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Protein

Endoglucanase A

Gene

celA

Organism
Bacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631Proton donorBy similarity
Active sitei252 – 2521NucleophileBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM5. Carbohydrate-Binding Module Family 5.
GH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase A (EC:3.2.1.4)
Alternative name(s):
Cellulase A
Endo-1,4-beta-glucanase A
Gene namesi
Name:celA
OrganismiBacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)
Taxonomic identifieri649639 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Endoglucanase APRO_0000184044Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP06566.
SMRiP06566. Positions 28-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01179.
OMAiATNIMYA.

Family and domain databases

Gene3Di2.10.10.20. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR003610. CBM_fam5/12.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02839. CBM_5_12. 2 hits.
PF00150. Cellulase. 1 hit.
[Graphical view]
SMARTiSM00495. ChtBD3. 2 hits.
[Graphical view]
SUPFAMiSSF51055. SSF51055. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLTTIFIV FTLALLFVGN STSANNGSVV EQNGQLSIQN GQLVNEHGDP
60 70 80 90 100
VQLKGMSSHG LQWYGQFVNY DSIKWLRDDW GITVFRAAMY TSSGGYIEDP
110 120 130 140 150
SVKEKVKEAV EAAIDLGIYV IIDWHILSDN DPNIYKEEAK EFFDEMSALY
160 170 180 190 200
GDYPNVIYEI ANEPNGHNVR WDSHIKPYAE EVIPVIRAND PNNIVIVGTA
210 220 230 240 250
TWSQDVHEAA DNQLDDPNVM YAFHFYAGTH GQQLRNQVDY ALSRGAAIFV
260 270 280 290 300
SEWGTSAATG DGGVFLDEAQ VWIDFMDERN LSWANWSLTH KDESSAALMP
310 320 330 340 350
GANPTGGWTA AELSPSGAFV REKIRESASI PPSDPTPPSD PDPGEPDPTP
360 370 380 390 400
PSDPGEYPAW DPNQIYTNEI VYHNGQLWQA KWWTQNQEPG ANQYGPWEPL
410 420 430 440 450
GDAPPSEPSD PPPPSEPEPD PGEPDPGEPD PGEPDPTPPS DPGEYPAWDP
460 470 480
TQIYTNEIVY HNGQLWQAKW WTQNQEPGYP YGPWEPLN
Length:488
Mass (Da):54,264
Last modified:December 31, 1987 - v1
Checksum:i97248E453D28D3B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14781 Genomic DNA. Translation: AAA22301.1.
PIRiA25156.
RefSeqiYP_004093451.1. NC_014829.1.

Genome annotation databases

KEGGibco:Bcell_0438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14781 Genomic DNA. Translation: AAA22301.1.
PIRiA25156.
RefSeqiYP_004093451.1. NC_014829.1.

3D structure databases

ProteinModelPortaliP06566.
SMRiP06566. Positions 28-329.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM5. Carbohydrate-Binding Module Family 5.
GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGibco:Bcell_0438.

Phylogenomic databases

KOiK01179.
OMAiATNIMYA.

Family and domain databases

Gene3Di2.10.10.20. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR003610. CBM_fam5/12.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02839. CBM_5_12. 2 hits.
PF00150. Cellulase. 1 hit.
[Graphical view]
SMARTiSM00495. ChtBD3. 2 hits.
[Graphical view]
SUPFAMiSSF51055. SSF51055. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequences of two cellulase genes from alkalophilic Bacillus sp. strain N-4 and their strong homology."
    Fukumori F., Sashihara N., Kudo T., Horikoshi K.
    J. Bacteriol. 168:479-485(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGUN1_BACCJ
AccessioniPrimary (citable) accession number: P06566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 31, 1987
Last sequence update: December 31, 1987
Last modified: March 31, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.