P06538 (DPOL_ADE12) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA polymerase
EC=2.7.7.7

Gene names

Name:

POL

Organism

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) [Complete proteome]

Taxonomic identifier

28282 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	1061 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Miscellaneous	This DNA polymerase requires a protein as a primer.
Sequence similarities	Belongs to the DNA polymerase type-B family.
Sequence caution	The sequence AAA42478.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	DNA replication
Ligand	DNA-binding
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro
Molecular_function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1061	1061	DNA polymerase		PRO_0000046496
Experimental info
	Sequence conflict	32	1	R → S in AAA42478. Ref.1
	Sequence conflict	162	1	V → L in AAA42478. Ref.1
	Sequence conflict	181 – 182	2	LQ → YN in AAA42478. Ref.1
	Sequence conflict	461	1	S → T in AAA42478. Ref.1
	Sequence conflict	575	1	L → F in AAA42478. Ref.1
	Sequence conflict	892	1	S → T in AAA42478. Ref.1
	Sequence conflict	1030	1	K → M in AAA42478. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P06538 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: 33FBA89C33065C08	FASTA	1,061	121,728
	10 20 30 40 50 60 MLFSLTDTMD SSRLYALISR FRPSRAEIWT CRSRGTVTLS VLAFEDPNGS GNAAEEEEDE 70 80 90 100 110 120 RQLPSGIDFP ICFLVRGRQV HLIQQIQPVQ RCEHCARFYK HQHECSVRRR DFYFHHINSH 130 140 150 160 170 180 SSNWWQEIHF FPIGSHPRTE RLFITYDVET YTWMGAFGKQ LVPFMLVMKL SGDDNLVKHA 190 200 210 220 230 240 LQLALELGWD QWEKDSTTFY CLTPEKMKVG QQFRTYRNRL QTSLATDLWM TFLQKNPHLS 250 260 270 280 290 300 QWAQEENGLV ALEDLSYEDL KRAPAIKGEP RFVELYIVGH NINGFDEIVL AAQVINNRLD 310 320 330 340 350 360 VPGPFKISRN FIPRAGKILF NDITFALPNP HYKKRTNFLL WEHGGCDDQD FKYQYLKVMV 370 380 390 400 410 420 RDTFALTHTS LRKAAQAYAL PVEKGCCPYK AVNQFYMLGS YRADANGFPL EEYWKDKEEY 430 440 450 460 470 480 LLNQELWKKK GEKNYNLIGE TLNYCALDVL VTASLVEKLR SSYAQFVTDA VGLDAAHFNV 490 500 510 520 530 540 FQRPTISSNS HAIFRQILYR AEKPQRTHLG PNILAPSHEL YDYVRASIRG GRCYPTYIGV 550 560 570 580 590 600 LKEPIYVYDI CGMYASALTH PMPWGPPLNP YERALAVRQW QVALENYTCK IDYFDKNLCP 610 620 630 640 650 660 GIFTIDADPP DENQLDVLPP FCSRKGGRLA WTNESLRGEV VTSVDLVTLH NRGWRLRLLS 670 680 690 700 710 720 DERTTIFPTW KCLAREYVQL NIAAKERADR DKNQTLRSIA KLLSNALYGS FATKLDNKKI 730 740 750 760 770 780 VFSDQMEESL MKEIAAGRLN IKSSSFIETD TLSTEVMPAF ERVYSPNQLA LVNSEAEESD 790 800 810 820 830 840 EDQGPAPFYS PPPENCEHVT YTYKPITFMD AEEGDMCLHT LESSNPLINN DRYPSHVASF 850 860 870 880 890 900 VLAWTRAFVS EWSEFLYEED RGIPLKDRPL KSVYGDTDSL FVTEKGRRLM ESQGKKRIKK 910 920 930 940 950 960 YGGKLVFDPS CPELTWSVEC ETVCSYCGAD AYSPESVFLA PKLYALKCLQ CPHCGSTSKG 970 980 990 1000 1010 1020 KIRAKGHATE ALSYDLMLKC YLAEAQGEDT RFSTSRLSLK RTLASAQPGA HPFTVTETTL 1030 1040 1050 1060 TRTLRPWKDK TLVHLDAHRL VPYSNSQPNP RNEEVCWIEM A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the genes encoded in early region 2b of human adenovirus type 12." Shu L., Hong J.S., Wei Y.-F., Engler J.A. Gene 46:187-195(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M14785 Genomic DNA. Translation: AAA42478.1. Different initiation. X73487 Genomic DNA. Translation: CAA51882.1.
PIR	DJAD12. S33933.
3D structure databases
ProteinModelPortal	P06538.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	CLSP2513875.
Family and domain databases
Gene3D	3.90.1600.10. 2 hits.
InterPro	IPR006172. DNA-dir_DNA_pol_B. IPR014382. DNA-dir_DNA_pol_B_adenovir. IPR017964. DNA-dir_DNA_pol_B_CS. IPR004868. DNA-dir_DNA_pol_B_mt/vir. IPR006134. DNA-dir_DNA_pol_B_multi_dom. IPR023211. DNA_pol_palm_dom. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00136. DNA_pol_B. 1 hit. PF03175. DNA_pol_B_2. 1 hit. [Graphical view]
PIRSF	PIRSF000788. DPol_ADV. 1 hit.
PRINTS	PR00106. DNAPOLB.
SMART	SM00486. POLBc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS00116. DNA_POLYMERASE_B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPOL_ADE12

Accession

Primary (citable) accession number: P06538

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program