##gff-version 3 P06685 UniProtKB Propeptide 1 5 . . . ID=PRO_0000002489;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7775468;Dbxref=PMID:7775468 P06685 UniProtKB Chain 6 1023 . . . ID=PRO_0000002490;Note=Sodium/potassium-transporting ATPase subunit alpha-1 P06685 UniProtKB Topological domain 6 87 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 88 108 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 109 131 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 132 152 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 153 288 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 289 308 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 309 320 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 321 338 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 339 772 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 773 792 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 793 802 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 803 823 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 824 843 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 844 866 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 867 918 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 919 938 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 939 951 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 952 970 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 971 985 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Transmembrane 986 1006 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Topological domain 1007 1023 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06685 UniProtKB Region 1 38 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06685 UniProtKB Region 82 84 . . . Note=Phosphoinositide-3 kinase binding P06685 UniProtKB Region 216 235 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06685 UniProtKB Region 596 717 . . . Note=Mediates interaction with SCN7A;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDN2 P06685 UniProtKB Active site 376 376 . . . Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06685 UniProtKB Binding site 487 487 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12730684;Dbxref=PMID:12730684 P06685 UniProtKB Binding site 717 717 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P06685 UniProtKB Binding site 721 721 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P06685 UniProtKB Modified residue 9 9 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDN2 P06685 UniProtKB Modified residue 10 10 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10473631;Dbxref=PMID:10473631 P06685 UniProtKB Modified residue 16 16 . . . Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7775468;Dbxref=PMID:7775468 P06685 UniProtKB Modified residue 21 21 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDN2 P06685 UniProtKB Modified residue 23 23 . . . Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:7775468,ECO:0000269|PubMed:9435504;Dbxref=PMID:7775468,PMID:9435504 P06685 UniProtKB Modified residue 40 40 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06685 UniProtKB Modified residue 47 47 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06685 UniProtKB Modified residue 228 228 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06685 UniProtKB Modified residue 260 260 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDN2 P06685 UniProtKB Modified residue 452 452 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06685 UniProtKB Modified residue 484 484 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06685 UniProtKB Modified residue 542 542 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05023 P06685 UniProtKB Modified residue 661 661 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDN2 P06685 UniProtKB Modified residue 668 668 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDN2 P06685 UniProtKB Modified residue 675 675 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDN2 P06685 UniProtKB Modified residue 943 943 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9435504;Dbxref=PMID:9435504 P06685 UniProtKB Mutagenesis 16 16 . . . Note=Dopamine fails to increase phosphoinositide-3 kinase activity and to promote its interaction with Na(+)/K(+) ATPase. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10823893;Dbxref=PMID:10823893 P06685 UniProtKB Mutagenesis 83 83 . . . Note=Dopamine fails to increase phosphoinositide-3 kinase activity and to promote its interaction with Na(+)/K(+) ATPase. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10823893;Dbxref=PMID:10823893 P06685 UniProtKB Mutagenesis 302 302 . . . Note=Results in altered sodium and potassium transport. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388404;Dbxref=PMID:30388404 P06685 UniProtKB Mutagenesis 303 303 . . . Note=Results in altered sodium and potassium transport. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388404;Dbxref=PMID:30388404 P06685 UniProtKB Mutagenesis 314 314 . . . Note=Abolishes targeting to the basolateral plasma membrane. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16914892;Dbxref=PMID:16914892 P06685 UniProtKB Mutagenesis 859 859 . . . Note=Results in altered sodium and potassium transport. M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30388404;Dbxref=PMID:30388404 P06685 UniProtKB Sequence conflict 68 69 . . . Note=AA->PV;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06685 UniProtKB Sequence conflict 175 175 . . . Note=G->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06685 UniProtKB Sequence conflict 188 188 . . . Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06685 UniProtKB Sequence conflict 335 335 . . . Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06685 UniProtKB Beta strand 394 396 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 403 405 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Helix 416 427 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 431 435 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 438 440 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Helix 442 444 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO8 P06685 UniProtKB Beta strand 447 449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Turn 451 453 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Helix 454 461 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Turn 462 464 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Helix 467 473 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 478 480 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Turn 483 485 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO8 P06685 UniProtKB Beta strand 489 494 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 496 500 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 502 509 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Helix 511 515 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 518 521 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 526 529 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO8 P06685 UniProtKB Helix 532 546 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Beta strand 556 558 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO8 P06685 UniProtKB Turn 562 564 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7 P06685 UniProtKB Turn 572 574 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1MO7