P06458 (VL1_BPV2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major capsid protein L1

Gene names

Name:

L1

Organism

Bovine papillomavirus type 2 [Complete proteome]

Taxonomic identifier

10560 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Deltapapillomavirus › Deltapapillomavirus 4

Virus host

Bos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell By similarity.
Subunit structure	Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the papillomaviridae L1 protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Cellular component	Virion
Developmental stage	Late protein
Molecular function	Capsid protein T=7 icosahedral capsid protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	T=7 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Major capsid protein L1		PRO_0000133476
Experimental info
	Sequence conflict	176	1	L → I in CAA25908. Ref.1
	Sequence conflict	323	1	N → D in CAA25908. Ref.1
	Sequence conflict	386	1	L → V in CAA25908. Ref.1
	Sequence conflict	442	1	K → R in CAA25908. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P06458 [UniParc]. Last modified July 1, 1989. Version 2. Checksum: 674728E3A884A068	FASTA	497	55,595
	10 20 30 40 50 60 MALWQQGQKL YLPPTPVSKV LCSETYVQRK SIFYHAETER LLTVGHPYYQ VTVGDKTVPK 70 80 90 100 110 120 VSANQFRVFK IQLPDPNQFA LPDRTVHNPS KERLVWAVIG VQVSRGQPLG GTVTGHPTFN 130 140 150 160 170 180 ALLDAENVNR KVTAQTTDDR KQTGLDAKQQ QILLLGCTPA EGEYWTTARP CVTDRLENGA 190 200 210 220 230 240 CPPLELKNKH IEDGDMMEIG FGAADFKTLN ASKSDLPLDI QNEICLYPDY LKMAEDAAGN 250 260 270 280 290 300 SMFFFARKEQ VYVRHIWTRG GSEKEAPSKD FYLKNGRGEE TLKIPSVHFG SPSGSLVSTD 310 320 330 340 350 360 NQIFNRPYWL FRAQGMNNGI AWNNLLFLTV GDNTRGTNLS ISVAADGNAL SEYDTGKFNL 370 380 390 400 410 420 YHRHMEEYKL AFILELCSVE ITAQTLSHLQ GLMPSVLQNW EIGVQPPASS ILEDTYRYIE 430 440 450 460 470 480 SPATKCASNV IPPKEDPYAG LKFWSIDLKE KLSLDLDQFP LGRRFLAQQG AGCSTVRKRA 490 VATRNSSKPA KRKKIKA

References

[1]	"Nucleotide sequence of bovine papillomavirus type 2 late region." Potter H.L., Meinke W.J. J. Gen. Virol. 66:187-193(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Groff D.E., Mitra R., Lancaster W.D. Submitted (MAY-1988) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01768 Genomic DNA. Translation: CAA25908.1. M20219 Genomic DNA. Translation: AAA66840.1.
PIR	P1WLB2. A31169.
3D structure databases
ProteinModelPortal	P06458.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.175.20. 1 hit.
InterPro	IPR002210. Capsid_L1_Papillomavir. IPR011222. dsDNA_vir_gr_I_capsid. [Graphical view]
Pfam	PF00500. Late_protein_L1. 1 hit. [Graphical view]
PRINTS	PR00865. HPVCAPSIDL1.
SUPFAM	SSF88648. dsDNA_vir_gr_I_capsid. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VL1_BPV2

Accession

Primary (citable) accession number: P06458

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program