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P06481

- US9_HHV11

UniProt

P06481 - US9_HHV11

Protein

Envelope protein US9

Gene

US9

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips.2 Publications

    GO - Biological processi

    1. intracellular transport of virus Source: CACAO

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope protein US9
    Alternative name(s):
    10 kDa protein
    Gene namesi
    ORF Names:US9
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host smooth endoplasmic reticulum membrane Curated; Single-pass type II membrane protein Curated. Host cell membrane Curated; Single-pass type II membrane protein Curated
    Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN), maybe through an interaction with PACS-1 sorting protein Potential.Curated

    GO - Cellular componenti

    1. host cell Golgi membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. host cell smooth endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. intracellular Source: GOC
    6. viral envelope Source: UniProtKB-KW
    7. viral tegument Source: InterPro
    8. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9090Envelope protein US9PRO_0000116132Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341Phosphoserine; by host CK2Sequence Analysis
    Modified residuei36 – 361Phosphoserine; by host CK2Sequence Analysis

    Post-translational modificationi

    Phosphorylated on serines within the acidic cluster, possibly by host CK2. Phosphorylation determines whether endocytosed viral US9 traffics to the trans-Golgi network or recycles to the cell membrane.Curated

    Keywords - PTMi

    Phosphoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6767IntravirionBy similarityAdd
    BLAST
    Topological domaini89 – 902Virion surfaceBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8821Helical; Signal-anchor for type II membrane proteinBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 3910Acidic

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi21 – 244Internalization motifSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 638Arg-rich (basic)

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR009278. Herpes_US9.
    [Graphical view]
    PfamiPF06072. Herpes_US9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P06481-1 [UniParc]FASTAAdd to Basket

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    MTSRLSDPNS SARSDMSVPL YPTASPVSVE AYYSESEDEA ANDFLVRMGR   50
    QQSVLRRRRR RTRCVGMVIA CLLVAVLSGG FGALLMWLLR 90
    Length:90
    Mass (Da):10,027
    Last modified:January 1, 1988 - v1
    Checksum:iF4D4DC2608BB38F7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291V → A in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00036 Genomic DNA. Translation: AAA96679.1.
    X14112 Genomic DNA. Translation: CAA32274.1.
    X02138 Genomic DNA. Translation: CAA26063.1.
    DQ889502 Genomic DNA. Translation: ABI63528.1.
    FJ593289 Genomic DNA. Translation: ACM62299.1.
    PIRiA05241. QQBE79.
    RefSeqiNP_044672.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00036 Genomic DNA. Translation: AAA96679.1 .
    X14112 Genomic DNA. Translation: CAA32274.1 .
    X02138 Genomic DNA. Translation: CAA26063.1 .
    DQ889502 Genomic DNA. Translation: ABI63528.1 .
    FJ593289 Genomic DNA. Translation: ACM62299.1 .
    PIRi A05241. QQBE79.
    RefSeqi NP_044672.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703452.

    Family and domain databases

    InterProi IPR009278. Herpes_US9.
    [Graphical view ]
    Pfami PF06072. Herpes_US9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dolan A., Donald S., Rixon F.J.
      J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    4. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    5. "Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid."
      LaVail J.H., Tauscher A.N., Sucher A., Harrabi O., Brandimarti R.
      Neuroscience 146:974-985(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
      Strain: F.
    6. "Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons."
      Snyder A., Polcicova K., Johnson D.C.
      J. Virol. 82:10613-10624(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: F.
    7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    8. "Comparison of the pseudorabies virus Us9 protein with homologs from other veterinary and human alphaherpesviruses."
      Lyman M.G., Kemp C.D., Taylor M.P., Enquist L.W.
      J. Virol. 83:6978-6986(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiUS9_HHV11
    AccessioniPrimary (citable) accession number: P06481
    Secondary accession number(s): B9VQK4, Q09I67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3