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P06484 (GG_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein G

Short name=gG
Alternative name(s):
gG-1
Gene names
Name:gG
ORF Names:US4
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemokine-binding protein that inhibits neutrophils' chemotaxis By similarity.

Subcellular location

Virion membrane; Single-pass type I membrane protein Potential Ref.7.

Sequence similarities

Belongs to the alphaherpesvirinae glycoprotein G family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 238214Envelope glycoprotein G
PRO_0000115767

Regions

Topological domain25 – 189165Virion surface Potential
Transmembrane190 – 21021Helical; Potential
Topological domain211 – 23828Intravirion Potential
Compositional bias79 – 857Poly-Glu

Amino acid modifications

Glycosylation281N-linked (GlcNAc...); by host Potential
Glycosylation491N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P06484 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: F7FDC2867E834B92

FASTA23825,239
        10         20         30         40         50         60 
MSQGAMRAVV PIIPFLLVLV GVSGVPTNVS STTQPQLQTT GRPSHEAPNM TQTGTTDSPT 

        70         80         90        100        110        120 
AISLTTPDHT PPMPSIGLEE EEEEEGAGDG EHLEGGDGTR DTLPQSPGPA FPLAEDVEKD 

       130        140        150        160        170        180 
KPNRPVVPSP DPNNSPARPE TSRPKTPPTI IGPLATRPTT RLTSKGRPLV PTPQHTPLFS 

       190        200        210        220        230 
FLTASPALDT LFVVSTVIHT LSFLCIGAMA THLCGGWSRR GRRTHPSVRY VCLPSERG 

« Hide

References

« Hide 'large scale' references
[1]"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dolan A., Donald S., Rixon F.J.
J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1."
Perry L.J., McGeoch D.J.
J. Gen. Virol. 69:2831-2846(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Variability of the glycoprotein G gene in clinical isolates of herpes simplex virus type 1."
Rekabdar E., Tunback P., Liljeqvist J.-A., Bergstroem T.
Clin. Diagn. Lab. Immunol. 6:826-831(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations."
Bowden R., Sakaoka H., Ward R., Donnelly P.
Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK013, Isolate SK027, Isolate SK095 and Isolate SK098.
[5]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[6]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[7]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L00036 Genomic DNA. Translation: AAA96684.1.
X14112 Genomic DNA. Translation: CAA32281.1.
X02138 Genomic DNA. Translation: CAA26058.1.
AF117122 Genomic DNA. Translation: AAD33228.1.
AY240789 Genomic DNA. Translation: AAP39675.1.
AY240790 Genomic DNA. Translation: AAP39678.1.
AY240791 Genomic DNA. Translation: AAP39681.1.
AY240794 Genomic DNA. Translation: AAP39690.1.
AY240801 Genomic DNA. Translation: AAP39711.1.
AY240811 Genomic DNA. Translation: AAP39741.1.
AY240820 Genomic DNA. Translation: AAP39768.1.
AY240823 Genomic DNA. Translation: AAP39777.1.
DQ889502 Genomic DNA. Translation: ABI63522.1.
FJ593289 Genomic DNA. Translation: ACM62293.1.
PIRQQBE74. A05239.
RefSeqNP_044666.1. NC_001806.1.

3D structure databases

ProteinModelPortalP06484.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2364696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703401.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameGG_HHV11
AccessionPrimary (citable) accession number: P06484
Secondary accession number(s): Q770H5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families