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Protein

Protein US2

Gene

US2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Protein US2
Gene namesi
ORF Names:US2
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294 Componenti: Genome

Subcellular locationi

  • Host cytoplasm By similarity
  • Host nucleus By similarity

  • Note: Found in association with the nuclear matrix of infected cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed; by host1 Publication
Chaini2 – 291290Protein US2PRO_0000116126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine; by host; partial1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Interacts with host KRT18.By similarity

Protein-protein interaction databases

BioGridi971433. 1 interaction.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 86Poly-Val

Sequence similaritiesi

Family and domain databases

InterProiIPR003485. Herpes_US2_varicellovirus.
[Graphical view]
PfamiPF02476. US2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVVVVNVMT LLDQNNALPR TSVDASPALW SFLLRQCRIL ASEPLGTPVV
60 70 80 90 100
VRPANLRRLA EPLMDLPKPT RPIVRTRSCR CPPNTTTGLF AEDSPLESTE
110 120 130 140 150
VVDAVACFRL LHRDQPSPPR LYHLWVVGAA DLCVPFLEYA QKIRLGVRFI
160 170 180 190 200
AIKTPDAWVG EPWAVPTRFL PEWTVAWTPF PAAPNHPLET LLSRYEYQYG
210 220 230 240 250
VVLPGTNGRE RDCMRWLRSL IALHKPHPAT PGPLTTSHPV RRPCCACMGM
260 270 280 290
PEVPDEQPTS PGRGPQETDP LIAVRGERPR LPHICYPVTT L
Length:291
Mass (Da):32,471
Last modified:January 23, 2007 - v3
Checksum:i7227D9F051FD3A78
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801R → C in strain: Nonneuroinvasive mutant HF10.
Natural varianti172 – 1721E → K in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA. Translation: CAA26056.1.
L00036 Genomic DNA. Translation: AAA96686.1.
X14112 Genomic DNA. Translation: CAA32279.1.
DQ889502 Genomic DNA. Translation: ABI63520.1.
FJ593289 Genomic DNA. Translation: ACM62291.1.
PIRiA05238. QQBE72.
RefSeqiNP_044664.1. NC_001806.1.

Genome annotation databases

GeneIDi2703399.
KEGGivg:2703399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA. Translation: CAA26056.1.
L00036 Genomic DNA. Translation: AAA96686.1.
X14112 Genomic DNA. Translation: CAA32279.1.
DQ889502 Genomic DNA. Translation: ABI63520.1.
FJ593289 Genomic DNA. Translation: ACM62291.1.
PIRiA05238. QQBE72.
RefSeqiNP_044664.1. NC_001806.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971433. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703399.
KEGGivg:2703399.

Family and domain databases

InterProiIPR003485. Herpes_US2_varicellovirus.
[Graphical view]
PfamiPF02476. US2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dolan A., Donald S., Rixon F.J.
    J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  4. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  5. Quadroni M., Greco A., Bienvenut W.V.
    Submitted (NOV-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-20; 21-35 AND 154-168, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2.

Entry informationi

Entry nameiUS02_HHV11
AccessioniPrimary (citable) accession number: P06485
Secondary accession number(s): B9VQJ6, Q09I75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.