Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hemoglobin subunit zeta

Gene

Hbz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

GO - Biological processi

  • erythrocyte maturation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit zeta
Alternative name(s):
Alpha-like embryonic globin chain x
Hemoglobin zeta chain
Zeta-globin
Gene namesi
Name:Hbz
Synonyms:Hba-x, Hbz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96019. Hba-x.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 142141Hemoglobin subunit zetaPRO_0000052852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP06467.
PRIDEiP06467.

PTM databases

iPTMnetiP06467.
PhosphoSiteiP06467.

Expressioni

Gene expression databases

BgeeiP06467.
ExpressionAtlasiP06467. differential.
GenevisibleiP06467. MM.

Interactioni

Subunit structurei

Heterotetramer of two zeta chains and beta-type chains.By similarity

Protein-protein interaction databases

IntActiP06467. 2 interactions.
MINTiMINT-4097211.
STRINGi10090.ENSMUSP00000020531.

Structurei

3D structure databases

ProteinModelPortaliP06467.
SMRiP06467. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP06467.
KOiK13826.
OMAiETHAAWD.
OrthoDBiEOG7KH9MP.
PhylomeDBiP06467.
TreeFamiTF332328.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002340. Haemoglobin_zeta.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00816. ZETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMKNERAI IMSMWEKMAA QAEPIGTETL ERLFCSYPQT KTYFPHFDLH
60 70 80 90 100
HGSQQLRAHG FKIMTAVGDA VKSIDNLSSA LTKLSELHAY ILRVDPVNFK
110 120 130 140
LLSHCLLVTM AARFPADFTP EVHEAWDKFM SILSSILTEK YR
Length:142
Mass (Da):16,235
Last modified:January 23, 2007 - v2
Checksum:i9E9D246806744851
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441F → L in AAA37794 (PubMed:6084630).Curated
Sequence conflicti108 – 1081V → L in AAA37702 (PubMed:2444404).Curated
Sequence conflicti118 – 1181F → N in AAA37702 (PubMed:2444404).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62302 Genomic DNA. Translation: CAA44187.1.
M26898 mRNA. Translation: AAA37702.1.
AK077590 mRNA. Translation: BAC36881.1.
BC051988 mRNA. Translation: AAH51988.1.
M13125 mRNA. Translation: AAA37794.1.
CCDSiCCDS24522.1.
PIRiA23283.
RefSeqiNP_034535.1. NM_010405.4.
UniGeneiMm.141758.

Genome annotation databases

EnsembliENSMUST00000020531; ENSMUSP00000020531; ENSMUSG00000055609.
GeneIDi15126.
KEGGimmu:15126.
UCSCiuc007ijj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62302 Genomic DNA. Translation: CAA44187.1.
M26898 mRNA. Translation: AAA37702.1.
AK077590 mRNA. Translation: BAC36881.1.
BC051988 mRNA. Translation: AAH51988.1.
M13125 mRNA. Translation: AAA37794.1.
CCDSiCCDS24522.1.
PIRiA23283.
RefSeqiNP_034535.1. NM_010405.4.
UniGeneiMm.141758.

3D structure databases

ProteinModelPortaliP06467.
SMRiP06467. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06467. 2 interactions.
MINTiMINT-4097211.
STRINGi10090.ENSMUSP00000020531.

PTM databases

iPTMnetiP06467.
PhosphoSiteiP06467.

Proteomic databases

PaxDbiP06467.
PRIDEiP06467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020531; ENSMUSP00000020531; ENSMUSG00000055609.
GeneIDi15126.
KEGGimmu:15126.
UCSCiuc007ijj.2. mouse.

Organism-specific databases

CTDi15126.
MGIiMGI:96019. Hba-x.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP06467.
KOiK13826.
OMAiETHAAWD.
OrthoDBiEOG7KH9MP.
PhylomeDBiP06467.
TreeFamiTF332328.

Miscellaneous databases

PROiP06467.
SOURCEiSearch...

Gene expression databases

BgeeiP06467.
ExpressionAtlasiP06467. differential.
GenevisibleiP06467. MM.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002340. Haemoglobin_zeta.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00816. ZETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization, expression, and evolution of the mouse embryonic zeta-globin gene."
    Leder A., Weir L., Leder P.
    Mol. Cell. Biol. 5:1025-1033(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression."
    Wilkinson D.G., Bailes J.A., Champion J.E., McMahon A.P.
    Development 99:493-500(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  5. "Molecular cloning and sequence analysis of a cDNA coding for the mouse alpha-like embryonic globin chain x."
    Farace M.-G., Hill A., Tripodi M., Padgett R.W., Raschella G., Gambari R., Fantoni A., Hutchison C.A. III, Edgell M.H.
    Gene 31:241-245(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-142.
    Tissue: Erythroid cell.

Entry informationi

Entry nameiHBAZ_MOUSE
AccessioniPrimary (citable) accession number: P06467
Secondary accession number(s): Q61654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.