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Protein

Protein E6

Gene

E6

Organism
Human papillomavirus type 6b
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional transactivator. Binds double-stranded DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 6737Sequence AnalysisAdd
BLAST
Zinc fingeri104 – 14037Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Transcription, Transcription regulation, Viral immunoevasion

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6
Gene namesi
Name:E6
OrganismiHuman papillomavirus type 6b
Taxonomic identifieri10600 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007676 Componenti: Genome

Subcellular locationi

  1. Host nucleus matrix By similarity

GO - Cellular componenti

  1. host cell nuclear matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Protein E6PRO_0000133326Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human zyxin.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MCM7P339932EBI-7069993,EBI-355924From a different organism.

Protein-protein interaction databases

IntActiP06462. 3 interactions.
MINTiMINT-104603.

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 6737Sequence AnalysisAdd
BLAST
Zinc fingeri104 – 14037Sequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESANASTSA TTIDQLCKTF NLSMHTLQIN CVFCKNALTT AEIYSYAYKH
60 70 80 90 100
LKVLFRGGYP YAACACCLEF HGKINQYRHF DYAGYATTVE EETKQDILDV
110 120 130 140 150
LIRCYLCHKP LCEVEKVKHI LTKARFIKLN CTWKGRCLHC WTTCMEDMLP
Length:150
Mass (Da):17,299
Last modified:January 1, 1988 - v1
Checksum:iF7C5EF80356A4DF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00203 Genomic DNA. Translation: CAA25018.1.
PIRiE20558. W6WL6.
RefSeqiNP_040296.1. NC_001355.1.

Genome annotation databases

GeneIDi1489368.
KEGGivg:1489368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00203 Genomic DNA. Translation: CAA25018.1.
PIRiE20558. W6WL6.
RefSeqiNP_040296.1. NC_001355.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06462. 3 interactions.
MINTiMINT-104603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489368.
KEGGivg:1489368.

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and genome organization of genital human papillomavirus type 6b."
    Schwarz E., Durst M., Demankowski C., Lattermann O., Zech R., Wolfsperger E., Suhai S., zur Hausen H.
    EMBO J. 2:2341-2348(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation."
    Degenhardt Y.Y., Silverstein S.
    J. Virol. 75:11791-11802(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZYXIN.

Entry informationi

Entry nameiVE6_HPV6B
AccessioniPrimary (citable) accession number: P06462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.