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P06481 (US9_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope protein US9
Alternative name(s):
10 kDa protein
Gene names
ORF Names:US9
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips. Ref.5 Ref.6

Subcellular location

Virion membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host smooth endoplasmic reticulum membrane; Single-pass type II membrane protein Probable. Host cell membrane; Single-pass type II membrane protein Potential. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein Potential. Ref.5 Ref.7 Ref.8

Post-translational modification

Phosphorylated on serines within the acidic cluster, possibly by host CK2 Potential. Phosphorylation determines whether endocytosed viral US9 traffics to the trans-Golgi network or recycles to the cell membrane Potential.

Sequence similarities

Belongs to the alphaherpesvirinae envelope protein US9 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9090Envelope protein US9
PRO_0000116132

Regions

Topological domain1 – 6767Intravirion By similarity
Transmembrane68 – 8821Helical; Signal-anchor for type II membrane protein; By similarity
Topological domain89 – 902Virion surface By similarity
Region30 – 3910Acidic
Motif21 – 244Internalization motif Potential
Compositional bias56 – 638Arg-rich (basic)

Amino acid modifications

Modified residue341Phosphoserine; by host CK2 Potential
Modified residue361Phosphoserine; by host CK2 Potential

Natural variations

Natural variant291V → A in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence LengthMass (Da)Tools
P06481 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: F4D4DC2608BB38F7

FASTA9010,027
        10         20         30         40         50         60 
MTSRLSDPNS SARSDMSVPL YPTASPVSVE AYYSESEDEA ANDFLVRMGR QQSVLRRRRR 

        70         80         90 
RTRCVGMVIA CLLVAVLSGG FGALLMWLLR 

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References

« Hide 'large scale' references
[1]"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dolan A., Donald S., Rixon F.J.
J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[4]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[5]"Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid."
LaVail J.H., Tauscher A.N., Sucher A., Harrabi O., Brandimarti R.
Neuroscience 146:974-985(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
Strain: F.
[6]"Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons."
Snyder A., Polcicova K., Johnson D.C.
J. Virol. 82:10613-10624(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: F.
[7]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.
[8]"Comparison of the pseudorabies virus Us9 protein with homologs from other veterinary and human alphaherpesviruses."
Lyman M.G., Kemp C.D., Taylor M.P., Enquist L.W.
J. Virol. 83:6978-6986(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L00036 Genomic DNA. Translation: AAA96679.1.
X14112 Genomic DNA. Translation: CAA32274.1.
X02138 Genomic DNA. Translation: CAA26063.1.
DQ889502 Genomic DNA. Translation: ABI63528.1.
FJ593289 Genomic DNA. Translation: ACM62299.1.
PIRQQBE79. A05241.
RefSeqNP_044672.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703452.

Phylogenomic databases

ProtClustDBCLSP2510183.

Family and domain databases

InterProIPR009278. Herpes_US9.
[Graphical view]
PfamPF06072. Herpes_US9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUS9_HHV11
AccessionPrimary (citable) accession number: P06481
Secondary accession number(s): B9VQK4, Q09I67
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families