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Protein

Immunoglobulin G-binding protein G

Gene

spg

Organism
Streptococcus sp. group G
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the constant Fc region of IgG with high affinity.

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin G-binding protein G
Short name:
IgG-binding protein G
Gene namesi
Name:spg
OrganismiStreptococcus sp. group G
Taxonomic identifieri1320 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000000565734 – 417Immunoglobulin G-binding protein GAdd BLAST384
PropeptideiPRO_0000005658418 – 448Removed by sortasePROSITE-ProRule annotationAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei417Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRIDEiP06654.

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi227 – 234Combined sources8
Beta strandi239 – 248Combined sources10
Helixi249 – 262Combined sources14
Turni264 – 266Combined sources3
Beta strandi268 – 272Combined sources5
Turni273 – 276Combined sources4
Beta strandi277 – 281Combined sources5
Beta strandi297 – 304Combined sources8
Beta strandi309 – 318Combined sources10
Helixi319 – 332Combined sources14
Beta strandi338 – 342Combined sources5
Turni343 – 346Combined sources4
Beta strandi347 – 351Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EM7X-ray2.00A228-282[»]
1GB1NMR-A228-282[»]
1IGCX-ray2.60A293-352[»]
1IGDX-ray1.10A293-352[»]
1LE3NMR-A267-282[»]
1MPENMR-A/B/C/D228-282[»]
1MVKX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L228-282[»]
1PGAX-ray2.07A228-282[»]
1PGBX-ray1.92A228-282[»]
1PGXX-ray1.66A288-369[»]
1PN5NMR-A228-282[»]
1Q10NMR-A/B228-282[»]
2GB1NMR-A228-282[»]
2IGDX-ray1.10A293-352[»]
2IGHNMR-A292-352[»]
2J52NMR-A228-282[»]
2J53NMR-A228-282[»]
2K0PNMR-A228-282[»]
2KBTNMR-A228-282[»]
2KLKOther-A/B229-282[»]
2LGINMR-A229-282[»]
2MBBNMR-A229-282[»]
2N7JNMR-A299-352[»]
2NMQNMR-A298-352[»]
2PLPNMR-A228-281[»]
2RMMNMR-A/B229-282[»]
2RPVNMR-A226-282[»]
3GB1NMR-A228-282[»]
3MP9X-ray1.20A/B227-282[»]
4KGRX-ray2.00A/B/C/D/E/F/G/H227-282[»]
4KGSX-ray1.95A/B227-282[»]
4KGTX-ray2.00A/B227-282[»]
ProteinModelPortaliP06654.
SMRiP06654.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 1401-1Add BLAST37
Repeati179 – 2151-2Add BLAST37
Repeati228 – 2822-1Add BLAST55
Repeati298 – 3522-2Add BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 2152 X 37 AA repeatsAdd BLAST112
Regioni228 – 3522 X 55 AA repeatsAdd BLAST125
Regioni386 – 4105 X 5 AA repeats of [DE]-D-A-K-KAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 418LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 111Ala-richAdd BLAST43

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR019948. Gram-positive_anchor.
IPR009063. Ig/albumin-bd.
IPR000724. IgG-bd_B.
IPR019950. M_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF00746. Gram_pos_anchor. 1 hit.
PF01378. IgG_binding_B. 2 hits.
[Graphical view]
PRINTSiPR00015. GPOSANCHOR.
SUPFAMiSSF46997. SSF46997. 2 hits.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKEKKVKYF LRKSAFGLAS VSAAFLVGST VFAVDSPIED TPIIRNGGEL
60 70 80 90 100
TNLLGNSETT LALRNEESAT ADLTAAAVAD TVAAAAAENA GAAAWEAAAA
110 120 130 140 150
ADALAKAKAD ALKEFNKYGV SDYYKNLINN AKTVEGIKDL QAQVVESAKK
160 170 180 190 200
ARISEATDGL SDFLKSQTPA EDTVKSIELA EAKVLANREL DKYGVSDYHK
210 220 230 240 250
NLINNAKTVE GVKELIDEIL AALPKTDTYK LILNGKTLKG ETTTEAVDAA
260 270 280 290 300
TAEKVFKQYA NDNGVDGEWT YDDATKTFTV TEKPEVIDAS ELTPAVTTYK
310 320 330 340 350
LVINGKTLKG ETTTKAVDAE TAEKAFKQYA NDNGVDGVWT YDDATKTFTV
360 370 380 390 400
TEMVTEVPGD APTEPEKPEA SIPLVPLTPA TPIAKDDAKK DDTKKEDAKK
410 420 430 440
PEAKKDDAKK AETLPTTGEG SNPFFTAAAL AVMAGAGALA VASKRKED
Length:448
Mass (Da):47,567
Last modified:January 1, 1988 - v1
Checksum:iA0759060C8F9E6CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 44II → N AA sequence (PubMed:1985908).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13825 Unassigned DNA. Translation: AAA03664.1.
PIRiA24496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13825 Unassigned DNA. Translation: AAA03664.1.
PIRiA24496.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EM7X-ray2.00A228-282[»]
1GB1NMR-A228-282[»]
1IGCX-ray2.60A293-352[»]
1IGDX-ray1.10A293-352[»]
1LE3NMR-A267-282[»]
1MPENMR-A/B/C/D228-282[»]
1MVKX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L228-282[»]
1PGAX-ray2.07A228-282[»]
1PGBX-ray1.92A228-282[»]
1PGXX-ray1.66A288-369[»]
1PN5NMR-A228-282[»]
1Q10NMR-A/B228-282[»]
2GB1NMR-A228-282[»]
2IGDX-ray1.10A293-352[»]
2IGHNMR-A292-352[»]
2J52NMR-A228-282[»]
2J53NMR-A228-282[»]
2K0PNMR-A228-282[»]
2KBTNMR-A228-282[»]
2KLKOther-A/B229-282[»]
2LGINMR-A229-282[»]
2MBBNMR-A229-282[»]
2N7JNMR-A299-352[»]
2NMQNMR-A298-352[»]
2PLPNMR-A228-281[»]
2RMMNMR-A/B229-282[»]
2RPVNMR-A226-282[»]
3GB1NMR-A228-282[»]
3MP9X-ray1.20A/B227-282[»]
4KGRX-ray2.00A/B/C/D/E/F/G/H227-282[»]
4KGSX-ray1.95A/B227-282[»]
4KGTX-ray2.00A/B227-282[»]
ProteinModelPortaliP06654.
SMRiP06654.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP06654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP06654.

Family and domain databases

InterProiIPR019948. Gram-positive_anchor.
IPR009063. Ig/albumin-bd.
IPR000724. IgG-bd_B.
IPR019950. M_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF00746. Gram_pos_anchor. 1 hit.
PF01378. IgG_binding_B. 2 hits.
[Graphical view]
PRINTSiPR00015. GPOSANCHOR.
SUPFAMiSSF46997. SSF46997. 2 hits.
TIGRFAMsiTIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPG1_STRSG
AccessioniPrimary (citable) accession number: P06654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.