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P06487 (GI_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein I

Short name=gI
Gene names
Name:gI
ORF Names:US7
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips. Ref.4 Ref.5

The heterodimer gE/gI serves as a receptor for the Fc part of human IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host Ig-mediated immune responses. Ref.4 Ref.5

Subunit structure

Interacts with gE; this interaction enhances the Fc receptor function of gE By similarity. Ref.4

Subcellular location

Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass type I membrane protein Potential. Host cell junction. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection. Ref.6 Ref.7

Sequence similarities

Belongs to the alphaherpesvirinae glycoprotein I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 390370Envelope glycoprotein I
PRO_0000115770

Regions

Topological domain21 – 276256Virion surface Potential
Transmembrane277 – 29721Helical; Potential
Topological domain298 – 39093Intravirion Potential

Amino acid modifications

Glycosylation1561N-linked (GlcNAc...); by host Potential
Glycosylation1751N-linked (GlcNAc...); by host Potential
Glycosylation2571N-linked (GlcNAc...); by host Potential

Natural variations

Natural variant731G → V in strain: Nonneuroinvasive mutant HF10.
Natural variant1651A → T in strain: Nonneuroinvasive mutant HF10.
Natural variant225 – 2317Missing in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence LengthMass (Da)Tools
P06487 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 39381B1D6B5F08C8

FASTA39041,370
        10         20         30         40         50         60 
MPCRPLQGLV LVGLWVCATS LVVRGPTVSL VSNSFVDAGA LGPDGVVEED LLILGELRFV 

        70         80         90        100        110        120 
GDQVPHTTYY DGGVELWHYP MGHKCPRVVH VVTVTACPRR PAVAFALCRA TDSTHSPAYP 

       130        140        150        160        170        180 
TLELNLAQQP LLRVQRATRD YAGVYVLRVW VGDAPNASLF VLGMAIAAEG TLAYNGSAYG 

       190        200        210        220        230        240 
SCDPKLLPSS APRLAPASVY QPAPNQASTP STTTSTPSTT IPAPSTTIPA PQASTTPFPT 

       250        260        270        280        290        300 
GDPKPQPPGV NHEPPSNATR ATRDSRYALT VTQIIQIAIP ASIIALVFLG SCICFIHRCQ 

       310        320        330        340        350        360 
RRYRRSRRPI YSPQMPTGIS CAVNEAAMAR LGAELKSHPS TPPKSRRRSS RTPMPSLTAI 

       370        380        390 
AEESEPAGAA GLPTPPVDPT TPTPTPPLLV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dolan A., Donald S., Rixon F.J.
J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[4]"Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI."
Johnson D.C., Frame M.C., Ligas M.W., Cross A.M., Stow N.D.
J. Virol. 62:1347-1354(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GLYCOPROTEIN E.
Strain: 17 syn+ and F.
[5]"pH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI."
Sprague E.R., Martin W.L., Bjorkman P.J.
J. Biol. Chem. 279:14184-14193(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: KOS.
[6]"Herpes simplex virus gE/gI must accumulate in the trans-Golgi network at early times and then redistribute to cell junctions to promote cell-cell spread."
Farnsworth A., Johnson D.C.
J. Virol. 80:3167-3179(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.
[7]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32284.1.
X02138 Genomic DNA. Translation: CAA26061.1.
L00036 Genomic DNA. Translation: AAA96681.1.
DQ889502 Genomic DNA. Translation: ABI63525.1.
FJ593289 Genomic DNA. Translation: ACM62296.1.
PIRQQBE77. A05243.
RefSeqNP_044669.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2364696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703446.

Phylogenomic databases

ProtClustDBPHA3291.

Family and domain databases

InterProIPR002874. Herpes_gI.
[Graphical view]
PfamPF01688. Herpes_gI. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGI_HHV11
AccessionPrimary (citable) accession number: P06487
Secondary accession number(s): B9VQK1, Q09I70
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families