1. NM_001291484.1.
NP_004354.3. NM_004363.4.
UniGenei Hs.709196.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E07 X-ray - A 35-676 [» ]
2QSQ X-ray 1.95 A/B 34-144 [» ]
2QST X-ray 2.90 A/B 34-144 [» ]
2VER NMR - N 35-144 [» ]
ProteinModelPortali P06731.
SMRi P06731. Positions 34-676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107478. 6 interactions.
DIPi DIP-57769N.
IntActi P06731. 5 interactions.
MINTi MINT-1472001.
STRINGi 9606.ENSP00000221992.

PTM databases

PhosphoSitei P06731.

Polymorphism databases

DMDMi 317373456.

Proteomic databases

MaxQBi P06731.
PaxDbi P06731.
PRIDEi P06731.

Protocols and materials databases

DNASUi 1048.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221992 ; ENSP00000221992 ; ENSG00000105388 .
ENST00000398599 ; ENSP00000381600 ; ENSG00000105388 .
ENST00000405816 ; ENSP00000385072 ; ENSG00000105388 .
GeneIDi 1048.
KEGGi hsa:1048.
UCSCi uc002orl.3. human. [P06731-1 ]

Organism-specific databases

CTDi 1048.
GeneCardsi GC19P042212.
H-InvDB HIX0027513.
HGNCi HGNC:1817. CEACAM5.
HPAi CAB000021.
CAB000022.
CAB002146.
HPA011041.
HPA019758.
MIMi 114890. gene.
neXtProti NX_P06731.
PharmGKBi PA26361.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265547.
HOGENOMi HOG000233417.
HOVERGENi HBG007922.
InParanoidi P06731.
KOi K06499.
OMAi GPDDPTI.
OrthoDBi EOG74BJS7.
PhylomeDBi P06731.
TreeFami TF336859.

Miscellaneous databases

ChiTaRSi CEACAM5. human.
EvolutionaryTracei P06731.
GeneWikii CEACAM5.
GenomeRNAii 1048.
NextBioi 35531126.
PROi P06731.
SOURCEi Search...

Gene expression databases

Bgeei P06731.
CleanExi HS_CEACAM5.
ExpressionAtlasi P06731. baseline and differential.
Genevestigatori P06731.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen."
    Beauchemin N., Benchimol S., Cournoyer D., Fuks A., Stanners C.P.
    Mol. Cell. Biol. 7:3221-3230(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-398.
  2. "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains."
    Barnett T., Goebel S.J., Nothdurft M.A., Elting J.J.
    Genomics 3:59-66(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-398.
  3. "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression."
    Schrewe H., Thompson J., Bona M., Hefta L.J.F., Maruya A., Hassauer M., Shively J.E., von Kleist S., Zimmermann W.
    Mol. Cell. Biol. 10:2738-2748(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-398.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence."
    Oikawa S., Nakazato H., Kosaki G.
    Biochem. Biophys. Res. Commun. 142:511-518(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-702 (ISOFORM 2), VARIANT GLU-398.
  6. "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure."
    Zimmermann W., Ortlieb B., Friedrich R., von Kleist S.
    Proc. Natl. Acad. Sci. U.S.A. 84:2960-2964(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 331-702 (ISOFORM 1), VARIANT GLU-398.
  7. "Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion."
    Taheri M., Saragovi U., Fuks A., Makkerh J., Mort J., Stanners C.P.
    J. Biol. Chem. 275:26935-26943(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF SER-66; TYR-68; LYS-69 AND GLN-78, SUBCELLULAR LOCATION.
  8. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-560.
    Tissue: Saliva.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-246.
    Tissue: Liver.
  10. "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23."
    Boehm M.K., Perkins S.J.
    FEBS Lett. 475:11-16(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 35-676.
  11. "Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation."
    Korotkova N., Yang Y., Le Trong I., Cota E., Demeler B., Marchant J., Thomas W.E., Stenkamp R.E., Moseley S.L., Matthews S.
    Mol. Microbiol. 67:420-434(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 34-144 IN COMPLEX WITH E.COLI DR ADHESIN, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-63; SER-66; VAL-73; ASP-74; GLN-78; ILE-125; LEU-129 AND GLU-133.

Entry informationi

Entry nameiCEAM5_HUMAN
AccessioniPrimary (citable) accession number: P06731
Secondary accession number(s): H9KVA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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