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P06560

- TRPC_CORGL

UniProt

P06560 - TRPC_CORGL

Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (26 Jul 2002)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain By similarity.By similarity

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

    Pathwayi

    GO - Molecular functioni

    1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan biosynthesis protein TrpCF
    Including the following 2 domains:
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpC
    Synonyms:trpCF
    Ordered Locus Names:Cgl3033, cg3362
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Tryptophan biosynthesis protein TrpCFPRO_0000154276Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi196627.cg3362.

    Structurei

    3D structure databases

    ProteinModelPortaliP06560.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 262262Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni263 – 474212N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the TrpC family.Curated
    In the C-terminal section; belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0134.
    KOiK13498.
    OMAiNKQEIKR.
    OrthoDBiEOG6WT8JX.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P06560-1 [UniParc]FASTAAdd to Basket

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    MTSNNLPTVL ESIVEGRRGH LEEIRARIAH VDVDALPKST RSLFDSLNQG    50
    RGGARFIMEC KSASPSLGMI REHYQPGEIA RVYSRYASGI SVLCEPDRFG 100
    GDYDHLATVA ATSHLPVLCK DFIIDPVQVH AARYFGADAI LLMLSVLDDE 150
    EYAALAAEAA RFDLDILTEV IDEEEVARAI KLGAKIFGVN HRNLHDLSID 200
    LDRSRRLSKL IPADAVLVSE SGVRDTETVR QLGGHSNAFL VGSQLTSQEN 250
    VDLAARELVY GPNKVCGLTS PSAAQTARAA GAVYGGLIFE EASPRNVSRE 300
    TLQKIIAAEP NLRYVAVSRR TSGYKDLLVD GIFAVQIHAP LQDSVEAEKA 350
    LIAAVREEVG PQVQVWRAIS MSSPLGAEVA AAVEGDVDKL ILDAHEGGSG 400
    EVFDWATVPA AVKAKSLLAG GISPDNAAQA LAVGCAGLDI NSGVEYPAGA 450
    GTWAGAKDAG ALLKIFATIS TFHY 474
    Length:474
    Mass (Da):50,477
    Last modified:July 26, 2002 - v2
    Checksum:iC347C7016BB97F9A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 892SG → AA in CAA28626. (PubMed:3808947)Curated
    Sequence conflicti110 – 1101A → G in CAA28626. (PubMed:3808947)Curated
    Sequence conflicti130 – 1312HA → RP in CAA28626. (PubMed:3808947)Curated
    Sequence conflicti153 – 1531A → D in CAA28626. (PubMed:3808947)Curated
    Sequence conflicti302 – 3021L → S in CAA28626. (PubMed:3808947)Curated
    Sequence conflicti343 – 3431D → G in CAA28626. (PubMed:3808947)Curated
    Sequence conflicti381 – 3833Missing in CAA28626. (PubMed:3808947)Curated
    Sequence conflicti454 – 47421AGAKD…STFHY → GWGERCRRAAENFRDHLHIP LLKV in CAA28626. (PubMed:3808947)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04960 Genomic DNA. Translation: CAA28626.1.
    BA000036 Genomic DNA. Translation: BAC00427.1.
    BX927157 Genomic DNA. Translation: CAF18973.1.
    PIRiE24723.
    RefSeqiNP_602226.2. NC_003450.3.
    YP_227283.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAC00427; BAC00427; BAC00427.
    CAF18973; CAF18973; cg3362.
    GeneIDi1020975.
    KEGGicgb:cg3362.
    cgl:NCgl2930.
    PATRICi21498118. VBICorGlu203724_2967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04960 Genomic DNA. Translation: CAA28626.1 .
    BA000036 Genomic DNA. Translation: BAC00427.1 .
    BX927157 Genomic DNA. Translation: CAF18973.1 .
    PIRi E24723.
    RefSeqi NP_602226.2. NC_003450.3.
    YP_227283.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali P06560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg3362.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC00427 ; BAC00427 ; BAC00427 .
    CAF18973 ; CAF18973 ; cg3362 .
    GeneIDi 1020975.
    KEGGi cgb:cg3362.
    cgl:NCgl2930.
    PATRICi 21498118. VBICorGlu203724_2967.

    Phylogenomic databases

    eggNOGi COG0134.
    KOi K13498.
    OMAi NKQEIKR.
    OrthoDBi EOG6WT8JX.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide and deduced amino acid sequences of the Brevibacterium lactofermentum tryptophan operon."
      Matsui K., Sano K., Ohtsubo E.
      Nucleic Acids Res. 14:10113-10114(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiTRPC_CORGL
    AccessioniPrimary (citable) accession number: P06560
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: July 26, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3