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P06484

- GG_HHV11

UniProt

P06484 - GG_HHV11

Protein

Envelope glycoprotein G

Gene

gG

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Chemokine-binding protein that inhibits neutrophils' chemotaxis.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein G
    Short name:
    gG
    Alternative name(s):
    gG-1
    Gene namesi
    Name:gG
    ORF Names:US4
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. viral envelope Source: UniProtKB-KW
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 238214Envelope glycoprotein GPRO_0000115767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi49 – 491N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP06484.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 189165Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini211 – 23828IntravirionSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi79 – 857Poly-Glu

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06484-1 [UniParc]FASTAAdd to Basket

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    MSQGAMRAVV PIIPFLLVLV GVSGVPTNVS STTQPQLQTT GRPSHEAPNM    50
    TQTGTTDSPT AISLTTPDHT PPMPSIGLEE EEEEEGAGDG EHLEGGDGTR 100
    DTLPQSPGPA FPLAEDVEKD KPNRPVVPSP DPNNSPARPE TSRPKTPPTI 150
    IGPLATRPTT RLTSKGRPLV PTPQHTPLFS FLTASPALDT LFVVSTVIHT 200
    LSFLCIGAMA THLCGGWSRR GRRTHPSVRY VCLPSERG 238
    Length:238
    Mass (Da):25,239
    Last modified:January 1, 1988 - v1
    Checksum:iF7FDC2867E834B92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00036 Genomic DNA. Translation: AAA96684.1.
    X14112 Genomic DNA. Translation: CAA32281.1.
    X02138 Genomic DNA. Translation: CAA26058.1.
    AF117122 Genomic DNA. Translation: AAD33228.1.
    AY240789 Genomic DNA. Translation: AAP39675.1.
    AY240790 Genomic DNA. Translation: AAP39678.1.
    AY240791 Genomic DNA. Translation: AAP39681.1.
    AY240794 Genomic DNA. Translation: AAP39690.1.
    AY240801 Genomic DNA. Translation: AAP39711.1.
    AY240811 Genomic DNA. Translation: AAP39741.1.
    AY240820 Genomic DNA. Translation: AAP39768.1.
    AY240823 Genomic DNA. Translation: AAP39777.1.
    DQ889502 Genomic DNA. Translation: ABI63522.1.
    FJ593289 Genomic DNA. Translation: ACM62293.1.
    PIRiA05239. QQBE74.
    RefSeqiNP_044666.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00036 Genomic DNA. Translation: AAA96684.1 .
    X14112 Genomic DNA. Translation: CAA32281.1 .
    X02138 Genomic DNA. Translation: CAA26058.1 .
    AF117122 Genomic DNA. Translation: AAD33228.1 .
    AY240789 Genomic DNA. Translation: AAP39675.1 .
    AY240790 Genomic DNA. Translation: AAP39678.1 .
    AY240791 Genomic DNA. Translation: AAP39681.1 .
    AY240794 Genomic DNA. Translation: AAP39690.1 .
    AY240801 Genomic DNA. Translation: AAP39711.1 .
    AY240811 Genomic DNA. Translation: AAP39741.1 .
    AY240820 Genomic DNA. Translation: AAP39768.1 .
    AY240823 Genomic DNA. Translation: AAP39777.1 .
    DQ889502 Genomic DNA. Translation: ABI63522.1 .
    FJ593289 Genomic DNA. Translation: ACM62293.1 .
    PIRi A05239. QQBE74.
    RefSeqi NP_044666.1. NC_001806.1.

    3D structure databases

    ProteinModelPortali P06484.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2364696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703401.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dolan A., Donald S., Rixon F.J.
      J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1."
      Perry L.J., McGeoch D.J.
      J. Gen. Virol. 69:2831-2846(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Variability of the glycoprotein G gene in clinical isolates of herpes simplex virus type 1."
      Rekabdar E., Tunback P., Liljeqvist J.-A., Bergstroem T.
      Clin. Diagn. Lab. Immunol. 6:826-831(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations."
      Bowden R., Sakaoka H., Ward R., Donnelly P.
      Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK013, Isolate SK027, Isolate SK095 and Isolate SK098.
    5. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    6. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiGG_HHV11
    AccessioniPrimary (citable) accession number: P06484
    Secondary accession number(s): Q770H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3