P06480 (GJ_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein J
Short name=gJ

Gene names

Name:	gJ
ORF Names:	US5

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	92 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell. Ref.7
Subcellular location	Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Host endosome membrane; Single-pass type I membrane protein Potential Ref.7 Ref.8.
Sequence similarities	Belongs to the alphaherpesvirinae glycoprotein J family.

Ontologies

Keywords
Cellular component	Host Golgi apparatus Host endoplasmic reticulum Host endosome Host membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	suppression by virus of host apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell host cell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell host cell endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 92	71	Glycoprotein J		PRO_0000115789
Regions
	Topological domain	22 – 49	28	Extracellular Potential
	Transmembrane	50 – 70	21	Helical; Potential
	Topological domain	71 – 92	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	30	1	N-linked (GlcNAc...); by host Potential

Sequences

	Sequence		Length	Mass (Da)
	P06480 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 14DA8BD9F18DA655	FASTA	92	9,556
	10 20 30 40 50 60 MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF AVPLVVGGLC 70 80 90 AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dolan A., Donald S., Rixon F.J. J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Bowden R.J. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK081, Isolate SK095, Isolate SK096, Isolate SK097, SK006 and SK027.
[4]	"Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations." Bowden R., Sakaoka H., Ward R., Donnelly P. Infect. Genet. Evol. 6:63-74(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12, Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005, Isolate SK006, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK027, Isolate SK081, Isolate SK095, Isolate SK096 and Isolate SK097.
[5]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[6]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[7]	"The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation." Aubert M., Chen Z., Lang R., Dang C.H., Fowler C., Sloan D.D., Jerome K.R. J. Virol. 82:617-629(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. Strain: F.
[8]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00036 Genomic DNA. Translation: AAA96683.1. X14112 Genomic DNA. Translation: CAA32282.1. X02138 Genomic DNA. Translation: CAA26059.1. AY240646 Genomic DNA. Translation: AAP39247.1. AY240647 Genomic DNA. Translation: AAP39250.1. AY240651 Genomic DNA. Translation: AAP39262.1. AY240655 Genomic DNA. Translation: AAP39274.1. AY240657 Genomic DNA. Translation: AAP39280.1. AY240658 Genomic DNA. Translation: AAP39283.1. AY240789 Genomic DNA. Translation: AAP39676.1. AY240790 Genomic DNA. Translation: AAP39679.1. AY240791 Genomic DNA. Translation: AAP39682.1. AY240794 Genomic DNA. Translation: AAP39691.1. AY240795 Genomic DNA. Translation: AAP39694.1. AY240796 Genomic DNA. Translation: AAP39697.1. AY240797 Genomic DNA. Translation: AAP39700.1. AY240800 Genomic DNA. Translation: AAP39709.1. AY240801 Genomic DNA. Translation: AAP39712.1. AY240802 Genomic DNA. Translation: AAP39715.1. AY240805 Genomic DNA. Translation: AAP39724.1. AY240806 Genomic DNA. Translation: AAP39727.1. AY240808 Genomic DNA. Translation: AAP39733.1. AY240809 Genomic DNA. Translation: AAP39736.1. AY240811 Genomic DNA. Translation: AAP39742.1. AY240812 Genomic DNA. Translation: AAP39745.1. AY240820 Genomic DNA. Translation: AAP39769.1. AY240821 Genomic DNA. Translation: AAP39772.1. AY240822 Genomic DNA. Translation: AAP39775.1. DQ889502 Genomic DNA. Translation: ABI63523.1. FJ593289 Genomic DNA. Translation: ACM62294.1.
PIR	QQBE75. A05240.
RefSeq	NP_044667.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703406.
Phylogenomic databases
ProtClustDB	CLSP2743221.
Family and domain databases
InterPro	IPR004913. Herpes_gJ. [Graphical view]
Pfam	PF03229. Alpha_GJ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GJ_HHV11

Accession

Primary (citable) accession number: P06480
Secondary accession number(s): Q771F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program