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P06462

- VE6_HPV6B

UniProt

P06462 - VE6_HPV6B

Protein

Protein E6

Gene

E6

Organism
Human papillomavirus type 6b
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transcriptional transactivator. Binds double-stranded DNA By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 6737Sequence AnalysisAdd
    BLAST
    Zinc fingeri104 – 14037Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Transcription, Transcription regulation, Viral immunoevasion

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein E6
    Gene namesi
    Name:E6
    OrganismiHuman papillomavirus type 6b
    Taxonomic identifieri10600 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007676: Genome

    Subcellular locationi

    Host nucleus matrix By similarity

    GO - Cellular componenti

    1. host cell nuclear matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Protein E6PRO_0000133326Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Subunit structurei

    Interacts with human zyxin.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MCM7P339932EBI-7069993,EBI-355924From a different organism.

    Protein-protein interaction databases

    IntActiP06462. 3 interactions.
    MINTiMINT-104603.

    Structurei

    3D structure databases

    ProteinModelPortaliP06462.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the papillomaviridae E6 protein family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 6737Sequence AnalysisAdd
    BLAST
    Zinc fingeri104 – 14037Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    InterProiIPR001334. E6.
    [Graphical view]
    PfamiPF00518. E6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P06462-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESANASTSA TTIDQLCKTF NLSMHTLQIN CVFCKNALTT AEIYSYAYKH    50
    LKVLFRGGYP YAACACCLEF HGKINQYRHF DYAGYATTVE EETKQDILDV 100
    LIRCYLCHKP LCEVEKVKHI LTKARFIKLN CTWKGRCLHC WTTCMEDMLP 150
    Length:150
    Mass (Da):17,299
    Last modified:January 1, 1988 - v1
    Checksum:iF7C5EF80356A4DF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00203 Genomic DNA. Translation: CAA25018.1.
    PIRiE20558. W6WL6.
    RefSeqiNP_040296.1. NC_001355.1.

    Genome annotation databases

    GeneIDi1489368.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00203 Genomic DNA. Translation: CAA25018.1 .
    PIRi E20558. W6WL6.
    RefSeqi NP_040296.1. NC_001355.1.

    3D structure databases

    ProteinModelPortali P06462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P06462. 3 interactions.
    MINTi MINT-104603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1489368.

    Family and domain databases

    InterProi IPR001334. E6.
    [Graphical view ]
    Pfami PF00518. E6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and genome organization of genital human papillomavirus type 6b."
      Schwarz E., Durst M., Demankowski C., Lattermann O., Zech R., Wolfsperger E., Suhai S., zur Hausen H.
      EMBO J. 2:2341-2348(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Interaction of zyxin, a focal adhesion protein, with the E6 protein from human papillomavirus type 6 results in its nuclear translocation."
      Degenhardt Y.Y., Silverstein S.
      J. Virol. 75:11791-11802(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZYXIN.

    Entry informationi

    Entry nameiVE6_HPV6B
    AccessioniPrimary (citable) accession number: P06462
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3