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P06480

- GJ_HHV11

UniProt

P06480 - GJ_HHV11

Protein

Envelope glycoprotein J

Gene

gJ

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell.1 Publication

    GO - Biological processi

    1. suppression by virus of host apoptotic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein J
    Gene namesi
    Name:gJ
    ORF Names:US5
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell endosome membrane Source: UniProtKB-SubCell
    3. host cell Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host endosome, Host Golgi apparatus, Host membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 9271Envelope glycoprotein JPRO_0000115789Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 4928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini71 – 9222CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR004913. Herpes_gJ.
    [Graphical view]
    PfamiPF03229. Alpha_GJ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF   50
    AVPLVVGGLC AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV 92
    Length:92
    Mass (Da):9,556
    Last modified:January 1, 1988 - v1
    Checksum:i14DA8BD9F18DA655
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00036 Genomic DNA. Translation: AAA96683.1.
    X14112 Genomic DNA. Translation: CAA32282.1.
    X02138 Genomic DNA. Translation: CAA26059.1.
    AY240646 Genomic DNA. Translation: AAP39247.1.
    AY240647 Genomic DNA. Translation: AAP39250.1.
    AY240651 Genomic DNA. Translation: AAP39262.1.
    AY240655 Genomic DNA. Translation: AAP39274.1.
    AY240657 Genomic DNA. Translation: AAP39280.1.
    AY240658 Genomic DNA. Translation: AAP39283.1.
    AY240789 Genomic DNA. Translation: AAP39676.1.
    AY240790 Genomic DNA. Translation: AAP39679.1.
    AY240791 Genomic DNA. Translation: AAP39682.1.
    AY240794 Genomic DNA. Translation: AAP39691.1.
    AY240795 Genomic DNA. Translation: AAP39694.1.
    AY240796 Genomic DNA. Translation: AAP39697.1.
    AY240797 Genomic DNA. Translation: AAP39700.1.
    AY240800 Genomic DNA. Translation: AAP39709.1.
    AY240801 Genomic DNA. Translation: AAP39712.1.
    AY240802 Genomic DNA. Translation: AAP39715.1.
    AY240805 Genomic DNA. Translation: AAP39724.1.
    AY240806 Genomic DNA. Translation: AAP39727.1.
    AY240808 Genomic DNA. Translation: AAP39733.1.
    AY240809 Genomic DNA. Translation: AAP39736.1.
    AY240811 Genomic DNA. Translation: AAP39742.1.
    AY240812 Genomic DNA. Translation: AAP39745.1.
    AY240820 Genomic DNA. Translation: AAP39769.1.
    AY240821 Genomic DNA. Translation: AAP39772.1.
    AY240822 Genomic DNA. Translation: AAP39775.1.
    DQ889502 Genomic DNA. Translation: ABI63523.1.
    FJ593289 Genomic DNA. Translation: ACM62294.1.
    PIRiA05240. QQBE75.
    RefSeqiNP_044667.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00036 Genomic DNA. Translation: AAA96683.1 .
    X14112 Genomic DNA. Translation: CAA32282.1 .
    X02138 Genomic DNA. Translation: CAA26059.1 .
    AY240646 Genomic DNA. Translation: AAP39247.1 .
    AY240647 Genomic DNA. Translation: AAP39250.1 .
    AY240651 Genomic DNA. Translation: AAP39262.1 .
    AY240655 Genomic DNA. Translation: AAP39274.1 .
    AY240657 Genomic DNA. Translation: AAP39280.1 .
    AY240658 Genomic DNA. Translation: AAP39283.1 .
    AY240789 Genomic DNA. Translation: AAP39676.1 .
    AY240790 Genomic DNA. Translation: AAP39679.1 .
    AY240791 Genomic DNA. Translation: AAP39682.1 .
    AY240794 Genomic DNA. Translation: AAP39691.1 .
    AY240795 Genomic DNA. Translation: AAP39694.1 .
    AY240796 Genomic DNA. Translation: AAP39697.1 .
    AY240797 Genomic DNA. Translation: AAP39700.1 .
    AY240800 Genomic DNA. Translation: AAP39709.1 .
    AY240801 Genomic DNA. Translation: AAP39712.1 .
    AY240802 Genomic DNA. Translation: AAP39715.1 .
    AY240805 Genomic DNA. Translation: AAP39724.1 .
    AY240806 Genomic DNA. Translation: AAP39727.1 .
    AY240808 Genomic DNA. Translation: AAP39733.1 .
    AY240809 Genomic DNA. Translation: AAP39736.1 .
    AY240811 Genomic DNA. Translation: AAP39742.1 .
    AY240812 Genomic DNA. Translation: AAP39745.1 .
    AY240820 Genomic DNA. Translation: AAP39769.1 .
    AY240821 Genomic DNA. Translation: AAP39772.1 .
    AY240822 Genomic DNA. Translation: AAP39775.1 .
    DQ889502 Genomic DNA. Translation: ABI63523.1 .
    FJ593289 Genomic DNA. Translation: ACM62294.1 .
    PIRi A05240. QQBE75.
    RefSeqi NP_044667.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2364696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703406.

    Family and domain databases

    InterProi IPR004913. Herpes_gJ.
    [Graphical view ]
    Pfami PF03229. Alpha_GJ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dolan A., Donald S., Rixon F.J.
      J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Bowden R.J.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK081, Isolate SK095, Isolate SK096, Isolate SK097, SK006 and SK027.
    4. "Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations."
      Bowden R., Sakaoka H., Ward R., Donnelly P.
      Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK006, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK027, Isolate SK081, Isolate SK095, Isolate SK096 and Isolate SK097.
    5. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    6. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    7. "The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation."
      Aubert M., Chen Z., Lang R., Dang C.H., Fowler C., Sloan D.D., Jerome K.R.
      J. Virol. 82:617-629(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
      Strain: F.
    8. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiGJ_HHV11
    AccessioniPrimary (citable) accession number: P06480
    Secondary accession number(s): Q771F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3