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Protein

Virion protein US10

Gene

US10

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 28313Sequence AnalysisAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Virion protein US10
Gene namesi
Name:US10
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Virion protein US10PRO_0000116145Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Expressed late in the infection cycle.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 12787Pro-richAdd
BLAST
Compositional biasi210 – 2134Poly-Pro

Sequence similaritiesi

Belongs to the herpesviridae US10 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 28313Sequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR000714. EHV_Unk.
[Graphical view]
PfamiPF02053. Gene66. 1 hit.
[Graphical view]
PRINTSiPR00957. GENE66.

Sequencei

Sequence statusi: Complete.

P06486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKRRGNVEI RVYYESVRTL RSRSHLKPSD RQQSPGHRVF PGSPGFRDHP
60 70 80 90 100
ENLGNPEYRE LPETPGYRVT PGIHDNPGLP GSPGLPGSPG LPGSPGPHAP
110 120 130 140 150
PANHVRLAGL YSPGKYAPLA SPDPFSPQHG AYARARVGIH TAVRVPPTGS
160 170 180 190 200
PTHTHLRQDP GDEPTSDDSG LYPLDARALA HLVMLPADHR AFFRTVVEVS
210 220 230 240 250
RMCAANVRDP PPPATGAMLG RHARLVHTQW LRANQETSPL WPWRTAAINF
260 270 280 290 300
ITTMAPRVQT HRHMHDLLMA CAFWCCLTHA STCSYAGLYS THCLHLFGAF
310
GCGDPALTPP LC
Length:312
Mass (Da):34,056
Last modified:January 1, 1988 - v1
Checksum:i12D01B0E7C920EA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA. Translation: CAA26064.2.
X00428 Genomic RNA. Translation: CAA25126.1.
L00036 Genomic DNA. Translation: AAA96678.1.
X14112 Genomic DNA. Translation: CAA32275.1.
PIRiA05242. QQBE07.

Genome annotation databases

KEGGivg:2703436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA. Translation: CAA26064.2.
X00428 Genomic RNA. Translation: CAA25126.1.
L00036 Genomic DNA. Translation: AAA96678.1.
X14112 Genomic DNA. Translation: CAA32275.1.
PIRiA05242. QQBE07.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGivg:2703436.

Family and domain databases

InterProiIPR000714. EHV_Unk.
[Graphical view]
PfamiPF02053. Gene66. 1 hit.
[Graphical view]
PRINTSiPR00957. GENE66.
ProtoNetiSearch...

Publicationsi

  1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dolan A., Donald S., Rixon F.J.
    J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence."
    Rixon F.J., McGeoch D.J.
    Nucleic Acids Res. 12:2473-2487(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The product of the US10 gene of herpes simplex virus type 1 is a capsid/tegument-associated phosphoprotein which copurifies with the nuclear matrix."
    Yamada H., Daikoku T., Yamashita Y., Jiang Y.M., Tsurumi T., Nishiyama Y.
    J. Gen. Virol. 78:2923-2931(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
    Strain: KOS.

Entry informationi

Entry nameiUS10_HHV11
AccessioniPrimary (citable) accession number: P06486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.