P06474RIR2_HHV1KRibonucleoside-diphosphate reductase small subunit1.17.4.1Ribonucleotide reductase small subunitRIR2UL40Human herpesvirus 1 (strain KOS)HHV-1Human herpes simplex virus 1VirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesOrthoherpesviridaeAlphaherpesvirinaeSimplexvirusSimplexvirus humanalpha1Human herpesvirus 1Homo sapiensHumanDetailed characterization of an apparently unspliced beta herpes simplex virus type 1 gene mapping in the interior of another.NUCLEOTIDE SEQUENCE [GENOMIC DNA]SEQUENCE REVISIONTinkering with a viral ribonucleotide reductase.REVIEWRibonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphateFe cationHeterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.Host membraneSingle-pass membrane proteinBelongs to the ribonucleoside diphosphate reductase small chain family.DNA replicationHost membraneIronMembraneMetal-bindingOxidoreductaseTransmembraneTransmembrane helixViral latencyViral reactivation from latencyFe cationFe cationFe cationFe cationFe cationFe cationFe cationMDSAAPALSPALTAHTGHSATADLAIQIPKCPDPERYFYTSQCPDINHLRSLSILNRWLETELVFVGDEEDVSKLSEGELSFYRFLFAFLSAADDLVTENLGGLSGLFEQKDILHYYVEQECIEVAHSRVYNIIQLVLFHNNDQARREYVAGTINHPAIRAKVDWLEARVRECASVPEKFILMILIEGIFFAASFAAIAYLRTNNLLRVTCQSNDLISRDEAVHTTASCYIYNNYLGGHAKPPPDRVYGLFRQAVEIEIGFIRSQAPTDSHILSPAALAAIENYVRFSADRLLGLIHMKPLFSAPPPDASFPLSLMSTDKHTNFFECRSTSYAGAVVNDL
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