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P06548

- BLA3_BACCE

UniProt

P06548 - BLA3_BACCE

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Protein
Beta-lactamase 3
Gene
blaZ
Organism
Bacillus cereus
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Acyl-ester intermediate By similarity
Active sitei191 – 1911Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 3 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase III
Gene namesi
Name:blaZ
OrganismiBacillus cereus
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929
Add
BLAST
Chaini30 – 316287Beta-lactamase 3
PRO_0000016968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi30 – 301N-palmitoyl cysteine Inferred
Lipidationi30 – 301S-diacylglycerol cysteine

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliP06548.
SMRiP06548. Positions 59-311.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2593Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06548-1 [UniParc]FASTAAdd to Basket

« Hide

MFVLNKFFTN SHYKKIVPVV LLSCATLIGC SNSNTQSESN KQTNQTNQVK    50
QENKRNHAFA KLEKEYNAKL GIYALDTSTN QTVAYHADDR FAFASTSKSL 100
AVGALLRQNS IEALDERITY TRKDLSNYNP ITEKHVDTGM TLKELADASV 150
RYSDSTAHNL ILKKLGGPSA FEKILREMGD TVTNSERFEP ELNEVNPGET 200
HDTSTPKAIA KTLQSFTLGT VLPSEKRELL VDWMKRNTTG DKLIRAGVPK 250
GWEVADKTGA GSYGTRNDIA IIWPPNKKPI VLSILSNHDK EDAEYDDTLI 300
ADATKIVLET LKVTNK 316
Length:316
Mass (Da):35,141
Last modified:January 1, 1988 - v1
Checksum:i27A082AB9CCBC9DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15195 Genomic DNA. Translation: AAA22274.1.
PIRiA27755. PNBSLC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15195 Genomic DNA. Translation: AAA22274.1 .
PIRi A27755. PNBSLC.

3D structure databases

ProteinModelPortali P06548.
SMRi P06548. Positions 59-311.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the blaZ gene encoding beta-lactamase III, a lipoprotein of Bacillus cereus 569/H."
    Hussain M., Pastor F.I.J., Lampen J.O.
    J. Bacteriol. 169:579-586(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 135-146.
    Strain: 569/H / NCTC 9945.
  2. "Beta-lactamase III of Bacillus cereus 569: membrane lipoprotein and secreted protein."
    Nielsen J.B., Lampen J.O.
    Biochemistry 22:4652-4656(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: DIACYLGLYCEROL AT CYS-30, PALMITOYLATION AT CYS-30.

Entry informationi

Entry nameiBLA3_BACCE
AccessioniPrimary (citable) accession number: P06548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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