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P06474 (RIR2_HHV1K) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase 38 kDa subunit
Ribonucleotide reductase small subunit
Gene names
Name:UL40
OrganismHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifier10306 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit UL39 (R1) and a homodimer of the small subunit UL40 (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Ribonucleoside-diphosphate reductase small chain
PRO_0000190504

Sites

Active site1311 By similarity
Metal binding941Iron 1 By similarity
Metal binding1241Iron 1 By similarity
Metal binding1241Iron 2 By similarity
Metal binding1271Iron 1 By similarity
Metal binding1871Iron 2 By similarity
Metal binding2211Iron 2 By similarity
Metal binding2241Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P06474 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 921DC04B9D278DE5

FASTA34037,966
        10         20         30         40         50         60 
MDSAAPALSP ALTAHTGHSA TADLAIQIPK CPDPERYFYT SQCPDINHLR SLSILNRWLE 

        70         80         90        100        110        120 
TELVFVGDEE DVSKLSEGEL SFYRFLFAFL SAADDLVTEN LGGLSGLFEQ KDILHYYVEQ 

       130        140        150        160        170        180 
ECIEVAHSRV YNIIQLVLFH NNDQARREYV AGTINHPAIR AKVDWLEARV RECASVPEKF 

       190        200        210        220        230        240 
ILMILIEGIF FAASFAAIAY LRTNNLLRVT CQSNDLISRD EAVHTTASCY IYNNYLGGHA 

       250        260        270        280        290        300 
KPPPDRVYGL FRQAVEIEIG FIRSQAPTDS HILSPAALAA IENYVRFSAD RLLGLIHMKP 

       310        320        330        340 
LFSAPPPDAS FPLSLMSTDK HTNFFECRST SYAGAVVNDL 

« Hide

References

[1]"Detailed characterization of an apparently unspliced beta herpes simplex virus type 1 gene mapping in the interior of another."
Draper K.G., Frink R.J., Wagner E.K.
J. Virol. 43:1123-1128(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Wagner E.K.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Tinkering with a viral ribonucleotide reductase."
Lembo D., Brune W.
Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02212 Genomic DNA. Translation: AAA66436.1.

3D structure databases

ProteinModelPortalP06474.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP06474.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_HHV1K
AccessionPrimary (citable) accession number: P06474
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1995
Last modified: December 11, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways