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P06486 (US10_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Virion protein US10
Gene names
Name:US10
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Virion tegument By similarity. Host nucleus matrix Ref.4.

Induction

Expressed late in the infection cycle.

Post-translational modification

Phosphorylated. Ref.4

Sequence similarities

Belongs to the herpesviridae US10 family.

Ontologies

Keywords
   Cellular componentHost nucleus
Virion
Virion tegument
   DomainZinc-finger
   LigandMetal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell nuclear matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral tegument

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Virion protein US10
PRO_0000116145

Regions

Zinc finger271 – 28313 Potential
Compositional bias41 – 12787Pro-rich
Compositional bias210 – 2134Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
P06486 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 12D01B0E7C920EA3

FASTA31234,056
        10         20         30         40         50         60 
MIKRRGNVEI RVYYESVRTL RSRSHLKPSD RQQSPGHRVF PGSPGFRDHP ENLGNPEYRE 

        70         80         90        100        110        120 
LPETPGYRVT PGIHDNPGLP GSPGLPGSPG LPGSPGPHAP PANHVRLAGL YSPGKYAPLA 

       130        140        150        160        170        180 
SPDPFSPQHG AYARARVGIH TAVRVPPTGS PTHTHLRQDP GDEPTSDDSG LYPLDARALA 

       190        200        210        220        230        240 
HLVMLPADHR AFFRTVVEVS RMCAANVRDP PPPATGAMLG RHARLVHTQW LRANQETSPL 

       250        260        270        280        290        300 
WPWRTAAINF ITTMAPRVQT HRHMHDLLMA CAFWCCLTHA STCSYAGLYS THCLHLFGAF 

       310 
GCGDPALTPP LC 

« Hide

References

[1]"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dolan A., Donald S., Rixon F.J.
J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence."
Rixon F.J., McGeoch D.J.
Nucleic Acids Res. 12:2473-2487(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"The product of the US10 gene of herpes simplex virus type 1 is a capsid/tegument-associated phosphoprotein which copurifies with the nuclear matrix."
Yamada H., Daikoku T., Yamashita Y., Jiang Y.M., Tsurumi T., Nishiyama Y.
J. Gen. Virol. 78:2923-2931(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
Strain: KOS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02138 Genomic DNA. Translation: CAA26064.2.
X00428 Genomic RNA. Translation: CAA25126.1.
L00036 Genomic DNA. Translation: AAA96678.1.
X14112 Genomic DNA. Translation: CAA32275.1.
PIRQQBE07. A05242.
RefSeqNP_044673.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703441.

Family and domain databases

InterProIPR000714. EHV_Unk.
[Graphical view]
PfamPF02053. Gene66. 1 hit.
[Graphical view]
PRINTSPR00957. GENE66.
ProtoNetSearch...

Entry information

Entry nameUS10_HHV11
AccessionPrimary (citable) accession number: P06486
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families