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Protein

Envelope glycoprotein G

Gene

gG

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chemokine-binding protein that inhibits neutrophils' chemotaxis.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein G
Short name:
gG
Alternative name(s):
gG-1
Gene namesi
Name:gG
ORF Names:US4
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 189165Virion surfaceSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 23828IntravirionSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 238214Envelope glycoprotein GPRO_0000115767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi49 – 491N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP06484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 857Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGAMRAVV PIIPFLLVLV GVSGVPTNVS STTQPQLQTT GRPSHEAPNM
60 70 80 90 100
TQTGTTDSPT AISLTTPDHT PPMPSIGLEE EEEEEGAGDG EHLEGGDGTR
110 120 130 140 150
DTLPQSPGPA FPLAEDVEKD KPNRPVVPSP DPNNSPARPE TSRPKTPPTI
160 170 180 190 200
IGPLATRPTT RLTSKGRPLV PTPQHTPLFS FLTASPALDT LFVVSTVIHT
210 220 230
LSFLCIGAMA THLCGGWSRR GRRTHPSVRY VCLPSERG
Length:238
Mass (Da):25,239
Last modified:January 1, 1988 - v1
Checksum:iF7FDC2867E834B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96684.1.
X14112 Genomic DNA. Translation: CAA32281.1.
X02138 Genomic DNA. Translation: CAA26058.1.
AF117122 Genomic DNA. Translation: AAD33228.1.
AY240789 Genomic DNA. Translation: AAP39675.1.
AY240790 Genomic DNA. Translation: AAP39678.1.
AY240791 Genomic DNA. Translation: AAP39681.1.
AY240794 Genomic DNA. Translation: AAP39690.1.
AY240801 Genomic DNA. Translation: AAP39711.1.
AY240811 Genomic DNA. Translation: AAP39741.1.
AY240820 Genomic DNA. Translation: AAP39768.1.
AY240823 Genomic DNA. Translation: AAP39777.1.
DQ889502 Genomic DNA. Translation: ABI63522.1.
FJ593289 Genomic DNA. Translation: ACM62293.1.
PIRiA05239. QQBE74.
RefSeqiNP_044666.1. NC_001806.1.

Genome annotation databases

GeneIDi2703401.
KEGGivg:2703401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96684.1.
X14112 Genomic DNA. Translation: CAA32281.1.
X02138 Genomic DNA. Translation: CAA26058.1.
AF117122 Genomic DNA. Translation: AAD33228.1.
AY240789 Genomic DNA. Translation: AAP39675.1.
AY240790 Genomic DNA. Translation: AAP39678.1.
AY240791 Genomic DNA. Translation: AAP39681.1.
AY240794 Genomic DNA. Translation: AAP39690.1.
AY240801 Genomic DNA. Translation: AAP39711.1.
AY240811 Genomic DNA. Translation: AAP39741.1.
AY240820 Genomic DNA. Translation: AAP39768.1.
AY240823 Genomic DNA. Translation: AAP39777.1.
DQ889502 Genomic DNA. Translation: ABI63522.1.
FJ593289 Genomic DNA. Translation: ACM62293.1.
PIRiA05239. QQBE74.
RefSeqiNP_044666.1. NC_001806.1.

3D structure databases

ProteinModelPortaliP06484.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2364696.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703401.
KEGGivg:2703401.

Miscellaneous databases

PROiP06484.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dolan A., Donald S., Rixon F.J.
    J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1."
    Perry L.J., McGeoch D.J.
    J. Gen. Virol. 69:2831-2846(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Variability of the glycoprotein G gene in clinical isolates of herpes simplex virus type 1."
    Rekabdar E., Tunback P., Liljeqvist J.-A., Bergstroem T.
    Clin. Diagn. Lab. Immunol. 6:826-831(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations."
    Bowden R., Sakaoka H., Ward R., Donnelly P.
    Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK013, Isolate SK027, Isolate SK095 and Isolate SK098.
  5. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  6. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.

Entry informationi

Entry nameiGG_HHV11
AccessioniPrimary (citable) accession number: P06484
Secondary accession number(s): Q770H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 29, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.