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Protein

Beta-crystallin S

Gene

CRYGS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin S
Alternative name(s):
Gamma-S-crystallin
Gamma-crystallin S
Gene namesi
Name:CRYGS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000575642 – 178Beta-crystallin SAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCurated1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP06504.
PRIDEiP06504.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003140.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004084.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi95 – 101Combined sources7
Helixi102 – 104Combined sources3
Beta strandi108 – 113Combined sources6
Helixi118 – 122Combined sources5
Beta strandi129 – 135Combined sources7
Beta strandi137 – 142Combined sources6
Turni143 – 145Combined sources3
Beta strandi146 – 152Combined sources7
Beta strandi154 – 159Combined sources6
Helixi160 – 163Combined sources4
Beta strandi172 – 175Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7HX-ray2.56A/B94-178[»]
ProteinModelPortaliP06504.
SMRiP06504.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06504.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 44Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini45 – 87Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini94 – 134Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini135 – 177Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 5N-terminal arm4
Regioni88 – 93Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP06504.
OMAiSIMEEWH.
OrthoDBiEOG091G0L2P.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAGTKITF FEDKNFQGRH YDSDCDCADF HMYLSRCNSI RVEGGTWAVY
60 70 80 90 100
ERPNFAGYMY ILPRGEYPEY QHWMGLNDRL SSCRAVHLSS GGQYKLQIFE
110 120 130 140 150
KGDFNGQMHE TTEDCPSIME QFHMREVHSC KVLEGAWIFY ELPNYRGRQY
160 170
LLDKKEYRKP VDWGAASPAV QSFRRIVE
Length:178
Mass (Da):20,928
Last modified:January 23, 2007 - v2
Checksum:i03953B5627186F1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03006 mRNA. Translation: CAA26791.1.
M21095, M21094 Genomic DNA. Translation: AAA30477.1.
PIRiA91017. CYBOS.
RefSeqiNP_776717.1. NM_174292.2.
UniGeneiBt.1647.

Genome annotation databases

EnsembliENSBTAT00000004084; ENSBTAP00000004084; ENSBTAG00000003140.
GeneIDi281724.
KEGGibta:281724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03006 mRNA. Translation: CAA26791.1.
M21095, M21094 Genomic DNA. Translation: AAA30477.1.
PIRiA91017. CYBOS.
RefSeqiNP_776717.1. NM_174292.2.
UniGeneiBt.1647.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7HX-ray2.56A/B94-178[»]
ProteinModelPortaliP06504.
SMRiP06504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004084.

Proteomic databases

PaxDbiP06504.
PRIDEiP06504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004084; ENSBTAP00000004084; ENSBTAG00000003140.
GeneIDi281724.
KEGGibta:281724.

Organism-specific databases

CTDi1427.

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP06504.
OMAiSIMEEWH.
OrthoDBiEOG091G0L2P.

Miscellaneous databases

EvolutionaryTraceiP06504.

Gene expression databases

BgeeiENSBTAG00000003140.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBS_BOVIN
AccessioniPrimary (citable) accession number: P06504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.