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Protein

Protein S100-A6

Gene

S100A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331Add BLAST14
Calcium bindingi61 – 722Add BLAST12

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • ion transmembrane transporter activity Source: Ensembl
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB
  • zinc ion binding Source: Ensembl

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • positive regulation of fibroblast proliferation Source: UniProtKB
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A6
Alternative name(s):
Calcyclin
Growth factor-inducible protein 2A9
MLN 4
Prolactin receptor-associated protein
Short name:
PRA
S100 calcium-binding protein A6
Gene namesi
Name:S100A6
Synonyms:CACY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10496. S100A6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6277.
OpenTargetsiENSG00000197956.
PharmGKBiPA34908.

Polymorphism and mutation databases

BioMutaiS100A6.
DMDMi116509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439841 – 90Protein S100-A6Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-acetyllysineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei47N6-acetyllysine; alternateBy similarity1
Modified residuei47N6-succinyllysine; alternateBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP06703.
MaxQBiP06703.
PaxDbiP06703.
PeptideAtlasiP06703.
PRIDEiP06703.
TopDownProteomicsiP06703.

2D gel databases

DOSAC-COBS-2DPAGEP06703.

PTM databases

iPTMnetiP06703.
PhosphoSitePlusiP06703.
SwissPalmiP06703.

Expressioni

Inductioni

Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.

Gene expression databases

BgeeiENSG00000197956.
CleanExiHS_S100A6.
ExpressionAtlasiP06703. baseline and differential.
GenevisibleiP06703. HS.

Organism-specific databases

HPAiCAB002601.
CAB040549.
HPA007575.

Interactioni

Subunit structurei

Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FKBP4Q027903EBI-352877,EBI-1047444
KPNA2P522923EBI-352877,EBI-349938
MDM2Q009872EBI-352877,EBI-389668
PEX5P505423EBI-352877,EBI-597835
PPIDP268823EBI-352877,EBI-6477155From a different organism.
S100BP042715EBI-352877,EBI-458391

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112185. 28 interactors.
IntActiP06703. 18 interactors.
MINTiMINT-3005220.
STRINGi9606.ENSP00000357708.

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi22 – 24Combined sources3
Beta strandi28 – 30Combined sources3
Helixi31 – 41Combined sources11
Helixi45 – 47Combined sources3
Helixi51 – 62Combined sources12
Turni63 – 65Combined sources3
Beta strandi67 – 69Combined sources3
Helixi70 – 84Combined sources15
Helixi86 – 88Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8UX-ray1.15A1-90[»]
1K96X-ray1.44A1-90[»]
1K9KX-ray1.76A/B1-90[»]
1K9PX-ray1.90A1-90[»]
2M1KNMR-B/D1-90[»]
4YBHX-ray2.40B1-90[»]
ProteinModelPortaliP06703.
SMRiP06703.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06703.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini48 – 83EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYT5. Eukaryota.
ENOG410Z6I6. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP06703.
OMAiQVVNFQE.
OrthoDBiEOG091G10JX.
PhylomeDBiP06703.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPLDQAIG LLVAIFHKYS GREGDKHTLS KKELKELIQK ELTIGSKLQD
60 70 80 90
AEIARLMEDL DRNKDQEVNF QEYVTFLGAL ALIYNEALKG
Length:90
Mass (Da):10,180
Last modified:January 1, 1988 - v1
Checksum:i860CBB1416ACBCA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01198227H → R.Corresponds to variant rs11974dbSNPEnsembl.1
Natural variantiVAR_01198369N → S.Corresponds to variant rs1802581dbSNPEnsembl.1
Natural variantiVAR_01198483I → T.Corresponds to variant rs1802582dbSNPEnsembl.1
Natural variantiVAR_02928190G → D.Corresponds to variant rs2228293dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14300 mRNA. Translation: AAA35886.1.
J02763 Genomic DNA. Translation: AAA51905.1.
M18981 mRNA. Translation: AAA51906.1.
AY034480 Genomic DNA. Translation: AAK59702.1.
BT006965 mRNA. Translation: AAP35611.1.
BX470102 Genomic DNA. Translation: CAI14752.1.
CH471121 Genomic DNA. Translation: EAW53318.1.
CH471121 Genomic DNA. Translation: EAW53320.1.
CH471121 Genomic DNA. Translation: EAW53321.1.
CH471121 Genomic DNA. Translation: EAW53322.1.
CH471121 Genomic DNA. Translation: EAW53323.1.
CH471121 Genomic DNA. Translation: EAW53324.1.
CH471121 Genomic DNA. Translation: EAW53325.1.
CH471121 Genomic DNA. Translation: EAW53326.1.
BC001431 mRNA. Translation: AAH01431.1.
BC009017 mRNA. Translation: AAH09017.1.
CCDSiCCDS1040.1.
PIRiA28363. BCHUY.
RefSeqiNP_055439.1. NM_014624.3.
XP_016857522.1. XM_017002033.1.
UniGeneiHs.275243.

Genome annotation databases

EnsembliENST00000368719; ENSP00000357708; ENSG00000197956.
ENST00000368720; ENSP00000357709; ENSG00000197956.
ENST00000496817; ENSP00000473589; ENSG00000197956.
GeneIDi6277.
KEGGihsa:6277.
UCSCiuc001fbw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14300 mRNA. Translation: AAA35886.1.
J02763 Genomic DNA. Translation: AAA51905.1.
M18981 mRNA. Translation: AAA51906.1.
AY034480 Genomic DNA. Translation: AAK59702.1.
BT006965 mRNA. Translation: AAP35611.1.
BX470102 Genomic DNA. Translation: CAI14752.1.
CH471121 Genomic DNA. Translation: EAW53318.1.
CH471121 Genomic DNA. Translation: EAW53320.1.
CH471121 Genomic DNA. Translation: EAW53321.1.
CH471121 Genomic DNA. Translation: EAW53322.1.
CH471121 Genomic DNA. Translation: EAW53323.1.
CH471121 Genomic DNA. Translation: EAW53324.1.
CH471121 Genomic DNA. Translation: EAW53325.1.
CH471121 Genomic DNA. Translation: EAW53326.1.
BC001431 mRNA. Translation: AAH01431.1.
BC009017 mRNA. Translation: AAH09017.1.
CCDSiCCDS1040.1.
PIRiA28363. BCHUY.
RefSeqiNP_055439.1. NM_014624.3.
XP_016857522.1. XM_017002033.1.
UniGeneiHs.275243.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8UX-ray1.15A1-90[»]
1K96X-ray1.44A1-90[»]
1K9KX-ray1.76A/B1-90[»]
1K9PX-ray1.90A1-90[»]
2M1KNMR-B/D1-90[»]
4YBHX-ray2.40B1-90[»]
ProteinModelPortaliP06703.
SMRiP06703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112185. 28 interactors.
IntActiP06703. 18 interactors.
MINTiMINT-3005220.
STRINGi9606.ENSP00000357708.

PTM databases

iPTMnetiP06703.
PhosphoSitePlusiP06703.
SwissPalmiP06703.

Polymorphism and mutation databases

BioMutaiS100A6.
DMDMi116509.

2D gel databases

DOSAC-COBS-2DPAGEP06703.

Proteomic databases

EPDiP06703.
MaxQBiP06703.
PaxDbiP06703.
PeptideAtlasiP06703.
PRIDEiP06703.
TopDownProteomicsiP06703.

Protocols and materials databases

DNASUi6277.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368719; ENSP00000357708; ENSG00000197956.
ENST00000368720; ENSP00000357709; ENSG00000197956.
ENST00000496817; ENSP00000473589; ENSG00000197956.
GeneIDi6277.
KEGGihsa:6277.
UCSCiuc001fbw.2. human.

Organism-specific databases

CTDi6277.
DisGeNETi6277.
GeneCardsiS100A6.
HGNCiHGNC:10496. S100A6.
HPAiCAB002601.
CAB040549.
HPA007575.
MIMi114110. gene.
neXtProtiNX_P06703.
OpenTargetsiENSG00000197956.
PharmGKBiPA34908.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYT5. Eukaryota.
ENOG410Z6I6. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP06703.
OMAiQVVNFQE.
OrthoDBiEOG091G10JX.
PhylomeDBiP06703.
TreeFamiTF332727.

Enzyme and pathway databases

BioCyciZFISH:G66-33816-MONOMER.

Miscellaneous databases

ChiTaRSiS100A6. human.
EvolutionaryTraceiP06703.
GeneWikiiS100A6.
GenomeRNAii6277.
PROiP06703.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197956.
CleanExiHS_S100A6.
ExpressionAtlasiP06703. baseline and differential.
GenevisibleiP06703. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10A6_HUMAN
AccessioniPrimary (citable) accession number: P06703
Secondary accession number(s): D3DV39, Q5RHS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 173 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein co-purified with the prolactin receptor.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.