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P06486

- US10_HHV11

UniProt

P06486 - US10_HHV11

Protein

Virion protein US10

Gene

US10

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri271 – 28313Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Virion protein US10
    Gene namesi
    Name:US10
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion tegument By similarity. Host nucleus matrix 1 Publication

    GO - Cellular componenti

    1. host cell nuclear matrix Source: UniProtKB-SubCell
    2. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Virion protein US10PRO_0000116145Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    Expressed late in the infection cycle.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 12787Pro-richAdd
    BLAST
    Compositional biasi210 – 2134Poly-Pro

    Sequence similaritiesi

    Belongs to the herpesviridae US10 family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri271 – 28313Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    InterProiIPR000714. EHV_Unk.
    [Graphical view]
    PfamiPF02053. Gene66. 1 hit.
    [Graphical view]
    PRINTSiPR00957. GENE66.

    Sequencei

    Sequence statusi: Complete.

    P06486-1 [UniParc]FASTAAdd to Basket

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    MIKRRGNVEI RVYYESVRTL RSRSHLKPSD RQQSPGHRVF PGSPGFRDHP    50
    ENLGNPEYRE LPETPGYRVT PGIHDNPGLP GSPGLPGSPG LPGSPGPHAP 100
    PANHVRLAGL YSPGKYAPLA SPDPFSPQHG AYARARVGIH TAVRVPPTGS 150
    PTHTHLRQDP GDEPTSDDSG LYPLDARALA HLVMLPADHR AFFRTVVEVS 200
    RMCAANVRDP PPPATGAMLG RHARLVHTQW LRANQETSPL WPWRTAAINF 250
    ITTMAPRVQT HRHMHDLLMA CAFWCCLTHA STCSYAGLYS THCLHLFGAF 300
    GCGDPALTPP LC 312
    Length:312
    Mass (Da):34,056
    Last modified:January 1, 1988 - v1
    Checksum:i12D01B0E7C920EA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02138 Genomic DNA. Translation: CAA26064.2.
    X00428 Genomic RNA. Translation: CAA25126.1.
    L00036 Genomic DNA. Translation: AAA96678.1.
    X14112 Genomic DNA. Translation: CAA32275.1.
    PIRiA05242. QQBE07.
    RefSeqiNP_044673.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02138 Genomic DNA. Translation: CAA26064.2 .
    X00428 Genomic RNA. Translation: CAA25126.1 .
    L00036 Genomic DNA. Translation: AAA96678.1 .
    X14112 Genomic DNA. Translation: CAA32275.1 .
    PIRi A05242. QQBE07.
    RefSeqi NP_044673.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703441.

    Family and domain databases

    InterProi IPR000714. EHV_Unk.
    [Graphical view ]
    Pfami PF02053. Gene66. 1 hit.
    [Graphical view ]
    PRINTSi PR00957. GENE66.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dolan A., Donald S., Rixon F.J.
      J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence."
      Rixon F.J., McGeoch D.J.
      Nucleic Acids Res. 12:2473-2487(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "The product of the US10 gene of herpes simplex virus type 1 is a capsid/tegument-associated phosphoprotein which copurifies with the nuclear matrix."
      Yamada H., Daikoku T., Yamashita Y., Jiang Y.M., Tsurumi T., Nishiyama Y.
      J. Gen. Virol. 78:2923-2931(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
      Strain: KOS.

    Entry informationi

    Entry nameiUS10_HHV11
    AccessioniPrimary (citable) accession number: P06486
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3