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P06623

- CN37_BOVIN

UniProt

P06623 - CN37_BOVIN

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Protein

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Gene
CNP
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin By similarity.

Catalytic activityi

Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei230 – 2301Proton acceptor By similarity
Binding sitei232 – 2321Substrate By similarity
Active sitei309 – 3091Proton donor By similarity
Binding sitei311 – 3111Substrate By similarity

GO - Molecular functioni

  1. 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. axonogenesis Source: Ensembl
  3. cyclic nucleotide catabolic process Source: InterPro
  4. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC:3.1.4.37)
Short name:
CNP
Short name:
CNPase
Gene namesi
Name:CNP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Membrane; Lipid-anchor. Melanosome By similarity
Note: Firmly bound to membrane structures of brain white matter.

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. melanosome Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-SubCell
  4. microtubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3973972',3'-cyclic-nucleotide 3'-phosphodiesterasePRO_0000089960Add
BLAST
Propeptidei398 – 4003Removed in mature form By similarityPRO_0000422295

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei397 – 3971Cysteine methyl ester By similarity
Lipidationi397 – 3971S-farnesyl cysteine By similarity

Post-translational modificationi

Met-1 may be removed after translation.

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP06623.

Interactioni

Subunit structurei

Exists as monomers and homodimers By similarity.

Protein-protein interaction databases

IntActiP06623. 1 interaction.
STRINGi9913.ENSBTAP00000036278.

Structurei

3D structure databases

ProteinModelPortaliP06623.
SMRiP06623. Positions 165-378.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG314041.
GeneTreeiENSGT00510000048410.
HOGENOMiHOG000111838.
HOVERGENiHBG001451.
InParanoidiP06623.
KOiK01121.
OMAiLWPNDVD.
OrthoDBiEOG78PVBC.
TreeFamiTF332157.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008431. CNPase.
IPR027417. P-loop_NTPase.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PANTHERiPTHR10156. PTHR10156. 1 hit.
PfamiPF05881. CNPase. 1 hit.
[Graphical view]
PIRSFiPIRSF000970. CNPase. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF55144. SSF55144. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06623-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSGAKDKP ELQFPFLQDE ETVATLQECK TLFILRGLPG SGKSTLARFI    50
VDKYRDGTKM VSADSYKITP GARGSFSEEY KQLDEDLAAC CRRDFRVLVL 100
DDTNHERERL EQLFELADQY QYQVVLVEPK TAWRLDCAQL KEKNQWQLSA 150
DDLKKLKPGL EKDFLPLYFG WFLTKKSSAA LWKTGQTFLE ELGNHKAFKK 200
ELRHFVSGDE PREKIELVTY FGKRPPGVLH CTTKFCDYGK AAGAEEYAQQ 250
DVVKKSYCKA FTLTISALFV TPKTTGARVE LSEQQLALWP NDVDKLSPSD 300
NLPRGSRAHI TLGCAGDVEA VQTGIDLLEI VRQEKGGSRG EEVGELSRGK 350
LYSLGSGRWM LSLAKKMEVR AIFTGYYGKG KAVPIRSGRK GGSFQSCTII 400
Length:400
Mass (Da):44,875
Last modified:July 1, 1993 - v2
Checksum:i3448FC367D647CF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02659 mRNA. Translation: AAA30456.1. Sequence problems.
Y00405 mRNA. Translation: CAA68466.1.
M27606 mRNA. Translation: AAA30457.1.
BC102820 mRNA. Translation: AAI02821.2.
PIRiA26861. ESBOP3.
RefSeqiNP_851336.1. NM_180993.2.
XP_005220719.1. XM_005220662.1.
UniGeneiBt.5517.

Genome annotation databases

EnsembliENSBTAT00000036420; ENSBTAP00000036278; ENSBTAG00000025762.
GeneIDi280752.
KEGGibta:280752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02659 mRNA. Translation: AAA30456.1 . Sequence problems.
Y00405 mRNA. Translation: CAA68466.1 .
M27606 mRNA. Translation: AAA30457.1 .
BC102820 mRNA. Translation: AAI02821.2 .
PIRi A26861. ESBOP3.
RefSeqi NP_851336.1. NM_180993.2.
XP_005220719.1. XM_005220662.1.
UniGenei Bt.5517.

3D structure databases

ProteinModelPortali P06623.
SMRi P06623. Positions 165-378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P06623. 1 interaction.
STRINGi 9913.ENSBTAP00000036278.

Proteomic databases

PRIDEi P06623.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000036420 ; ENSBTAP00000036278 ; ENSBTAG00000025762 .
GeneIDi 280752.
KEGGi bta:280752.

Organism-specific databases

CTDi 1267.

Phylogenomic databases

eggNOGi NOG314041.
GeneTreei ENSGT00510000048410.
HOGENOMi HOG000111838.
HOVERGENi HBG001451.
InParanoidi P06623.
KOi K01121.
OMAi LWPNDVD.
OrthoDBi EOG78PVBC.
TreeFami TF332157.

Miscellaneous databases

NextBioi 20804919.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR008431. CNPase.
IPR027417. P-loop_NTPase.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view ]
PANTHERi PTHR10156. PTHR10156. 1 hit.
Pfami PF05881. CNPase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000970. CNPase. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF55144. SSF55144. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and amino acid sequence of bovine brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase."
    Kurihara T., Fowler A.V., Takahashi Y.
    J. Biol. Chem. 262:3256-3261(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Erratum
    Kurihara T., Fowler A.V., Takahashi Y.
    J. Biol. Chem. 262:16754-16754(1987)
    Cited for: SEQUENCE REVISION TO 318.
  3. "Nucleotide sequence of bovine retina 2',3'-cyclic nucleotide 3'-phosphohydrolase."
    Vogel U.S., Thompson R.J.
    Nucleic Acids Res. 15:7204-7204(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  4. "Molecular cloning of the myelin specific enzyme 2',3'-cyclic-nucleotide 3'-phosphohydrolase."
    Vogel U.S., Thompson R.J.
    FEBS Lett. 218:261-265(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCN37_BOVIN
AccessioniPrimary (citable) accession number: P06623
Secondary accession number(s): Q3SZJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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