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Protein

H-2 class II histocompatibility antigen, A-U beta chain

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-U beta chain
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 224ExtracellularSequence analysisAdd BLAST197
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 263CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000001899928 – 263H-2 class II histocompatibility antigen, A-U beta chainAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 104PROSITE-ProRule annotation
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi143 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP06344.
PRIDEiP06344.

Interactioni

Protein-protein interaction databases

MINTiMINT-243466.

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 45Combined sources12
Turni46 – 49Combined sources4
Beta strandi50 – 59Combined sources10
Beta strandi62 – 68Combined sources7
Turni69 – 71Combined sources3
Beta strandi73 – 78Combined sources6
Helixi79 – 81Combined sources3
Turni82 – 84Combined sources3
Helixi85 – 91Combined sources7
Helixi93 – 102Combined sources10
Helixi104 – 111Combined sources8
Turni112 – 118Combined sources7
Beta strandi124 – 129Combined sources6
Beta strandi135 – 137Combined sources3
Beta strandi140 – 151Combined sources12
Beta strandi154 – 159Combined sources6
Beta strandi162 – 164Combined sources3
Beta strandi168 – 170Combined sources3
Beta strandi177 – 179Combined sources3
Beta strandi181 – 188Combined sources8
Beta strandi196 – 202Combined sources7
Beta strandi210 – 215Combined sources6
Turni216 – 218Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K2DX-ray2.20B28-216[»]
1U3HX-ray2.42D/H28-215[»]
2P24X-ray2.15B28-224[»]
2PXYX-ray2.23D29-217[»]
2Z31X-ray2.70D28-216[»]
ProteinModelPortaliP06344.
SMRiP06344.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06344.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 211Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 120Beta-1Add BLAST93
Regioni121 – 214Beta-2Add BLAST94
Regioni215 – 224Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQIPSLLL LAAVVVLMVL SSPGTEGGDS ERHFVVQFQP FCYFTNGTQR
60 70 80 90 100
IRYVTRYIYN REEYLRFDSD VGEYRAVTEL GRPDAEYYNK QYLERTRAEL
110 120 130 140 150
DTVCRYNYEE TEVPTSLRRL EQPNVVISLS RTEALNHHNT LVCSVTDFYP
160 170 180 190 200
AKIKVRWFRN GQEETVGVSS TQLIRNGDWT FQVLVMLEMT PRRGEVYTCH
210 220 230 240 250
VEHPSLKSPI TVEWRAQSES ARSKMLSGIG GCVLGVIFLG LGLFIRHRSQ
260
KGPRGPPPAG LLQ
Length:263
Mass (Da):30,041
Last modified:January 1, 1988 - v1
Checksum:i1ECEF8669CF91389
GO

Sequence databases

PIRiA02239. HLMSBU.
UniGeneiMm.254067.

Cross-referencesi

Sequence databases

PIRiA02239. HLMSBU.
UniGeneiMm.254067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K2DX-ray2.20B28-216[»]
1U3HX-ray2.42D/H28-215[»]
2P24X-ray2.15B28-224[»]
2PXYX-ray2.23D29-217[»]
2Z31X-ray2.70D28-216[»]
ProteinModelPortaliP06344.
SMRiP06344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-243466.

Proteomic databases

MaxQBiP06344.
PRIDEiP06344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG012730.

Miscellaneous databases

EvolutionaryTraceiP06344.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHB2U_MOUSE
AccessioniPrimary (citable) accession number: P06344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.