Reviewed, UniProtKB/Swiss-Prot P06623 (CN37_BOVIN)

Names and origin

Protein names

Recommended name:
    2',3'-cyclic-nucleotide 3'-phosphodiesterase
      Short name=CNPase
      Short name=CNP
    EC=3.1.4.37

Gene names

Name:

CNP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.
Subcellular location	Membrane. Melanosome By similarity. Note: Firmly bound to membrane structures of brain white matter.
Post-translational modification	Met-1 may be removed after translation.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
Cellular component	Membrane
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	RNA metabolic process Inferred from electronic annotation. Source: InterPro cyclic nucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CABP1	Q9NZU7	1	EBI-907934,EBI-907894	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	2',3'-cyclic-nucleotide 3'-phosphodiesterase		PRO_0000089960
Sites
	Active site	230	1	By similarity
	Active site	309	1	By similarity
Amino acid modifications
	Modified residue	352	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06623-1 [UniParc]. Last modified July 1, 1993. Version 2. Checksum: 3448FC367D647CF8	FASTA	400	44,875
	10 20 30 40 50 60 MSSSGAKDKP ELQFPFLQDE ETVATLQECK TLFILRGLPG SGKSTLARFI VDKYRDGTKM 70 80 90 100 110 120 VSADSYKITP GARGSFSEEY KQLDEDLAAC CRRDFRVLVL DDTNHERERL EQLFELADQY 130 140 150 160 170 180 QYQVVLVEPK TAWRLDCAQL KEKNQWQLSA DDLKKLKPGL EKDFLPLYFG WFLTKKSSAA 190 200 210 220 230 240 LWKTGQTFLE ELGNHKAFKK ELRHFVSGDE PREKIELVTY FGKRPPGVLH CTTKFCDYGK 250 260 270 280 290 300 AAGAEEYAQQ DVVKKSYCKA FTLTISALFV TPKTTGARVE LSEQQLALWP NDVDKLSPSD 310 320 330 340 350 360 NLPRGSRAHI TLGCAGDVEA VQTGIDLLEI VRQEKGGSRG EEVGELSRGK LYSLGSGRWM 370 380 390 400 LSLAKKMEVR AIFTGYYGKG KAVPIRSGRK GGSFQSCTII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and amino acid sequence of bovine brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase." Kurihara T., Fowler A.V., Takahashi Y. J. Biol. Chem. 262:3256-3261(1987) [PubMed: 3029107] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	Erratum Kurihara T., Fowler A.V., Takahashi Y. J. Biol. Chem. 262:16754-16754(1987) Cited for: SEQUENCE REVISION TO 318.
[3]	"Nucleotide sequence of bovine retina 2',3'-cyclic nucleotide 3'-phosphohydrolase." Vogel U.S., Thompson R.J. Nucleic Acids Res. 15:7204-7204(1987) [PubMed: 2821502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[4]	"Molecular cloning of the myelin specific enzyme 2',3'-cyclic-nucleotide 3'-phosphohydrolase." Vogel U.S., Thompson R.J. FEBS Lett. 218:261-265(1987) [PubMed: 3036592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	J02659 mRNA. Translation: AAA30456.1. Sequence problems. Y00405 mRNA. Translation: CAA68466.1. M27606 mRNA. Translation: AAA30457.1. BC102820 mRNA. Translation: AAI02821.2.
IPI	IPI00717655.
PIR	ESBOP3. A26861.
RefSeq	NP_851336.1.
UniGene	Bt.5517
3D structure databases
SMR	P06623. Positions 165-378.
ModBase	Search...
Protein-protein interaction databases
IntAct	P06623. 1 interaction.
Genome annotation databases
Ensembl	ENSBTAG00000025762. Bos taurus. [Contig view]
GeneID	280752.
KEGG	bta:280752.
Phylogenomic databases
HOVERGEN	P06623.
Enzyme and pathway databases
BRENDA	3.1.4.37. 251.
Family and domain databases
InterPro	IPR008431. CNPase. [Graphical view]
PANTHER	PTHR10156. CNPase. 1 hit.
Pfam	PF05881. CNPase. 1 hit. [Graphical view]
PIRSF	PIRSF000970. CNPase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CN37_BOVIN

Accession

Primary (citable) accession number: P06623
Secondary accession number(s): Q3SZJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)