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P06515 (CHSY_ANTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismAntirrhinum majus (Garden snapdragon)
Taxonomic identifier4151 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeAntirrhineaeAntirrhinum

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Chalcone synthase
PRO_0000215952

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
P06515 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 5969FE2705CE3FF1

FASTA39042,636
        10         20         30         40         50         60 
MVTVEEVRRA QRAEGPATVL AIGTATPANC VDQSTYPDYY FRITNSEHMT ELKEKFKRMC 

        70         80         90        100        110        120 
DKSNIKRRYM HLTEEILKEN PAMCEYMAPS LDARQDIVVV EVPRLGKEAA QKAIKEWGQP 

       130        140        150        160        170        180 
KSKITHLVFC TTSGVDMPGA DYQLTKLLGL RPSVKRFMMY QQGCFAGGTV LRMAKDLAEN 

       190        200        210        220        230        240 
NAGARVLVVC SEITAVTFRG PADTHLDSLV GQALFGDGAA AVIVGSDPVV GVERPLFQIV 

       250        260        270        280        290        300 
TAAQTLLPDS HGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLKEAFDPL GISDWNSVFW 

       310        320        330        340        350        360 
IAHPGGPAIL DQVEEKLGLK PEKLRSTRQV LSEYGNMSSA CVLFILDEMR KSSAKEGMST 

       370        380        390 
TGEGLDWGVL FGFGPGLTVE TVVLHSVPLN 

« Hide

References

[1]"Structure of the chalcone synthase gene of Antirrhinum majus."
Sommer H., Saedler H.
Mol. Gen. Genet. 202:429-434(1986)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03710 Genomic DNA. Translation: CAA27338.1.
PIRSYSKCD. S07312.

3D structure databases

ProteinModelPortalP06515.
SMRP06515. Positions 3-389.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_ANTMA
AccessionPrimary (citable) accession number: P06515
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways