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P06480

- GJ_HHV11

UniProt

P06480 - GJ_HHV11

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Protein
Envelope glycoprotein J
Gene
gJ, US5
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell.1 Publication

GO - Biological processi

  1. suppression by virus of host apoptotic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein J
Gene namesi
Name:gJ
ORF Names:US5
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction. Host endosome membrane; Single-pass type I membrane protein Reviewed prediction 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 4928Extracellular Reviewed prediction
Add
BLAST
Transmembranei50 – 7021Helical; Reviewed prediction
Add
BLAST
Topological domaini71 – 9222Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. host cell endosome membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host endosome, Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 9271Envelope glycoprotein J
PRO_0000115789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR004913. Herpes_gJ.
[Graphical view]
PfamiPF03229. Alpha_GJ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06480-1 [UniParc]FASTAAdd to Basket

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MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF   50
AVPLVVGGLC AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV 92
Length:92
Mass (Da):9,556
Last modified:January 1, 1988 - v1
Checksum:i14DA8BD9F18DA655
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00036 Genomic DNA. Translation: AAA96683.1.
X14112 Genomic DNA. Translation: CAA32282.1.
X02138 Genomic DNA. Translation: CAA26059.1.
AY240646 Genomic DNA. Translation: AAP39247.1.
AY240647 Genomic DNA. Translation: AAP39250.1.
AY240651 Genomic DNA. Translation: AAP39262.1.
AY240655 Genomic DNA. Translation: AAP39274.1.
AY240657 Genomic DNA. Translation: AAP39280.1.
AY240658 Genomic DNA. Translation: AAP39283.1.
AY240789 Genomic DNA. Translation: AAP39676.1.
AY240790 Genomic DNA. Translation: AAP39679.1.
AY240791 Genomic DNA. Translation: AAP39682.1.
AY240794 Genomic DNA. Translation: AAP39691.1.
AY240795 Genomic DNA. Translation: AAP39694.1.
AY240796 Genomic DNA. Translation: AAP39697.1.
AY240797 Genomic DNA. Translation: AAP39700.1.
AY240800 Genomic DNA. Translation: AAP39709.1.
AY240801 Genomic DNA. Translation: AAP39712.1.
AY240802 Genomic DNA. Translation: AAP39715.1.
AY240805 Genomic DNA. Translation: AAP39724.1.
AY240806 Genomic DNA. Translation: AAP39727.1.
AY240808 Genomic DNA. Translation: AAP39733.1.
AY240809 Genomic DNA. Translation: AAP39736.1.
AY240811 Genomic DNA. Translation: AAP39742.1.
AY240812 Genomic DNA. Translation: AAP39745.1.
AY240820 Genomic DNA. Translation: AAP39769.1.
AY240821 Genomic DNA. Translation: AAP39772.1.
AY240822 Genomic DNA. Translation: AAP39775.1.
DQ889502 Genomic DNA. Translation: ABI63523.1.
FJ593289 Genomic DNA. Translation: ACM62294.1.
PIRiA05240. QQBE75.
RefSeqiNP_044667.1. NC_001806.1.

Genome annotation databases

GeneIDi2703406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00036 Genomic DNA. Translation: AAA96683.1 .
X14112 Genomic DNA. Translation: CAA32282.1 .
X02138 Genomic DNA. Translation: CAA26059.1 .
AY240646 Genomic DNA. Translation: AAP39247.1 .
AY240647 Genomic DNA. Translation: AAP39250.1 .
AY240651 Genomic DNA. Translation: AAP39262.1 .
AY240655 Genomic DNA. Translation: AAP39274.1 .
AY240657 Genomic DNA. Translation: AAP39280.1 .
AY240658 Genomic DNA. Translation: AAP39283.1 .
AY240789 Genomic DNA. Translation: AAP39676.1 .
AY240790 Genomic DNA. Translation: AAP39679.1 .
AY240791 Genomic DNA. Translation: AAP39682.1 .
AY240794 Genomic DNA. Translation: AAP39691.1 .
AY240795 Genomic DNA. Translation: AAP39694.1 .
AY240796 Genomic DNA. Translation: AAP39697.1 .
AY240797 Genomic DNA. Translation: AAP39700.1 .
AY240800 Genomic DNA. Translation: AAP39709.1 .
AY240801 Genomic DNA. Translation: AAP39712.1 .
AY240802 Genomic DNA. Translation: AAP39715.1 .
AY240805 Genomic DNA. Translation: AAP39724.1 .
AY240806 Genomic DNA. Translation: AAP39727.1 .
AY240808 Genomic DNA. Translation: AAP39733.1 .
AY240809 Genomic DNA. Translation: AAP39736.1 .
AY240811 Genomic DNA. Translation: AAP39742.1 .
AY240812 Genomic DNA. Translation: AAP39745.1 .
AY240820 Genomic DNA. Translation: AAP39769.1 .
AY240821 Genomic DNA. Translation: AAP39772.1 .
AY240822 Genomic DNA. Translation: AAP39775.1 .
DQ889502 Genomic DNA. Translation: ABI63523.1 .
FJ593289 Genomic DNA. Translation: ACM62294.1 .
PIRi A05240. QQBE75.
RefSeqi NP_044667.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2364696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703406.

Family and domain databases

InterProi IPR004913. Herpes_gJ.
[Graphical view ]
Pfami PF03229. Alpha_GJ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dolan A., Donald S., Rixon F.J.
    J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Bowden R.J.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK081, Isolate SK095, Isolate SK096, Isolate SK097, SK006 and SK027.
  4. "Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations."
    Bowden R., Sakaoka H., Ward R., Donnelly P.
    Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK006, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK027, Isolate SK081, Isolate SK095, Isolate SK096 and Isolate SK097.
  5. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  6. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  7. "The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation."
    Aubert M., Chen Z., Lang R., Dang C.H., Fowler C., Sloan D.D., Jerome K.R.
    J. Virol. 82:617-629(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
    Strain: F.
  8. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.

Entry informationi

Entry nameiGJ_HHV11
AccessioniPrimary (citable) accession number: P06480
Secondary accession number(s): Q771F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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