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P06485

- US02_HHV11

UniProt

P06485 - US02_HHV11

Protein

Protein US2

Gene

US2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein US2
    Gene namesi
    ORF Names:US2
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host cytoplasm By similarity. Host nucleus By similarity
    Note: Found in association with the nuclear matrix of infected cells.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed; by host1 Publication
    Chaini2 – 291290Protein US2PRO_0000116126Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine; by host; partial1 Publication

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Interacts with host KRT18.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 86Poly-Val

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003485. Herpes_US2_varicellovirus.
    [Graphical view]
    PfamiPF02476. US2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06485-1 [UniParc]FASTAAdd to Basket

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    MGVVVVNVMT LLDQNNALPR TSVDASPALW SFLLRQCRIL ASEPLGTPVV    50
    VRPANLRRLA EPLMDLPKPT RPIVRTRSCR CPPNTTTGLF AEDSPLESTE 100
    VVDAVACFRL LHRDQPSPPR LYHLWVVGAA DLCVPFLEYA QKIRLGVRFI 150
    AIKTPDAWVG EPWAVPTRFL PEWTVAWTPF PAAPNHPLET LLSRYEYQYG 200
    VVLPGTNGRE RDCMRWLRSL IALHKPHPAT PGPLTTSHPV RRPCCACMGM 250
    PEVPDEQPTS PGRGPQETDP LIAVRGERPR LPHICYPVTT L 291
    Length:291
    Mass (Da):32,471
    Last modified:January 23, 2007 - v3
    Checksum:i7227D9F051FD3A78
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801R → C in strain: Nonneuroinvasive mutant HF10.
    Natural varianti172 – 1721E → K in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02138 Genomic DNA. Translation: CAA26056.1.
    L00036 Genomic DNA. Translation: AAA96686.1.
    X14112 Genomic DNA. Translation: CAA32279.1.
    DQ889502 Genomic DNA. Translation: ABI63520.1.
    FJ593289 Genomic DNA. Translation: ACM62291.1.
    PIRiA05238. QQBE72.
    RefSeqiNP_044664.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703399.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02138 Genomic DNA. Translation: CAA26056.1 .
    L00036 Genomic DNA. Translation: AAA96686.1 .
    X14112 Genomic DNA. Translation: CAA32279.1 .
    DQ889502 Genomic DNA. Translation: ABI63520.1 .
    FJ593289 Genomic DNA. Translation: ACM62291.1 .
    PIRi A05238. QQBE72.
    RefSeqi NP_044664.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703399.

    Family and domain databases

    InterProi IPR003485. Herpes_US2_varicellovirus.
    [Graphical view ]
    Pfami PF02476. US2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dolan A., Donald S., Rixon F.J.
      J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    4. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    5. Quadroni M., Greco A., Bienvenut W.V.
      Submitted (NOV-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-20; 21-35 AND 154-168, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2.

    Entry informationi

    Entry nameiUS02_HHV11
    AccessioniPrimary (citable) accession number: P06485
    Secondary accession number(s): B9VQJ6, Q09I75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3