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P06486

- US10_HHV11

UniProt

P06486 - US10_HHV11

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Protein

Virion protein US10

Gene

US10

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 28313Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Virion protein US10
Gene namesi
Name:US10
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion tegument By similarity. Host nucleus matrix 1 Publication

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. viral tegument Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Virion protein US10PRO_0000116145Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Expressed late in the infection cycle.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 12787Pro-richAdd
BLAST
Compositional biasi210 – 2134Poly-Pro

Sequence similaritiesi

Belongs to the herpesviridae US10 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 28313Sequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR000714. EHV_Unk.
[Graphical view]
PfamiPF02053. Gene66. 1 hit.
[Graphical view]
PRINTSiPR00957. GENE66.

Sequencei

Sequence statusi: Complete.

P06486-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MIKRRGNVEI RVYYESVRTL RSRSHLKPSD RQQSPGHRVF PGSPGFRDHP
60 70 80 90 100
ENLGNPEYRE LPETPGYRVT PGIHDNPGLP GSPGLPGSPG LPGSPGPHAP
110 120 130 140 150
PANHVRLAGL YSPGKYAPLA SPDPFSPQHG AYARARVGIH TAVRVPPTGS
160 170 180 190 200
PTHTHLRQDP GDEPTSDDSG LYPLDARALA HLVMLPADHR AFFRTVVEVS
210 220 230 240 250
RMCAANVRDP PPPATGAMLG RHARLVHTQW LRANQETSPL WPWRTAAINF
260 270 280 290 300
ITTMAPRVQT HRHMHDLLMA CAFWCCLTHA STCSYAGLYS THCLHLFGAF
310
GCGDPALTPP LC
Length:312
Mass (Da):34,056
Last modified:January 1, 1988 - v1
Checksum:i12D01B0E7C920EA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02138 Genomic DNA. Translation: CAA26064.2.
X00428 Genomic RNA. Translation: CAA25126.1.
L00036 Genomic DNA. Translation: AAA96678.1.
X14112 Genomic DNA. Translation: CAA32275.1.
PIRiA05242. QQBE07.
RefSeqiNP_044673.1. NC_001806.1.

Genome annotation databases

GeneIDi2703441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02138 Genomic DNA. Translation: CAA26064.2 .
X00428 Genomic RNA. Translation: CAA25126.1 .
L00036 Genomic DNA. Translation: AAA96678.1 .
X14112 Genomic DNA. Translation: CAA32275.1 .
PIRi A05242. QQBE07.
RefSeqi NP_044673.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703441.

Family and domain databases

InterProi IPR000714. EHV_Unk.
[Graphical view ]
Pfami PF02053. Gene66. 1 hit.
[Graphical view ]
PRINTSi PR00957. GENE66.
ProtoNeti Search...

Publicationsi

  1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dolan A., Donald S., Rixon F.J.
    J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence."
    Rixon F.J., McGeoch D.J.
    Nucleic Acids Res. 12:2473-2487(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The product of the US10 gene of herpes simplex virus type 1 is a capsid/tegument-associated phosphoprotein which copurifies with the nuclear matrix."
    Yamada H., Daikoku T., Yamashita Y., Jiang Y.M., Tsurumi T., Nishiyama Y.
    J. Gen. Virol. 78:2923-2931(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
    Strain: KOS.

Entry informationi

Entry nameiUS10_HHV11
AccessioniPrimary (citable) accession number: P06486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3