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Protein

Heat shock protein Hsp-16.41

Gene

hsp-16.41

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: WormBase

GO - Biological processi

  • defense response to Gram-negative bacterium Source: WormBase
  • endoplasmic reticulum unfolded protein response Source: WormBase
  • response to heat Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-CEL-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein Hsp-16.41
Gene namesi
Name:hsp-16.41
Synonyms:hsp16-41
ORF Names:Y46H3A.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY46H3A.2; CE22003; WBGene00002018; hsp-16.41.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Heat shock protein Hsp-16.41PRO_0000125960Add
BLAST

Proteomic databases

EPDiP06581.
PaxDbiP06581.
PRIDEiP06581.

Interactioni

GO - Molecular functioni

  • unfolded protein binding Source: WormBase

Protein-protein interaction databases

IntActiP06581. 2 interactions.
STRINGi6239.Y46H3A.2.

Structurei

3D structure databases

ProteinModelPortaliP06581.
SMRiP06581. Positions 46-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
InParanoidiP06581.
OMAiGHHEERT.
OrthoDBiEOG7WHHBK.
PhylomeDBiP06581.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMLRSPYSD SNALDHFLDE LTGSVQFPYW RNADHNSFNF SDNIGEIVND
60 70 80 90 100
ESKFSVQLDV SHFKPENLKI KLDGRELKIE GIQETKSEHG YLKRSFSKMI
110 120 130 140
LLPEDADLPS VKSAISNEGK LQIEAPKKTN SSRSIPINFV AKH
Length:143
Mass (Da):16,252
Last modified:January 1, 1988 - v1
Checksum:iC1D0F59D26E36C24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14334 Genomic DNA. Translation: AAA28070.1. Sequence problems.
FO081307 Genomic DNA. Translation: CCD70650.1.
X01577 mRNA. Translation: CAA25732.1.
PIRiA25199. HHKW41.
RefSeqiNP_872116.2. NM_182316.4.
UniGeneiCel.24670.

Genome annotation databases

EnsemblMetazoaiY46H3A.2; Y46H3A.2; WBGene00002018.
GeneIDi178660.
KEGGicel:CELE_Y46H3A.2.
UCSCiY46H3A.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14334 Genomic DNA. Translation: AAA28070.1. Sequence problems.
FO081307 Genomic DNA. Translation: CCD70650.1.
X01577 mRNA. Translation: CAA25732.1.
PIRiA25199. HHKW41.
RefSeqiNP_872116.2. NM_182316.4.
UniGeneiCel.24670.

3D structure databases

ProteinModelPortaliP06581.
SMRiP06581. Positions 46-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06581. 2 interactions.
STRINGi6239.Y46H3A.2.

Proteomic databases

EPDiP06581.
PaxDbiP06581.
PRIDEiP06581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY46H3A.2; Y46H3A.2; WBGene00002018.
GeneIDi178660.
KEGGicel:CELE_Y46H3A.2.
UCSCiY46H3A.2. c. elegans.

Organism-specific databases

CTDi178660.
WormBaseiY46H3A.2; CE22003; WBGene00002018; hsp-16.41.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
InParanoidiP06581.
OMAiGHHEERT.
OrthoDBiEOG7WHHBK.
PhylomeDBiP06581.

Enzyme and pathway databases

ReactomeiR-CEL-3371571. HSF1-dependent transactivation.

Miscellaneous databases

NextBioi902038.
PROiP06581.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements."
    Jones D., Russnak R.H., Kay R.J., Candido E.P.M.
    J. Biol. Chem. 261:12006-12015(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Cloning and analysis of cDNA sequences coding for two 16 kilodalton heat shock proteins (hsps) in Caenorhabditis elegans: homology with the small hsps of Drosophila."
    Russnak R.H., Jones D., Candido E.P.M.
    Nucleic Acids Res. 11:3187-3205(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-143.

Entry informationi

Entry nameiHSP16_CAEEL
AccessioniPrimary (citable) accession number: P06581
Secondary accession number(s): P02514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.