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Protein

Segmentation protein even-skipped

Gene

eve

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair-rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi70 – 12960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • adult heart development Source: FlyBase
  • anterior/posterior axis specification, embryo Source: FlyBase
  • blastoderm segmentation Source: FlyBase
  • cell fate commitment Source: FlyBase
  • cell fate determination Source: FlyBase
  • central nervous system development Source: FlyBase
  • cephalic furrow formation Source: FlyBase
  • germ-band extension Source: FlyBase
  • heart development Source: FlyBase
  • heart morphogenesis Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • muscle organ development Source: FlyBase
  • negative regulation of cardioblast cell fate specification Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • nervous system development Source: FlyBase
  • periodic partitioning by pair rule gene Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • posterior head segmentation Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of myoblast fusion Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • trunk segmentation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Pair-rule protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP06602.

Names & Taxonomyi

Protein namesi
Recommended name:
Segmentation protein even-skipped
Gene namesi
Name:eve
ORF Names:CG2328
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000606. eve.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Segmentation protein even-skippedPRO_0000049060Add
BLAST

Proteomic databases

PaxDbiP06602.
PRIDEiP06602.

Expressioni

Gene expression databases

BgeeiP06602.
ExpressionAtlasiP06602. differential.
GenevisibleiP06602. DM.

Interactioni

Protein-protein interaction databases

BioGridi61867. 10 interactions.
STRINGi7227.FBpp0087478.

Structurei

Secondary structure

1
376
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi79 – 9113Combined sources
Helixi97 – 10711Combined sources
Helixi111 – 12717Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JGGX-ray2.00A/B70-129[»]
ProteinModelPortaliP06602.
SMRiP06602. Positions 72-128.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06602.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi165 – 17915Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the even-skipped homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0844. Eukaryota.
ENOG4111RMB. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000148791.
InParanoidiP06602.
KOiK09320.
OMAiPNECLSS.
OrthoDBiEOG7M98GX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGYRTYNME SHHAHHDASP VDQKPLVVDL LATQYGKPQT PPPSPNECLS
60 70 80 90 100
SPDNSLNGSR GSEIPADPSV RRYRTAFTRD QLGRLEKEFY KENYVSRPRR
110 120 130 140 150
CELAAQLNLP ESTIKVWFQN RRMKDKRQRI AVAWPYAAVY SDPAFAASIL
160 170 180 190 200
QAAANSVGMP YPPYAPAAAA AAAAAAAVAT NPMMATGMPP MGMPQMPTMQ
210 220 230 240 250
MPGHSGHAGH PSPYGQYRYT PYHIPARPAP PHPAGPHMHH PHMMGSSATG
260 270 280 290 300
SSYSAGAAGL LGALPSATCY TGLGVGVPKT QTPPLDLQSS SSPHSSTLSL
310 320 330 340 350
SPVGSDHAKV FDRSPVAQSA PSVPAPAPLT TTSPLPAPGL LMPSAKRPAS
360 370
DMSPPPTTTV IAEPKPKLFK PYKTEA
Length:376
Mass (Da):39,970
Last modified:December 1, 2000 - v3
Checksum:i59058E0634B1BED0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001L → V in AAA28522 (PubMed:2877745).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14767 Genomic DNA. Translation: AAA28522.1.
X05138 mRNA. Translation: CAA28784.1.
AE013599 Genomic DNA. Translation: AAF58865.1.
U32087 Genomic DNA. Translation: AAB05358.1.
U32088 Genomic DNA. Translation: AAB05359.1.
U32089 Genomic DNA. Translation: AAB05360.1.
U32090 Genomic DNA. Translation: AAB05361.1.
U32091 Genomic DNA. Translation: AAB05362.1.
PIRiA26066.
RefSeqiNP_523670.2. NM_078946.4.
UniGeneiDm.18510.

Genome annotation databases

EnsemblMetazoaiFBtr0088390; FBpp0087478; FBgn0000606.
GeneIDi36039.
KEGGidme:Dmel_CG2328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14767 Genomic DNA. Translation: AAA28522.1.
X05138 mRNA. Translation: CAA28784.1.
AE013599 Genomic DNA. Translation: AAF58865.1.
U32087 Genomic DNA. Translation: AAB05358.1.
U32088 Genomic DNA. Translation: AAB05359.1.
U32089 Genomic DNA. Translation: AAB05360.1.
U32090 Genomic DNA. Translation: AAB05361.1.
U32091 Genomic DNA. Translation: AAB05362.1.
PIRiA26066.
RefSeqiNP_523670.2. NM_078946.4.
UniGeneiDm.18510.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JGGX-ray2.00A/B70-129[»]
ProteinModelPortaliP06602.
SMRiP06602. Positions 72-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61867. 10 interactions.
STRINGi7227.FBpp0087478.

Proteomic databases

PaxDbiP06602.
PRIDEiP06602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088390; FBpp0087478; FBgn0000606.
GeneIDi36039.
KEGGidme:Dmel_CG2328.

Organism-specific databases

CTDi36039.
FlyBaseiFBgn0000606. eve.

Phylogenomic databases

eggNOGiKOG0844. Eukaryota.
ENOG4111RMB. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000148791.
InParanoidiP06602.
KOiK09320.
OMAiPNECLSS.
OrthoDBiEOG7M98GX.

Enzyme and pathway databases

SignaLinkiP06602.

Miscellaneous databases

EvolutionaryTraceiP06602.
GenomeRNAii36039.
NextBioi796502.
PROiP06602.

Gene expression databases

BgeeiP06602.
ExpressionAtlasiP06602. differential.
GenevisibleiP06602. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box."
    McDonald P.M., Ingham P., Struhl G.
    Cell 47:721-734(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization and localization of the even-skipped protein of Drosophila."
    Frasch M., Hoey T., Rushlow C., Doyle H., Levine M.
    EMBO J. 6:749-759(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "Evolutionary dynamics of the enhancer region of even-skipped in Drosophila."
    Ludwig M.Z., Kreitman M.
    Mol. Biol. Evol. 12:1002-1011(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58.
    Strain: AF-S, FL-S, Oregon-RC, WA-F and ZM56.
  6. "Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity."
    Hirsch J.A., Aggarwal A.K.
    EMBO J. 14:6280-6291(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 70-189.

Entry informationi

Entry nameiEVE_DROME
AccessioniPrimary (citable) accession number: P06602
Secondary accession number(s): P07667, Q9V5E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 1, 2000
Last modified: May 11, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.