P06485 (US02_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein US2

Gene names

ORF Names:

US2

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with host KRT18 By similarity.
Subcellular location	Host cytoplasm By similarity. Host nucleus By similarity. Note: Found in association with the nuclear matrix of infected cells By similarity.
Sequence similarities	Belongs to the herpesviridae HHV-1 US2 protein family.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Host cytoplasm Host nucleus
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed; by host Ref.5
	Chain	2 – 291	290	Protein US2		PRO_0000116126
Regions
	Compositional bias	3 – 8	6	Poly-Val
Amino acid modifications
	Modified residue	2	1	N-acetylglycine; by host; partial Ref.5
Natural variations
	Natural variant	80	1	R → C in strain: Nonneuroinvasive mutant HF10.
	Natural variant	172	1	E → K in strain: Nonneuroinvasive mutant HF10.

Sequences

	Sequence		Length	Mass (Da)
	P06485 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 7227D9F051FD3A78	FASTA	291	32,471
	10 20 30 40 50 60 MGVVVVNVMT LLDQNNALPR TSVDASPALW SFLLRQCRIL ASEPLGTPVV VRPANLRRLA 70 80 90 100 110 120 EPLMDLPKPT RPIVRTRSCR CPPNTTTGLF AEDSPLESTE VVDAVACFRL LHRDQPSPPR 130 140 150 160 170 180 LYHLWVVGAA DLCVPFLEYA QKIRLGVRFI AIKTPDAWVG EPWAVPTRFL PEWTVAWTPF 190 200 210 220 230 240 PAAPNHPLET LLSRYEYQYG VVLPGTNGRE RDCMRWLRSL IALHKPHPAT PGPLTTSHPV 250 260 270 280 290 RRPCCACMGM PEVPDEQPTS PGRGPQETDP LIAVRGERPR LPHICYPVTT L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dolan A., Donald S., Rixon F.J. J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[4]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[5]	Quadroni M., Greco A., Bienvenut W.V. Submitted (NOV-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-20; 21-35 AND 154-168, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02138 Genomic DNA. Translation: CAA26056.1. L00036 Genomic DNA. Translation: AAA96686.1. X14112 Genomic DNA. Translation: CAA32279.1. DQ889502 Genomic DNA. Translation: ABI63520.1. FJ593289 Genomic DNA. Translation: ACM62291.1.
PIR	QQBE72. A05238.
RefSeq	NP_044664.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703399.
Phylogenomic databases
ProtClustDB	CLSP2510176.
Family and domain databases
InterPro	IPR003485. Herpes_US2_varicellovirus. [Graphical view]
Pfam	PF02476. US2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

US02_HHV11

Accession

Primary (citable) accession number: P06485
Secondary accession number(s): B9VQJ6, Q09I75

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program