Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P06480 (GJ_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein J
Gene names
Name:gJ
ORF Names:US5
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell. Ref.7

Subcellular location

Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Host endosome membrane; Single-pass type I membrane protein Potential Ref.7 Ref.8.

Sequence similarities

Belongs to the alphaherpesvirinae glycoprotein J family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 9271Envelope glycoprotein J
PRO_0000115789

Regions

Topological domain22 – 4928Extracellular Potential
Transmembrane50 – 7021Helical; Potential
Topological domain71 – 9222Cytoplasmic Potential

Amino acid modifications

Glycosylation301N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P06480 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 14DA8BD9F18DA655

FASTA929,556
        10         20         30         40         50         60 
MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF AVPLVVGGLC 

        70         80         90 
AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dolan A., Donald S., Rixon F.J.
J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Bowden R.J.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK081, Isolate SK095, Isolate SK096, Isolate SK097, SK006 and SK027.
[4]"Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations."
Bowden R., Sakaoka H., Ward R., Donnelly P.
Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK006, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK027, Isolate SK081, Isolate SK095, Isolate SK096 and Isolate SK097.
[5]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[6]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[7]"The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation."
Aubert M., Chen Z., Lang R., Dang C.H., Fowler C., Sloan D.D., Jerome K.R.
J. Virol. 82:617-629(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
Strain: F.
[8]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L00036 Genomic DNA. Translation: AAA96683.1.
X14112 Genomic DNA. Translation: CAA32282.1.
X02138 Genomic DNA. Translation: CAA26059.1.
AY240646 Genomic DNA. Translation: AAP39247.1.
AY240647 Genomic DNA. Translation: AAP39250.1.
AY240651 Genomic DNA. Translation: AAP39262.1.
AY240655 Genomic DNA. Translation: AAP39274.1.
AY240657 Genomic DNA. Translation: AAP39280.1.
AY240658 Genomic DNA. Translation: AAP39283.1.
AY240789 Genomic DNA. Translation: AAP39676.1.
AY240790 Genomic DNA. Translation: AAP39679.1.
AY240791 Genomic DNA. Translation: AAP39682.1.
AY240794 Genomic DNA. Translation: AAP39691.1.
AY240795 Genomic DNA. Translation: AAP39694.1.
AY240796 Genomic DNA. Translation: AAP39697.1.
AY240797 Genomic DNA. Translation: AAP39700.1.
AY240800 Genomic DNA. Translation: AAP39709.1.
AY240801 Genomic DNA. Translation: AAP39712.1.
AY240802 Genomic DNA. Translation: AAP39715.1.
AY240805 Genomic DNA. Translation: AAP39724.1.
AY240806 Genomic DNA. Translation: AAP39727.1.
AY240808 Genomic DNA. Translation: AAP39733.1.
AY240809 Genomic DNA. Translation: AAP39736.1.
AY240811 Genomic DNA. Translation: AAP39742.1.
AY240812 Genomic DNA. Translation: AAP39745.1.
AY240820 Genomic DNA. Translation: AAP39769.1.
AY240821 Genomic DNA. Translation: AAP39772.1.
AY240822 Genomic DNA. Translation: AAP39775.1.
DQ889502 Genomic DNA. Translation: ABI63523.1.
FJ593289 Genomic DNA. Translation: ACM62294.1.
PIRQQBE75. A05240.
RefSeqNP_044667.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2364696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703406.

Family and domain databases

InterProIPR004913. Herpes_gJ.
[Graphical view]
PfamPF03229. Alpha_GJ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGJ_HHV11
AccessionPrimary (citable) accession number: P06480
Secondary accession number(s): Q771F7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families