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P06560

- TRPC_CORGL

UniProt

P06560 - TRPC_CORGL

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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Synonyms:trpCF
Ordered Locus Names:Cgl3033, cg3362
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Tryptophan biosynthesis protein TrpCFPRO_0000154276Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi196627.cg3362.

Structurei

3D structure databases

ProteinModelPortaliP06560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 262262Indole-3-glycerol phosphate synthaseAdd
BLAST
Regioni263 – 474212N-(5'-phosphoribosyl)anthranilate isomeraseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0134.
KOiK13498.
OMAiNKQEIKR.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06560-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTSNNLPTVL ESIVEGRRGH LEEIRARIAH VDVDALPKST RSLFDSLNQG
60 70 80 90 100
RGGARFIMEC KSASPSLGMI REHYQPGEIA RVYSRYASGI SVLCEPDRFG
110 120 130 140 150
GDYDHLATVA ATSHLPVLCK DFIIDPVQVH AARYFGADAI LLMLSVLDDE
160 170 180 190 200
EYAALAAEAA RFDLDILTEV IDEEEVARAI KLGAKIFGVN HRNLHDLSID
210 220 230 240 250
LDRSRRLSKL IPADAVLVSE SGVRDTETVR QLGGHSNAFL VGSQLTSQEN
260 270 280 290 300
VDLAARELVY GPNKVCGLTS PSAAQTARAA GAVYGGLIFE EASPRNVSRE
310 320 330 340 350
TLQKIIAAEP NLRYVAVSRR TSGYKDLLVD GIFAVQIHAP LQDSVEAEKA
360 370 380 390 400
LIAAVREEVG PQVQVWRAIS MSSPLGAEVA AAVEGDVDKL ILDAHEGGSG
410 420 430 440 450
EVFDWATVPA AVKAKSLLAG GISPDNAAQA LAVGCAGLDI NSGVEYPAGA
460 470
GTWAGAKDAG ALLKIFATIS TFHY
Length:474
Mass (Da):50,477
Last modified:July 26, 2002 - v2
Checksum:iC347C7016BB97F9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 892SG → AA in CAA28626. (PubMed:3808947)Curated
Sequence conflicti110 – 1101A → G in CAA28626. (PubMed:3808947)Curated
Sequence conflicti130 – 1312HA → RP in CAA28626. (PubMed:3808947)Curated
Sequence conflicti153 – 1531A → D in CAA28626. (PubMed:3808947)Curated
Sequence conflicti302 – 3021L → S in CAA28626. (PubMed:3808947)Curated
Sequence conflicti343 – 3431D → G in CAA28626. (PubMed:3808947)Curated
Sequence conflicti381 – 3833Missing in CAA28626. (PubMed:3808947)Curated
Sequence conflicti454 – 47421AGAKD…STFHY → GWGERCRRAAENFRDHLHIP LLKV in CAA28626. (PubMed:3808947)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04960 Genomic DNA. Translation: CAA28626.1.
BA000036 Genomic DNA. Translation: BAC00427.1.
BX927157 Genomic DNA. Translation: CAF18973.1.
PIRiE24723.
RefSeqiNP_602226.2. NC_003450.3.
YP_227283.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAC00427; BAC00427; BAC00427.
CAF18973; CAF18973; cg3362.
GeneIDi1020975.
3345646.
KEGGicgl:NCgl2930.
PATRICi21498118. VBICorGlu203724_2967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04960 Genomic DNA. Translation: CAA28626.1 .
BA000036 Genomic DNA. Translation: BAC00427.1 .
BX927157 Genomic DNA. Translation: CAF18973.1 .
PIRi E24723.
RefSeqi NP_602226.2. NC_003450.3.
YP_227283.1. NC_006958.1.

3D structure databases

ProteinModelPortali P06560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg3362.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC00427 ; BAC00427 ; BAC00427 .
CAF18973 ; CAF18973 ; cg3362 .
GeneIDi 1020975.
3345646.
KEGGi cgl:NCgl2930.
PATRICi 21498118. VBICorGlu203724_2967.

Phylogenomic databases

eggNOGi COG0134.
KOi K13498.
OMAi NKQEIKR.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
UPA00035 ; UER00043 .

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide and deduced amino acid sequences of the Brevibacterium lactofermentum tryptophan operon."
    Matsui K., Sano K., Ohtsubo E.
    Nucleic Acids Res. 14:10113-10114(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiTRPC_CORGL
AccessioniPrimary (citable) accession number: P06560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 26, 2002
Last modified: November 26, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3