P06571 (ERMG_LYSSH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
rRNA adenine N-6-methyltransferase
EC=2.1.1.-

Alternative name(s):
Erythromycin resistance protein
Macrolide-lincosamide-streptogramin B resistance protein

Gene names

Name:

ermG

Organism

Lysinibacillus sphaericus (Bacillus sphaericus)

Taxonomic identifier

1421 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Lysinibacillus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in erythromycin resistance.
Catalytic activity	S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine.
Sequence similarities	Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA (adenine-N6,N6-)-dimethyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	rRNA adenine N-6-methyltransferase		PRO_0000101673

Sequences

	Sequence		Length	Mass (Da)
	P06571 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: E64A1714B32225EF	FASTA	244	28,557
	10 20 30 40 50 60 MNKVNIKDSQ NFITSKYHIE KIMNCISLDE KDNIFEIGAG KGHFTAELVK RCNFVTAIEI 70 80 90 100 110 120 DSKLCEVTRN KLLNYPNYQI VNDDILKFTF PSHNPYKIFG SIPYNISTNI IRKIVFESSA 130 140 150 160 170 180 TISYLIVEYG FAKRLLDTNR SLALLLMAEV DISILAKIPR YYFHPKPKVD SALIVLKRKP 190 200 210 220 230 240 AKMAFKERKK YETFVMKWVN KEYEKLFTKN QFNKALKHAR IYDINNISFE QFVSLFNSYK IFNG

References

[1]	"Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus." Monod M., Mohan S., Dubnau D. J. Bacteriol. 169:340-350(1987) [PubMed: 3025178] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15332 Genomic DNA. Translation: AAA22419.1.
PIR	C26930.
3D structure databases
ProteinModelPortal	P06571.
SMR	P06571. Positions 9-243.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR023165. rRNA_Ade_diMease-like. IPR020596. rRNA_Ade_Mease_Trfase_CS. IPR001737. rRNA_Ade_methylase_transferase. IPR020598. rRNA_Ade_methylase_Trfase_N. [Graphical view]
Gene3D	G3DSA:1.10.8.100. rRNA_Ade_diMease-like. 1 hit.
PANTHER	PTHR11727. RRNA_meth_trans. 1 hit.
Pfam	PF00398. RrnaAD. 1 hit. [Graphical view]
SMART	SM00650. rADc. 1 hit. [Graphical view]
PROSITE	PS01131. RRNA_A_DIMETH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERMG_LYSSH

Accession

Primary (citable) accession number: P06571

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	May 31, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program