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P06687

- AT1A3_RAT

UniProt

P06687 - AT1A3_RAT

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Protein
Sodium/potassium-transporting ATPase subunit alpha-3
Gene
Atp1a3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei366 – 36614-aspartylphosphate intermediate By similarity
Metal bindingi707 – 7071Magnesium By similarity
Metal bindingi711 – 7111Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: RGD
  2. D1 dopamine receptor binding Source: RGD
  3. cation-transporting ATPase activity Source: RGD
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. sodium:potassium-exchanging ATPase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. ATP hydrolysis coupled proton transport Source: RGD
  3. adult locomotory behavior Source: Ensembl
  4. ionotropic glutamate receptor signaling pathway Source: Ensembl
  5. memory Source: Ensembl
  6. potassium ion transport Source: RGD
  7. response to drug Source: Ensembl
  8. sodium ion transmembrane transport Source: GOC
  9. sodium ion transport Source: RGD
  10. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

SABIO-RKP06687.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
Gene namesi
Name:Atp1a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2169. Atp1a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7777Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei78 – 9821Helical; Reviewed prediction
Add
BLAST
Topological domaini99 – 12123Extracellular Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Topological domaini143 – 278136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei279 – 29820Helical; Reviewed prediction
Add
BLAST
Topological domaini299 – 31012Extracellular Reviewed prediction
Add
BLAST
Transmembranei311 – 32818Helical; Reviewed prediction
Add
BLAST
Topological domaini329 – 762434Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei763 – 78220Helical; Reviewed prediction
Add
BLAST
Topological domaini783 – 79210Extracellular Reviewed prediction
Transmembranei793 – 81321Helical; Reviewed prediction
Add
BLAST
Topological domaini814 – 83320Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei834 – 85623Helical; Reviewed prediction
Add
BLAST
Topological domaini857 – 90852Extracellular Reviewed prediction
Add
BLAST
Transmembranei909 – 92820Helical; Reviewed prediction
Add
BLAST
Topological domaini929 – 94113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei942 – 96019Helical; Reviewed prediction
Add
BLAST
Topological domaini961 – 97515Extracellular Reviewed prediction
Add
BLAST
Transmembranei976 – 99621Helical; Reviewed prediction
Add
BLAST
Topological domaini997 – 101317Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. axon Source: RGD
  3. dendritic spine head Source: RGD
  4. dendritic spine neck Source: RGD
  5. endoplasmic reticulum Source: UniProtKB
  6. myelin sheath Source: RGD
  7. nucleus Source: Ensembl
  8. plasma membrane Source: UniProtKB
  9. sodium:potassium-exchanging ATPase complex Source: RGD
  10. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10131013Sodium/potassium-transporting ATPase subunit alpha-3
PRO_0000046300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651Phosphoserine By similarity
Modified residuei548 – 5481Phosphotyrosine By similarity
Modified residuei933 – 9331Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP06687.
PRIDEiP06687.

PTM databases

PhosphoSiteiP06687.

Expressioni

Gene expression databases

GenevestigatoriP06687.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Protein-protein interaction databases

BioGridi246401. 5 interactions.
IntActiP06687. 2 interactions.
MINTiMINT-7138201.

Structurei

3D structure databases

ProteinModelPortaliP06687.
SMRiP06687. Positions 20-1013.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 743Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00560000076866.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
KOiK01539.
OMAiFQTHPEN.
OrthoDBiEOG7327N0.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06687-1 [UniParc]FASTAAdd to Basket

« Hide

MGDKKDDKSS PKKSKAKERR DLDDLKKEVA MTEHKMSVEE VCRKYNTDCV     50
QGLTHSKAQE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SILLWIGAIL 100
CFLAYGIQAG TEDDPSGDNL YLGIVLAAVV IITGCFSYYQ EAKSSKIMES 150
FKNMVPQQAL VIREGEKMQV NAEEVVVGDL VEIKGGDRVP ADLRIISAHG 200
CKVDNSSLTG ESEPQTRSPD CTHDNPLETR NITFFSTNCV EGTARGVVVA 250
TGDRTVMGRI ATLASGLEVG KTPIAIEIEH FIQLITGVAV FLGVSFFILS 300
LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN 350
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTEDQSGTS 400
FDKSSHTWVA LSHIAGLCNR AVFKGGQDNI PVLKRDVAGD ASESALLKCI 450
ELSSGSVKLM RERNKKVAEI PFNSTNKYQL SIHETEDPND NRYLLVMKGA 500
PERILDRCAT ILLQGKEQPL DEEMKEAFQN AYLELGGLGE RVLGFCHYYL 550
PEEQFPKGFA FDCDDVNFTT DNLCFVGLMS MIDPPRAAVP DAVGKCRSAG 600
IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA 650
KACVIHGTDL KDFTSEQIDE ILQNHTEIVF ARTSPQQKLI IVEGCQRQGA 700
IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL LDDNFASIVT 750
GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LLFIMANIPL PLGTITILCI 800
DLGTDMVPAI SLAYEAAESD IMKRQPRNPR TDKLVNERLI SMAYGQIGMI 850
QALGGFFSYF VILAENGFLP GNLVGIRLNW DDRTVNDLED SYGQQWTYEQ 900
RKVVEFTCHT AFFVSIVVVQ WADLIICKTR RNSVFQQGMK NKILIFGLFE 950
ETALAAFLSY CPGMDVALRM YPLKPSWWFC AFPYSFLIFV YDEIRKLILR 1000
RNPGGWVEKE TYY 1013
Length:1,013
Mass (Da):111,692
Last modified:October 18, 2001 - v2
Checksum:i72F051406284EA8A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 33MGD → MNL in AAA41672. 1 Publication
Sequence conflicti104 – 1041A → R in AAA41672. 1 Publication
Sequence conflicti114 – 1141D → E in AAA41672. 1 Publication
Sequence conflicti128 – 1281A → G in AAA41672. 1 Publication
Sequence conflicti149 – 1491E → Q in AAA41672. 1 Publication
Sequence conflicti152 – 1521K → T in AAA41672. 1 Publication
Sequence conflicti166 – 1661E → D in AAA41672. 1 Publication
Sequence conflicti192 – 1943DLR → ELG in AAA41672. 1 Publication
Sequence conflicti200 – 2001G → R in AAA41672. 1 Publication
Sequence conflicti339 – 3391Missing in AAA41672. 1 Publication
Sequence conflicti621 – 6211V → K in AAA41672. 1 Publication
Sequence conflicti807 – 8093VPA → DPT in AAA41672. 1 Publication
Sequence conflicti908 – 9081C → F in AAA40777. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14513 mRNA. Translation: AAA40777.1.
X05883 mRNA. Translation: CAA29307.1.
M28648 mRNA. Translation: AAA41672.1.
PIRiC24639.
RefSeqiNP_036638.1. NM_012506.1.
UniGeneiRn.87329.

Genome annotation databases

EnsembliENSRNOT00000027497; ENSRNOP00000027497; ENSRNOG00000020263.
GeneIDi24213.
KEGGirno:24213.
UCSCiRGD:2169. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14513 mRNA. Translation: AAA40777.1 .
X05883 mRNA. Translation: CAA29307.1 .
M28648 mRNA. Translation: AAA41672.1 .
PIRi C24639.
RefSeqi NP_036638.1. NM_012506.1.
UniGenei Rn.87329.

3D structure databases

ProteinModelPortali P06687.
SMRi P06687. Positions 20-1013.
ModBasei Search...

Protein-protein interaction databases

BioGridi 246401. 5 interactions.
IntActi P06687. 2 interactions.
MINTi MINT-7138201.

PTM databases

PhosphoSitei P06687.

Proteomic databases

PaxDbi P06687.
PRIDEi P06687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027497 ; ENSRNOP00000027497 ; ENSRNOG00000020263 .
GeneIDi 24213.
KEGGi rno:24213.
UCSCi RGD:2169. rat.

Organism-specific databases

CTDi 478.
RGDi 2169. Atp1a3.

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00560000076866.
HOGENOMi HOG000265622.
HOVERGENi HBG004298.
KOi K01539.
OMAi FQTHPEN.
OrthoDBi EOG7327N0.

Enzyme and pathway databases

SABIO-RK P06687.

Miscellaneous databases

NextBioi 602625.

Gene expression databases

Genevestigatori P06687.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain."
    Shull G.E., Greeb J., Lingrel J.B.
    Biochemistry 25:8125-8132(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences."
    Hara Y., Urayama O., Kawakami K., Nojima H., Nagamune H., Kojima T., Ohta T., Nagano K., Nakao M.
    J. Biochem. 102:43-58(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications."
    Herrera V.L.M., Emanuel J.R., Ruiz-Opazo N., Levenson R., Nadal-Ginard B.
    J. Cell Biol. 105:1855-1865(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-930.
    Tissue: Brain and Liver.
  4. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 58-64; 147-152; 246-254; 260-271; 425-434; 436-448; 517-525; 587-595; 620-648; 734-763 AND 878-883, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiAT1A3_RAT
AccessioniPrimary (citable) accession number: P06687
Secondary accession number(s): Q16732, Q9Z1G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 18, 2001
Last modified: June 11, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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