##gff-version 3 P06494 UniProtKB Signal peptide 1 22 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P06494 UniProtKB Chain 23 1257 . . . ID=PRO_0000016671;Note=Receptor tyrosine-protein kinase erbB-2 P06494 UniProtKB Topological domain 23 654 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06494 UniProtKB Transmembrane 655 677 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06494 UniProtKB Topological domain 678 1257 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06494 UniProtKB Domain 722 989 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P06494 UniProtKB Region 678 691 . . . Note=Required for interaction with KPNB1 and EEA1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06494 UniProtKB Region 1029 1181 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06494 UniProtKB Region 1197 1199 . . . Note=Interaction with PIK3C2B;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06494 UniProtKB Region 1200 1257 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06494 UniProtKB Motif 678 691 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250 P06494 UniProtKB Compositional bias 1222 1244 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P06494 UniProtKB Active site 847 847 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 P06494 UniProtKB Binding site 728 736 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P06494 UniProtKB Binding site 755 755 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P06494 UniProtKB Modified residue 879 879 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Modified residue 1056 1056 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06494 UniProtKB Modified residue 1080 1080 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06494 UniProtKB Modified residue 1085 1085 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P06494 UniProtKB Modified residue 1109 1109 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Modified residue 1114 1114 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Modified residue 1141 1141 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Modified residue 1168 1168 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Modified residue 1198 1198 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Modified residue 1250 1250 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Glycosylation 68 68 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Glycosylation 188 188 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Glycosylation 260 260 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:12610629,ECO:0007744|PDB:1N8Y;Dbxref=PMID:12610629 P06494 UniProtKB Glycosylation 532 532 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06494 UniProtKB Glycosylation 573 573 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06494 UniProtKB Glycosylation 631 631 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06494 UniProtKB Disulfide bond 26 53 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 163 193 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 196 205 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 200 213 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 221 228 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 225 236 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 237 245 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 241 253 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 256 265 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 269 296 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 300 312 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 316 332 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 335 339 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 343 368 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 476 506 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 513 522 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 517 530 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 533 542 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 546 562 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 565 578 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 569 586 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 589 598 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 602 625 . . . Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1N8Y P06494 UniProtKB Disulfide bond 628 636 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Disulfide bond 632 644 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P06494 UniProtKB Natural variant 661 661 . . . Note=In oncogenic NEU. V->E P06494 UniProtKB Sequence conflict 145 145 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06494 UniProtKB Sequence conflict 505 509 . . . Note=LCVSS->CGLE;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06494 UniProtKB Beta strand 25 27 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 39 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 54 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 72 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 79 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 84 88 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Turn 109 111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 112 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 153 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 170 173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 176 178 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 201 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 205 209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 228 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 233 235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 241 243 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 245 249 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 252 261 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 264 268 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 272 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 290 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 295 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 310 315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 320 324 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 330 334 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 349 351 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Turn 359 361 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 362 365 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 369 377 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 379 383 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Turn 386 389 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 395 401 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 406 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 411 414 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 424 426 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Turn 439 441 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 442 448 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 464 470 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 483 486 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 494 499 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Turn 507 510 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 518 520 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 522 526 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 530 538 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 541 544 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 547 553 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 558 561 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 573 575 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 577 582 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 583 585 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 586 594 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 597 601 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 604 606 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 615 619 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Beta strand 623 627 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N8Y P06494 UniProtKB Helix 650 669 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IIJ P06494 UniProtKB Helix 670 674 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IIJ P06494 UniProtKB Helix 675 679 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1IIJ