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Protein

T-cell surface antigen CD2

Gene

CD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

GO - Molecular functioni

  • receptor activity Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • cell surface receptor signaling pathway Source: UniProtKB
  • heterotypic cell-cell adhesion Source: UniProtKB
  • leukocyte migration Source: Reactome
  • membrane raft polarization Source: UniProtKB
  • natural killer cell activation Source: UniProtKB
  • positive regulation of interferon-gamma secretion Source: UniProtKB
  • positive regulation of interleukin-8 secretion Source: UniProtKB
  • positive regulation of myeloid dendritic cell activation Source: UniProtKB
  • positive regulation of tumor necrosis factor production Source: UniProtKB
  • regulation of T cell differentiation Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
  • T cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116824-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
SignaLinkiP06729.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface antigen CD2
Alternative name(s):
Erythrocyte receptor
LFA-2
LFA-3 receptor
Rosette receptor
T-cell surface antigen T11/Leu-5
CD_antigen: CD2
Gene namesi
Name:CD2
Synonyms:SRBC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1639. CD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 209ExtracellularSequence analysisAdd BLAST185
Transmembranei210 – 235HelicalSequence analysisAdd BLAST26
Topological domaini236 – 351CytoplasmicSequence analysisAdd BLAST116

GO - Cellular componenti

  • anchored component of plasma membrane Source: Ensembl
  • cell-cell junction Source: Ensembl
  • cell surface Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: Ensembl
  • external side of plasma membrane Source: MGI
  • extracellular region Source: Ensembl
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67K → R: Loss of LFA-3 binding. 1 Publication1
Mutagenesisi70Q → K: Loss of LFA-3 binding. 1 Publication1
Mutagenesisi110Y → D: Loss of LFA-3 and CD59 binding. 1 Publication1
Mutagenesisi111D → H: Loss of LFA-3 and CD59 binding. 1 Publication1

Organism-specific databases

DisGeNETi914.
OpenTargetsiENSG00000116824.
PharmGKBiPA26198.

Chemistry databases

ChEMBLiCHEMBL2040.
DrugBankiDB00092. Alefacept.

Polymorphism and mutation databases

BioMutaiCD2.
DMDMi160370002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001460025 – 351T-cell surface antigen CD2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...)1
Disulfide bondi139 ↔ 2031 Publication
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi146 ↔ 1861 Publication
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP06729.
PeptideAtlasiP06729.
PRIDEiP06729.

PTM databases

iPTMnetiP06729.
PhosphoSitePlusiP06729.
UniCarbKBiP06729.

Expressioni

Gene expression databases

BgeeiENSG00000116824.
CleanExiHS_CD2.
ExpressionAtlasiP06729. baseline and differential.
GenevisibleiP06729. HS.

Organism-specific databases

HPAiCAB002430.
HPA003883.

Interactioni

Subunit structurei

Interacts with CD2AP (By similarity). Interacts with PSTPIP1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CD2APQ9Y5K64EBI-3912464,EBI-298152
CD2BP2O954003EBI-3912464,EBI-768015
SH3KBP1Q96B973EBI-3912464,EBI-346595

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107352. 16 interactors.
IntActiP06729. 8 interactors.
MINTiMINT-99488.
STRINGi9606.ENSP00000358490.

Chemistry databases

BindingDBiP06729.

Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 36Combined sources6
Beta strandi41 – 43Combined sources3
Beta strandi52 – 61Combined sources10
Helixi62 – 64Combined sources3
Beta strandi67 – 71Combined sources5
Helixi73 – 75Combined sources3
Beta strandi77 – 80Combined sources4
Beta strandi84 – 86Combined sources3
Turni88 – 90Combined sources3
Beta strandi92 – 94Combined sources3
Helixi99 – 101Combined sources3
Beta strandi103 – 111Combined sources9
Beta strandi116 – 127Combined sources12
Beta strandi134 – 138Combined sources5
Turni139 – 142Combined sources4
Beta strandi143 – 147Combined sources5
Beta strandi155 – 162Combined sources8
Beta strandi164 – 170Combined sources7
Beta strandi172 – 175Combined sources4
Beta strandi180 – 189Combined sources10
Beta strandi194 – 203Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDBNMR-A25-129[»]
1GYANMR-A25-129[»]
1HNFX-ray2.50A25-206[»]
1L2ZNMR-B294-304[»]
1QA9X-ray3.20A/C28-129[»]
2J6OX-ray2.22C324-333[»]
2J7IX-ray2.90C/D324-333[»]
ProteinModelPortaliP06729.
SMRiP06729.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06729.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 128Ig-like V-typeAdd BLAST104
Domaini129 – 209Ig-like C2-typeAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 75LFA-3 (CD58) binding region 1Add BLAST15
Regioni106 – 120LFA-3 (CD58) binding region 2Add BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi282 – 338Pro-richAdd BLAST57

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW98. Eukaryota.
ENOG410Y7BE. LUCA.
GeneTreeiENSGT00390000009232.
HOGENOMiHOG000276890.
HOVERGENiHBG000262.
InParanoidiP06729.
KOiK06449.
OMAiGTQVHQQ.
OrthoDBiEOG091G0M7A.
PhylomeDBiP06729.
TreeFamiTF335971.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015632. CD2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF05790. C2-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01870. CD2ANTIGEN.
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM
60 70 80 90 100
SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD
110 120 130 140 150
DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN
160 170 180 190 200
GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP
210 220 230 240 250
VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE
260 270 280 290 300
TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP
310 320 330 340 350
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS

N
Length:351
Mass (Da):39,448
Last modified:October 23, 2007 - v2
Checksum:iA03D853C3B618917
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287G → A (PubMed:3490670).Curated1
Sequence conflicti339 – 351HGAAE…SPSSN → MGQQKTHCPLPLIKKDRNCL FQ in AAA51946 (PubMed:3490670).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035504217C → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_017104266H → Q.3 PublicationsCorresponds to variant rs699738dbSNPEnsembl.1
Natural variantiVAR_033608339H → N.Corresponds to variant rs35880225dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19806
, M19798, M19800, M19802, M19804 Genomic DNA. Translation: AAA53095.1.
M16445 mRNA. Translation: AAA51738.1.
M14362 mRNA. Translation: AAA35571.1.
M16336 mRNA. Translation: AAA51946.1.
X07871
, X07872, X07873, X07874 Genomic DNA. Translation: CAA30721.1.
AL135798 Genomic DNA. Translation: CAC14840.1.
BC033583 mRNA. Translation: AAH33583.1.
CCDSiCCDS889.1.
PIRiA28967. RWHUC2.
RefSeqiNP_001315538.1. NM_001328609.1.
NP_001758.2. NM_001767.4.
UniGeneiHs.523500.

Genome annotation databases

EnsembliENST00000369478; ENSP00000358490; ENSG00000116824.
GeneIDi914.
KEGGihsa:914.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CD2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19806
, M19798, M19800, M19802, M19804 Genomic DNA. Translation: AAA53095.1.
M16445 mRNA. Translation: AAA51738.1.
M14362 mRNA. Translation: AAA35571.1.
M16336 mRNA. Translation: AAA51946.1.
X07871
, X07872, X07873, X07874 Genomic DNA. Translation: CAA30721.1.
AL135798 Genomic DNA. Translation: CAC14840.1.
BC033583 mRNA. Translation: AAH33583.1.
CCDSiCCDS889.1.
PIRiA28967. RWHUC2.
RefSeqiNP_001315538.1. NM_001328609.1.
NP_001758.2. NM_001767.4.
UniGeneiHs.523500.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDBNMR-A25-129[»]
1GYANMR-A25-129[»]
1HNFX-ray2.50A25-206[»]
1L2ZNMR-B294-304[»]
1QA9X-ray3.20A/C28-129[»]
2J6OX-ray2.22C324-333[»]
2J7IX-ray2.90C/D324-333[»]
ProteinModelPortaliP06729.
SMRiP06729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107352. 16 interactors.
IntActiP06729. 8 interactors.
MINTiMINT-99488.
STRINGi9606.ENSP00000358490.

Chemistry databases

BindingDBiP06729.
ChEMBLiCHEMBL2040.
DrugBankiDB00092. Alefacept.

PTM databases

iPTMnetiP06729.
PhosphoSitePlusiP06729.
UniCarbKBiP06729.

Polymorphism and mutation databases

BioMutaiCD2.
DMDMi160370002.

Proteomic databases

PaxDbiP06729.
PeptideAtlasiP06729.
PRIDEiP06729.

Protocols and materials databases

DNASUi914.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369478; ENSP00000358490; ENSG00000116824.
GeneIDi914.
KEGGihsa:914.

Organism-specific databases

CTDi914.
DisGeNETi914.
GeneCardsiCD2.
H-InvDBHIX0000931.
HGNCiHGNC:1639. CD2.
HPAiCAB002430.
HPA003883.
MIMi186990. gene.
neXtProtiNX_P06729.
OpenTargetsiENSG00000116824.
PharmGKBiPA26198.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW98. Eukaryota.
ENOG410Y7BE. LUCA.
GeneTreeiENSGT00390000009232.
HOGENOMiHOG000276890.
HOVERGENiHBG000262.
InParanoidiP06729.
KOiK06449.
OMAiGTQVHQQ.
OrthoDBiEOG091G0M7A.
PhylomeDBiP06729.
TreeFamiTF335971.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116824-MONOMER.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
SignaLinkiP06729.

Miscellaneous databases

EvolutionaryTraceiP06729.
GeneWikiiCD2.
GenomeRNAii914.
PROiP06729.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116824.
CleanExiHS_CD2.
ExpressionAtlasiP06729. baseline and differential.
GenevisibleiP06729. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015632. CD2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF05790. C2-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01870. CD2ANTIGEN.
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCD2_HUMAN
AccessioniPrimary (citable) accession number: P06729
Secondary accession number(s): Q96TE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 190 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.