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Protein

Protein US2

Gene

US2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Protein US2
Gene namesi
ORF Names:US2
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Host cytoplasm By similarity
  • Host nucleus By similarity

  • Note: Found in association with the nuclear matrix of infected cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by host1 Publication
ChainiPRO_00001161262 – 291Protein US2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine; by host; partial1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP06485.

Interactioni

Subunit structurei

Interacts with host KRT18.By similarity

Protein-protein interaction databases

BioGridi971433. 2 interactors.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 8Poly-Val6

Sequence similaritiesi

Family and domain databases

InterProiIPR003485. Herpes_US2_varicellovirus.
IPR007110. Ig-like_dom.
[Graphical view]
PfamiPF02476. US2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVVVVNVMT LLDQNNALPR TSVDASPALW SFLLRQCRIL ASEPLGTPVV
60 70 80 90 100
VRPANLRRLA EPLMDLPKPT RPIVRTRSCR CPPNTTTGLF AEDSPLESTE
110 120 130 140 150
VVDAVACFRL LHRDQPSPPR LYHLWVVGAA DLCVPFLEYA QKIRLGVRFI
160 170 180 190 200
AIKTPDAWVG EPWAVPTRFL PEWTVAWTPF PAAPNHPLET LLSRYEYQYG
210 220 230 240 250
VVLPGTNGRE RDCMRWLRSL IALHKPHPAT PGPLTTSHPV RRPCCACMGM
260 270 280 290
PEVPDEQPTS PGRGPQETDP LIAVRGERPR LPHICYPVTT L
Length:291
Mass (Da):32,471
Last modified:January 23, 2007 - v3
Checksum:i7227D9F051FD3A78
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti80R → C in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti172E → K in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA. Translation: CAA26056.1.
L00036 Genomic DNA. Translation: AAA96686.1.
X14112 Genomic DNA. Translation: CAA32279.1.
DQ889502 Genomic DNA. Translation: ABI63520.1.
FJ593289 Genomic DNA. Translation: ACM62291.1.
PIRiA05238. QQBE72.
RefSeqiYP_009137137.1. NC_001806.2.

Genome annotation databases

GeneIDi2703399.
KEGGivg:2703399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA. Translation: CAA26056.1.
L00036 Genomic DNA. Translation: AAA96686.1.
X14112 Genomic DNA. Translation: CAA32279.1.
DQ889502 Genomic DNA. Translation: ABI63520.1.
FJ593289 Genomic DNA. Translation: ACM62291.1.
PIRiA05238. QQBE72.
RefSeqiYP_009137137.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971433. 2 interactors.

Proteomic databases

PRIDEiP06485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703399.
KEGGivg:2703399.

Family and domain databases

InterProiIPR003485. Herpes_US2_varicellovirus.
IPR007110. Ig-like_dom.
[Graphical view]
PfamiPF02476. US2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUS02_HHV11
AccessioniPrimary (citable) accession number: P06485
Secondary accession number(s): B9VQJ6, Q09I75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.