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Protein

Beta-crystallin S

Gene

CRYGS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin S
Alternative name(s):
Gamma-S-crystallin
Gamma-crystallin S
Gene namesi
Name:CRYGS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 178177Beta-crystallin SPRO_0000057564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCurated

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP06504.
PRIDEiP06504.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004084.

Structurei

Secondary structure

1
178
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi95 – 1017Combined sources
Helixi102 – 1043Combined sources
Beta strandi108 – 1136Combined sources
Helixi118 – 1225Combined sources
Beta strandi129 – 1357Combined sources
Beta strandi137 – 1426Combined sources
Turni143 – 1453Combined sources
Beta strandi146 – 1527Combined sources
Beta strandi154 – 1596Combined sources
Helixi160 – 1634Combined sources
Beta strandi172 – 1754Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A7HX-ray2.56A/B94-178[»]
ProteinModelPortaliP06504.
SMRiP06504. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06504.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 4439Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini45 – 8743Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini94 – 13441Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini135 – 17743Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 54N-terminal arm
Regioni88 – 936Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP06504.
OMAiQSFRRIM.
OrthoDBiEOG70CR7Z.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAGTKITF FEDKNFQGRH YDSDCDCADF HMYLSRCNSI RVEGGTWAVY
60 70 80 90 100
ERPNFAGYMY ILPRGEYPEY QHWMGLNDRL SSCRAVHLSS GGQYKLQIFE
110 120 130 140 150
KGDFNGQMHE TTEDCPSIME QFHMREVHSC KVLEGAWIFY ELPNYRGRQY
160 170
LLDKKEYRKP VDWGAASPAV QSFRRIVE
Length:178
Mass (Da):20,928
Last modified:January 23, 2007 - v2
Checksum:i03953B5627186F1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03006 mRNA. Translation: CAA26791.1.
M21095, M21094 Genomic DNA. Translation: AAA30477.1.
PIRiA91017. CYBOS.
RefSeqiNP_776717.1. NM_174292.2.
UniGeneiBt.1647.

Genome annotation databases

EnsembliENSBTAT00000004084; ENSBTAP00000004084; ENSBTAG00000003140.
GeneIDi281724.
KEGGibta:281724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03006 mRNA. Translation: CAA26791.1.
M21095, M21094 Genomic DNA. Translation: AAA30477.1.
PIRiA91017. CYBOS.
RefSeqiNP_776717.1. NM_174292.2.
UniGeneiBt.1647.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A7HX-ray2.56A/B94-178[»]
ProteinModelPortaliP06504.
SMRiP06504. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004084.

Proteomic databases

PaxDbiP06504.
PRIDEiP06504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004084; ENSBTAP00000004084; ENSBTAG00000003140.
GeneIDi281724.
KEGGibta:281724.

Organism-specific databases

CTDi1427.

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP06504.
OMAiQSFRRIM.
OrthoDBiEOG70CR7Z.

Miscellaneous databases

EvolutionaryTraceiP06504.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Beta s-crystallin: structure and evolution of a distinct member of the beta gamma-superfamily."
    Quax-Jeuken Y., Driessen H.P.C., Leunissen J., Quax W.J., de Jong W.W., Bloemendal H.
    EMBO J. 4:2597-2602(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the bovine eye lens gamma s-crystallin gene (formerly beta s)."
    van Rens G.L.M., Raats J.M.H., Driessen H.P.C., Oldenburg M., Wijnen J.T., Khan P.M., de Jong W.W., Bloemendal H.
    Gene 78:225-233(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis."
    Basak A.K., Kroone R.C., Lubsen N.H., Naylor C.E., Jaenicke R., Slingsby C.
    Protein Eng. 11:337-344(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.56 ANGSTROMS) OF 93-178.

Entry informationi

Entry nameiCRBS_BOVIN
AccessioniPrimary (citable) accession number: P06504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.