P06583 (AT1B1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1

Gene names

Name:

ATP1B1

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Sodium/potassium-transporting ATPase subunit beta-1		PRO_0000219096
Regions
	Topological domain	1 – 34	34	Cytoplasmic Potential
	Transmembrane	35 – 62	28	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	63 – 303	241	Extracellular Potential
Amino acid modifications
	Modified residue	101	1	Phosphotyrosine By similarity
	Glycosylation	158	1	N-linked (GlcNAc...) Ref.2
	Glycosylation	193	1	N-linked (GlcNAc...) Ref.2
	Glycosylation	265	1	N-linked (GlcNAc...) Ref.2
	Disulfide bond	126 ↔ 149
	Disulfide bond	159 ↔ 175		Ref.2
	Disulfide bond	213 ↔ 276

Sequences

	Sequence		Length	Mass (Da)
	P06583 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 7E956AA6D5015318	FASTA	303	35,240
	10 20 30 40 50 60 MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT 70 80 90 100 110 120 ISEFKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEE YVRNIVRFLE KYKDSAQKDE 130 140 150 160 170 180 MIFEDCGNMP SEIKERGEFN NERGERKVCR FKLEWLGNCS GINDETYGYR DGKPCVLIKL 190 200 210 220 230 240 NRVLGFKPKP PKNESLEAYP VMKYSPYVLP VQCTGKRDED KDRIGNVEYF GLGGYPGFPL 250 260 270 280 290 300 QYYPYYGKLL QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE VKS

References

[1]	"Molecular cloning and sequence analysis of the (Na+ + K+)-ATPase beta subunit from dog kidney." Brown T.A., Horowitz B., Miller R.P., McDonough A.A., Farley R.A. Biochim. Biophys. Acta 912:244-253(1987) [PubMed: 3030434] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Kidney.
[2]	"All three potential N-glycosylation sites of the dog kidney (Na+ + K+)-ATPase beta-subunit contain oligosaccharide." Miller R.P., Farley R.A. Biochim. Biophys. Acta 954:50-57(1988) [PubMed: 2833926] [Abstract] Cited for: GLYCOSYLATION AT ASN-158; ASN-193 AND ASN-265.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X05297 mRNA. Translation: CAA28917.1.
PIR	PWDGB. S07148.
RefSeq	NP_001003283.1. NM_001003283.1.
UniGene	Cfa.3835.
3D structure databases
ProteinModelPortal	P06583.
SMR	P06583. Positions 28-73.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403966.
KEGG	cfa:403966.
Organism-specific databases
CTD	481.
Phylogenomic databases
eggNOG	maNOG04343.
GeneTree	ENSGT00550000074530.
HOVERGEN	HBG050603.
InParanoid	P06583.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. IPR015565. ATPase_P-typ_Na/K-dep_b1su. [Graphical view]
KO	K01540.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit. PTHR11523:SF10. Na/K_ATPaseBeta1. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT1B1_CANFA

Accession

Primary (citable) accession number: P06583

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	November 16, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program