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P06727

- APOA4_HUMAN

UniProt

P06727 - APOA4_HUMAN

Protein

Apolipoprotein A-IV

Gene

APOA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 165 (01 Oct 2014)
      Sequence version 3 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

    GO - Molecular functioni

    1. antioxidant activity Source: HGNC
    2. cholesterol transporter activity Source: BHF-UCL
    3. copper ion binding Source: HGNC
    4. lipid binding Source: BHF-UCL
    5. lipid transporter activity Source: ProtInc
    6. phosphatidylcholine binding Source: BHF-UCL
    7. phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
    8. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. cholesterol efflux Source: BHF-UCL
    2. cholesterol homeostasis Source: BHF-UCL
    3. cholesterol metabolic process Source: BHF-UCL
    4. chylomicron assembly Source: BHF-UCL
    5. chylomicron remodeling Source: BHF-UCL
    6. high-density lipoprotein particle remodeling Source: BHF-UCL
    7. hydrogen peroxide catabolic process Source: HGNC
    8. innate immune response in mucosa Source: BHF-UCL
    9. leukocyte cell-cell adhesion Source: BHF-UCL
    10. lipid homeostasis Source: BHF-UCL
    11. lipid transport Source: BHF-UCL
    12. lipoprotein metabolic process Source: Reactome
    13. multicellular organismal lipid catabolic process Source: BHF-UCL
    14. negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
    15. phosphatidylcholine metabolic process Source: BHF-UCL
    16. phospholipid efflux Source: BHF-UCL
    17. phototransduction, visible light Source: Reactome
    18. positive regulation of cholesterol esterification Source: BHF-UCL
    19. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
    20. positive regulation of lipoprotein lipase activity Source: BHF-UCL
    21. positive regulation of triglyceride catabolic process Source: BHF-UCL
    22. protein-lipid complex assembly Source: BHF-UCL
    23. regulation of cholesterol transport Source: BHF-UCL
    24. regulation of intestinal cholesterol absorption Source: Ensembl
    25. removal of superoxide radicals Source: HGNC
    26. response to lipid hydroperoxide Source: HGNC
    27. response to stilbenoid Source: Ensembl
    28. retinoid metabolic process Source: Reactome
    29. reverse cholesterol transport Source: BHF-UCL
    30. small molecule metabolic process Source: Reactome
    31. very-low-density lipoprotein particle remodeling Source: BHF-UCL

    Keywords - Biological processi

    Lipid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.
    REACT_75925. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein A-IV
    Short name:
    Apo-AIV
    Short name:
    ApoA-IV
    Alternative name(s):
    Apolipoprotein A4
    Gene namesi
    Name:APOA4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:602. APOA4.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. chylomicron Source: BHF-UCL
    3. cytosol Source: Reactome
    4. early endosome Source: Reactome
    5. endoplasmic reticulum lumen Source: Reactome
    6. extracellular region Source: UniProtKB
    7. extracellular space Source: BHF-UCL
    8. extracellular vesicular exosome Source: UniProt
    9. high-density lipoprotein particle Source: BHF-UCL
    10. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    Chylomicron, HDL, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 396376Apolipoprotein A-IVPRO_0000001975Add
    BLAST

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP06727.
    PaxDbiP06727.
    PeptideAtlasiP06727.
    PRIDEiP06727.

    2D gel databases

    DOSAC-COBS-2DPAGEP06727.
    REPRODUCTION-2DPAGEIPI00304273.
    SWISS-2DPAGEP06727.

    PTM databases

    PhosphoSiteiP06727.

    Miscellaneous databases

    PMAP-CutDBA8MSL6.

    Expressioni

    Tissue specificityi

    Synthesized primarily in the intestine and secreted in plasma.

    Gene expression databases

    BgeeiP06727.
    CleanExiHS_APOA4.
    GenevestigatoriP06727.

    Organism-specific databases

    HPAiHPA001352.
    HPA002549.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    DIPiDIP-38333N.
    IntActiP06727. 1 interaction.
    STRINGi9606.ENSP00000350425.

    Structurei

    Secondary structure

    1
    396
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi97 – 11317
    Helixi114 – 1163
    Helixi117 – 223107
    Helixi224 – 2263
    Helixi231 – 27646
    Beta strandi278 – 2803
    Helixi282 – 30726
    Helixi310 – 32920

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S84X-ray2.40A/B84-355[»]
    ProteinModelPortaliP06727.
    SMRiP06727. Positions 25-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati33 – 54221Add
    BLAST
    Repeati60 – 81222Add
    BLAST
    Repeati82 – 103223Add
    BLAST
    Repeati115 – 136224Add
    BLAST
    Repeati137 – 158225Add
    BLAST
    Repeati159 – 180226Add
    BLAST
    Repeati181 – 202227Add
    BLAST
    Repeati203 – 224228Add
    BLAST
    Repeati225 – 246229Add
    BLAST
    Repeati247 – 2682210Add
    BLAST
    Repeati269 – 2861811Add
    BLAST
    Repeati287 – 3082212Add
    BLAST
    Repeati309 – 3302213Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 33029813 X 22 AA approximate tandem repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi372 – 38918Gln/Glu-richAdd
    BLAST

    Domaini

    Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.

    Sequence similaritiesi

    Belongs to the apolipoprotein A1/A4/E family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG42418.
    HOGENOMiHOG000037942.
    HOVERGENiHBG105707.
    InParanoidiP06727.
    OrthoDBiEOG7K9K48.
    PhylomeDBiP06727.
    TreeFamiTF334458.

    Family and domain databases

    InterProiIPR000074. ApoA1_A4_E.
    [Graphical view]
    PfamiPF01442. Apolipoprotein. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06727-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLKAVVLTL ALVAVAGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ    50
    KSELTQQLNA LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE 100
    EIGKELEELR ARLLPHANEV SQKIGDNLRE LQQRLEPYAD QLRTQVNTQA 150
    EQLRRQLTPY AQRMERVLRE NADSLQASLR PHADELKAKI DQNVEELKGR 200
    LTPYADEFKV KIDQTVEELR RSLAPYAQDT QEKLNHQLEG LTFQMKKNAE 250
    ELKARISASA EELRQRLAPL AEDVRGNLRG NTEGLQKSLA ELGGHLDQQV 300
    EEFRRRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK 350
    VNSFFSTFKE KESQDKTLSL PELEQQQEQQ QEQQQEQVQM LAPLES 396
    Length:396
    Mass (Da):45,399
    Last modified:March 7, 2006 - v3
    Checksum:i193753196CA2FA4A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1603TPY → DPL in AAA51744. (PubMed:3755616)Curated
    Sequence conflicti158 – 1603TPY → DPL in AAA51745. (PubMed:3095836)Curated
    Sequence conflicti327 – 3271Q → T in AAA96731. (PubMed:3036793)Curated
    Sequence conflicti327 – 3271Q → T in AAA51748. (PubMed:3080432)Curated

    Polymorphismi

    Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles. The sequence shown represents allele APOA-IV*1.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131V → M in allele APOA-IV*1D. 2 Publications
    VAR_000626
    Natural varianti44 – 441E → K in Budapest-2. 1 Publication
    VAR_000627
    Natural varianti74 – 741G → S.
    Corresponds to variant rs5102 [ dbSNP | Ensembl ].
    VAR_014610
    Natural varianti77 – 771Q → H.1 Publication
    VAR_025444
    Natural varianti147 – 1471N → S in allele APOA-IV*1B. 3 Publications
    Corresponds to variant rs5104 [ dbSNP | Ensembl ].
    VAR_000628
    Natural varianti161 – 1611A → S in Seattle-3. 2 Publications
    VAR_000629
    Natural varianti178 – 1781S → L in Seattle-1; may contribute to the development of familial combined hyperlipidemia. 1 Publication
    VAR_000630
    Natural varianti185 – 1851E → K in allele APOA-IV*3. 1 Publication
    VAR_000631
    Natural varianti187 – 1871K → E in allele APOA-IV*0A; associated with H-380. 1 Publication
    VAR_000632
    Natural varianti250 – 2501E → K in allele APOA-IV*3A. 1 Publication
    VAR_000633
    Natural varianti264 – 2641R → Q in Seattle-2; may contribute to the development of familial combined hyperlipidemia. 1 Publication
    Corresponds to variant rs2238008 [ dbSNP | Ensembl ].
    VAR_000634
    Natural varianti279 – 2791R → K.2 Publications
    Corresponds to variant rs1042372 [ dbSNP | Ensembl ].
    VAR_025443
    Natural varianti305 – 3051R → C in Budapest-1. 1 Publication
    VAR_000635
    Natural varianti307 – 3071V → L.
    Corresponds to variant rs5108 [ dbSNP | Ensembl ].
    VAR_014611
    Natural varianti367 – 3671T → S in allele APOA-IV*1A and allele Budapest-1. 3 Publications
    Corresponds to variant rs675 [ dbSNP | Ensembl ].
    VAR_000636
    Natural varianti380 – 3801Q → H in allele APOA-IV*2 and allele APOA-IV*0A; associated with E-187 in allele APOA-IV*0A. 7 Publications
    Corresponds to variant rs5110 [ dbSNP | Ensembl ].
    VAR_000637
    Natural varianti381 – 3811Q → QEQQQ in allele APOA-IV*0 and allele APOA-IV*5; allele APOA-IV*5 is further defined by a silent nucleotide substitution. 1 Publication
    VAR_000638

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13654 mRNA. Translation: AAA51744.1.
    M14642 Genomic DNA. Translation: AAA51745.1.
    J02758 Genomic DNA. Translation: AAA96731.1.
    X13629 mRNA. Translation: CAA31955.1.
    AY422950 Genomic DNA. Translation: AAQ91809.1.
    AY555191 Genomic DNA. Translation: AAS68228.1.
    AP006216 Genomic DNA. No translation available.
    BC074764 mRNA. Translation: AAH74764.1.
    BC113594 mRNA. Translation: AAI13595.1.
    BC113596 mRNA. Translation: AAI13597.1.
    M14566 mRNA. Translation: AAA51748.1.
    CCDSiCCDS31681.1.
    PIRiA94137. LPHUA4.
    UniGeneiHs.1247.

    Genome annotation databases

    EnsembliENST00000357780; ENSP00000350425; ENSG00000110244.
    UCSCiuc001pps.1. human.

    Polymorphism databases

    DMDMi93163358.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13654 mRNA. Translation: AAA51744.1 .
    M14642 Genomic DNA. Translation: AAA51745.1 .
    J02758 Genomic DNA. Translation: AAA96731.1 .
    X13629 mRNA. Translation: CAA31955.1 .
    AY422950 Genomic DNA. Translation: AAQ91809.1 .
    AY555191 Genomic DNA. Translation: AAS68228.1 .
    AP006216 Genomic DNA. No translation available.
    BC074764 mRNA. Translation: AAH74764.1 .
    BC113594 mRNA. Translation: AAI13595.1 .
    BC113596 mRNA. Translation: AAI13597.1 .
    M14566 mRNA. Translation: AAA51748.1 .
    CCDSi CCDS31681.1.
    PIRi A94137. LPHUA4.
    UniGenei Hs.1247.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S84 X-ray 2.40 A/B 84-355 [» ]
    ProteinModelPortali P06727.
    SMRi P06727. Positions 25-389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38333N.
    IntActi P06727. 1 interaction.
    STRINGi 9606.ENSP00000350425.

    PTM databases

    PhosphoSitei P06727.

    Polymorphism databases

    DMDMi 93163358.

    2D gel databases

    DOSAC-COBS-2DPAGE P06727.
    REPRODUCTION-2DPAGE IPI00304273.
    SWISS-2DPAGE P06727.

    Proteomic databases

    MaxQBi P06727.
    PaxDbi P06727.
    PeptideAtlasi P06727.
    PRIDEi P06727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357780 ; ENSP00000350425 ; ENSG00000110244 .
    UCSCi uc001pps.1. human.

    Organism-specific databases

    GeneCardsi GC11M116692.
    HGNCi HGNC:602. APOA4.
    HPAi HPA001352.
    HPA002549.
    MIMi 107690. gene.
    neXtProti NX_P06727.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42418.
    HOGENOMi HOG000037942.
    HOVERGENi HBG105707.
    InParanoidi P06727.
    OrthoDBi EOG7K9K48.
    PhylomeDBi P06727.
    TreeFami TF334458.

    Enzyme and pathway databases

    Reactomei REACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.
    REACT_75925. Amyloids.

    Miscellaneous databases

    PMAP-CutDB A8MSL6.
    PROi P06727.
    SOURCEi Search...

    Gene expression databases

    Bgeei P06727.
    CleanExi HS_APOA4.
    Genevestigatori P06727.

    Family and domain databases

    InterProi IPR000074. ApoA1_A4_E.
    [Graphical view ]
    Pfami PF01442. Apolipoprotein. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV."
      Karathanasis S.K., Yunis I.
      Biochemistry 25:3962-3970(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-279.
    2. "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)."
      Karathanasis S.K., Oettgen P., Haddad I.A., Antonarakis S.E.
      Proc. Natl. Acad. Sci. U.S.A. 83:8457-8461(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-279.
    3. "Structure and expression of the human apolipoprotein A-IV gene."
      Elshourbagy N.A., Walker D.W., Paik Y.K., Boguski M.S., Freeman M., Gordon J.I., Taylor J.M.
      J. Biol. Chem. 262:7973-7981(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT APOA-IV*2 HIS-380.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-13; HIS-77; SER-147; SER-161; SER-367 AND HIS-380.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-147.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Colon.
    8. "The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III."
      Elshourbagy N.A., Walker D.W., Boguski M.S., Gordon J.I., Taylor J.M.
      J. Biol. Chem. 261:1998-2002(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-396, VARIANT APOA-IV*2 HIS-380.
    9. "Biosynthesis of human preapolipoprotein A-IV."
      Gordon J.I., Bisgaier C.L., Sims H.F., Sachdev O.P., Glickman R.M., Strauss A.W.
      J. Biol. Chem. 259:468-474(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: SIGNAL SEQUENCE CLEAVAGE SITE.
    10. "Genetic polymorphism of apolipoprotein A-IV."
      Lohse P., Brewer H.B. Jr.
      Curr. Opin. Lipidol. 2:90-95(1991)
      Cited for: REVIEW ON POLYMORPHISM.
    11. "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene."
      Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
      J. Biol. Chem. 265:10061-10064(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALLELES APOA-IV*1 AND APOA-IV*2, VARIANT HIS-380.
    12. "Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1."
      Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
      J. Biol. Chem. 265:12734-12739(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALLELES A-IV*0 AND A-IV*3, VARIANTS LYS-250 AND GLU-GLN-GLN-GLN-381 INS.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "The structure of dimeric apolipoprotein A-IV and its mechanism of self-association."
      Deng X., Morris J., Dressmen J., Tubb M.R., Tso P., Jerome W.G., Davidson W.S., Thompson T.B.
      Structure 20:767-779(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 84-355, SUBUNIT.
    15. "The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360."
      Tenkanen H., Lukka M., Jauhiainen M., Metso J., Baumann M., Peltonen L., Ehnholm C.
      Arterioscler. Thromb. 11:851-856(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-380.
    16. "Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys)."
      Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
      J. Biol. Chem. 266:13513-13518(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALLELES A-IV*0; A-IV*1; A-IV*2 AND A-IV*3, VARIANTS LYS-185; GLU-187; SER-367 AND HIS-380.
    17. Erratum
      Lohse P., Kindt M.R., Rader D.J., Brewer H.B. Jr.
      J. Biol. Chem. 266:19866-19866(1991)
    18. "Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population."
      von Eckardstein A., Funke H., Schulte M., Erren M., Schulte H., Assmann G.
      Am. J. Hum. Genet. 50:1115-1128(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MET-13.
    19. "A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127."
      Tenkanen H., Koskinen P., Metso J., Baumann M., Lukka M., Kauppinen-Makelin R., Kontula K., Taskinen M.R., Manttari M., Manninen V., Ehnholm C.
      Biochim. Biophys. Acta 1138:27-33(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-147.
    20. "Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism."
      Kamboh M.I., Williams E.R., Law J.C., Aston C.E., Bunker C.H., Ferrell R.E., Pollitzer W.S.
      Genet. Epidemiol. 9:379-388(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALLELE A-IV*5, VARIANT GLU-GLN-GLN-GLN-381 INS.
    21. "Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants."
      Menzel H.J., Dieplinger H., Sandholzer C., Karadi I., Utermann G., Csaszar A.
      Hum. Mutat. 5:58-65(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS BUDAPEST-2 LYS-44; BUDAPEST-1 CYS-305 AND SER-367.
    22. "Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity."
      Deeb S.S., Nevin D.N., Iwasaki L., Brunzell J.D.
      Hum. Mutat. 8:319-325(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SEATTLE-3 SER-161; SEATTLE-1 LEU-178 AND SEATTLE-2 GLN-264.
    23. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
      Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-380.

    Entry informationi

    Entry nameiAPOA4_HUMAN
    AccessioniPrimary (citable) accession number: P06727
    Secondary accession number(s): A8MSL6, Q14CW8, Q6Q787
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 165 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3