P06486 (US10_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Virion protein US10

Gene names

Name:

US10

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Virion tegument By similarity. Host nucleus matrix Ref.4.
Induction	Expressed late in the infection cycle.
Post-translational modification	Phosphorylated. Ref.4
Sequence similarities	Belongs to the herpesviridae US10 family.

Ontologies

Keywords
Cellular component	Host nucleus Virion Virion tegument
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nuclear matrix Inferred from electronic annotation. Source: UniProtKB-SubCell viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Virion protein US10		PRO_0000116145
Regions
	Zinc finger	271 – 283	13	Potential
	Compositional bias	41 – 127	87	Pro-rich
	Compositional bias	210 – 213	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	P06486 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 12D01B0E7C920EA3	FASTA	312	34,056
	10 20 30 40 50 60 MIKRRGNVEI RVYYESVRTL RSRSHLKPSD RQQSPGHRVF PGSPGFRDHP ENLGNPEYRE 70 80 90 100 110 120 LPETPGYRVT PGIHDNPGLP GSPGLPGSPG LPGSPGPHAP PANHVRLAGL YSPGKYAPLA 130 140 150 160 170 180 SPDPFSPQHG AYARARVGIH TAVRVPPTGS PTHTHLRQDP GDEPTSDDSG LYPLDARALA 190 200 210 220 230 240 HLVMLPADHR AFFRTVVEVS RMCAANVRDP PPPATGAMLG RHARLVHTQW LRANQETSPL 250 260 270 280 290 300 WPWRTAAINF ITTMAPRVQT HRHMHDLLMA CAFWCCLTHA STCSYAGLYS THCLHLFGAF 310 GCGDPALTPP LC

References

[1]	"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dolan A., Donald S., Rixon F.J. J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence." Rixon F.J., McGeoch D.J. Nucleic Acids Res. 12:2473-2487(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"The product of the US10 gene of herpes simplex virus type 1 is a capsid/tegument-associated phosphoprotein which copurifies with the nuclear matrix." Yamada H., Daikoku T., Yamashita Y., Jiang Y.M., Tsurumi T., Nishiyama Y. J. Gen. Virol. 78:2923-2931(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION. Strain: KOS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02138 Genomic DNA. Translation: CAA26064.2. X00428 Genomic RNA. Translation: CAA25126.1. L00036 Genomic DNA. Translation: AAA96678.1. X14112 Genomic DNA. Translation: CAA32275.1.
PIR	QQBE07. A05242.
RefSeq	NP_044673.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703441.
Phylogenomic databases
ProtClustDB	CLSP2510184.
Family and domain databases
InterPro	IPR000714. EHV_Unk. [Graphical view]
Pfam	PF02053. Gene66. 1 hit. [Graphical view]
PRINTS	PR00957. GENE66.
ProtoNet	Search...

Entry information

Entry name

US10_HHV11

Accession

Primary (citable) accession number: P06486

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program