Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P06485 (US02_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein US2
Gene names
ORF Names:US2
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with host KRT18 By similarity.

Subcellular location

Host cytoplasm By similarity. Host nucleus By similarity. Note: Found in association with the nuclear matrix of infected cells By similarity.

Sequence similarities

Belongs to the herpesviridae HHV-1 US2 protein family.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentHost cytoplasm
Host nucleus
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host Ref.5
Chain2 – 291290Protein US2
PRO_0000116126

Regions

Compositional bias3 – 86Poly-Val

Amino acid modifications

Modified residue21N-acetylglycine; by host; partial Ref.5

Natural variations

Natural variant801R → C in strain: Nonneuroinvasive mutant HF10.
Natural variant1721E → K in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence LengthMass (Da)Tools
P06485 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 7227D9F051FD3A78

FASTA29132,471
        10         20         30         40         50         60 
MGVVVVNVMT LLDQNNALPR TSVDASPALW SFLLRQCRIL ASEPLGTPVV VRPANLRRLA 

        70         80         90        100        110        120 
EPLMDLPKPT RPIVRTRSCR CPPNTTTGLF AEDSPLESTE VVDAVACFRL LHRDQPSPPR 

       130        140        150        160        170        180 
LYHLWVVGAA DLCVPFLEYA QKIRLGVRFI AIKTPDAWVG EPWAVPTRFL PEWTVAWTPF 

       190        200        210        220        230        240 
PAAPNHPLET LLSRYEYQYG VVLPGTNGRE RDCMRWLRSL IALHKPHPAT PGPLTTSHPV 

       250        260        270        280        290 
RRPCCACMGM PEVPDEQPTS PGRGPQETDP LIAVRGERPR LPHICYPVTT L 

« Hide

References

« Hide 'large scale' references
[1]"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dolan A., Donald S., Rixon F.J.
J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[4]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[5]Quadroni M., Greco A., Bienvenut W.V.
Submitted (NOV-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-20; 21-35 AND 154-168, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02138 Genomic DNA. Translation: CAA26056.1.
L00036 Genomic DNA. Translation: AAA96686.1.
X14112 Genomic DNA. Translation: CAA32279.1.
DQ889502 Genomic DNA. Translation: ABI63520.1.
FJ593289 Genomic DNA. Translation: ACM62291.1.
PIRQQBE72. A05238.
RefSeqNP_044664.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703399.

Phylogenomic databases

ProtClustDBCLSP2510176.

Family and domain databases

InterProIPR003485. Herpes_US2_varicellovirus.
[Graphical view]
PfamPF02476. US2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUS02_HHV11
AccessionPrimary (citable) accession number: P06485
Secondary accession number(s): B9VQJ6, Q09I75
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families