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Protein

Prothymosin alpha

Gene

PTMA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Biological processi

  • histone exchange Source: Ensembl
  • transcription, DNA-templated Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:PTMA
Synonyms:TMSA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9623. PTMA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5757.
OpenTargetsiENSG00000187514.
PharmGKBiPA33966.

Polymorphism and mutation databases

BioMutaiPTMA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232551 – 111Prothymosin alphaAdd BLAST111
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00002992502 – 111Prothymosin alpha, N-terminally processedAdd BLAST110
PeptideiPRO_00000298652 – 29Thymosin alpha-1Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in Prothymosin alpha, N-terminally processedCombined sources2 Publications1
Modified residuei2PhosphoserineCombined sources1 Publication1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15N6-acetyllysine; alternateCombined sources1
Modified residuei15N6-succinyllysine; alternateBy similarity1
Modified residuei102PhosphothreonineCombined sources1
Modified residuei103N6-acetyllysineBy similarity1
Modified residuei107PhosphothreonineCombined sources1

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP06454.
MaxQBiP06454.
PaxDbiP06454.
PeptideAtlasiP06454.
PRIDEiP06454.
TopDownProteomicsiP06454-1. [P06454-1]
P06454-2. [P06454-2]

PTM databases

iPTMnetiP06454.
PhosphoSitePlusiP06454.

Miscellaneous databases

PMAP-CutDBP06454.

Expressioni

Gene expression databases

BgeeiENSG00000187514.
CleanExiHS_PTMA.
ExpressionAtlasiP06454. baseline and differential.
GenevisibleiP06454. HS.

Organism-specific databases

HPAiHPA047183.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KEAP1Q141455EBI-10194874,EBI-751001
TERF2IPQ9NYB02EBI-2682091,EBI-750109

Protein-protein interaction databases

BioGridi111724. 67 interactors.
DIPiDIP-40743N.
IntActiP06454. 13 interactors.
MINTiMINT-138772.
STRINGi9606.ENSP00000344547.

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Helixi9 – 28Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L9INMR-A2-29[»]
2MNQNMR-A2-29[»]
ProteinModelPortaliP06454.
SMRiP06454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 101Asp/Glu-rich (acidic)Add BLAST60

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
GeneTreeiENSGT00730000111051.
HOGENOMiHOG000089972.
InParanoidiP06454.
KOiK13784.
TreeFamiTF350357.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P06454-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAE NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAESATGKR AAEDDEDDDV
110
DTKKQKTDED D
Length:111
Mass (Da):12,203
Last modified:January 23, 2007 - v2
Checksum:i910BBF9D8D14B8E7
GO
Isoform 2 (identifier: P06454-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: Missing.

Show »
Length:110
Mass (Da):12,074
Checksum:i3A76436E79930993
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01150840Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14630 mRNA. Translation: AAA61182.1.
M14483 mRNA. Translation: AAA61183.1.
M67480, J04797 Genomic DNA. Translation: AAA63240.1.
M67480, J04797 Genomic DNA. Translation: AAA63239.1.
M26708 mRNA. Translation: AAA60213.1.
AF348514 mRNA. Translation: AAK30146.1.
BC051265 mRNA. Translation: AAH51265.1.
BC066905 mRNA. Translation: AAH66905.1.
BC070480 mRNA. Translation: AAH70480.1.
BC071647 mRNA. Translation: AAH71647.1.
BC071879 mRNA. Translation: AAH71879.1.
S56449 Genomic DNA. Translation: AAD13882.1.
CCDSiCCDS42833.1. [P06454-1]
CCDS46541.1. [P06454-2]
PIRiA42004. TNHUA.
C33356.
RefSeqiNP_001092755.1. NM_001099285.1. [P06454-1]
NP_002814.3. NM_002823.4. [P06454-2]
UniGeneiHs.459927.

Genome annotation databases

EnsembliENST00000341369; ENSP00000344547; ENSG00000187514. [P06454-1]
ENST00000409115; ENSP00000386819; ENSG00000187514. [P06454-2]
GeneIDi5757.
KEGGihsa:5757.
UCSCiuc002vsc.5. human. [P06454-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14630 mRNA. Translation: AAA61182.1.
M14483 mRNA. Translation: AAA61183.1.
M67480, J04797 Genomic DNA. Translation: AAA63240.1.
M67480, J04797 Genomic DNA. Translation: AAA63239.1.
M26708 mRNA. Translation: AAA60213.1.
AF348514 mRNA. Translation: AAK30146.1.
BC051265 mRNA. Translation: AAH51265.1.
BC066905 mRNA. Translation: AAH66905.1.
BC070480 mRNA. Translation: AAH70480.1.
BC071647 mRNA. Translation: AAH71647.1.
BC071879 mRNA. Translation: AAH71879.1.
S56449 Genomic DNA. Translation: AAD13882.1.
CCDSiCCDS42833.1. [P06454-1]
CCDS46541.1. [P06454-2]
PIRiA42004. TNHUA.
C33356.
RefSeqiNP_001092755.1. NM_001099285.1. [P06454-1]
NP_002814.3. NM_002823.4. [P06454-2]
UniGeneiHs.459927.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L9INMR-A2-29[»]
2MNQNMR-A2-29[»]
ProteinModelPortaliP06454.
SMRiP06454.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111724. 67 interactors.
DIPiDIP-40743N.
IntActiP06454. 13 interactors.
MINTiMINT-138772.
STRINGi9606.ENSP00000344547.

PTM databases

iPTMnetiP06454.
PhosphoSitePlusiP06454.

Polymorphism and mutation databases

BioMutaiPTMA.

Proteomic databases

EPDiP06454.
MaxQBiP06454.
PaxDbiP06454.
PeptideAtlasiP06454.
PRIDEiP06454.
TopDownProteomicsiP06454-1. [P06454-1]
P06454-2. [P06454-2]

Protocols and materials databases

DNASUi5757.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341369; ENSP00000344547; ENSG00000187514. [P06454-1]
ENST00000409115; ENSP00000386819; ENSG00000187514. [P06454-2]
GeneIDi5757.
KEGGihsa:5757.
UCSCiuc002vsc.5. human. [P06454-1]

Organism-specific databases

CTDi5757.
DisGeNETi5757.
GeneCardsiPTMA.
HGNCiHGNC:9623. PTMA.
HPAiHPA047183.
MIMi188390. gene.
neXtProtiNX_P06454.
OpenTargetsiENSG00000187514.
PharmGKBiPA33966.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
GeneTreeiENSGT00730000111051.
HOGENOMiHOG000089972.
InParanoidiP06454.
KOiK13784.
TreeFamiTF350357.

Miscellaneous databases

ChiTaRSiPTMA. human.
GeneWikiiThymosin_%CE%B11.
GenomeRNAii5757.
PMAP-CutDBP06454.
PROiP06454.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187514.
CleanExiHS_PTMA.
ExpressionAtlasiP06454. baseline and differential.
GenevisibleiP06454. HS.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTMA_HUMAN
AccessioniPrimary (citable) accession number: P06454
Secondary accession number(s): Q15249, Q15592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.