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Protein

Major capsid protein

Gene

MCP

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation1 Publication
  • Host nucleus UniRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157021 – 1374Major capsid proteinAdd BLAST1374

Proteomic databases

PRIDEiP06491.

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL26P102103EBI-7608705,EBI-8621986

Protein-protein interaction databases

BioGridi971410. 1 interactor.
IntActiP06491. 4 interactors.
MINTiMINT-6732551.

Structurei

Secondary structure

11374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi487 – 489Combined sources3
Helixi498 – 506Combined sources9
Helixi510 – 514Combined sources5
Beta strandi548 – 550Combined sources3
Beta strandi572 – 574Combined sources3
Helixi579 – 581Combined sources3
Turni584 – 586Combined sources3
Helixi589 – 600Combined sources12
Helixi608 – 619Combined sources12
Helixi626 – 633Combined sources8
Helixi638 – 643Combined sources6
Helixi645 – 658Combined sources14
Helixi668 – 676Combined sources9
Helixi679 – 681Combined sources3
Helixi684 – 706Combined sources23
Helixi714 – 716Combined sources3
Helixi719 – 723Combined sources5
Beta strandi737 – 739Combined sources3
Helixi740 – 746Combined sources7
Turni750 – 752Combined sources3
Beta strandi764 – 767Combined sources4
Beta strandi771 – 773Combined sources3
Beta strandi782 – 784Combined sources3
Beta strandi789 – 793Combined sources5
Beta strandi796 – 798Combined sources3
Helixi803 – 814Combined sources12
Helixi816 – 821Combined sources6
Beta strandi826 – 830Combined sources5
Helixi832 – 839Combined sources8
Turni857 – 859Combined sources3
Helixi867 – 869Combined sources3
Helixi875 – 881Combined sources7
Helixi888 – 892Combined sources5
Helixi893 – 898Combined sources6
Beta strandi907 – 912Combined sources6
Beta strandi928 – 939Combined sources12
Turni948 – 952Combined sources5
Beta strandi953 – 957Combined sources5
Helixi967 – 971Combined sources5
Turni978 – 980Combined sources3
Helixi981 – 984Combined sources4
Helixi992 – 994Combined sources3
Helixi997 – 999Combined sources3
Beta strandi1000 – 1002Combined sources3
Helixi1004 – 1012Combined sources9
Helixi1017 – 1027Combined sources11
Helixi1033 – 1042Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NO7X-ray2.90A/B451-1054[»]
ProteinModelPortaliP06491.
SMRiP06491.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06491.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P06491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPNRDPPG YRYAAAMVPT GSLLSTIEVA SHRRLFDFFS RVRSDANSLY
60 70 80 90 100
DVEFDALLGS YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH
110 120 130 140 150
QPLIARDGPH PIEQPTHNYM TKIIDRRALN AAFSLATEAI ALLTGEALDG
160 170 180 190 200
TGIGAHRQLR AIQQLARNVQ AVLGAFERGT ADQMLHVLLE KAPPLALLLP
210 220 230 240 250
MQRYLDNGRL ATRVARATLV AELKRSFCET SFFLGKAGHR REAVEAWLVD
260 270 280 290 300
LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAPIKQRLLQ SFLKVEDTEA
310 320 330 340 350
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLEMQ EEQLDLNRQT
360 370 380 390 400
LDELESAPQT TRVRADLVSI GEKLVFLEAL EKRIYAATNV PYPLVGAMDL
410 420 430 440 450
TFVLPLGLFN PVMERFAAHA GDLVPAPGHP DPRAFPPRQL FFWGKDRQVL
460 470 480 490 500
RLSLEHAIGT VCHPSLMNVD AAVGGLNRDP VEAANPYGAY VAAPAGPAAD
510 520 530 540 550
MQQLFLNAWG QRLAHGRVRW VAEGQMTPEQ FMQPDNANLA LELHPAFDFF
560 570 580 590 600
VGVADVELPG GDVPPAGPGE IQATWRVVNG NLPLALCPAA FRDARGLELG
610 620 630 640 650
VGRHAMAPAT IAAVRGAFDD RNYPAVFYLL QAAIHGSEHV FCALARLVVQ
660 670 680 690 700
CITSYWNNTR CAAFVNDYSL VSYVVTYLGG DLPEECMAVY RDLVAHVEAL
710 720 730 740 750
AQLVDDFTLT GPELGGQAQA ELNHLMRDPA LLPPLVWDCD ALMRRAALDR
760 770 780 790 800
HRDCRVSAGG HDPVYAAACN VATADFNRND GQLLHNTQAR AADAADDRPH
810 820 830 840 850
RGADWTVHHK IYYYVMVPAF SRGRCCTAGV RFDRVYATLQ NMVVPEIAPG
860 870 880 890 900
EECPSDPVTD PAHPLHPANL VANTVNAMFH NGRVVVDGPA MLTLQVLAHN
910 920 930 940 950
MAERTTALLC SAAPDAGANT ASTTNMRIFD GALHAGILLM APQHLDHTIQ
960 970 980 990 1000
NGDYFYPLPV HALFAGADHV ANAPNFPPAL RDLSRQVPLV PPALGANYFS
1010 1020 1030 1040 1050
SIRQPVVQHV RESAAGENAL TYALMAGYFK ISPVALHHQL KTGLHPGFGF
1060 1070 1080 1090 1100
TVVRQDRFVT ENVLFSERAS EAYFLGQLQV ARHETGGGVN FTLTQPRANV
1110 1120 1130 1140 1150
DLGVGYTAVV ATATVRNPVT DMGNLPQNFY LGRGAPPLLD NAAAVYLRNA
1160 1170 1180 1190 1200
VVAGNRLGPA QPVPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVSTDVNYFR
1210 1220 1230 1240 1250
RPCNPRGRAA GGVYAGDKEG DVTALMYDHG QSDPSRAFAA TANPWASQRF
1260 1270 1280 1290 1300
SYGDLLYNGA YHLNGASPVL SPCFKFFTSA DIAAKHRCLE RLIVETGSAV
1310 1320 1330 1340 1350
STATAASDVQ FKRPPGCREL VEDPCGLFQE AYPLTCASDP ALLRSARNGE
1360 1370
AHARETHFAQ YLVYDASPLK GLAL
Length:1,374
Mass (Da):149,084
Last modified:January 1, 1988 - v1
Checksum:i859C76E2EADE05B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32332.1.
X04467 Genomic DNA. Translation: CAA28154.1.
PIRiA27239. VCBE17.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32332.1.
X04467 Genomic DNA. Translation: CAA28154.1.
PIRiA27239. VCBE17.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NO7X-ray2.90A/B451-1054[»]
ProteinModelPortaliP06491.
SMRiP06491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971410. 1 interactor.
IntActiP06491. 4 interactors.
MINTiMINT-6732551.

Proteomic databases

PRIDEiP06491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP06491.

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCP_HHV11
AccessioniPrimary (citable) accession number: P06491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.