Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P06462 (VE6_HPV6B) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein E6
Gene names
Name:E6
OrganismHuman papillomavirus type 6b [Complete proteome]
Taxonomic identifier10600 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional transactivator. Binds double-stranded DNA By similarity.

Subunit structure

Interacts with human zyxin. Ref.2

Subcellular location

Host nucleus matrix By similarity.

Sequence similarities

Belongs to the papillomaviridae E6 protein family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MCM7P339932EBI-7069993,EBI-355924From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 150150Protein E6
PRO_0000133326

Regions

Zinc finger31 – 6737 Potential
Zinc finger104 – 14037 Potential

Sequences

Sequence LengthMass (Da)Tools
P06462 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: F7C5EF80356A4DF9

FASTA15017,299
        10         20         30         40         50         60 
MESANASTSA TTIDQLCKTF NLSMHTLQIN CVFCKNALTT AEIYSYAYKH LKVLFRGGYP 

        70         80         90        100        110        120 
YAACACCLEF HGKINQYRHF DYAGYATTVE EETKQDILDV LIRCYLCHKP LCEVEKVKHI 

       130        140        150 
LTKARFIKLN CTWKGRCLHC WTTCMEDMLP 

« Hide

References

[1]"DNA sequence and genome organization of genital human papillomavirus type 6b."
Schwarz E., Durst M., Demankowski C., Lattermann O., Zech R., Wolfsperger E., Suhai S., zur Hausen H.
EMBO J. 2:2341-2348(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation."
Degenhardt Y.Y., Silverstein S.
J. Virol. 75:11791-11802(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ZYXIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00203 Genomic DNA. Translation: CAA25018.1.
PIRW6WL6. E20558.
RefSeqNP_040296.1. NC_001355.1.

3D structure databases

ProteinModelPortalP06462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP06462. 3 interactions.
MINTMINT-104603.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1489368.

Phylogenomic databases

ProtClustDBPHA2779.

Family and domain databases

InterProIPR001334. E6.
[Graphical view]
PfamPF00518. E6. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVE6_HPV6B
AccessionPrimary (citable) accession number: P06462
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families