P06484 (GG_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Envelope glycoprotein G
Short name=gG

Alternative name(s):
gG-1

Gene names

Name:	gG
ORF Names:	US4

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Chemokine-binding protein that inhibits neutrophils' chemotaxis By similarity.
Subcellular location	Virion membrane; Single-pass type I membrane protein Potential Ref.7.
Sequence similarities	Belongs to the alphaherpesvirinae glycoprotein G family.

Ontologies

Keywords
Cellular component	Membrane Viral envelope protein Virion
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 238	214	Envelope glycoprotein G		PRO_0000115767
Regions
	Topological domain	25 – 189	165	Virion surface Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Topological domain	211 – 238	28	Intravirion Potential
	Compositional bias	79 – 85	7	Poly-Glu
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	49	1	N-linked (GlcNAc...); by host Potential

Sequences

	Sequence		Length	Mass (Da)
	P06484 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: F7FDC2867E834B92	FASTA	238	25,239
	10 20 30 40 50 60 MSQGAMRAVV PIIPFLLVLV GVSGVPTNVS STTQPQLQTT GRPSHEAPNM TQTGTTDSPT 70 80 90 100 110 120 AISLTTPDHT PPMPSIGLEE EEEEEGAGDG EHLEGGDGTR DTLPQSPGPA FPLAEDVEKD 130 140 150 160 170 180 KPNRPVVPSP DPNNSPARPE TSRPKTPPTI IGPLATRPTT RLTSKGRPLV PTPQHTPLFS 190 200 210 220 230 FLTASPALDT LFVVSTVIHT LSFLCIGAMA THLCGGWSRR GRRTHPSVRY VCLPSERG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dolan A., Donald S., Rixon F.J. J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1." Perry L.J., McGeoch D.J. J. Gen. Virol. 69:2831-2846(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Variability of the glycoprotein G gene in clinical isolates of herpes simplex virus type 1." Rekabdar E., Tunback P., Liljeqvist J.-A., Bergstroem T. Clin. Diagn. Lab. Immunol. 6:826-831(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations." Bowden R., Sakaoka H., Ward R., Donnelly P. Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK013, Isolate SK027, Isolate SK095 and Isolate SK098.
[5]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[6]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[7]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00036 Genomic DNA. Translation: AAA96684.1. X14112 Genomic DNA. Translation: CAA32281.1. X02138 Genomic DNA. Translation: CAA26058.1. AF117122 Genomic DNA. Translation: AAD33228.1. AY240789 Genomic DNA. Translation: AAP39675.1. AY240790 Genomic DNA. Translation: AAP39678.1. AY240791 Genomic DNA. Translation: AAP39681.1. AY240794 Genomic DNA. Translation: AAP39690.1. AY240801 Genomic DNA. Translation: AAP39711.1. AY240811 Genomic DNA. Translation: AAP39741.1. AY240820 Genomic DNA. Translation: AAP39768.1. AY240823 Genomic DNA. Translation: AAP39777.1. DQ889502 Genomic DNA. Translation: ABI63522.1. FJ593289 Genomic DNA. Translation: ACM62293.1.
PIR	QQBE74. A05239.
RefSeq	NP_044666.1. NC_001806.1.
3D structure databases
ProteinModelPortal	P06484.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703401.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

GG_HHV11

Accession

Primary (citable) accession number: P06484
Secondary accession number(s): Q770H5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program