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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE), Anthranilate synthase component 2 (trpG)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Tryptophan biosynthesis protein TrpCF (trpC)
  4. Tryptophan biosynthesis protein TrpCF (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Isomerase, Lyase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciCORYNE:G18NG-12654-MONOMER
UniPathwayiUPA00035; UER00042
UPA00035; UER00043

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Synonyms:trpCF
Ordered Locus Names:Cgl3033, cg3362
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001542761 – 474Tryptophan biosynthesis protein TrpCFAdd BLAST474

Proteomic databases

PRIDEiP06560

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi196627.cg3362

Structurei

3D structure databases

ProteinModelPortaliP06560
SMRiP06560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 262Indole-3-glycerol phosphate synthaseAdd BLAST262
Regioni263 – 474N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST212

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiENOG4105DK0 Bacteria
COG0134 LUCA
COG0135 LUCA
KOiK13498
OMAiYDIIGIN

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 2 hits
PROSITEiView protein in PROSITE
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

P06560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNNLPTVL ESIVEGRRGH LEEIRARIAH VDVDALPKST RSLFDSLNQG
60 70 80 90 100
RGGARFIMEC KSASPSLGMI REHYQPGEIA RVYSRYASGI SVLCEPDRFG
110 120 130 140 150
GDYDHLATVA ATSHLPVLCK DFIIDPVQVH AARYFGADAI LLMLSVLDDE
160 170 180 190 200
EYAALAAEAA RFDLDILTEV IDEEEVARAI KLGAKIFGVN HRNLHDLSID
210 220 230 240 250
LDRSRRLSKL IPADAVLVSE SGVRDTETVR QLGGHSNAFL VGSQLTSQEN
260 270 280 290 300
VDLAARELVY GPNKVCGLTS PSAAQTARAA GAVYGGLIFE EASPRNVSRE
310 320 330 340 350
TLQKIIAAEP NLRYVAVSRR TSGYKDLLVD GIFAVQIHAP LQDSVEAEKA
360 370 380 390 400
LIAAVREEVG PQVQVWRAIS MSSPLGAEVA AAVEGDVDKL ILDAHEGGSG
410 420 430 440 450
EVFDWATVPA AVKAKSLLAG GISPDNAAQA LAVGCAGLDI NSGVEYPAGA
460 470
GTWAGAKDAG ALLKIFATIS TFHY
Length:474
Mass (Da):50,477
Last modified:July 26, 2002 - v2
Checksum:iC347C7016BB97F9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88 – 89SG → AA in CAA28626 (PubMed:3808947).Curated2
Sequence conflicti110A → G in CAA28626 (PubMed:3808947).Curated1
Sequence conflicti130 – 131HA → RP in CAA28626 (PubMed:3808947).Curated2
Sequence conflicti153A → D in CAA28626 (PubMed:3808947).Curated1
Sequence conflicti302L → S in CAA28626 (PubMed:3808947).Curated1
Sequence conflicti343D → G in CAA28626 (PubMed:3808947).Curated1
Sequence conflicti381 – 383Missing in CAA28626 (PubMed:3808947).Curated3
Sequence conflicti454 – 474AGAKD…STFHY → GWGERCRRAAENFRDHLHIP LLKV in CAA28626 (PubMed:3808947).CuratedAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04960 Genomic DNA Translation: CAA28626.1
BA000036 Genomic DNA Translation: BAC00427.1
BX927157 Genomic DNA Translation: CAF18973.1
PIRiE24723
RefSeqiNP_602226.2, NC_003450.3
WP_011015582.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAC00427; BAC00427; BAC00427
CAF18973; CAF18973; cg3362
GeneIDi1020975
KEGGicgb:cg3362
cgl:NCgl2930
PATRICifig|196627.13.peg.2967

Similar proteinsi

Entry informationi

Entry nameiTRPC_CORGL
AccessioniPrimary (citable) accession number: P06560
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 26, 2002
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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