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P06481

- US9_HHV11

UniProt

P06481 - US9_HHV11

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Protein

Envelope protein US9

Gene

US9

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips.2 Publications

GO - Biological processi

  1. intracellular transport of virus Source: CACAO
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein US9
Alternative name(s):
10 kDa protein
Gene namesi
ORF Names:US9
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host smooth endoplasmic reticulum membrane Curated; Single-pass type II membrane protein Curated. Host cell membrane Curated; Single-pass type II membrane protein Curated
Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein (Potential).Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767IntravirionBy similarityAdd
BLAST
Transmembranei68 – 8821Helical; Signal-anchor for type II membrane proteinBy similarityAdd
BLAST
Topological domaini89 – 902Virion surfaceBy similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell plasma membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. intracellular Source: GOC
  6. viral envelope Source: UniProtKB-KW
  7. viral tegument Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090Envelope protein US9PRO_0000116132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Phosphoserine; by host CK2Sequence Analysis
Modified residuei36 – 361Phosphoserine; by host CK2Sequence Analysis

Post-translational modificationi

Phosphorylated on serines within the acidic cluster, possibly by host CK2. Phosphorylation determines whether endocytosed viral US9 traffics to the trans-Golgi network or recycles to the cell membrane.Curated

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 3910Acidic

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 244Internalization motifSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 638Arg-rich (basic)

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR009278. Herpes_US9.
[Graphical view]
PfamiPF06072. Herpes_US9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06481-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSRLSDPNS SARSDMSVPL YPTASPVSVE AYYSESEDEA ANDFLVRMGR
60 70 80 90
QQSVLRRRRR RTRCVGMVIA CLLVAVLSGG FGALLMWLLR
Length:90
Mass (Da):10,027
Last modified:January 1, 1988 - v1
Checksum:iF4D4DC2608BB38F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291V → A in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96679.1.
X14112 Genomic DNA. Translation: CAA32274.1.
X02138 Genomic DNA. Translation: CAA26063.1.
DQ889502 Genomic DNA. Translation: ABI63528.1.
FJ593289 Genomic DNA. Translation: ACM62299.1.
PIRiA05241. QQBE79.
RefSeqiNP_044672.1. NC_001806.1.

Genome annotation databases

GeneIDi2703452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96679.1 .
X14112 Genomic DNA. Translation: CAA32274.1 .
X02138 Genomic DNA. Translation: CAA26063.1 .
DQ889502 Genomic DNA. Translation: ABI63528.1 .
FJ593289 Genomic DNA. Translation: ACM62299.1 .
PIRi A05241. QQBE79.
RefSeqi NP_044672.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703452.

Family and domain databases

InterProi IPR009278. Herpes_US9.
[Graphical view ]
Pfami PF06072. Herpes_US9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dolan A., Donald S., Rixon F.J.
    J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  4. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  5. "Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid."
    LaVail J.H., Tauscher A.N., Sucher A., Harrabi O., Brandimarti R.
    Neuroscience 146:974-985(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
    Strain: F.
  6. "Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons."
    Snyder A., Polcicova K., Johnson D.C.
    J. Virol. 82:10613-10624(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: F.
  7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  8. "Comparison of the pseudorabies virus Us9 protein with homologs from other veterinary and human alphaherpesviruses."
    Lyman M.G., Kemp C.D., Taylor M.P., Enquist L.W.
    J. Virol. 83:6978-6986(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUS9_HHV11
AccessioniPrimary (citable) accession number: P06481
Secondary accession number(s): B9VQK4, Q09I67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3