Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein E6

Gene

E6

Organism
Human papillomavirus type 6b
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional transactivator. Binds double-stranded DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 67Sequence analysisAdd BLAST37
Zinc fingeri104 – 140Sequence analysisAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Transcription, Transcription regulation, Viral immunoevasion

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6
Gene namesi
Name:E6
OrganismiHuman papillomavirus type 6b
Taxonomic identifieri10600 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007676 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001333261 – 150Protein E6Add BLAST150

Proteomic databases

PRIDEiP06462.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human zyxin.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MCM7P339932EBI-7069993,EBI-355924From a different organism.
UBE3AQ050862EBI-7069993,EBI-954357From a different organism.

Protein-protein interaction databases

IntActiP06462. 7 interactors.
MINTiMINT-104603.

Structurei

3D structure databases

ProteinModelPortaliP06462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 67Sequence analysisAdd BLAST37
Zinc fingeri104 – 140Sequence analysisAdd BLAST37

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESANASTSA TTIDQLCKTF NLSMHTLQIN CVFCKNALTT AEIYSYAYKH
60 70 80 90 100
LKVLFRGGYP YAACACCLEF HGKINQYRHF DYAGYATTVE EETKQDILDV
110 120 130 140 150
LIRCYLCHKP LCEVEKVKHI LTKARFIKLN CTWKGRCLHC WTTCMEDMLP
Length:150
Mass (Da):17,299
Last modified:January 1, 1988 - v1
Checksum:iF7C5EF80356A4DF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00203 Genomic DNA. Translation: CAA25018.1.
PIRiE20558. W6WL6.
RefSeqiNP_040296.1. NC_001355.1.

Genome annotation databases

GeneIDi1489368.
KEGGivg:1489368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00203 Genomic DNA. Translation: CAA25018.1.
PIRiE20558. W6WL6.
RefSeqiNP_040296.1. NC_001355.1.

3D structure databases

ProteinModelPortaliP06462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06462. 7 interactors.
MINTiMINT-104603.

Proteomic databases

PRIDEiP06462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489368.
KEGGivg:1489368.

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVE6_HPV6B
AccessioniPrimary (citable) accession number: P06462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 5, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.