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Protein

T-cell surface antigen CD2

Gene

CD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

GO - Molecular functioni

  • protein homodimerization activity Source: Ensembl
  • receptor activity Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • cell-cell adhesion Source: UniProtKB
  • cell surface receptor signaling pathway Source: UniProtKB
  • heterotypic cell-cell adhesion Source: UniProtKB
  • leukocyte migration Source: Reactome
  • membrane raft polarization Source: UniProtKB
  • natural killer cell activation Source: UniProtKB
  • positive regulation of interferon-gamma secretion Source: UniProtKB
  • positive regulation of interleukin-8 secretion Source: UniProtKB
  • positive regulation of myeloid dendritic cell activation Source: UniProtKB
  • positive regulation of tumor necrosis factor production Source: UniProtKB
  • regulation of T cell differentiation Source: UniProtKB
  • T cell activation Source: UniProtKB

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
SignaLinkiP06729

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface antigen CD2
Alternative name(s):
Erythrocyte receptor
LFA-2
LFA-3 receptor
Rosette receptor
T-cell surface antigen T11/Leu-5
CD_antigen: CD2
Gene namesi
Name:CD2
Synonyms:SRBC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116824.4
HGNCiHGNC:1639 CD2
MIMi186990 gene
neXtProtiNX_P06729

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 209ExtracellularSequence analysisAdd BLAST185
Transmembranei210 – 235HelicalSequence analysisAdd BLAST26
Topological domaini236 – 351CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67K → R: Loss of CD58 binding. 1 Publication1
Mutagenesisi70Q → K: Loss of CD58 binding. 1 Publication1
Mutagenesisi110Y → D: Loss of CD58 and CD59 binding. 1 Publication1
Mutagenesisi111D → H: Loss of CD58 and CD59 binding. 1 Publication1

Organism-specific databases

DisGeNETi914
OpenTargetsiENSG00000116824
PharmGKBiPA26198

Chemistry databases

ChEMBLiCHEMBL2040
DrugBankiDB00092 Alefacept

Polymorphism and mutation databases

BioMutaiCD2
DMDMi160370002

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001460025 – 351T-cell surface antigen CD2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi139 ↔ 2031 Publication
Glycosylationi141N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi146 ↔ 1861 Publication
Glycosylationi150N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP06729
PeptideAtlasiP06729
PRIDEiP06729

PTM databases

GlyConnecti586
iPTMnetiP06729
PhosphoSitePlusiP06729
UniCarbKBiP06729

Expressioni

Gene expression databases

BgeeiENSG00000116824
CleanExiHS_CD2
ExpressionAtlasiP06729 baseline and differential
GenevisibleiP06729 HS

Organism-specific databases

HPAiCAB002430
HPA003883

Interactioni

Subunit structurei

Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (PubMed:10380930). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (PubMed:9857189).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein homodimerization activity Source: Ensembl
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107352, 16 interactors
ELMiP06729
IntActiP06729, 10 interactors
MINTiP06729
STRINGi9606.ENSP00000358490

Chemistry databases

BindingDBiP06729

Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 36Combined sources6
Beta strandi41 – 43Combined sources3
Beta strandi52 – 61Combined sources10
Helixi62 – 64Combined sources3
Beta strandi67 – 71Combined sources5
Helixi73 – 75Combined sources3
Beta strandi77 – 80Combined sources4
Beta strandi84 – 86Combined sources3
Turni88 – 90Combined sources3
Beta strandi92 – 94Combined sources3
Helixi99 – 101Combined sources3
Beta strandi103 – 111Combined sources9
Beta strandi116 – 127Combined sources12
Beta strandi134 – 138Combined sources5
Turni139 – 142Combined sources4
Beta strandi143 – 147Combined sources5
Beta strandi155 – 162Combined sources8
Beta strandi164 – 170Combined sources7
Beta strandi172 – 175Combined sources4
Beta strandi180 – 189Combined sources10
Beta strandi194 – 203Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDBNMR-A25-129[»]
1GYANMR-A25-129[»]
1HNFX-ray2.50A25-206[»]
1L2ZNMR-B294-304[»]
1QA9X-ray3.20A/C28-129[»]
2J6OX-ray2.22C324-333[»]
2J7IX-ray2.90C/D324-333[»]
ProteinModelPortaliP06729
SMRiP06729
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06729

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 128Ig-like V-typeAdd BLAST104
Domaini129 – 209Ig-like C2-typeAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 75CD58 binding region 11 PublicationAdd BLAST15
Regioni106 – 120CD58 binding region 21 PublicationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi282 – 338Pro-richAdd BLAST57

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW98 Eukaryota
ENOG410Y7BE LUCA
GeneTreeiENSGT00390000009232
HOGENOMiHOG000276890
HOVERGENiHBG000262
InParanoidiP06729
KOiK06449
OMAiGTQVHQQ
OrthoDBiEOG091G0M7A
PhylomeDBiP06729
TreeFamiTF335971

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015632 CD2
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR008424 Ig_C2-set
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF05790 C2-set, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01870 CD2ANTIGEN
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM
60 70 80 90 100
SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD
110 120 130 140 150
DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN
160 170 180 190 200
GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP
210 220 230 240 250
VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE
260 270 280 290 300
TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP
310 320 330 340 350
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS

N
Length:351
Mass (Da):39,448
Last modified:October 23, 2007 - v2
Checksum:iA03D853C3B618917
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287G → A (PubMed:3490670).Curated1
Sequence conflicti339 – 351HGAAE…SPSSN → MGQQKTHCPLPLIKKDRNCL FQ in AAA51946 (PubMed:3490670).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035504217C → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_017104266H → Q3 PublicationsCorresponds to variant dbSNP:rs699738Ensembl.1
Natural variantiVAR_033608339H → N. Corresponds to variant dbSNP:rs35880225Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19806
, M19798, M19800, M19802, M19804 Genomic DNA Translation: AAA53095.1
M16445 mRNA Translation: AAA51738.1
M14362 mRNA Translation: AAA35571.1
M16336 mRNA Translation: AAA51946.1
X07871
, X07872, X07873, X07874 Genomic DNA Translation: CAA30721.1
AL135798 Genomic DNA No translation available.
BC033583 mRNA Translation: AAH33583.1
CCDSiCCDS889.1
PIRiA28967 RWHUC2
RefSeqiNP_001315538.1, NM_001328609.1
NP_001758.2, NM_001767.4
UniGeneiHs.523500

Genome annotation databases

EnsembliENST00000369478; ENSP00000358490; ENSG00000116824
GeneIDi914
KEGGihsa:914

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD2_HUMAN
AccessioniPrimary (citable) accession number: P06729
Secondary accession number(s): Q96TE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 23, 2007
Last modified: April 25, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health