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P06487

- GI_HHV11

UniProt

P06487 - GI_HHV11

Protein

Envelope glycoprotein I

Gene

gI

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.
    The heterodimer gE/gI serves as a receptor for the Fc part of human IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host Ig-mediated immune responses.

    GO - Biological processi

    1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein I
    Short name:
    gI
    Gene namesi
    Name:gI
    ORF Names:US7
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion membrane; Single-pass membrane protein. Host cell membrane Curated; Single-pass type I membrane protein Curated. Host cell junction. Host Golgi apparatus membrane; Single-pass type I membrane protein
    Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection.

    GO - Cellular componenti

    1. host cell Golgi membrane Source: UniProtKB-SubCell
    2. host cell junction Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell junction, Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 390370Envelope glycoprotein IPRO_0000115770Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi156 – 1561N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi175 – 1751N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with gE; this interaction enhances the Fc receptor function of gE.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 276256Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini298 – 39093IntravirionSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR002874. Herpes_gI.
    [Graphical view]
    PfamiPF01688. Herpes_gI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06487-1 [UniParc]FASTAAdd to Basket

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    MPCRPLQGLV LVGLWVCATS LVVRGPTVSL VSNSFVDAGA LGPDGVVEED    50
    LLILGELRFV GDQVPHTTYY DGGVELWHYP MGHKCPRVVH VVTVTACPRR 100
    PAVAFALCRA TDSTHSPAYP TLELNLAQQP LLRVQRATRD YAGVYVLRVW 150
    VGDAPNASLF VLGMAIAAEG TLAYNGSAYG SCDPKLLPSS APRLAPASVY 200
    QPAPNQASTP STTTSTPSTT IPAPSTTIPA PQASTTPFPT GDPKPQPPGV 250
    NHEPPSNATR ATRDSRYALT VTQIIQIAIP ASIIALVFLG SCICFIHRCQ 300
    RRYRRSRRPI YSPQMPTGIS CAVNEAAMAR LGAELKSHPS TPPKSRRRSS 350
    RTPMPSLTAI AEESEPAGAA GLPTPPVDPT TPTPTPPLLV 390
    Length:390
    Mass (Da):41,370
    Last modified:January 1, 1988 - v1
    Checksum:i39381B1D6B5F08C8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti73 – 731G → V in strain: Nonneuroinvasive mutant HF10.
    Natural varianti165 – 1651A → T in strain: Nonneuroinvasive mutant HF10.
    Natural varianti225 – 2317Missing in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32284.1.
    X02138 Genomic DNA. Translation: CAA26061.1.
    L00036 Genomic DNA. Translation: AAA96681.1.
    DQ889502 Genomic DNA. Translation: ABI63525.1.
    FJ593289 Genomic DNA. Translation: ACM62296.1.
    PIRiA05243. QQBE77.
    RefSeqiNP_044669.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32284.1 .
    X02138 Genomic DNA. Translation: CAA26061.1 .
    L00036 Genomic DNA. Translation: AAA96681.1 .
    DQ889502 Genomic DNA. Translation: ABI63525.1 .
    FJ593289 Genomic DNA. Translation: ACM62296.1 .
    PIRi A05243. QQBE77.
    RefSeqi NP_044669.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2364696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703446.

    Family and domain databases

    InterProi IPR002874. Herpes_gI.
    [Graphical view ]
    Pfami PF01688. Herpes_gI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dolan A., Donald S., Rixon F.J.
      J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    3. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    4. "Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI."
      Johnson D.C., Frame M.C., Ligas M.W., Cross A.M., Stow N.D.
      J. Virol. 62:1347-1354(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GLYCOPROTEIN E.
      Strain: 17 syn+ and F.
    5. "pH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI."
      Sprague E.R., Martin W.L., Bjorkman P.J.
      J. Biol. Chem. 279:14184-14193(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: KOS.
    6. "Herpes simplex virus gE/gI must accumulate in the trans-Golgi network at early times and then redistribute to cell junctions to promote cell-cell spread."
      Farnsworth A., Johnson D.C.
      J. Virol. 80:3167-3179(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiGI_HHV11
    AccessioniPrimary (citable) accession number: P06487
    Secondary accession number(s): B9VQK1, Q09I70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3