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Protein

Keratin, type I cytoskeletal 10

Gene

KRT10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei379Stutter1

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
Cytokeratin VIB
Cytokeratin-10
Short name:
CK-10
Cytokeratin-6B
Keratin-10
Short name:
K10
Gene namesi
Name:KRT10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636411 – 526Keratin, type I cytoskeletal 10Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP06394.
PeptideAtlasiP06394.
PRIDEiP06394.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017140.

Structurei

3D structure databases

ProteinModelPortaliP06394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 126HeadAdd BLAST126
Regioni127 – 437RodAdd BLAST311
Regioni127 – 162Coil 1AAdd BLAST36
Regioni163 – 183Linker 1Add BLAST21
Regioni184 – 275Coil 1BAdd BLAST92
Regioni276 – 298Linker 12Add BLAST23
Regioni299 – 437Coil 2Add BLAST139
Regioni438 – 526TailAdd BLAST89

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJX. Eukaryota.
ENOG410YDXS. LUCA.
HOGENOMiHOG000205605.
HOVERGENiHBG013015.
InParanoidiP06394.
KOiK07604.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRYSSSKQ YSSSRSGGGG GGGSSLRISS SKGSLGGGYS SGGFSGGSFS
60 70 80 90 100
RGSSAGGCFG GSSSIYGGGL GSGFGGGYGS SFGGSYGGSF GGGYGGGGFG
110 120 130 140 150
GGSFGGGSFG GGLGGGFGDG GLISGNQKIT MQNLNDRLAS YLDKVRALEE
160 170 180 190 200
SNYELEVKIK EWYEKYGNSR QREPRDYSKY YQTIDDLKNQ IFNLTTDNAN
210 220 230 240 250
ILIQVDNARL AADDFRLKYE NEVTLRQSVE ADINGLRRVL DELTLTKTDL
260 270 280 290 300
EMQIESLTEE LAYLKKNHEE EMRDLQNVST GDVNVEMNAA PGVDLTELLN
310 320 330 340 350
NMRSQYEQLA EKNRRDAEAW FNEKSKELTT EINSNLEQVS SHKSEITELR
360 370 380 390 400
RTIQGLEIEL QSQLALKQSL EASLAETEGR YCVQLSQIQS QISSLEEQLQ
410 420 430 440 450
QIRAETECQN AEYQQLLDIK IRLENEIQTY RSLLEGEGSS GGGSYGGGRG
460 470 480 490 500
YGGSSGGGGG GYGGGSSSGG YGGGSSSGGG HGGSSGGSYG GGSSSGGGHG
510 520
GGSSSGGHKS TTTGSVGESS SKGPRY
Length:526
Mass (Da):54,848
Last modified:January 1, 1988 - v1
Checksum:iBF6B53C809FBDA48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti467 – 488SSGGY…SSGGS → PAAATAAEVQRWRPRRSFRR Q (PubMed:6209405).CuratedAdd BLAST22
Sequence conflicti494 – 503SSGGGHGGGS → PVAVARRRK (PubMed:6209405).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02870 Genomic DNA. Translation: CAA26626.1.
PIRiA02941. KRBOVI.
RefSeqiNP_776802.1. NM_174377.1.
UniGeneiBt.8.

Genome annotation databases

GeneIDi281888.
KEGGibta:281888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02870 Genomic DNA. Translation: CAA26626.1.
PIRiA02941. KRBOVI.
RefSeqiNP_776802.1. NM_174377.1.
UniGeneiBt.8.

3D structure databases

ProteinModelPortaliP06394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017140.

Proteomic databases

PaxDbiP06394.
PeptideAtlasiP06394.
PRIDEiP06394.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281888.
KEGGibta:281888.

Organism-specific databases

CTDi3858.

Phylogenomic databases

eggNOGiENOG410IGJX. Eukaryota.
ENOG410YDXS. LUCA.
HOGENOMiHOG000205605.
HOVERGENiHBG013015.
InParanoidiP06394.
KOiK07604.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C10_BOVIN
AccessioniPrimary (citable) accession number: P06394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.