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P06491

- MCP_HHV11

UniProt

P06491 - MCP_HHV11

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Protein

Major capsid protein

Gene
UL19
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein
Short name:
MCP
Alternative name(s):
Capsid protein VP5
Gene namesi
Name:UL19
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion. Host nucleus 1 Publication

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. T=16 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374Major capsid proteinPRO_0000115702Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL26P102103EBI-7608705,EBI-8621986

Protein-protein interaction databases

IntActiP06491. 3 interactions.
MINTiMINT-6732551.

Structurei

Secondary structure

1
1374
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi487 – 4893
Helixi498 – 5069
Helixi510 – 5145
Beta strandi548 – 5503
Beta strandi572 – 5743
Helixi579 – 5813
Turni584 – 5863
Helixi589 – 60012
Helixi608 – 61912
Helixi626 – 6338
Helixi638 – 6436
Helixi645 – 65814
Helixi668 – 6769
Helixi679 – 6813
Helixi684 – 70623
Helixi714 – 7163
Helixi719 – 7235
Beta strandi737 – 7393
Helixi740 – 7467
Turni750 – 7523
Beta strandi764 – 7674
Beta strandi771 – 7733
Beta strandi782 – 7843
Beta strandi789 – 7935
Beta strandi796 – 7983
Helixi803 – 81412
Helixi816 – 8216
Beta strandi826 – 8305
Helixi832 – 8398
Turni857 – 8593
Helixi867 – 8693
Helixi875 – 8817
Helixi888 – 8925
Helixi893 – 8986
Beta strandi907 – 9126
Beta strandi928 – 93912
Turni948 – 9525
Beta strandi953 – 9575
Helixi967 – 9715
Turni978 – 9803
Helixi981 – 9844
Helixi992 – 9943
Helixi997 – 9993
Beta strandi1000 – 10023
Helixi1004 – 10129
Helixi1017 – 102711
Helixi1033 – 104210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NO7X-ray2.90A/B451-1054[»]
ProteinModelPortaliP06491.
SMRiP06491. Positions 484-1045.

Miscellaneous databases

EvolutionaryTraceiP06491.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P06491-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPNRDPPG YRYAAAMVPT GSLLSTIEVA SHRRLFDFFS RVRSDANSLY     50
DVEFDALLGS YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH 100
QPLIARDGPH PIEQPTHNYM TKIIDRRALN AAFSLATEAI ALLTGEALDG 150
TGIGAHRQLR AIQQLARNVQ AVLGAFERGT ADQMLHVLLE KAPPLALLLP 200
MQRYLDNGRL ATRVARATLV AELKRSFCET SFFLGKAGHR REAVEAWLVD 250
LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAPIKQRLLQ SFLKVEDTEA 300
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLEMQ EEQLDLNRQT 350
LDELESAPQT TRVRADLVSI GEKLVFLEAL EKRIYAATNV PYPLVGAMDL 400
TFVLPLGLFN PVMERFAAHA GDLVPAPGHP DPRAFPPRQL FFWGKDRQVL 450
RLSLEHAIGT VCHPSLMNVD AAVGGLNRDP VEAANPYGAY VAAPAGPAAD 500
MQQLFLNAWG QRLAHGRVRW VAEGQMTPEQ FMQPDNANLA LELHPAFDFF 550
VGVADVELPG GDVPPAGPGE IQATWRVVNG NLPLALCPAA FRDARGLELG 600
VGRHAMAPAT IAAVRGAFDD RNYPAVFYLL QAAIHGSEHV FCALARLVVQ 650
CITSYWNNTR CAAFVNDYSL VSYVVTYLGG DLPEECMAVY RDLVAHVEAL 700
AQLVDDFTLT GPELGGQAQA ELNHLMRDPA LLPPLVWDCD ALMRRAALDR 750
HRDCRVSAGG HDPVYAAACN VATADFNRND GQLLHNTQAR AADAADDRPH 800
RGADWTVHHK IYYYVMVPAF SRGRCCTAGV RFDRVYATLQ NMVVPEIAPG 850
EECPSDPVTD PAHPLHPANL VANTVNAMFH NGRVVVDGPA MLTLQVLAHN 900
MAERTTALLC SAAPDAGANT ASTTNMRIFD GALHAGILLM APQHLDHTIQ 950
NGDYFYPLPV HALFAGADHV ANAPNFPPAL RDLSRQVPLV PPALGANYFS 1000
SIRQPVVQHV RESAAGENAL TYALMAGYFK ISPVALHHQL KTGLHPGFGF 1050
TVVRQDRFVT ENVLFSERAS EAYFLGQLQV ARHETGGGVN FTLTQPRANV 1100
DLGVGYTAVV ATATVRNPVT DMGNLPQNFY LGRGAPPLLD NAAAVYLRNA 1150
VVAGNRLGPA QPVPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVSTDVNYFR 1200
RPCNPRGRAA GGVYAGDKEG DVTALMYDHG QSDPSRAFAA TANPWASQRF 1250
SYGDLLYNGA YHLNGASPVL SPCFKFFTSA DIAAKHRCLE RLIVETGSAV 1300
STATAASDVQ FKRPPGCREL VEDPCGLFQE AYPLTCASDP ALLRSARNGE 1350
AHARETHFAQ YLVYDASPLK GLAL 1374
Length:1,374
Mass (Da):149,084
Last modified:January 1, 1988 - v1
Checksum:i859C76E2EADE05B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32332.1.
X04467 Genomic DNA. Translation: CAA28154.1.
PIRiA27239. VCBE17.
RefSeqiNP_044620.1. NC_001806.1.

Genome annotation databases

GeneIDi2703368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32332.1 .
X04467 Genomic DNA. Translation: CAA28154.1 .
PIRi A27239. VCBE17.
RefSeqi NP_044620.1. NC_001806.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NO7 X-ray 2.90 A/B 451-1054 [» ]
ProteinModelPortali P06491.
SMRi P06491. Positions 484-1045.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P06491. 3 interactions.
MINTi MINT-6732551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703368.

Miscellaneous databases

EvolutionaryTracei P06491.

Family and domain databases

InterProi IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view ]
Pfami PF03122. Herpes_MCP. 1 hit.
[Graphical view ]
PRINTSi PR00235. HSVCAPSIDMCP.
SUPFAMi SSF103417. SSF103417. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence of the major capsid protein gene of herpes simplex virus type 1."
    Davison B.A.J., Scott J.E.
    J. Gen. Virol. 67:2279-2286(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
    Davison M.D., Rixon F.J., Davison A.J.
    J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 202-211 AND 607-616.
  4. "Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes."
    Newcomb W.W., Trus B.L., Booy F.P., Steven A.C., Wall J.S., Brown J.C.
    J. Mol. Biol. 232:499-511(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Localization of the herpes simplex virus type 1 major capsid protein VP5 to the cell nucleus requires the abundant scaffolding protein VP22a."
    Nicholson P., Addison C., Cross A.M., Kennard J., Preston V.G., Rixon F.J.
    J. Gen. Virol. 75:1091-1099(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Identification of a minimal hydrophobic domain in the herpes simplex virus type 1 scaffolding protein which is required for interaction with the major capsid protein."
    Hong Z., Beaudet-Miller M., Durkin J., Zhang R., Kwong A.D.
    J. Virol. 70:533-540(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VP22A.
  7. "Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins."
    Rixon F.J., Addison C., McGregor A., Macnab S.J., Nicholson P., Preston V.G., Tatman J.D.
    J. Gen. Virol. 77:2251-2260(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VP19C AND VP23.
  8. "Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: location of UL25 product in the capsid and demonstration that it binds DNA."
    Ogasawara M., Suzutani T., Yoshida I., Azuma M.
    J. Virol. 75:1427-1436(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL25.
  9. "Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids."
    Desai P., Akpa J.C., Person S.
    J. Virol. 77:391-404(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VP26.
    Strain: KOS.
  10. "Structure of the herpesvirus major capsid protein."
    Bowman B.R., Baker M.L., Rixon F.J., Chiu W., Quiocho F.A.
    EMBO J. 22:757-765(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 451-1054.

Entry informationi

Entry nameiMCP_HHV11
AccessioniPrimary (citable) accession number: P06491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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