SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P06727

- APOA4_HUMAN

UniProt

P06727 - APOA4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Apolipoprotein A-IV
Gene
APOA4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

GO - Molecular functioni

  1. antioxidant activity Source: HGNC
  2. cholesterol transporter activity Source: BHF-UCL
  3. copper ion binding Source: HGNC
  4. lipid binding Source: BHF-UCL
  5. lipid transporter activity Source: ProtInc
  6. phosphatidylcholine binding Source: BHF-UCL
  7. phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
  8. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. cholesterol efflux Source: BHF-UCL
  2. cholesterol homeostasis Source: BHF-UCL
  3. cholesterol metabolic process Source: BHF-UCL
  4. chylomicron assembly Source: BHF-UCL
  5. chylomicron remodeling Source: BHF-UCL
  6. high-density lipoprotein particle remodeling Source: BHF-UCL
  7. hydrogen peroxide catabolic process Source: HGNC
  8. innate immune response in mucosa Source: BHF-UCL
  9. leukocyte cell-cell adhesion Source: BHF-UCL
  10. lipid homeostasis Source: BHF-UCL
  11. lipid transport Source: BHF-UCL
  12. lipoprotein metabolic process Source: Reactome
  13. multicellular organismal lipid catabolic process Source: BHF-UCL
  14. negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
  15. phosphatidylcholine metabolic process Source: BHF-UCL
  16. phospholipid efflux Source: BHF-UCL
  17. phototransduction, visible light Source: Reactome
  18. positive regulation of cholesterol esterification Source: BHF-UCL
  19. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
  20. positive regulation of lipoprotein lipase activity Source: BHF-UCL
  21. positive regulation of triglyceride catabolic process Source: BHF-UCL
  22. protein-lipid complex assembly Source: BHF-UCL
  23. regulation of cholesterol transport Source: BHF-UCL
  24. regulation of intestinal cholesterol absorption Source: Ensembl
  25. removal of superoxide radicals Source: HGNC
  26. response to lipid hydroperoxide Source: HGNC
  27. response to stilbenoid Source: Ensembl
  28. retinoid metabolic process Source: Reactome
  29. reverse cholesterol transport Source: BHF-UCL
  30. small molecule metabolic process Source: Reactome
  31. very-low-density lipoprotein particle remodeling Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_24968. Retinoid metabolism and transport.
REACT_6841. Chylomicron-mediated lipid transport.
REACT_75925. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-IV
Short name:
Apo-AIV
Short name:
ApoA-IV
Alternative name(s):
Apolipoprotein A4
Gene namesi
Name:APOA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:602. APOA4.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. chylomicron Source: BHF-UCL
  3. cytosol Source: Reactome
  4. early endosome Source: Reactome
  5. endoplasmic reticulum lumen Source: Reactome
  6. extracellular region Source: UniProtKB
  7. extracellular space Source: BHF-UCL
  8. extracellular vesicular exosome Source: UniProt
  9. high-density lipoprotein particle Source: BHF-UCL
  10. very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020
Add
BLAST
Chaini21 – 396376Apolipoprotein A-IV
PRO_0000001975Add
BLAST

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP06727.
PaxDbiP06727.
PeptideAtlasiP06727.
PRIDEiP06727.

2D gel databases

DOSAC-COBS-2DPAGEP06727.
REPRODUCTION-2DPAGEIPI00304273.
SWISS-2DPAGEP06727.

PTM databases

PhosphoSiteiP06727.

Miscellaneous databases

PMAP-CutDBA8MSL6.

Expressioni

Tissue specificityi

Synthesized primarily in the intestine and secreted in plasma.

Gene expression databases

BgeeiP06727.
CleanExiHS_APOA4.
GenevestigatoriP06727.

Organism-specific databases

HPAiHPA001352.
HPA002549.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

DIPiDIP-38333N.
IntActiP06727. 1 interaction.
STRINGi9606.ENSP00000350425.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi97 – 11317
Helixi114 – 1163
Helixi117 – 223107
Helixi224 – 2263
Helixi231 – 27646
Beta strandi278 – 2803
Helixi282 – 30726
Helixi310 – 32920

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S84X-ray2.40A/B84-355[»]
ProteinModelPortaliP06727.
SMRiP06727. Positions 25-389.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati33 – 54221
Add
BLAST
Repeati60 – 81222
Add
BLAST
Repeati82 – 103223
Add
BLAST
Repeati115 – 136224
Add
BLAST
Repeati137 – 158225
Add
BLAST
Repeati159 – 180226
Add
BLAST
Repeati181 – 202227
Add
BLAST
Repeati203 – 224228
Add
BLAST
Repeati225 – 246229
Add
BLAST
Repeati247 – 2682210
Add
BLAST
Repeati269 – 2861811
Add
BLAST
Repeati287 – 3082212
Add
BLAST
Repeati309 – 3302213
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 33029813 X 22 AA approximate tandem repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi372 – 38918Gln/Glu-rich
Add
BLAST

Domaini

Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG42418.
HOGENOMiHOG000037942.
HOVERGENiHBG105707.
InParanoidiP06727.
OrthoDBiEOG7K9K48.
PhylomeDBiP06727.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA1_A4_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06727-1 [UniParc]FASTAAdd to Basket

« Hide

MFLKAVVLTL ALVAVAGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ    50
KSELTQQLNA LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE 100
EIGKELEELR ARLLPHANEV SQKIGDNLRE LQQRLEPYAD QLRTQVNTQA 150
EQLRRQLTPY AQRMERVLRE NADSLQASLR PHADELKAKI DQNVEELKGR 200
LTPYADEFKV KIDQTVEELR RSLAPYAQDT QEKLNHQLEG LTFQMKKNAE 250
ELKARISASA EELRQRLAPL AEDVRGNLRG NTEGLQKSLA ELGGHLDQQV 300
EEFRRRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK 350
VNSFFSTFKE KESQDKTLSL PELEQQQEQQ QEQQQEQVQM LAPLES 396
Length:396
Mass (Da):45,399
Last modified:March 7, 2006 - v3
Checksum:i193753196CA2FA4A
GO

Polymorphismi

Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles. The sequence shown represents allele APOA-IV*1.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131V → M in allele APOA-IV*1D. 2 Publications
VAR_000626
Natural varianti44 – 441E → K in Budapest-2. 1 Publication
VAR_000627
Natural varianti74 – 741G → S.
Corresponds to variant rs5102 [ dbSNP | Ensembl ].
VAR_014610
Natural varianti77 – 771Q → H.1 Publication
VAR_025444
Natural varianti147 – 1471N → S in allele APOA-IV*1B. 3 Publications
Corresponds to variant rs5104 [ dbSNP | Ensembl ].
VAR_000628
Natural varianti161 – 1611A → S in Seattle-3. 2 Publications
VAR_000629
Natural varianti178 – 1781S → L in Seattle-1; may contribute to the development of familial combined hyperlipidemia. 1 Publication
VAR_000630
Natural varianti185 – 1851E → K in allele APOA-IV*3. 1 Publication
VAR_000631
Natural varianti187 – 1871K → E in allele APOA-IV*0A; associated with H-380. 1 Publication
VAR_000632
Natural varianti250 – 2501E → K in allele APOA-IV*3A. 1 Publication
VAR_000633
Natural varianti264 – 2641R → Q in Seattle-2; may contribute to the development of familial combined hyperlipidemia. 1 Publication
Corresponds to variant rs2238008 [ dbSNP | Ensembl ].
VAR_000634
Natural varianti279 – 2791R → K.2 Publications
Corresponds to variant rs1042372 [ dbSNP | Ensembl ].
VAR_025443
Natural varianti305 – 3051R → C in Budapest-1. 1 Publication
VAR_000635
Natural varianti307 – 3071V → L.
Corresponds to variant rs5108 [ dbSNP | Ensembl ].
VAR_014611
Natural varianti367 – 3671T → S in allele APOA-IV*1A and allele Budapest-1. 3 Publications
Corresponds to variant rs675 [ dbSNP | Ensembl ].
VAR_000636
Natural varianti380 – 3801Q → H in allele APOA-IV*2 and allele APOA-IV*0A; associated with E-187 in allele APOA-IV*0A. 7 Publications
Corresponds to variant rs5110 [ dbSNP | Ensembl ].
VAR_000637
Natural varianti381 – 3811Q → QEQQQ in allele APOA-IV*0 and allele APOA-IV*5; allele APOA-IV*5 is further defined by a silent nucleotide substitution.
VAR_000638

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1603TPY → DPL in AAA51744. 1 Publication
Sequence conflicti158 – 1603TPY → DPL in AAA51745. 1 Publication
Sequence conflicti327 – 3271Q → T in AAA96731. 1 Publication
Sequence conflicti327 – 3271Q → T in AAA51748. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13654 mRNA. Translation: AAA51744.1.
M14642 Genomic DNA. Translation: AAA51745.1.
J02758 Genomic DNA. Translation: AAA96731.1.
X13629 mRNA. Translation: CAA31955.1.
AY422950 Genomic DNA. Translation: AAQ91809.1.
AY555191 Genomic DNA. Translation: AAS68228.1.
AP006216 Genomic DNA. No translation available.
BC074764 mRNA. Translation: AAH74764.1.
BC113594 mRNA. Translation: AAI13595.1.
BC113596 mRNA. Translation: AAI13597.1.
M14566 mRNA. Translation: AAA51748.1.
CCDSiCCDS31681.1.
PIRiA94137. LPHUA4.
UniGeneiHs.1247.

Genome annotation databases

EnsembliENST00000357780; ENSP00000350425; ENSG00000110244.
UCSCiuc001pps.1. human.

Polymorphism databases

DMDMi93163358.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13654 mRNA. Translation: AAA51744.1 .
M14642 Genomic DNA. Translation: AAA51745.1 .
J02758 Genomic DNA. Translation: AAA96731.1 .
X13629 mRNA. Translation: CAA31955.1 .
AY422950 Genomic DNA. Translation: AAQ91809.1 .
AY555191 Genomic DNA. Translation: AAS68228.1 .
AP006216 Genomic DNA. No translation available.
BC074764 mRNA. Translation: AAH74764.1 .
BC113594 mRNA. Translation: AAI13595.1 .
BC113596 mRNA. Translation: AAI13597.1 .
M14566 mRNA. Translation: AAA51748.1 .
CCDSi CCDS31681.1.
PIRi A94137. LPHUA4.
UniGenei Hs.1247.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3S84 X-ray 2.40 A/B 84-355 [» ]
ProteinModelPortali P06727.
SMRi P06727. Positions 25-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-38333N.
IntActi P06727. 1 interaction.
STRINGi 9606.ENSP00000350425.

PTM databases

PhosphoSitei P06727.

Polymorphism databases

DMDMi 93163358.

2D gel databases

DOSAC-COBS-2DPAGE P06727.
REPRODUCTION-2DPAGE IPI00304273.
SWISS-2DPAGE P06727.

Proteomic databases

MaxQBi P06727.
PaxDbi P06727.
PeptideAtlasi P06727.
PRIDEi P06727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357780 ; ENSP00000350425 ; ENSG00000110244 .
UCSCi uc001pps.1. human.

Organism-specific databases

GeneCardsi GC11M116692.
HGNCi HGNC:602. APOA4.
HPAi HPA001352.
HPA002549.
MIMi 107690. gene.
neXtProti NX_P06727.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42418.
HOGENOMi HOG000037942.
HOVERGENi HBG105707.
InParanoidi P06727.
OrthoDBi EOG7K9K48.
PhylomeDBi P06727.
TreeFami TF334458.

Enzyme and pathway databases

Reactomei REACT_24968. Retinoid metabolism and transport.
REACT_6841. Chylomicron-mediated lipid transport.
REACT_75925. Amyloids.

Miscellaneous databases

PMAP-CutDB A8MSL6.
PROi P06727.
SOURCEi Search...

Gene expression databases

Bgeei P06727.
CleanExi HS_APOA4.
Genevestigatori P06727.

Family and domain databases

InterProi IPR000074. ApoA1_A4_E.
[Graphical view ]
Pfami PF01442. Apolipoprotein. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV."
    Karathanasis S.K., Yunis I.
    Biochemistry 25:3962-3970(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-279.
  2. "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)."
    Karathanasis S.K., Oettgen P., Haddad I.A., Antonarakis S.E.
    Proc. Natl. Acad. Sci. U.S.A. 83:8457-8461(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-279.
  3. "Structure and expression of the human apolipoprotein A-IV gene."
    Elshourbagy N.A., Walker D.W., Paik Y.K., Boguski M.S., Freeman M., Gordon J.I., Taylor J.M.
    J. Biol. Chem. 262:7973-7981(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT APOA-IV*2 HIS-380.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-13; HIS-77; SER-147; SER-161; SER-367 AND HIS-380.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-147.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Colon.
  8. "The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III."
    Elshourbagy N.A., Walker D.W., Boguski M.S., Gordon J.I., Taylor J.M.
    J. Biol. Chem. 261:1998-2002(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-396, VARIANT APOA-IV*2 HIS-380.
  9. "Biosynthesis of human preapolipoprotein A-IV."
    Gordon J.I., Bisgaier C.L., Sims H.F., Sachdev O.P., Glickman R.M., Strauss A.W.
    J. Biol. Chem. 259:468-474(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIGNAL SEQUENCE CLEAVAGE SITE.
  10. "Genetic polymorphism of apolipoprotein A-IV."
    Lohse P., Brewer H.B. Jr.
    Curr. Opin. Lipidol. 2:90-95(1991)
    Cited for: REVIEW ON POLYMORPHISM.
  11. "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene."
    Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
    J. Biol. Chem. 265:10061-10064(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALLELES APOA-IV*1 AND APOA-IV*2, VARIANT HIS-380.
  12. "Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1."
    Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
    J. Biol. Chem. 265:12734-12739(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALLELES A-IV*0 AND A-IV*3, VARIANTS LYS-250 AND GLU-GLN-GLN-GLN-381 INS.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "The structure of dimeric apolipoprotein A-IV and its mechanism of self-association."
    Deng X., Morris J., Dressmen J., Tubb M.R., Tso P., Jerome W.G., Davidson W.S., Thompson T.B.
    Structure 20:767-779(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 84-355, SUBUNIT.
  15. "The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360."
    Tenkanen H., Lukka M., Jauhiainen M., Metso J., Baumann M., Peltonen L., Ehnholm C.
    Arterioscler. Thromb. 11:851-856(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HIS-380.
  16. "Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys)."
    Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
    J. Biol. Chem. 266:13513-13518(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALLELES A-IV*0; A-IV*1; A-IV*2 AND A-IV*3, VARIANTS LYS-185; GLU-187; SER-367 AND HIS-380.
  17. Erratum
    Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
    J. Biol. Chem. 266:19866-19866(1991)
  18. "Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population."
    von Eckardstein A., Funke H., Schulte M., Erren M., Schulte H., Assmann G.
    Am. J. Hum. Genet. 50:1115-1128(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MET-13.
  19. "A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127."
    Tenkanen H., Koskinen P., Metso J., Baumann M., Lukka M., Kauppinen-Makelin R., Kontula K., Taskinen M.R., Manttari M., Manninen V., Ehnholm C.
    Biochim. Biophys. Acta 1138:27-33(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-147.
  20. "Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism."
    Kamboh M.I., Williams E.R., Law J.C., Aston C.E., Bunker C.H., Ferrell R.E., Pollitzer W.S.
    Genet. Epidemiol. 9:379-388(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALLELE A-IV*5, VARIANT GLU-GLN-GLN-GLN-381 INS.
  21. "Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants."
    Menzel H.J., Dieplinger H., Sandholzer C., Karadi I., Utermann G., Csaszar A.
    Hum. Mutat. 5:58-65(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS BUDAPEST-2 LYS-44; BUDAPEST-1 CYS-305 AND SER-367.
  22. "Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity."
    Deeb S.S., Nevin D.N., Iwasaki L., Brunzell J.D.
    Hum. Mutat. 8:319-325(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SEATTLE-3 SER-161; SEATTLE-1 LEU-178 AND SEATTLE-2 GLN-264.
  23. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
    Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
    Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HIS-380.

Entry informationi

Entry nameiAPOA4_HUMAN
AccessioniPrimary (citable) accession number: P06727
Secondary accession number(s): A8MSL6, Q14CW8, Q6Q787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 164 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi