Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P06623 (CN37_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2',3'-cyclic-nucleotide 3'-phosphodiesterase

Short name=CNP
Short name=CNPase
EC=3.1.4.37
Gene names
Name:CNP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin By similarity.

Catalytic activity

Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.

Subunit structure

Exists as monomers and homodimers By similarity.

Subcellular location

Membrane; Lipid-anchor. Melanosome By similarity. Note: Firmly bound to membrane structures of brain white matter.

Post-translational modification

Met-1 may be removed after translation.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3973972',3'-cyclic-nucleotide 3'-phosphodiesterase
PRO_0000089960
Propeptide398 – 4003Removed in mature form By similarity
PRO_0000422295

Sites

Active site2301Proton acceptor By similarity
Active site3091Proton donor By similarity
Binding site2321Substrate By similarity
Binding site3111Substrate By similarity

Amino acid modifications

Modified residue3971Cysteine methyl ester By similarity
Lipidation3971S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P06623 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: 3448FC367D647CF8

FASTA40044,875
        10         20         30         40         50         60 
MSSSGAKDKP ELQFPFLQDE ETVATLQECK TLFILRGLPG SGKSTLARFI VDKYRDGTKM 

        70         80         90        100        110        120 
VSADSYKITP GARGSFSEEY KQLDEDLAAC CRRDFRVLVL DDTNHERERL EQLFELADQY 

       130        140        150        160        170        180 
QYQVVLVEPK TAWRLDCAQL KEKNQWQLSA DDLKKLKPGL EKDFLPLYFG WFLTKKSSAA 

       190        200        210        220        230        240 
LWKTGQTFLE ELGNHKAFKK ELRHFVSGDE PREKIELVTY FGKRPPGVLH CTTKFCDYGK 

       250        260        270        280        290        300 
AAGAEEYAQQ DVVKKSYCKA FTLTISALFV TPKTTGARVE LSEQQLALWP NDVDKLSPSD 

       310        320        330        340        350        360 
NLPRGSRAHI TLGCAGDVEA VQTGIDLLEI VRQEKGGSRG EEVGELSRGK LYSLGSGRWM 

       370        380        390        400 
LSLAKKMEVR AIFTGYYGKG KAVPIRSGRK GGSFQSCTII 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and amino acid sequence of bovine brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase."
Kurihara T., Fowler A.V., Takahashi Y.
J. Biol. Chem. 262:3256-3261(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Erratum
Kurihara T., Fowler A.V., Takahashi Y.
J. Biol. Chem. 262:16754-16754(1987)
Cited for: SEQUENCE REVISION TO 318.
[3]"Nucleotide sequence of bovine retina 2',3'-cyclic nucleotide 3'-phosphohydrolase."
Vogel U.S., Thompson R.J.
Nucleic Acids Res. 15:7204-7204(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[4]"Molecular cloning of the myelin specific enzyme 2',3'-cyclic-nucleotide 3'-phosphohydrolase."
Vogel U.S., Thompson R.J.
FEBS Lett. 218:261-265(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02659 mRNA. Translation: AAA30456.1. Sequence problems.
Y00405 mRNA. Translation: CAA68466.1.
M27606 mRNA. Translation: AAA30457.1.
BC102820 mRNA. Translation: AAI02821.2.
PIRESBOP3. A26861.
RefSeqNP_851336.1. NM_180993.2.
XP_005220719.1. XM_005220662.1.
UniGeneBt.5517.

3D structure databases

ProteinModelPortalP06623.
SMRP06623. Positions 165-378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP06623. 1 interaction.
STRING9913.ENSBTAP00000036278.

Proteomic databases

PRIDEP06623.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000036420; ENSBTAP00000036278; ENSBTAG00000025762.
GeneID280752.
KEGGbta:280752.

Organism-specific databases

CTD1267.

Phylogenomic databases

eggNOGNOG314041.
GeneTreeENSGT00510000048410.
HOGENOMHOG000111838.
HOVERGENHBG001451.
InParanoidP06623.
KOK01121.
OMALWPNDVD.
OrthoDBEOG78PVBC.
TreeFamTF332157.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR008431. CNPase.
IPR027417. P-loop_NTPase.
IPR009097. RNA_ligase/cNuc_Pdiesterase.
[Graphical view]
PANTHERPTHR10156. PTHR10156. 1 hit.
PfamPF05881. CNPase. 1 hit.
[Graphical view]
PIRSFPIRSF000970. CNPase. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
SSF55144. SSF55144. 1 hit.
ProtoNetSearch...

Other

NextBio20804919.

Entry information

Entry nameCN37_BOVIN
AccessionPrimary (citable) accession number: P06623
Secondary accession number(s): Q3SZJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families