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P06491

- MCP_HHV11

UniProt

P06491 - MCP_HHV11

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Protein

Major capsid protein

Gene

UL19

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.1 Publication

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein
Short name:
MCP
Alternative name(s):
Capsid protein VP5
Gene namesi
Name:UL19
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion 1 Publication. Host nucleus 1 Publication

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. T=16 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374Major capsid proteinPRO_0000115702Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL26P102103EBI-7608705,EBI-8621986

Protein-protein interaction databases

IntActiP06491. 4 interactions.
MINTiMINT-6732551.

Structurei

Secondary structure

1
1374
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi487 – 4893Combined sources
Helixi498 – 5069Combined sources
Helixi510 – 5145Combined sources
Beta strandi548 – 5503Combined sources
Beta strandi572 – 5743Combined sources
Helixi579 – 5813Combined sources
Turni584 – 5863Combined sources
Helixi589 – 60012Combined sources
Helixi608 – 61912Combined sources
Helixi626 – 6338Combined sources
Helixi638 – 6436Combined sources
Helixi645 – 65814Combined sources
Helixi668 – 6769Combined sources
Helixi679 – 6813Combined sources
Helixi684 – 70623Combined sources
Helixi714 – 7163Combined sources
Helixi719 – 7235Combined sources
Beta strandi737 – 7393Combined sources
Helixi740 – 7467Combined sources
Turni750 – 7523Combined sources
Beta strandi764 – 7674Combined sources
Beta strandi771 – 7733Combined sources
Beta strandi782 – 7843Combined sources
Beta strandi789 – 7935Combined sources
Beta strandi796 – 7983Combined sources
Helixi803 – 81412Combined sources
Helixi816 – 8216Combined sources
Beta strandi826 – 8305Combined sources
Helixi832 – 8398Combined sources
Turni857 – 8593Combined sources
Helixi867 – 8693Combined sources
Helixi875 – 8817Combined sources
Helixi888 – 8925Combined sources
Helixi893 – 8986Combined sources
Beta strandi907 – 9126Combined sources
Beta strandi928 – 93912Combined sources
Turni948 – 9525Combined sources
Beta strandi953 – 9575Combined sources
Helixi967 – 9715Combined sources
Turni978 – 9803Combined sources
Helixi981 – 9844Combined sources
Helixi992 – 9943Combined sources
Helixi997 – 9993Combined sources
Beta strandi1000 – 10023Combined sources
Helixi1004 – 10129Combined sources
Helixi1017 – 102711Combined sources
Helixi1033 – 104210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NO7X-ray2.90A/B451-1054[»]
ProteinModelPortaliP06491.
SMRiP06491. Positions 484-1045.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06491.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P06491-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPNRDPPG YRYAAAMVPT GSLLSTIEVA SHRRLFDFFS RVRSDANSLY
60 70 80 90 100
DVEFDALLGS YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH
110 120 130 140 150
QPLIARDGPH PIEQPTHNYM TKIIDRRALN AAFSLATEAI ALLTGEALDG
160 170 180 190 200
TGIGAHRQLR AIQQLARNVQ AVLGAFERGT ADQMLHVLLE KAPPLALLLP
210 220 230 240 250
MQRYLDNGRL ATRVARATLV AELKRSFCET SFFLGKAGHR REAVEAWLVD
260 270 280 290 300
LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAPIKQRLLQ SFLKVEDTEA
310 320 330 340 350
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLEMQ EEQLDLNRQT
360 370 380 390 400
LDELESAPQT TRVRADLVSI GEKLVFLEAL EKRIYAATNV PYPLVGAMDL
410 420 430 440 450
TFVLPLGLFN PVMERFAAHA GDLVPAPGHP DPRAFPPRQL FFWGKDRQVL
460 470 480 490 500
RLSLEHAIGT VCHPSLMNVD AAVGGLNRDP VEAANPYGAY VAAPAGPAAD
510 520 530 540 550
MQQLFLNAWG QRLAHGRVRW VAEGQMTPEQ FMQPDNANLA LELHPAFDFF
560 570 580 590 600
VGVADVELPG GDVPPAGPGE IQATWRVVNG NLPLALCPAA FRDARGLELG
610 620 630 640 650
VGRHAMAPAT IAAVRGAFDD RNYPAVFYLL QAAIHGSEHV FCALARLVVQ
660 670 680 690 700
CITSYWNNTR CAAFVNDYSL VSYVVTYLGG DLPEECMAVY RDLVAHVEAL
710 720 730 740 750
AQLVDDFTLT GPELGGQAQA ELNHLMRDPA LLPPLVWDCD ALMRRAALDR
760 770 780 790 800
HRDCRVSAGG HDPVYAAACN VATADFNRND GQLLHNTQAR AADAADDRPH
810 820 830 840 850
RGADWTVHHK IYYYVMVPAF SRGRCCTAGV RFDRVYATLQ NMVVPEIAPG
860 870 880 890 900
EECPSDPVTD PAHPLHPANL VANTVNAMFH NGRVVVDGPA MLTLQVLAHN
910 920 930 940 950
MAERTTALLC SAAPDAGANT ASTTNMRIFD GALHAGILLM APQHLDHTIQ
960 970 980 990 1000
NGDYFYPLPV HALFAGADHV ANAPNFPPAL RDLSRQVPLV PPALGANYFS
1010 1020 1030 1040 1050
SIRQPVVQHV RESAAGENAL TYALMAGYFK ISPVALHHQL KTGLHPGFGF
1060 1070 1080 1090 1100
TVVRQDRFVT ENVLFSERAS EAYFLGQLQV ARHETGGGVN FTLTQPRANV
1110 1120 1130 1140 1150
DLGVGYTAVV ATATVRNPVT DMGNLPQNFY LGRGAPPLLD NAAAVYLRNA
1160 1170 1180 1190 1200
VVAGNRLGPA QPVPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVSTDVNYFR
1210 1220 1230 1240 1250
RPCNPRGRAA GGVYAGDKEG DVTALMYDHG QSDPSRAFAA TANPWASQRF
1260 1270 1280 1290 1300
SYGDLLYNGA YHLNGASPVL SPCFKFFTSA DIAAKHRCLE RLIVETGSAV
1310 1320 1330 1340 1350
STATAASDVQ FKRPPGCREL VEDPCGLFQE AYPLTCASDP ALLRSARNGE
1360 1370
AHARETHFAQ YLVYDASPLK GLAL
Length:1,374
Mass (Da):149,084
Last modified:January 1, 1988 - v1
Checksum:i859C76E2EADE05B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32332.1.
X04467 Genomic DNA. Translation: CAA28154.1.
PIRiA27239. VCBE17.
RefSeqiNP_044620.1. NC_001806.1.

Genome annotation databases

GeneIDi2703368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32332.1 .
X04467 Genomic DNA. Translation: CAA28154.1 .
PIRi A27239. VCBE17.
RefSeqi NP_044620.1. NC_001806.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NO7 X-ray 2.90 A/B 451-1054 [» ]
ProteinModelPortali P06491.
SMRi P06491. Positions 484-1045.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P06491. 4 interactions.
MINTi MINT-6732551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703368.

Miscellaneous databases

EvolutionaryTracei P06491.

Family and domain databases

InterProi IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view ]
Pfami PF03122. Herpes_MCP. 1 hit.
[Graphical view ]
PRINTSi PR00235. HSVCAPSIDMCP.
SUPFAMi SSF103417. SSF103417. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence of the major capsid protein gene of herpes simplex virus type 1."
    Davison B.A.J., Scott J.E.
    J. Gen. Virol. 67:2279-2286(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
    Davison M.D., Rixon F.J., Davison A.J.
    J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 202-211 AND 607-616.
  4. "Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes."
    Newcomb W.W., Trus B.L., Booy F.P., Steven A.C., Wall J.S., Brown J.C.
    J. Mol. Biol. 232:499-511(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Localization of the herpes simplex virus type 1 major capsid protein VP5 to the cell nucleus requires the abundant scaffolding protein VP22a."
    Nicholson P., Addison C., Cross A.M., Kennard J., Preston V.G., Rixon F.J.
    J. Gen. Virol. 75:1091-1099(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Identification of a minimal hydrophobic domain in the herpes simplex virus type 1 scaffolding protein which is required for interaction with the major capsid protein."
    Hong Z., Beaudet-Miller M., Durkin J., Zhang R., Kwong A.D.
    J. Virol. 70:533-540(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VP22A.
  7. "Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins."
    Rixon F.J., Addison C., McGregor A., Macnab S.J., Nicholson P., Preston V.G., Tatman J.D.
    J. Gen. Virol. 77:2251-2260(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VP19C AND VP23.
  8. "Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: location of UL25 product in the capsid and demonstration that it binds DNA."
    Ogasawara M., Suzutani T., Yoshida I., Azuma M.
    J. Virol. 75:1427-1436(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL25.
  9. "Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids."
    Desai P., Akpa J.C., Person S.
    J. Virol. 77:391-404(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VP26.
    Strain: KOS.
  10. "Structure of the herpesvirus major capsid protein."
    Bowman B.R., Baker M.L., Rixon F.J., Chiu W., Quiocho F.A.
    EMBO J. 22:757-765(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 451-1054.

Entry informationi

Entry nameiMCP_HHV11
AccessioniPrimary (citable) accession number: P06491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3