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Protein

Envelope glycoprotein J

Gene

gJ

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein J
Gene namesi
Name:gJ
ORF Names:US5
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 49ExtracellularSequence analysisAdd BLAST28
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 92CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host endosome, Host Golgi apparatus, Host membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000011578922 – 92Envelope glycoprotein JAdd BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR004913. Herpes_gJ.
[Graphical view]
PfamiPF03229. Alpha_GJ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF
60 70 80 90
AVPLVVGGLC AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV
Length:92
Mass (Da):9,556
Last modified:January 1, 1988 - v1
Checksum:i14DA8BD9F18DA655
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96683.1.
X14112 Genomic DNA. Translation: CAA32282.1.
X02138 Genomic DNA. Translation: CAA26059.1.
AY240646 Genomic DNA. Translation: AAP39247.1.
AY240647 Genomic DNA. Translation: AAP39250.1.
AY240651 Genomic DNA. Translation: AAP39262.1.
AY240655 Genomic DNA. Translation: AAP39274.1.
AY240657 Genomic DNA. Translation: AAP39280.1.
AY240658 Genomic DNA. Translation: AAP39283.1.
AY240789 Genomic DNA. Translation: AAP39676.1.
AY240790 Genomic DNA. Translation: AAP39679.1.
AY240791 Genomic DNA. Translation: AAP39682.1.
AY240794 Genomic DNA. Translation: AAP39691.1.
AY240795 Genomic DNA. Translation: AAP39694.1.
AY240796 Genomic DNA. Translation: AAP39697.1.
AY240797 Genomic DNA. Translation: AAP39700.1.
AY240800 Genomic DNA. Translation: AAP39709.1.
AY240801 Genomic DNA. Translation: AAP39712.1.
AY240802 Genomic DNA. Translation: AAP39715.1.
AY240805 Genomic DNA. Translation: AAP39724.1.
AY240806 Genomic DNA. Translation: AAP39727.1.
AY240808 Genomic DNA. Translation: AAP39733.1.
AY240809 Genomic DNA. Translation: AAP39736.1.
AY240811 Genomic DNA. Translation: AAP39742.1.
AY240812 Genomic DNA. Translation: AAP39745.1.
AY240820 Genomic DNA. Translation: AAP39769.1.
AY240821 Genomic DNA. Translation: AAP39772.1.
AY240822 Genomic DNA. Translation: AAP39775.1.
DQ889502 Genomic DNA. Translation: ABI63523.1.
FJ593289 Genomic DNA. Translation: ACM62294.1.
PIRiA05240. QQBE75.
RefSeqiYP_009137140.1. NC_001806.2.

Genome annotation databases

GeneIDi2703406.
KEGGivg:2703406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA. Translation: AAA96683.1.
X14112 Genomic DNA. Translation: CAA32282.1.
X02138 Genomic DNA. Translation: CAA26059.1.
AY240646 Genomic DNA. Translation: AAP39247.1.
AY240647 Genomic DNA. Translation: AAP39250.1.
AY240651 Genomic DNA. Translation: AAP39262.1.
AY240655 Genomic DNA. Translation: AAP39274.1.
AY240657 Genomic DNA. Translation: AAP39280.1.
AY240658 Genomic DNA. Translation: AAP39283.1.
AY240789 Genomic DNA. Translation: AAP39676.1.
AY240790 Genomic DNA. Translation: AAP39679.1.
AY240791 Genomic DNA. Translation: AAP39682.1.
AY240794 Genomic DNA. Translation: AAP39691.1.
AY240795 Genomic DNA. Translation: AAP39694.1.
AY240796 Genomic DNA. Translation: AAP39697.1.
AY240797 Genomic DNA. Translation: AAP39700.1.
AY240800 Genomic DNA. Translation: AAP39709.1.
AY240801 Genomic DNA. Translation: AAP39712.1.
AY240802 Genomic DNA. Translation: AAP39715.1.
AY240805 Genomic DNA. Translation: AAP39724.1.
AY240806 Genomic DNA. Translation: AAP39727.1.
AY240808 Genomic DNA. Translation: AAP39733.1.
AY240809 Genomic DNA. Translation: AAP39736.1.
AY240811 Genomic DNA. Translation: AAP39742.1.
AY240812 Genomic DNA. Translation: AAP39745.1.
AY240820 Genomic DNA. Translation: AAP39769.1.
AY240821 Genomic DNA. Translation: AAP39772.1.
AY240822 Genomic DNA. Translation: AAP39775.1.
DQ889502 Genomic DNA. Translation: ABI63523.1.
FJ593289 Genomic DNA. Translation: ACM62294.1.
PIRiA05240. QQBE75.
RefSeqiYP_009137140.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2364696.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703406.
KEGGivg:2703406.

Miscellaneous databases

PROiP06480.

Family and domain databases

InterProiIPR004913. Herpes_gJ.
[Graphical view]
PfamiPF03229. Alpha_GJ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGJ_HHV11
AccessioniPrimary (citable) accession number: P06480
Secondary accession number(s): Q771F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.