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Protein

Keratin, type I cytoskeletal 10

Gene

KRT10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in the establishment of the epidermal barrier on plantar skin.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei379Stutter1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
Cytokeratin VIB
Cytokeratin-10
Short name:
CK-10
Cytokeratin-6B
Keratin-10
Short name:
K10
Gene namesi
Name:KRT10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636411 – 526Keratin, type I cytoskeletal 10Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Disulfide bondi382InterchainBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP06394
PeptideAtlasiP06394
PRIDEiP06394

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Heterodimer with KRT1. Two heterodimers of KRT1 and KRT10 form a heterotetramer. The KRT10 subunit in the heterotetramer is probably disulfide-linked.By similarity

Protein-protein interaction databases

IntActiP06394, 1 interactor
STRINGi9913.ENSBTAP00000017140

Structurei

3D structure databases

ProteinModelPortaliP06394
SMRiP06394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 441IF rodPROSITE-ProRule annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 126HeadAdd BLAST126
Regioni127 – 162Coil 1AAdd BLAST36
Regioni163 – 183Linker 1Add BLAST21
Regioni184 – 275Coil 1BAdd BLAST92
Regioni276 – 298Linker 12Add BLAST23
Regioni299 – 437Coil 2Add BLAST139
Regioni438 – 526TailAdd BLAST89

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJX Eukaryota
ENOG410YDXS LUCA
HOGENOMiHOG000205605
HOVERGENiHBG013015
InParanoidiP06394
KOiK07604

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P06394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRYSSSKQ YSSSRSGGGG GGGSSLRISS SKGSLGGGYS SGGFSGGSFS
60 70 80 90 100
RGSSAGGCFG GSSSIYGGGL GSGFGGGYGS SFGGSYGGSF GGGYGGGGFG
110 120 130 140 150
GGSFGGGSFG GGLGGGFGDG GLISGNQKIT MQNLNDRLAS YLDKVRALEE
160 170 180 190 200
SNYELEVKIK EWYEKYGNSR QREPRDYSKY YQTIDDLKNQ IFNLTTDNAN
210 220 230 240 250
ILIQVDNARL AADDFRLKYE NEVTLRQSVE ADINGLRRVL DELTLTKTDL
260 270 280 290 300
EMQIESLTEE LAYLKKNHEE EMRDLQNVST GDVNVEMNAA PGVDLTELLN
310 320 330 340 350
NMRSQYEQLA EKNRRDAEAW FNEKSKELTT EINSNLEQVS SHKSEITELR
360 370 380 390 400
RTIQGLEIEL QSQLALKQSL EASLAETEGR YCVQLSQIQS QISSLEEQLQ
410 420 430 440 450
QIRAETECQN AEYQQLLDIK IRLENEIQTY RSLLEGEGSS GGGSYGGGRG
460 470 480 490 500
YGGSSGGGGG GYGGGSSSGG YGGGSSSGGG HGGSSGGSYG GGSSSGGGHG
510 520
GGSSSGGHKS TTTGSVGESS SKGPRY
Length:526
Mass (Da):54,848
Last modified:January 1, 1988 - v1
Checksum:iBF6B53C809FBDA48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti467 – 488SSGGY…SSGGS → PAAATAAEVQRWRPRRSFRR Q (PubMed:6209405).CuratedAdd BLAST22
Sequence conflicti494 – 503SSGGGHGGGS → PVAVARRRK (PubMed:6209405).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02870 Genomic DNA Translation: CAA26626.1
PIRiA02941 KRBOVI
RefSeqiNP_776802.1, NM_174377.1
UniGeneiBt.8

Genome annotation databases

GeneIDi281888
KEGGibta:281888

Similar proteinsi

Entry informationi

Entry nameiK1C10_BOVIN
AccessioniPrimary (citable) accession number: P06394
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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