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Protein

Envelope protein US9

Gene

US9

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips.2 Publications

GO - Biological processi

  • intracellular transport of virus Source: CACAO
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein US9
Alternative name(s):
10 kDa protein
Gene namesi
ORF Names:US9
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767IntravirionBy similarityAdd
BLAST
Transmembranei68 – 8821Helical; Signal-anchor for type II membrane proteinBy similarityAdd
BLAST
Topological domaini89 – 902Virion surfaceBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090Envelope protein US9PRO_0000116132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Phosphoserine; by host CK2Sequence analysis
Modified residuei36 – 361Phosphoserine; by host CK2Sequence analysis

Post-translational modificationi

Phosphorylated on serines within the acidic cluster, possibly by host CK2. Phosphorylation determines whether endocytosed viral US9 traffics to the trans-Golgi network or recycles to the cell membrane.Curated

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 3910Acidic

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 244Internalization motifSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 638Arg-rich (basic)

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR009278. Herpes_US9.
[Graphical view]
PfamiPF06072. Herpes_US9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRLSDPNS SARSDMSVPL YPTASPVSVE AYYSESEDEA ANDFLVRMGR
60 70 80 90
QQSVLRRRRR RTRCVGMVIA CLLVAVLSGG FGALLMWLLR
Length:90
Mass (Da):10,027
Last modified:January 1, 1988 - v1
Checksum:iF4D4DC2608BB38F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291V → A in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96679.1.
X14112 Genomic DNA. Translation: CAA32274.1.
X02138 Genomic DNA. Translation: CAA26063.1.
DQ889502 Genomic DNA. Translation: ABI63528.1.
FJ593289 Genomic DNA. Translation: ACM62299.1.
PIRiA05241. QQBE79.
RefSeqiYP_009137145.1. NC_001806.2.

Genome annotation databases

GeneIDi2703452.
KEGGivg:2703452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96679.1.
X14112 Genomic DNA. Translation: CAA32274.1.
X02138 Genomic DNA. Translation: CAA26063.1.
DQ889502 Genomic DNA. Translation: ABI63528.1.
FJ593289 Genomic DNA. Translation: ACM62299.1.
PIRiA05241. QQBE79.
RefSeqiYP_009137145.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703452.
KEGGivg:2703452.

Family and domain databases

InterProiIPR009278. Herpes_US9.
[Graphical view]
PfamiPF06072. Herpes_US9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUS9_HHV11
AccessioniPrimary (citable) accession number: P06481
Secondary accession number(s): B9VQK4, Q09I67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.