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P06491 (MCP_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major capsid protein

Short name=MCP
Alternative name(s):
Capsid protein VP5
Gene names
Name:UL19
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length1374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins. Ref.4

Subunit structure

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25. Ref.6 Ref.7 Ref.8 Ref.9

Subcellular location

Virion. Host nucleus Ref.5.

Sequence similarities

Belongs to the herpesviridae major capsid protein family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UL26P102103EBI-7608705,EBI-8621986

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13741374Major capsid protein
PRO_0000115702

Secondary structure

.......................................................................................... 1374
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P06491 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 859C76E2EADE05B7

FASTA1,374149,084
        10         20         30         40         50         60 
MAAPNRDPPG YRYAAAMVPT GSLLSTIEVA SHRRLFDFFS RVRSDANSLY DVEFDALLGS 

        70         80         90        100        110        120 
YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH QPLIARDGPH PIEQPTHNYM 

       130        140        150        160        170        180 
TKIIDRRALN AAFSLATEAI ALLTGEALDG TGIGAHRQLR AIQQLARNVQ AVLGAFERGT 

       190        200        210        220        230        240 
ADQMLHVLLE KAPPLALLLP MQRYLDNGRL ATRVARATLV AELKRSFCET SFFLGKAGHR 

       250        260        270        280        290        300 
REAVEAWLVD LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAPIKQRLLQ SFLKVEDTEA 

       310        320        330        340        350        360 
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLEMQ EEQLDLNRQT LDELESAPQT 

       370        380        390        400        410        420 
TRVRADLVSI GEKLVFLEAL EKRIYAATNV PYPLVGAMDL TFVLPLGLFN PVMERFAAHA 

       430        440        450        460        470        480 
GDLVPAPGHP DPRAFPPRQL FFWGKDRQVL RLSLEHAIGT VCHPSLMNVD AAVGGLNRDP 

       490        500        510        520        530        540 
VEAANPYGAY VAAPAGPAAD MQQLFLNAWG QRLAHGRVRW VAEGQMTPEQ FMQPDNANLA 

       550        560        570        580        590        600 
LELHPAFDFF VGVADVELPG GDVPPAGPGE IQATWRVVNG NLPLALCPAA FRDARGLELG 

       610        620        630        640        650        660 
VGRHAMAPAT IAAVRGAFDD RNYPAVFYLL QAAIHGSEHV FCALARLVVQ CITSYWNNTR 

       670        680        690        700        710        720 
CAAFVNDYSL VSYVVTYLGG DLPEECMAVY RDLVAHVEAL AQLVDDFTLT GPELGGQAQA 

       730        740        750        760        770        780 
ELNHLMRDPA LLPPLVWDCD ALMRRAALDR HRDCRVSAGG HDPVYAAACN VATADFNRND 

       790        800        810        820        830        840 
GQLLHNTQAR AADAADDRPH RGADWTVHHK IYYYVMVPAF SRGRCCTAGV RFDRVYATLQ 

       850        860        870        880        890        900 
NMVVPEIAPG EECPSDPVTD PAHPLHPANL VANTVNAMFH NGRVVVDGPA MLTLQVLAHN 

       910        920        930        940        950        960 
MAERTTALLC SAAPDAGANT ASTTNMRIFD GALHAGILLM APQHLDHTIQ NGDYFYPLPV 

       970        980        990       1000       1010       1020 
HALFAGADHV ANAPNFPPAL RDLSRQVPLV PPALGANYFS SIRQPVVQHV RESAAGENAL 

      1030       1040       1050       1060       1070       1080 
TYALMAGYFK ISPVALHHQL KTGLHPGFGF TVVRQDRFVT ENVLFSERAS EAYFLGQLQV 

      1090       1100       1110       1120       1130       1140 
ARHETGGGVN FTLTQPRANV DLGVGYTAVV ATATVRNPVT DMGNLPQNFY LGRGAPPLLD 

      1150       1160       1170       1180       1190       1200 
NAAAVYLRNA VVAGNRLGPA QPVPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVSTDVNYFR 

      1210       1220       1230       1240       1250       1260 
RPCNPRGRAA GGVYAGDKEG DVTALMYDHG QSDPSRAFAA TANPWASQRF SYGDLLYNGA 

      1270       1280       1290       1300       1310       1320 
YHLNGASPVL SPCFKFFTSA DIAAKHRCLE RLIVETGSAV STATAASDVQ FKRPPGCREL 

      1330       1340       1350       1360       1370 
VEDPCGLFQE AYPLTCASDP ALLRSARNGE AHARETHFAQ YLVYDASPLK GLAL 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence of the major capsid protein gene of herpes simplex virus type 1."
Davison B.A.J., Scott J.E.
J. Gen. Virol. 67:2279-2286(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
Davison M.D., Rixon F.J., Davison A.J.
J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 202-211 AND 607-616.
[4]"Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes."
Newcomb W.W., Trus B.L., Booy F.P., Steven A.C., Wall J.S., Brown J.C.
J. Mol. Biol. 232:499-511(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Localization of the herpes simplex virus type 1 major capsid protein VP5 to the cell nucleus requires the abundant scaffolding protein VP22a."
Nicholson P., Addison C., Cross A.M., Kennard J., Preston V.G., Rixon F.J.
J. Gen. Virol. 75:1091-1099(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Identification of a minimal hydrophobic domain in the herpes simplex virus type 1 scaffolding protein which is required for interaction with the major capsid protein."
Hong Z., Beaudet-Miller M., Durkin J., Zhang R., Kwong A.D.
J. Virol. 70:533-540(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH VP22A.
[7]"Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins."
Rixon F.J., Addison C., McGregor A., Macnab S.J., Nicholson P., Preston V.G., Tatman J.D.
J. Gen. Virol. 77:2251-2260(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH VP19C AND VP23.
[8]"Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: location of UL25 product in the capsid and demonstration that it binds DNA."
Ogasawara M., Suzutani T., Yoshida I., Azuma M.
J. Virol. 75:1427-1436(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL25.
[9]"Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids."
Desai P., Akpa J.C., Person S.
J. Virol. 77:391-404(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH VP26.
Strain: KOS.
[10]"Structure of the herpesvirus major capsid protein."
Bowman B.R., Baker M.L., Rixon F.J., Chiu W., Quiocho F.A.
EMBO J. 22:757-765(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 451-1054.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32332.1.
X04467 Genomic DNA. Translation: CAA28154.1.
PIRVCBE17. A27239.
RefSeqNP_044620.1. NC_001806.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NO7X-ray2.90A/B451-1054[»]
ProteinModelPortalP06491.
SMRP06491. Positions 484-1045.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP06491. 3 interactions.
MINTMINT-6732551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703368.

Family and domain databases

InterProIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSPR00235. HSVCAPSIDMCP.
SUPFAMSSF103417. SSF103417. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP06491.

Entry information

Entry nameMCP_HHV11
AccessionPrimary (citable) accession number: P06491
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references