Envelope glycoprotein I precursor - Human herpesvirus 1 (strain 17) (HHV-1)

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P06487 (GI_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Envelope glycoprotein I
Short name=gI

Gene names

Name:	gI
ORF Names:	US7

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus ›

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips. Ref.4 Ref.5 The heterodimer gE/gI serves as a receptor for the Fc part of human IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host Ig-mediated immune responses. Ref.4 Ref.5
Subunit structure	Interacts with gE; this interaction enhances the Fc receptor function of gE By similarity. Ref.4
Subcellular location	Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass type I membrane protein Potential. Host cell junction. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection. Ref.6 Ref.7
Sequence similarities	Belongs to the alphaherpesvirinae glycoprotein I family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral immunoevasion
Cellular component	Host Golgi apparatus Host cell junction Host cell membrane Host membrane Membrane Viral envelope protein Virion
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	evasion or tolerance by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell host cell junction Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Potential

Chain

21 – 390

370

Envelope glycoprotein I

PRO_0000115770

Regions

Topological domain

21 – 276

256

Virion surface Potential

Transmembrane

277 – 297

Helical; Potential

Topological domain

298 – 390

Intravirion Potential

Amino acid modifications

Glycosylation

156

N-linked (GlcNAc...); by host Potential

Glycosylation

175

N-linked (GlcNAc...); by host Potential

Glycosylation

257

N-linked (GlcNAc...); by host Potential

Natural variations

Natural variant

G → V in strain: Nonneuroinvasive mutant HF10.

Natural variant

165

A → T in strain: Nonneuroinvasive mutant HF10.

Natural variant

225 – 231

Missing in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence

Length

Mass (Da)

Tools

P06487 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 39381B1D6B5F08C8
Show »

FASTA

390

41,370

        10         20         30         40         50         60 
MPCRPLQGLV LVGLWVCATS LVVRGPTVSL VSNSFVDAGA LGPDGVVEED LLILGELRFV 

        70         80         90        100        110        120 
GDQVPHTTYY DGGVELWHYP MGHKCPRVVH VVTVTACPRR PAVAFALCRA TDSTHSPAYP 

       130        140        150        160        170        180 
TLELNLAQQP LLRVQRATRD YAGVYVLRVW VGDAPNASLF VLGMAIAAEG TLAYNGSAYG 

       190        200        210        220        230        240 
SCDPKLLPSS APRLAPASVY QPAPNQASTP STTTSTPSTT IPAPSTTIPA PQASTTPFPT 

       250        260        270        280        290        300 
GDPKPQPPGV NHEPPSNATR ATRDSRYALT VTQIIQIAIP ASIIALVFLG SCICFIHRCQ 

       310        320        330        340        350        360 
RRYRRSRRPI YSPQMPTGIS CAVNEAAMAR LGAELKSHPS TPPKSRRRSS RTPMPSLTAI 

       370        380        390 
AEESEPAGAA GLPTPPVDPT TPTPTPPLLV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dolan A., Donald S., Rixon F.J. J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[3]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[4]	"Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI." Johnson D.C., Frame M.C., Ligas M.W., Cross A.M., Stow N.D. J. Virol. 62:1347-1354(1988) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH GLYCOPROTEIN E. Strain: 17 syn+ and F.
[5]	"pH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI." Sprague E.R., Martin W.L., Bjorkman P.J. J. Biol. Chem. 279:14184-14193(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Strain: KOS.
[6]	"Herpes simplex virus gE/gI must accumulate in the trans-Golgi network at early times and then redistribute to cell junctions to promote cell-cell spread." Farnsworth A., Johnson D.C. J. Virol. 80:3167-3179(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.
[7]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32284.1. X02138 Genomic DNA. Translation: CAA26061.1. L00036 Genomic DNA. Translation: AAA96681.1. DQ889502 Genomic DNA. Translation: ABI63525.1. FJ593289 Genomic DNA. Translation: ACM62296.1.
PIR	QQBE77. A05243.
RefSeq	NP_044669.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703446.
Phylogenomic databases
ProtClustDB	PHA3291.
Family and domain databases
InterPro	IPR002874. Herpes_gI. [Graphical view]
Pfam	PF01688. Herpes_gI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GI_HHV11

Accession

Primary (citable) accession number: P06487
Secondary accession number(s): B9VQK1, Q09I70

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents