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Protein

Sporulation initiation phosphotransferase B

Gene

spo0B

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Key element in the phosphorelay regulating sporulation initiation. Acts on spo0A. Mediates reversible phosphoryl transfer from spo0F to spo0A.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Sensory transduction, Sporulation

Enzyme and pathway databases

BioCyciBSUB:BSU27930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation initiation phosphotransferase B (EC:2.7.-.-)
Alternative name(s):
Stage 0 sporulation protein B
Stage 0 sporulation protein D
Gene namesi
Name:spo0B
Synonyms:spo0D
Ordered Locus Names:BSU27930
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30H → A: Loss of sporulation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720521 – 192Sporulation initiation phosphotransferase BAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Phosphohistidine1 Publication1

Post-translational modificationi

Phosphorylated by spo0F.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP06535.

PTM databases

iPTMnetiP06535.

Expressioni

Developmental stagei

Expressed during sporulation.

Interactioni

Subunit structurei

Homodimer. Dimerization is essential for activity as both monomers contribute to the formation of the active site.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015266.

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 44Combined sources30
Helixi48 – 69Combined sources22
Turni70 – 72Combined sources3
Helixi74 – 82Combined sources9
Helixi83 – 85Combined sources3
Beta strandi89 – 99Combined sources11
Turni104 – 106Combined sources3
Helixi107 – 124Combined sources18
Beta strandi127 – 129Combined sources3
Beta strandi132 – 138Combined sources7
Beta strandi142 – 154Combined sources13
Helixi159 – 161Combined sources3
Helixi163 – 166Combined sources4
Beta strandi175 – 180Combined sources6
Beta strandi182 – 191Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F51X-ray3.00A/B/C/D11-192[»]
1IXMX-ray2.60A/B1-192[»]
2FTKX-ray3.05A/B/C/D1-192[»]
ProteinModelPortaliP06535.
SMRiP06535.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06535.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000097276.
KOiK06375.
OMAiRHARHDW.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.30. 1 hit.
InterProiIPR003661. HisK_dim/P.
IPR016120. Sig_transdc_His_kin_SpoOB.
IPR016122. SpoOB_C.
[Graphical view]
PfamiPF14682. SPOB_ab. 1 hit.
[Graphical view]
SMARTiSM01317. SPOB_ab. 1 hit.
[Graphical view]
SUPFAMiSSF55890. SSF55890. 1 hit.

Sequencei

Sequence statusi: Complete.

P06535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVSKNQEE NISDTALTNE LIHLLGHSRH DWMNKLQLIK GNLSLQKYDR
60 70 80 90 100
VFEMIEEMVI DAKHESKLSN LKTPHLAFDF LTFNWKTHYM TLEYEVLGEI
110 120 130 140 150
KDLSAYDQKL AKLMRKLFHL FDQAVSRESE NHLTVSLQTD HPDRQLILYL
160 170 180 190
DFHGAFADPS AFDDIRQNGY EDVDIMRFEI TSHECLIEIG LD
Length:192
Mass (Da):22,543
Last modified:January 1, 1988 - v1
Checksum:i3A9A38B5FFB55647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02655 Genomic DNA. Translation: CAA26489.1.
M24537 Genomic DNA. Translation: AAA22504.1.
K02664 Genomic DNA. Translation: AAB05348.1.
AL009126 Genomic DNA. Translation: CAB14753.1.
PIRiA22974. SZBS0B.
RefSeqiNP_390671.1. NC_000964.3.
WP_004399131.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14753; CAB14753; BSU27930.
GeneIDi935956.
KEGGibsu:BSU27930.
PATRICi18977456. VBIBacSub10457_2917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02655 Genomic DNA. Translation: CAA26489.1.
M24537 Genomic DNA. Translation: AAA22504.1.
K02664 Genomic DNA. Translation: AAB05348.1.
AL009126 Genomic DNA. Translation: CAB14753.1.
PIRiA22974. SZBS0B.
RefSeqiNP_390671.1. NC_000964.3.
WP_004399131.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F51X-ray3.00A/B/C/D11-192[»]
1IXMX-ray2.60A/B1-192[»]
2FTKX-ray3.05A/B/C/D1-192[»]
ProteinModelPortaliP06535.
SMRiP06535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015266.

PTM databases

iPTMnetiP06535.

Proteomic databases

PaxDbiP06535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14753; CAB14753; BSU27930.
GeneIDi935956.
KEGGibsu:BSU27930.
PATRICi18977456. VBIBacSub10457_2917.

Phylogenomic databases

HOGENOMiHOG000097276.
KOiK06375.
OMAiRHARHDW.

Enzyme and pathway databases

BioCyciBSUB:BSU27930-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP06535.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.30. 1 hit.
InterProiIPR003661. HisK_dim/P.
IPR016120. Sig_transdc_His_kin_SpoOB.
IPR016122. SpoOB_C.
[Graphical view]
PfamiPF14682. SPOB_ab. 1 hit.
[Graphical view]
SMARTiSM01317. SPOB_ab. 1 hit.
[Graphical view]
SUPFAMiSSF55890. SSF55890. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSP0B_BACSU
AccessioniPrimary (citable) accession number: P06535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.